期刊
ONCOTARGETS AND THERAPY
卷 11, 期 -, 页码 2901-2910出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S160911
关键词
breast neoplasm; prognostic factors; lymphocytes; neutrophil-to-lymphocyte ratio
Purpose: Breast cancer (BC) is a highly heterogeneous disease presenting a broad range of clinical and molecular characteristics. In the past years, a growing body of evidence demonstrated that immune response plays a significant role in cancer outcome. However, immune prognostic markers are not completely validated in clinical practice in BC patients. Materials and methods: With the aim to characterize immune features, several parameters were analyzed in peripheral blood at diagnosis of 85 nonmetastatic BC patients between April 2011 and My 2014. Results: With a median follow-up of 38.6 months, peripheral blood analysis of BC patients (stages I, II, and III) showed that total lymphocyte and T lymphocyte counts were augmented in nonrelapsed patients. Also, a higher neutrophil-to-lymphocytes ratio was associated with prolonged disease-tree survival. Natural killer cell receptor analysis revealed that early activation receptor CD69 was associated with a better outcome. Conclusion: This preliminary evidence is in accordance with the concept of immune surveillance. We suggest an immune phenotype that provides relevant prognostic information in early-stage BC patients and which could he useful in the decision-making process.
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