Article
Chemistry, Organic
Yang Yang, Niklas Henrik Fischer, Maria Teresa Oliveira, Gul Barg Hadaf, Jian Liu, Theis Brock-Nannestad, Frederik Diness, Ji-Woong Lee
Summary: CO2-mediated chemoselective S-Michael addition reactions offer high selectivity in the presence of competing nucleophilic functional groups, providing practical reaction conditions for cysteine modification reactions when high chemoselectivity is required.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yoshiya Sekiguchi, Naohiko Yoshikai
Summary: An enantioselective conjugate addition reaction using a zinc homoenolate catalytically generated from cyclopropanol and added to an alpha,beta-unsaturated ketone was reported. The reaction produced highly substituted cyclopentene derivatives with good to high enantioselectivities through intramolecular aldol condensation of 1,6-diketones. The use of a chiral amino alcohol as a ligand-accelerated the catalysis of the homoenolate generation and its conjugate addition.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Annalena Gaertner, Lukas Meier, Merle Arrowsmith, Maximilian Dietz, Ivo Krummenacher, Ruediger Bertermann, Felipe Fantuzzi, Holger Braunschweig
Summary: The stepwise reduction of a doubly cyclic alkyl(amino)carbene (CAAC)-stabilized 2,3-bis(dibromoboryl)naphthalene enables the isolation of various organic compounds, including boryl radicals, diborete, and cyclic bis(alkylidene)diboron dianion. The diborete exhibits biradical character and a highly strained structure.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Inorganic & Nuclear
Mahendra K. Sharma, Christoph Wolper, Stephan Schulz
Summary: Gallaphosphene reacts with polar X-H bonds at ambient temperature, showing selective 1,2 addition at the polar Ga-P double bond. The resulting complexes were characterized using IR and NMR spectroscopy, elemental analysis, and single-crystal X-ray diffraction.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Organic
Debojyoti Bag, Harpreet Kour, Nirjhar Saha, Kamal, Harish Holla, Prasad Bharatam, Sanghapal D. Sawant
Summary: A general electrophilic iodocyclization/nucleophile addition cascade transformation for 1,2-alkynediones was reported, enabling the synthesis of various oxygen heterocycles and regioselective alkyne hydroxylation. Furan-tethered ynediones led to the construction of exo-enol ethers via carbonyl-alkyne cyclization-initiated heteroarene dearomatization, whereas other (hetero)arene-, alkenyl-, and alkyl-tethered ynediones resulted in the formation of highly functionalized 3(2H)-furanones. The developed domino protocols allow for the construction of important heterocyclic scaffolds and the installation of two functional groups in a single operation, with water as a nucleophile enabling regioselective alkyne hydroxylation via furanone ring opening.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Debojyoti Bag, Harpreet Kour, Nirjhar Saha, Kamal, Harish Holla, Prasad V. Bharatam, Sanghapal D. Sawant
Summary: A general electrophilic iodocyclization/nucleophile addition cascade transformation for 1,2-alkynediones is reported, leading to the synthesis of various oxygen heterocycles and regioselective alkyne hydroxylation. The reaction allows the construction of important heterocyclic scaffolds and the installation of two functional groups in a single operation.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Xin Li, Songtao He, Qiuling Song
Summary: A novel diethylzinc-mediated radical 1,2-addition of perfluoroalkyl iodides to unactivated alkenes and alkynes has been developed, providing a new way to generate an ethyl difluoroacetate radical. This method is highly efficient with full conversions of substrates, high yields of products, and minimal byproducts, without the need for column chromatography purifications. The mild conditions of this protocol allow for excellent functional group compatibility.
Article
Engineering, Environmental
Wanjun Zhao, Haiyang Wang, Dylan J. Kline, Xizheng Wang, Tao Wu, Jianbing Xu, Hui Ren, Michael R. Zachariah
Summary: In this study, the reactivity of nano boron and micron boron with copper oxide was significantly enhanced by the addition of nano titanium. The interaction between titanium oxide and boron oxide, as well as the higher flame temperature, contributed to the increased reactivity.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Javier Teresa, Marina Velado, Roberto Fernandez de la Pradilla, Alma Viso, Blanca Lozano, Mariola Tortosa
Summary: In this work, the catalytic enantioselective cross-coupling of 1,2-bisboronic esters is described. Previous studies on group specific cross coupling have been limited to the use of geminal bis-boronates. This desymmetrization provides a novel approach for preparing enantioenriched cyclopropyl boronates with three contiguous stereocenters, which can be further derivatized through selective functionalization of the carbon-boron bond. Our results suggest that the enantiodetermining step of transmetallation occurs with retention of stereochemistry at carbon.
