Article
Gastroenterology & Hepatology
Sahar Tabatabavakili, Wesam Aleyadeh, Orlando Cerrocchi, Harry L. A. Janssen, Bettina E. Hansen, Isaac I. Bogoch, Jordan J. Feld
Summary: Sexual transmission of HCV is uncommon in HIV-negative MSM PrEP users, but there are higher rates of other STIs. Routine risk-based HCV surveillance and periodic STI monitoring are recommended for PrEP users.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
Alana G. Hudson, Robert A. Bonacci, Anne C. Moorman, McKenna Penley, Suzanne M. Wilson, Jessica L. Hoffman, Erica R. Thomasson, R. Paul McClung, Danae Bixler
Summary: Among 65 cases of HIV outbreak among persons who inject drugs (PWID) in West Virginia (2019-2021), 94% were diagnosed with hepatitis C a median of 46 months before HIV diagnosis. Diagnosis of hepatitis C among PWID should lead to improved access to prevention and treatment services.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Laurent Cotte, Laurent Hocqueloux, Maeva Lefebvre, Pierre Pradat, Firouze Bani-Sadr, Thomas Huleux, Isabelle Poizot-Martin, Pascal Pugliese, David Rey, Andre Cabie
Summary: A significant shift in HCV epidemiology was observed in people living with HIV in France from 2012 to 2018, with a decrease in overall HCV prevalence but an increase in new infections among men who have sex with men (MSM), making MSM the primary group for HCV transmission in 2018.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Alia Alassad, Mhd Jawad Al Rahwanji, Amal Yousfan, Sally Al Moualem, Arwa Farhat, Lama A. Youssef
Summary: The seroprevalence of HBV, HCV, and HIV has decreased in Syria over an 18-year period, possibly due to the implementation of the HBV vaccine, a strong national health system, conservative sociocultural values, and isolation.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Oncology
Sung-Shuo Kao, Chia-Jung Li, James Cheng-Chung Wei, Cheng-Li Lin, Renin Chang, Yao-Min Hung
Summary: Previous studies have suggested a link between HCV and HPV-associated head and neck cancers. However, limited studies have examined the association between HPV infection and the risk of new-onset hepatocellular carcinoma (HCC) among chronic hepatitis C (CHC) patients. This study found that HPV infection was associated with a lower risk of subsequent HCC among CHC patients.
Article
Infectious Diseases
Mawuena Binka, Zahid Ahmad Butt, Geoffrey McKee, Maryam Darvishian, Darrel Cook, Stanley Wong, Amanda Yu, Maria Alvarez, Hasina Samji, Jason Wong, Mel Krajden, Naveed Zafar Janjua
Summary: This study examined factors associated with HBV and/or HCV and/or HIV infection among different ethnic groups in a large population-based cohort in British Columbia, Canada. It found variations in risk factor distributions among individuals of different ethnic backgrounds, highlighting the need for tailored infection screening approaches for different ethnic groups.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Yu Fang, Chung-Yu Chen, Hsien-Chung Yu, Pei-Chin Lin
Summary: This retrospective cohort study used Taiwan's National Health Insurance Research Database to evaluate the difference in incidence of neuropsychological disorders (NPDs) between chronic hepatitis C patients receiving interferon therapy and direct-acting antivirals (DAAs) therapy. The study found that patients receiving DAA therapy had a lower risk of NPDs compared to those receiving interferon therapy during the 6-month period after treatment completion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Po-Yao Hsu, Yu-Ju Wei, Po-Cheng Liang, Jia-Jung Lee, Sheng-Wen Niu, Jiun-Chi Huang, Cheng-Ting Hsu, Tyng-Yuan Jang, Ching- Huang, Yi-Hung Lin, Ming-Yen Hsieh, Meng-Hsuan Hsieh, Szu-Chia Chen, Chia-Yen Dai, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Jer-Ming Chang, Ming-Lun Yeh, Chung-Feng Huang, Yi-Wen Chiu, Shang-Jyh Hwang, Wan-Long Chuang, Ming-Lung Yu
Summary: Hemodialysis patients are at increased risk of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. This study found that hemodialysis patients with HCV exhibited a higher burden of comorbidities, especially in ischemic heart diseases, respiratory disorders, and mental/behavioral disorders, compared to patients with HBV and those without viral hepatitis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Dae Hyun Lim, Jae Yoon Jeong, Seongwoo Nam, Jongkyoung Choi, Hyeok Choon Kwon, Yong Bum Yoon, Yeonjae Kim, BumSik Chin
Summary: In Korea, HCV/HIV-coinfected patients receiving antiviral treatment were younger, had a higher proportion of men, a higher incidence of genotype 1a, and less advanced fibrosis compared to HCV-monoinfected patients. In actual clinical settings, HCV/HIV-coinfected patients showed excellent SVR to DAA treatment, similar to HCV-monoinfected patients.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Virology
Xizi Deng, Zhiwei Liang, Weiping Cai, Feng Li, Junbin Li, Fengyu Hu, Yun Lan
Summary: This study revealed the diversity and distribution of HCV subgenotypes among HIV/HCV-coinfected patients in Guangdong, China. Marital status was found to potentially influence the formation of HCV transmission networks.
