Article
Endocrinology & Metabolism
Benedict Herhaus, Niklas Joisten, Inga Wessels, Philipp Zimmer, Katja Petrowski
Summary: Psychological stress and physical stress both affect the kynurenine pathway and inflammatory mediators, but the metabolic response is more pronounced after physical stress, suggesting an exercise-induced neuroprotective mechanism.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Samy Hakroush, Desiree Tampe, Peter Korsten, Philipp Stroebel, Michael Zeisberg, Bjorn Tampe
Summary: Renal involvement is a common and severe complication of AAV, with histopathological subgrouping and ARRS being predictive of long-term ESRD. In critically ill AAV patients requiring intensive care treatment, certain histopathological findings can predict the severity of AKI and need for RRT, while global glomerular scarring is a strong predictor of failure to recover from RRT after remission induction therapy. Further prospective studies are needed to explore the implications of these findings for therapeutic decision making in this patient subgroup.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Francois Lamontagne, Marie-Helene Masse, Julie Menard, Sheila Sprague, Ruxandra Pinto, Daren K. Heyland, Deborah J. Cook, Marie-Claude Battista, Andrew G. Day, Gordon H. Guyatt, Salmaan Kanji, Rachael Parke, Shay P. McGuinness, Bharath-Kumar Tirupakuzhi Vijayaraghavan, Djillali Annane, Dian Cohen, Yaseen M. Arabi, Brigitte Bolduc, Nicole Marinoff, Bram Rochwerg, Tina Millen, Maureen O. Meade, Lori Hand, Irene Watpool, Rebecca Porteous, Paul J. Young, Frederick D'Aragon, Emilie P. Belley-Cote, Elaine Carbonneau, France Clarke, David M. Maslove, Miranda Hunt, Michael Chasse, Martine Lebrasseur, Francois Lauzier, Sangeeta Mehta, Hector Quiroz-Martinez, Oleksa G. Rewa, Emmanuel Charbonney, Andrew J. E. Seely, Demetrios J. Kutsogiannis, Remi LeBlanc, Armand Mekontso-Dessap, Tina S. Mele, Alexis F. Turgeon, Gordon Wood, Sandeep S. Kohli, Jason Shahin, Pawel Twardowski, Neill K. J. Adhikari
Summary: A study on the use of intravenous vitamin C in adult sepsis patients receiving vasopressor therapy in the ICU showed that there is a higher risk of death or persistent organ dysfunction compared to placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Food Science & Technology
Qi Zhan, Rui Wang, Kiran Thakur, Jing-Yu Feng, Yun-Yang Zhu, Jian-Guo Zhang, Zhao-Jun Wei
Summary: Nutrition-gut cross-talk and the metabolism of B vitamins play vital roles in maintaining intestinal function and gut microbiome diversity. While some organisms can synthesize B vitamins, others rely on dietary intake and gut microbial production. This sharing and exchange of B vitamins contribute to gut homeostasis and may have implications in brain energy metabolism.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Surgery
Nicolo Pecorelli, Stefano Turi, Maria Teresa Salvioni, Giovanni Guarneri, Pietro Barbieri, Alessia Vallorani, Domenico Tamburrino, Stefano Crippa, Stefano Partelli, Luigi Beretta, Massimo Falconi
Summary: This study aimed to determine the predictors of unplanned ICU admission in patients undergoing pancreatectomy and compare outcomes between direct and late ICU admission. The study found that patient comorbidities, surgical complexity, and lactic acidosis at the end of surgery were associated with unplanned postoperative ICU admission. Late ICU admission had higher mortality rates compared to direct admission.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Gastroenterology & Hepatology
Constantine J. J. Karvellas, Thierry Gustot, Javier Fernandez
Summary: Acute on chronic liver failure (ACLF) is the development of organ failure(s) in cirrhosis patients and has a high short-term mortality rate. Medical management of ACLF needs to consider the relationship between the underlying chronic liver disease/cirrhosis, precipitating insult, and involved organ systems. Intensive care management of ACLF focuses on promptly recognizing and treating triggering events and providing aggressive support for failing organs to ensure successful liver transplantation or recovery. The complexity of managing ACLF patients arises from their propensity to develop new organ failures and complications like infections or bleeding. A multidisciplinary team with expertise in critical care and transplant medicine is best suited for the management of critically ill ACLF patients. This review aims to identify common complications of ACLF and describe the appropriate management for critically ill patients awaiting liver transplantation, including organ support, prognostic assessment, and determining the likelihood of recovery.