Review
Chemistry, Inorganic & Nuclear
Anna Pintus, Massimiliano Arca
Summary: This review provides a comprehensive report on the synthetic pathways, structural features, properties, and main applications of 1,2-diselenolene metal complexes, and compares them with the more widely investigated 1,2-dithiolene isologues.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Farshad Shiri, Alireza Ariafard
Summary: This study demonstrates that the oxidative addition of hypervalent iodine PhICl2 to Au(I) complexes LAuAr follows an unprecedented stepwise mechanism. The energy of the Au(I) d(x2-y2) orbital determines the ease of the oxidative addition reaction; the fewer electron-withdrawing substituents present on the Ar ligand, the higher the energy of the d(x2)-(y2) orbital and the easier the oxidative addition.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Jingwen Wei, Yangyang Xing, Xiaohan Ye, Bao Nguyen, Lukasz Wojtas, Xin Hong, Xiaodong Shi
Summary: In this study, a new synthetic strategy for enantioselective 1,2-dihydropyridine synthesis was reported. Using the gold-catalyzed intermolecular condensation of amine and diyne-ene, the synthesis was achieved through a formal [3+2+1] fashion with up to 95% yield and up to 99% enantiomeric excess (e.e.).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Marta Meazza, Carlos M. Cruz, Ana M. Ortuno, Juan M. Cuerva, Luis Crovetto, Ramon Rios
Summary: The study reports a novel synthetic method for enantioselective addition of alkyl BODIPYs to Morita-Baylis-Hillman (MBH) carbonates using cinchona alkaloids as efficient catalysts with high enantioselectivities and total diastereoselectivity. Photophysical and electronic circular dichroism studies of the dyes were performed to evaluate their parameters and explore potential applications in bioimaging. Time-dependent density functional theory calculations supported the findings.
Article
Chemistry, Inorganic & Nuclear
Jan Vrana, Vlastimil Nemec, Maksim A. Samsonov, Ales Ruzicka
Summary: 2-Benzhydryl-4-methyl-6-(1,1 '-diphenyl-2-phenyl-ethyl)aniline was prepared through a three-step process, resulting in a compound with high molecular volume that reacts with phosphorus trichloride and triethylamine to give a monomeric chloro(imino)phosphine.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Luca De Angelis, Graham C. Haug, Gildardo Rivera, Soumen Biswas, Ammar Al-Sayyed, Hadi Arman, Oleg Larionov, Michael P. Doyle
Summary: One important reaction of 1,2,3-triazines is the inverse electron demand Diels-Alder (IEDDA) cycloaddition with a dienophile, which proceeds through nucleophilic addition to the triazine followed by N-2 loss and cyclization. Previous studies have not provided a comprehensive understanding of the site of nucleophilic addition on the triazine. This study investigated the C-, N-, H-, O-, and S-nucleophilic additions on 1,2,3-triazine and 1,2,3-triazine-1-oxide frameworks and revealed the differentiation of addition at the 4- and 6-positions. Computational studies further examined the factors influencing the outcomes of these reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Nathan C. Thacker, Zekai Lin, Teng Zhang, James C. Gilhula, Carter W. Abney, Wenbin Lin
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Article
Chemistry, Physical
Carter W. Abney, Jacob T. Patterson, James C. Gilhula, Li Wang, Dale K. Hensley, Jihua Chen, Guo Shiou Foo, Zili Wu, Sheng Dai
JOURNAL OF MATERIALS CHEMISTRY A
(2017)
Article
Chemistry, Multidisciplinary
C. W. Abney, J. C. Gilhula, K. Lu, W. Lin
ADVANCED MATERIALS
(2014)
Article
Engineering, Environmental
James C. Gilhula, Jacob T. Patterson, Neil J. Williams, Ram Itani, Kathryn M. L. Taylor-Pashow, Carter W. Abney
JOURNAL OF HAZARDOUS MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
James C. Gilhula, Alexander T. Radosevich
Article
Nanoscience & Nanotechnology
Marek Piechowicz, Carter W. Abney, Nathan C. Thacker, James C. Gilhula, Youfu Wang, Samuel S. Veroneau, Aiguo Hu, Wenbin Lin
ACS APPLIED MATERIALS & INTERFACES
(2017)
Article
Chemistry, Multidisciplinary
Alexander M. Prophet, Kritanjan Polley, Gary J. Van Berkel, David T. Limmer, Kevin R. Wilson
Summary: The oxidation kinetics of iodide by ozone at the air-water interface is studied in single microdroplets. Molecular simulations and kinetic modeling are used to understand the underlying multiphase mechanism.
