期刊
JOURNAL OF FUNCTIONAL FOODS
卷 40, 期 -, 页码 261-271出版社
ELSEVIER
DOI: 10.1016/j.jff.2017.11.004
关键词
Dendrobium officinale; Polysaccharide; Glucose metabolism; Glycogen synthesis; Glucose metabolism enzymes; PI3K/Akt signaling pathway
资金
- National Natural Science Foundation of China [81373300]
- Youth Science Foundation [31500283]
This study aimed to explore the therapeutic effects of Dendrobium officinale polysaccharide (DOP), an active ingredient isolated from the water extract of Dendrobium officinale, in streptozotocin (STZ)-induced type 2 diabetic BALB/c mice and its potential mechanisms. Our results showed that DOP had beneficial effects in ameliorating hyperglycemia, insulin resistance and dyslipidemia. Additionally, DOP promoted glycogen synthesis via regulating the expression of glycogen synthase kinase 3 beta (GSK-3 beta), glycogen synthase (GS) and glucose transporter 4 (GLUT4) in the liver or muscle. Moreover, DOP reduced the blood glucose levels via the regulation of glucose metabolizing enzyme activity including pyruvate kinase (PK), hexokinase (HK) and phosphoenolpyruvate carboxykinase (PEPCK) in the liver. Furthermore, mechanistic studies illustrated that DOP could up-regulate the expression of PI3K/Akt signaling proteins both in vivo and in vitro. Our findings revealed that DOP improves glucose metabolism disorder by promoting glycogen synthesis and regulating the activity of glucose metabolism enzymes.
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