Article
Medicine, General & Internal
Xiaofei Li, Shuang Wu, Yuexiao Yu
Summary: Aspirin use may be independently associated with a reduced risk of hepatocellular carcinoma in patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, but may increase the risk of gastrointestinal bleeding. These findings need to be validated in clinical trials.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Eveline Hofmann, Bernard Surial, Noemie Boillat-Blanco, Huldrych F. Guenthard, Marcel Stoeckle, Enos Bernasconi, Patrick Schmid, Alexandra Calmy, Franziska Suter-Riniker, Andri Rauch, Gilles Wandeler, Charles Beguelin
Summary: In the Swiss HIV Cohort Study, researchers found that 27% of HIV-suppressed individuals with chronic hepatitis B virus (HBV) infection had HBV replication after two years on tenofovir. However, 77% of them were able to achieve suppression thereafter. Self-reported adherence to therapy and HBV viral load at tenofovir initiation were identified as predictors of persistent replication.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Noboru Urata, Tsunamasa Watanabe, Noboru Hirashima, Yoshiyuki Yokomaku, Junji Imamura, Yasumasa Iwatani, Masaaki Shimada, Yasuhito Tanaka
Summary: In HIV/HBV coinfected patients, IRIS can cause hepatic flare and lead to loss of HBsAg, but the specific factors leading to HBsAg clearance remain unclear. This study found that patients in the HBsAg clearance group had higher concentrations of various cytokines and chemokines in their serum.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Hsiao-Sang Chu, Olivia J. Killeen, Yi-Ting Hsieh, Tung-Hung Su, H. Kaz Soong, Chung-Liang Shih, Fung-Rong Hu
Summary: This study aims to investigate the rationality of the allocation guidelines in a hepatitis B endemic area that uses corneas from hepatitis B donors. The results showed that allocating corneas from HBsAg(+) or anti-HBc(+) donors to HBsAg(+) or hepatitis B surface antibody recipients maximizes cornea usage from hepatitis B donors without compromising transplant safety.
Review
Gastroenterology & Hepatology
Michael Evan Rogers, William F. Balistreri
Summary: Chronic hepatitis C virus (HCV) infection is a significant global public health burden, with over 400000 deaths attributed to HCV in 2015. The World Health Organization (WHO) has set the ambitious goal of eliminating HCV by 2030, but the issue of HCV infection in children and adolescents remains significant. In the United States, HCV infection rates in women of childbearing age and pregnant women have increased alongside the opioid epidemic, highlighting the need to focus on the younger population under 18 years old.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Infectious Diseases
Guilherme Calvet, Maria Ogrzewalska, Wagner Tassinari, Lusiele Guaraldo, Paola Resende, Trevon Fuller, Stephanie Penetra, Michele Borges, Anielle Pina-Costa, Ezequias Martins, Isabella Moraes, Heloisa Santos, Luana Damasceno, Fernando Medeiros-Filho, Otavio Espindola, Fernando Mota, Valeria Nacife, Alex Pauvolid-Correa, Jimmy Whitworth, Chris Smith, Marilda Siqueira, Patricia Brasil
Summary: Saliva is a reliable sample for detecting SARS-CoV-2, especially in symptomatic children and adolescents during the circulation of the Omicron variant.