LIVER INTERNATIONAL
(2023)
Review
Anesthesiology
N. Boyer, K. Horne, N. M. Selby, L. G. Forni
Summary: Kidney disease is common in intensive care units and can greatly impact prescribing and therapeutic management due to the kidneys' role in maintaining whole body homeostasis. This review explores the pathophysiology of acute kidney injury and chronic kidney disease in critically ill patients. It covers various aspects of renal dysfunction management, including kidney replacement therapy, acute kidney injury management, and the use of novel biomarkers for identifying and stratifying patients. Early involvement of nephrology specialists can improve outcomes and provide valuable guidance for patients with end stage kidney disease or already known to nephrology services. Ongoing research questions within this field are also discussed.
Article
Medical Laboratory Technology
Yuichiro Shimoyama, Noriko Kadono, Osamu Umegaki, Toshiaki Minami
Summary: The combination of NGAL and ΔNGAL with inflammation-based prognostic scores provides better prediction of mortality in septic patients, particularly on day 2 after ICU admission and beyond.
CLINICA CHIMICA ACTA
(2021)
Article
Multidisciplinary Sciences
Ryoung-Eun Ko, Sungeun Kim, Jihye Lee, Sojin Park, Daehwan Bae, Ki Hong Choi, Taek Kyu Park, Chi Ryang Chung, Jeong Hoon Yang
Summary: This study examines the clinical phenotypes of delirium in cardiac intensive care unit (CICU) patients and their relationship with clinical outcomes. The results show that delirium is common in CICU patients and is associated with increased in-hospital mortality. Septic delirium and hypoxic delirium are the most common delirium phenotypes.
Article
Gastroenterology & Hepatology
Osvely Mendez-Guerrero, Daniel A. Calle-Rodas, Eduardo Cervantes-Alvarez, Elisa Alatorre-Arenas, Juanita Perez-Escobar, Nalu Navarro-Alvarez, Aldo Torre
Summary: ACLF patients with renal and brain failure have significantly higher mortality rates, indicating that these factors are independent predictors of 28-and 90-day mortality.
ANNALS OF HEPATOLOGY
(2021)
Article
Nursing
Kelly Calkins, Peninnah Kako, Jill Guttormson
Summary: The study examines barriers and facilitators of recovery for critical illness survivors who lack dedicated outpatient care. Participants faced various barriers at home but showed resilience in overcoming them. Seeking support from family and friends, lifestyle adaptations, and creative management of medical needs were found to support recovery, while unmet needs like mental health issues and coordination of care left survivors feeling unsupported by healthcare providers.
JOURNAL OF ADVANCED NURSING
(2021)
Article
Immunology
Tazio Maleitzke, Sijia Zhou, Dario Zocholl, Florian Nima Fleckenstein, David Alexander Back, Julius Maximilian Plewe, Jerome Weber, Tobias Winkler, Ulrich Stoeckle, Serafeim Tsitsilonis, Sven Maerdian
Summary: Knife crime has increased in Northern Europe, leading to an increase in stab injury cases. This study aims to analyze routine laboratory parameters and their association with ICU admission, hospitalization, and surgeries in stab injury patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mariya A. Kovaleva, Abigail C. Jones, Christine Cleary Kimpel, Jana Lauderdale, Carla M. Sevin, Joanna L. Stollings, James C. Jackson, Leanne M. Boehm
Summary: This study aimed to explore patient and informal caregiver experiences with a telemedicine ICU-RC. The study found that participants found the telemedicine delivery convenient, time-saving, and conducive to thorough discussions. Participants appreciated the information, reassurance, and validation provided by the ICU-RC. The study results help to improve the delivery and content of telemedicine ICU-RCs.
Review
Critical Care Medicine
Alexandra Hetherington, Filipe S. Cardoso, Erica L. W. Lester, Constantine J. Karvellas
Summary: The article reviews the surgical and critical care management of liver trauma, which is one of the most common abdominal injuries due to its size and location. The article summarizes the classification, treatment strategies, and management goals in the acute phase of traumatic liver injuries, highlighting the importance of multidisciplinary care in experienced liver surgery centers.
CURRENT OPINION IN CRITICAL CARE
(2022)
Review
Chemistry, Medicinal
Frederike T. Fellendorf, Nina Bonkat, Nina Dalkner, Elena M. D. Schoenthaler, Mirko Manchia, Dietmar Fuchs, Eva Z. Reininghaus
Summary: This review highlights the inconsistent findings on KYN/TRP ratio in severe mental disorders. Although there are indications of inflammation associated with elevated IDO activity, no conclusive statements can be made. Considering factors such as inflammatory processes, metabolic activities, and psychological/neuropsychiatric symptoms are crucial for a deeper understanding of the underlying mechanisms.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Geriatrics & Gerontology
Ivo W. Soliman, Susannah Leaver, Hans Flaatten, Jesper Fjolner, Bernhard Wernly, Raphael R. Bruno, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Jakob Wollborn, Maria Jose Arche Banzo, Kristina Fuest, Brian Marsh, Finn H. Andersen, Rui Moreno, Ariane Boumendil, Bertrand Guidet, Christian Jung, Dylan W. De Lange
Summary: This study aims to assess the health-related quality of life (HRQoL) in ICU patients surviving COVID-19 and identify areas for intervention. The findings indicate that the Clinical Frailty Scale (CFS) is associated with subjective quality of life in critically ill older COVID-19 patients, while Katz ADL is not significantly associated.
