期刊
FRONTIERS IN NEURAL CIRCUITS
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncir.2017.00111
关键词
serotonin; central fatigue; spinal cord; motor behavior; motor control; turtle; motoneuron; gain modulation
资金
- Inge Berthelsens legat Fonden
- Owensenske Fond
- Simon Fougner Hartmanns Familiefond
- Agnes and Poul Friis Fond
- Lundbeck Foundation
- Carlsbergfondet
- Laege Sofus Carl Emil Friis og Hustru Olga Doris Friis' Legat
Motor fatigue occurring during prolonged physical activity has both peripheral and central origins. It was previously demonstrated that the excitability of motoneurons was decreased when a spillover of serotonin could activate extrasynaptic 5-HT1A receptors at the axon initial segment (AIS) of motoneurons. Here we investigated the impact of massive synaptic release of serotonin on motor behavior in an integrated preparation of the adult turtle performing fictive scratching behaviors. We found that a prolonged electrical stimulation of the raphe spinal pathway induced a reversible inhibition of the motor behavior that lasted several tens of seconds. The effect disappeared when the spinal cord was perfused with an antagonist for 5-HT1A receptors. By demonstrating a direct impact of serotonin on motor behavior, we suggest a central role of this monoamine behind central fatigue.
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