BMC INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Lara E. Coelho, Thiago S. Torres, Emilia M. Jalil, Sandra W. Cardoso, Ronaldo I. Moreira, Guilherme A. Calvet, Antonio G. Pacheco, Valdilea G. Veloso, Beatriz Grinsztejn, Paula M. Luz
Summary: A study in Rio de Janeiro, Brazil, found that despite the universal access to antiretroviral therapy, there are still disparities in mortality rates among people living with HIV based on gender and sexual orientation. Men with unknown sexual orientation and men who have sex with women had higher death hazard ratios compared to men who have sex with men. However, there was no significant difference in death hazard ratios for cisgender and transgender women.
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Urology & Nephrology
Denise Mafra, Livia Alvarenga, Marcia Ribeiro, Beatriz G. Baptista, Susane Fanton, Bruna R. Paiva, Liana Trugilho, Julie Ann Kemp, Marcelo Alves-Ribeiro, Ludmila F. M. F. Cardozo
Summary: This study aimed to evaluate the expression of Bach1 mRNA in different treatments for chronic kidney disease (CKD). The results showed that Bach1 mRNA expression was significantly higher in patients undergoing hemodialysis compared to peritoneal dialysis and nondialysis patients. This suggests that Bach1 may be a therapeutic target for regulating inflammation in CKD patients.
HEMODIALYSIS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Otavio Melo Espindola, Trevon L. Fuller, Mia Ferreira de Araujo, Luis Fernando Lopez Tort, Lusiele Guaraldo, Guilherme Calvet, Paola Resende, Myrna Bonaldo, Jimmy Whitworth, Chris Smith, Marilda Siqueira, Patricia Brasil
Summary: COVID-19 vaccines have reduced rates of severe infection requiring hospitalization but are less effective against SARS-CoV-2 variants in preventing symptomatic infection. This study examined the antibodies generated after complete vaccination and boosting, finding that binding antibodies decayed slowly in individuals under 60 with hybrid immunity. Neutralizing antibodies against Omicron BA.1 were lower compared to other variants. The response to the first booster dose was stronger than the response to the second booster dose. Monitoring the effects of SARS-CoV-2 mutations on disease severity and therapeutic effectiveness is important.
SCIENTIFIC REPORTS
(2023)
Article
Infectious Diseases
Clarisse da Silveira Bressan, Maria de Lourdes Benamor Teixeira, Maria Isabel Fragoso da Silveira Gouvea, Anielle de Pina-Costa, Heloisa Ferreira Pinto Santos, Guilherme Amaral Calvet, Otilia Lupi, Andre Machado Siqueira, Rogerio Valls-de-Souza, Clarissa Valim, Patricia Brasil
Summary: This study describes the most common etiologies of acute febrile illnesses observed over a 16-year period in a national reference center for tropical diseases research in Rio de Janeiro, Brazil. Parasitic diseases and tropical infections were found to be the most common diagnoses, with limited accuracy in clinical symptoms and traditional diagnostic methods. Therefore, there is a need for improvement in diagnostic technologies and surveillance capacity.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Biology
Karina dos Santos, Eliane Lopes Rosado, Ana Carolina Proenca da Fonseca, Gabriella Pinto Belfort, Leticia Barbosa Gabriel da Silva, Marcelo Ribeiro-Alves, Veronica Marques Zembrzuski, Mario Campos Jr., Lenita Zajdenverg, Michele Drehmer, J. Alfredo Martinez, Claudia Saunders
Summary: In a nutrigenetic trial in Rio de Janeiro, Brazil, the factors influencing hypertensive disorders of pregnancy (HDP) were analyzed. The study found that black skin color, previous preeclampsia, elevated blood pressure in the third trimester, elevated blood pressure in the first trimester, mean blood pressure, and high HbA1c level were significant risk factors for HDP. However, dietetic and genotypic features did not have a significant impact on the outcome.