Article
Anesthesiology
Kamil Polok, Jakub Fronczek, Peter Vernon van Heerden, Hans Flaatten, Bertrand Guidet, Dylan W. De Lange, Jesper Fjolner, Susannah Leaver, Michael Beil, Sigal Sviri, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Dorota Studzinska, Michael Joannidis, Sandra Oeyen, Brian Marsh, Finn H. Andersen, Rui Moreno, Maurizio Cecconi, Christian Jung, Wojciech Szczeklik
Summary: This study investigated the relationship between early tracheostomy and outcomes for elderly patients with COVID-19, finding that early tracheostomy did not have a significant impact on 3-month mortality, ICU length of stay, or duration of mechanical ventilation.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Rehabilitation
Sabrina Eggmann, Martin L. Verra, Valentine Stefanicki, Angela Kindler, Joerg C. Schefold, Bjoern Zante, Caroline H. G. Bastiaenen
Summary: This study investigated the predictive validity of the CPAx tool in critically ill adults at ICU discharge for their 90-day outcomes. The results showed that the CPAx had good accuracy in predicting a return to home within 90 days, but was not associated with subsequent health-related quality of life.
DISABILITY AND REHABILITATION
(2023)
Article
Cardiac & Cardiovascular Systems
Raphael Romano Bruno, Bernhard Wernly, Georg Wolff, Jesper Fjolner, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Detlef Kindgen-Milles, Philipp Heinrich Baldia, Malte Kelm, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Arzu Topeli, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Eumorfia Kondili, Brian Marsh, Finn H. Andersen, Rui Moreno, Susannah Leaver, Ariane Boumendil, Dylan W. De Lange, Bertrand Guidet, Hans Flaatten, Christian Jung
Summary: Pre-existing chronic heart failure in critically ill older COVID-19 patients was not independently associated with 30-day mortality after adjusting for confounders.
Article
Nursing
Marie-Madlen Jeitziner, Beatrice Jenni-Moser, Bjoern Zante, Katja Erne, Maria Brauchle, Sarah A. Moser, Joerg C. Schefold, Karin Amrein, Magdalena Hoffmann
Summary: This study assessed the opinions and experiences of healthcare professionals, former patients, and their families during the first wave of the COVID-19 pandemic. It found that family support in the intensive care unit was perceived as highly important, and virtual contact through video calls and websites was implemented to establish confidence in the treatment.
INTENSIVE AND CRITICAL CARE NURSING
(2023)
Article
Anesthesiology
Mark Borthwick, Anders Granholm, Soren Marker, Mette Krag, Theis Lange, Matt P. Wise, Stepani Bendel, Frederik Keus, Anne Berit Guttormsen, Joerg C. Schefold, Jorn Wetterslev, Anders Perner, Morten Hylander Moller
Summary: Critically ill patients are at risk of gastrointestinal bleeding, and pharmacological stress ulcer prophylaxis (SUP) is commonly used to minimize this risk. The effect of enteral nutrition as SUP on GI bleeding rates is uncertain, with conflicting data and variable practice. This study aims to explore the association between enteral nutrition and GI bleeding rates in ICU patients and evaluate any interactions with pharmacologic SUP. The results may provide important insights for guiding practice and designing future clinical trials on the effect of enteral nutrition on GI bleeding.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Review
Pharmacology & Pharmacy
Livia Mueller, Michel Moser, Josef Prazak, Daniel G. Fuster, Joerg C. Schefold, Patrick Zuercher
Summary: This study investigated the impact of renal dysfunction and renal replacement therapy (RRT) on the outcomes of metformin-associated lactic acidosis (MALA). Higher ingested metformin dose and plasma/serum creatinine levels were associated with a better outcome. Patients receiving RRT had higher plasma/serum creatinine levels, higher lactate levels, and lower arterial pH. Survival was similar in patients with or without need for RRT.