Article
Immunology
Stephanie L. S. Penetra, Heloisa F. P. Santos, Paola Cristina Resende, Leonardo Soares Bastos, Michele F. B. da Silva, Anielle Pina-Costa, Renata Serrano Lopes, Leonardo Saboia-Vahia, Any Caroline Alves de Oliveira, Elisa Cavalcante Pereira, Fernando Medeiros Filho, Mayumi D. Wakimoto, Guilherme A. Calvet, Trevon L. Fuller, Jimmy Whitworth, Christopher Smith, Karin Nielsen-Saines, Marilia Sa Carvalho, Otavio M. Espindola, Lusiele Guaraldo, Marilda M. Siqueira, Patricia Brasil
Summary: This household-based prospective cohort study in Rio de Janeiro followed individuals with confirmed COVID-19 and their household contacts from April 2020 to June 2022. The study identified 98 reinfections, with 71 confirmed by genomic analyses in both infections. Vaccination was found to reduce the risk of reinfection during the pre-Omicron period, but even booster vaccines had no effect during the Omicron period. Most reinfections were asymptomatic or milder than primary infections, highlighting the importance of active surveillance in vaccinated individuals. The study emphasized the need to continuously update SARS CoV-2 vaccines and administer booster doses regularly, following the strategy used in influenza immunization programs.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Angie R. Lopez, Ezequias B. Martins, Anielle de Pina-Costa, Ana Beatriz Pacheco-Silva, Marcel T. Ferreira, Roxana F. Mamani, Paula J. T. Detepo, Otilia Lupi, Clarisse S. Bressan, Guilherme A. Calvet, Michele F. B. Silva, Maria de Fatima Ferreira-da-Cruz, Fernanda de Bruycker-Nogueira, Ana Maria B. Filippis, Claudio Tadeu Daniel-Ribeiro, Andre Siqueira, Patricia Brasil
Summary: This article reports a case of a 40-year-old previously healthy woman who died of acute respiratory distress syndrome caused by severe respiratory vivax malaria after 5 days of treatment with chloroquine and primaquine. The respiratory symptoms appeared 48 hours after the initiation of anti-malarial drugs, raising the hypothesis that the drugs may have been involved in the complication. The article highlights the importance of early diagnosis of vivax malaria.
Article
Dentistry, Oral Surgery & Medicine
Tatiana Jorge Fernandes, Maria Ogrzewalska, Ezequias Batista Martins, Marilda Agudo Mendonca Teixeira de Siqueira, Patricia Brasil, Guilherme Amaral Calvet
Summary: This study evaluated the prevalence of oral manifestations in ambulatory unvaccinated symptomatic patients with suspected and confirmed SARS-CoV-2 infection. The results showed no significant difference in the prevalence of oral manifestations between rRT-PCR-positive and rRT-PCR-negative patients. Xerostomia and dysgeusia/ageusia were the most common oral manifestations.
Article
Cell Biology
Rajeshwer S. Sankhala, Vincent Dussupt, Gina Donofrio, Gregory D. Gromowski, Rafael A. De La Barrera, Rafael A. Larocca, Letzibeth Mendez-Rivera, Anna Lee, Misook Choe, Weam Zaky, Grace Mantus, Jaime L. Jensen, Wei-Hung Chen, Neelakshi Gohain, Hongjun Bai, Michael K. McCracken, Rosemarie D. Mason, David Leggat, Bonnie M. Slike, Ursula Tran, Ningbo Jian, Peter Abbink, Rebecca Peterson, Eric Araujo Mendes, Rafael Freitas de Oliveira Franca, Guilherme Amaral Calvet, Ana Maria Bispo de Filippis, Adrian McDermott, Mayda Hernandez, Amie Albertus, Edgar Davidson, Benjamin J. Doranz, Morgane Rolland, Merlin L. Robb, Rebecca M. Lynch, Dan H. Barouch, Richard G. Jarman, Stephen J. Thomas, Kayvon Modjarrad, Nelson L. Michael, Shelly J. Krebs, M. Gordon Joyce
Summary: This study identified and characterized specific antibodies against Zika virus (ZIKV) in infected monkeys, revealing their structural features and functional potential. These findings have important implications for the development of vaccines, diagnostics, and therapeutics.
Article
Health Care Sciences & Services
Mayara Secco Torres Silva, Carolina Coutinho, Thiago Silva Torres, Eduardo Peixoto, Ronaldo Ismerio, Flavia Lessa, Estevao Portela Nunes, Brenda Hoagland, Amanda Dolores Echeverria Guevara, Matheus Oliveira Bastos, Isabel Cristina Ferreira Tavares, Maria Pia Diniz Ribeiro, Maria Roberta Meneguetti Seravalli Ramos, Hugo Boechat Andrade, Ana Paula Lovetro Santana, Marilia Santini-Oliveira, Juliana Barbosa Santos Netto, Paula Reges, Monica Avelar Magalhaes, Leonardo Azevedo Silva Rosadas, Sandro Nazer, Luciane Velasque, Sandra Wagner Cardoso, Edson Elias da Silva, Valdilea Goncalves Veloso, Mayumi Duarte Wakimoto, Beatriz Grinsztejn, INI Fiocruz Mpox Study Grp
Summary: This study reports characteristics of suspected and confirmed mpox cases in Rio de Janeiro, Brazil. The findings show significant differences between confirmed and non-confirmed cases in terms of age, gender, sexual behavior, and HIV infection rate. The study suggests that mpox transmission in Rio de Janeiro has evolved into a local epidemic, with sexual contact playing a crucial role and high rates of coinfection with other STIs. Preventive measures need to address stigma and social vulnerabilities.
LANCET REGIONAL HEALTH-AMERICAS
(2023)
Article
Infectious Diseases
Trevon L. Fuller, Leonardo Bastos, Marilia Sa Carvalho, Paola Cristina Resende, Luana Damasceno, Oswaldo Goncalves Cruz, Fernando Medeiros, Guilherme Calvet, Lusiele Guaraldo, Karin Nielsen-Saines, James Whitworth, Christopher Smith, Marilda Siqueira, Patricia Brasil
Summary: This study conducted in Brazil found that children have a lower risk of transmitting SARS-CoV-2 to their household members compared to adults. Most children were infected by symptomatic adults, usually their mothers. Vaccination not only protects the vaccinated individual from severe illness, but also prevents onward transmission to household contacts.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2023)
Article
Public, Environmental & Occupational Health
Kerstin D. Rosenberger, Lam Phung Khanh, Frank Tobian, Ngoun Chanpheaktra, Varun Kumar, Lucy Chai See Lum, Jameela Sathar, Ernesto Pleite's Sandoval, Gabriela M. Maron, Ida Safitri Laksono, Yodi Mahendradhata, Malabika Sarker, Ridwanur Rahman, Andrea Caprara, Bruno Souza Benevides, Ernesto T. A. Marques, Tereza Magalhaes, Patricia Brasil, Guilherme Amaral Calvet, Adriana Tami, Sarah E. Bethencourt, Tam Dong Thi Hoai, Kieu Nguyen Tan Thanh, Ngoc Tran Van, Nam Nguyen Tran, Viet Do Chau, Sophie Yacoub, Kinh Nguyen Van, Maria G. Guzman, Pedro A. Martinez, Quyen Nguyen Than Ha, Cameron P. Simmons, Bridget A. Wills, Ronald B. Geskus, Thomas Jaenisch
Summary: This study aimed to improve the early diagnosis of dengue, especially in resource-limited settings where distinguishing dengue from other febrile illnesses is crucial. The study found that platelet count and white blood cell count were strongly associated with dengue, and the importance of serial measurements over time was highlighted.
LANCET GLOBAL HEALTH
(2023)
Article
Virology
Ezequias B. Martins, Marcel S. B. Quintana, Michele F. B. Silva, Fernanda de Bruycker-Nogueira, Isabella C. V. Moraes, Cintia D. S. Rodrigues, Carolina C. Santos, Simone A. Sampaio, Anielle Pina-Costa, Allison A. Fabri, Vinicius Guerra-Campos, Nieli R. C. Faria, Ana Maria B. Filippis, Patricia Brasil, Guilherme A. Calvet
Summary: This study identifies female sex, diarrhea, severe joint pain, and CHIKV real-time reverse transcription polymerase chain reaction positivity as predictors of persistent chronic joint pain in patients with Chikungunya. Early detection of the CHIKV virus in alternative body fluids such as saliva and urine is important for preventing and controlling chronic pain.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Parasitology
Otavio Espindola, Paola C. Resende, Lusiele Guaraldo, Guilherme Amaral Calvet, Trevon L. Fuller, Stephanie Lema Suarez Penetra, Heloisa Ferreira Pinto Santos, Anielle Pina-Costa, Michele Fernanda Borges da Silva, Isabella Campos Vargas Moraes, Fernando Medeiros, Jimmy Whitworth, Christopher Smith, Karin Nielsen-Saines, Marilda M. Siqueira, Patricia Brasil
Summary: This case report aims to characterize the clinical features of acute XBB.1.5 infection followed by Long COVID-19. The study followed a 73-year old female resident of Rio de Janeiro with laboratory-confirmed SARS-CoV-2 during acute infection and subsequent months. The SARS-CoV-2 lineage was determined by genome sequencing.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2023)