Letter
Anesthesiology
Georg Wolff, Bernhard Wernly, Hans Flaatten, Jesper Fjolner, Raphael Romano Bruno, Antonio Artigas, Bernardo Bollen C. Pinto, Joerg C. Schefold, Malte Kelm, Stephan Binneboessel, Philipp Baldia, Michael Beil, Sigal Sivri, Peter Vernon van Heerden, Wojciech Szczeklik, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Maria Flamm, Brian H. Marsh, Finn H. Andersen, Rui Moreno, Ariane W. Boumendil, Dylan W. De Lange, Bertrand Guidet, Susannah Leaver, Christian Jung, COVIP Study Grp
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Article
Infectious Diseases
Timo Mayerhoefer, Sebastian Klein, Bernhard Wernly, Hans Flaatten, Bertrand Guidet, Dylan W. De Lange, Jesper Fjolner, Susannah Leaver, Michael Beil, Sigal Sviri, Raphael Romano Bruno, Antonio Artigas, Peter Vernon van Heerden, Bernardo Bollen Pinto, Joerg C. Schefold, Rui Moreno, Maurizio Cecconi, Wojciech Szczeklik, Christian Jung, Michael Joannidis
Summary: This study investigated the impact of diabetes mellitus on 90-day mortality in a high-risk cohort of critically ill patients over 70 years of age. The study found that patients with diabetes had a significantly higher 90-day mortality rate compared to those without diabetes. This suggests that diabetes is a relevant risk factor for COVID-19 in old critically ill patients.
Article
Medicine, Research & Experimental
Sascha David, Christian Bode, Klaus Stahl
Summary: This is a clinical trial evaluating the impact of early therapeutic plasma exchange (TPE) on patients with septic shock. The researchers hypothesize that TPE can mitigate the maladaptive host response, thereby limiting organ dysfunction and improving survival. This study has the potential to change the current treatment standard for this condition.
Article
Critical Care Medicine
Magdalena Hoffmann, Marie-Madlen Jeitziner, Regina Riedl, Gerhard Mueller, Andreas Peer, Adelbert Bachlechner, Patrik Heindl, Harald Burgsteiner, Joerg C. Schefold, Dirk von Lewinski, Philipp Eller, Thomas Pieber, Gerald Sendlhofer, Karin Amrein
Summary: Family members of critically ill patients often experience significant PTSD symptoms, and online information about intensive care does not lead to a reduction in these symptoms.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Anna Messmer, Urs Pietsch, Martin Siegemund, Philipp Buehler, Jan Waskowski, Martin Muller, Dominik E. Uehlinger, Alexa Hollinger, Miodrag Filipovic, David Berger, Joerg C. Schefold, Carmen A. Pfortmueller
Summary: The study aims to assess the efficacy and feasibility of an early de-resuscitation protocol in patients with septic shock. Fluid management will be performed according to the REDUCE protocol, and outcomes will include cumulative fluid balances, number of patients with fluid overload, feasibility, safety outcomes, and patient-centered outcomes.
Article
Critical Care Medicine
Kamil Polok, Jakub Fronczek, Bertrand Guidet, Antonio Artigas, Dylan W. De Lange, Jesper Fjolner, Susannah Leaver, Michael Beil, Sigal Sviri, Raphael Romano Bruno, Bernhard Wernly, Bernardo Bollen Pinto, Joerg C. Schefold, Dorota Studzinska, Michael Joannidis, Sandra Oeyen, Brian Marsh, Finn H. Andersen, Rui Moreno, Maurizio Cecconi, Hans Flaatten, Christian Jung, Wojciech Szczeklik
Summary: This study compared the outcomes of older critically ill patients treated with non-invasive ventilation (NIV) during and before the COVID-19 pandemic. The results showed that older patients aged 80 years and above treated with NIV during the COVID-19 pandemic had worse outcomes in terms of mortality, intubation rate, and NIV failure compared to the pre-pandemic era.
ANNALS OF INTENSIVE CARE
(2023)
Article
Medicine, General & Internal
Aileen C. Naef, Samuel E. J. Knobel, Nicole Ruettgers, Marilyne Rossier, Marie-Madlen Jeitziner, Bjoern Zante, Rene M. Muri, Joerg C. Schefold, Tobias Nef, Stephan M. Gerber
Summary: Elevated sound pressure levels in the ICU negatively impact patient and staff health. This study identified sources such as cleaning, admission, discharge, and renal interventions that contribute to high sound pressure levels. Recognizing these sources can help target future interventions and create a healthier environment.
FRONTIERS IN MEDICINE
(2023)
Article
Critical Care Medicine
Rudolf Likar, Ilia Aroyo, Katrin Bangert, Bjorn Degen, Rainer Dziewas, Oliver Galvan, Michaela Trapl Grundschober, Markus Kostenberger, Paul Muhle, Joerg C. Schefold, Patrick Zuercher
Summary: This article presents expert opinions on the diagnosis and management of dysphagia in ICU patients. The panel suggests adopting clinical algorithms to promote standardized and high-quality care, and proposes two clinical management algorithms to improve early detection and effective treatment of dysphagia in ICU patients.
JOURNAL OF CRITICAL CARE
(2024)