Article
Chemistry, Multidisciplinary
Rong Zhang, Jiajing Lan, Fei Wang, Shumei Chen, Jian Zhang
Summary: By utilizing 1,1'-ferrocene dicarboxylic acid as a chelating and surface protection ligand, we have synthesized multi-nuclear indium oxide clusters with varying nuclear sizes, including heptanuclear and thirteen-nuclear clusters. These clusters possess labile coordination sites, allowing for structural modification and self-assembly, resulting in the formation of various cluster structures.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Chemistry, Multidisciplinary
Chang-Hee Lee, Sookil Park, Sanggil Kim, Ji Young Hyun, Hyun Soo Lee, Injae Shin
Summary: The epidermal growth factor receptor (EGFR) is a cell-surface glycoprotein involved in cell proliferation and tumor development. This study used a fluorescently labeled EGFR to investigate its time-dependent endocytosis in live cells and found that appended glycans affect EGFR internalization. Additionally, the study detected sialic acid residues attached to EGFR on the live cell surface using FRET-based imaging. This research provides valuable insights into the cellular functions of EGFR.
Article
Chemistry, Multidisciplinary
Subhankar Sahu, Lokesh Kumar, Sumita Das, Dipti Gupta, Ruchi Anand
Summary: This study proposes a strategy that combines organic electronics with biosensor scaffolds to create a compact device for monitoring environmental aromatic pollution. By coupling biosensing protein MopR with an organic electrochemical transistor (OECT), a sensor module capable of efficient detection of phenol was designed. Exclusive phenol detection with minimal loss of sensitivity could be achieved in complex pollutant mixtures and real environmental samples.
Review
Chemistry, Multidisciplinary
Changseok Lee, Hyung-Joon Kang, Sungwoo Hong
Summary: The formation of C-N bonds through hydroamination reactions catalyzed by nickel hydrides has been a topic of recent interest. This approach offers a way to efficiently transform a variety of alkene and alkyne substrates into compounds enriched with C-N bonds. The review provides a concise overview of the underlying reaction mechanisms and aims to stimulate further progress in NiH-catalytic techniques and catalyst design.
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Dmitry L. Lipilin, Mikhail O. Zubkov, Mikhail D. Kosobokov, Alexander D. Dilman
Summary: This article describes a direct photocatalytic method for the thiolation of unprotected acids, which was previously challenging. By using a thionocarbonate reagent with an N-O bond, the efficient conversion of carboxylic acids to thiols is achieved.
Article
Chemistry, Multidisciplinary
Jason Malenfant, Lucille Kuster, Yohann Gagne, Kouassi Signo, Maxime Denis, Sylvain Canesi, Mathieu Frenette
Summary: Raman microscopy can reveal compound-specific vibrational fingerprints without sample preparation. The combination of efficient theoretical calculations and a user-friendly software can accurately predict peak positions and provide match scores to assist with structure determination.
Article
Chemistry, Multidisciplinary
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
Summary: Essential trace metals play crucial roles in the survival and virulence of bacterial pathogens. Helicobacter pylori requires nickel for colonization and persistence in the stomach, and NixA is an essential nickel transporter in this process. This study characterizes the selectivity and electrogenic nature of NixA-mediated nickel transport.
Article
Chemistry, Multidisciplinary
Tarali Devi, Kuheli Dutta, Jennifer Deutscher, Stefan Mebs, Uwe Kuhlmann, Michael Haumann, Beatrice Cula, Holger Dau, Peter Hildebrandt, Kallol Ray
Summary: This study emphasizes the importance of subtle electronic changes and secondary interactions in the stability of biologically relevant metal-dioxygen intermediates. It also shows that the role of the chloride ligand in stabilizing the Fe-III-(OOBu)-Bu-t moiety can extend to other anions, including the thiolate ligand.
Article
Chemistry, Multidisciplinary
Jacqueline R. Santhouse, Jeremy M. G. Leung, Lillian T. Chong, W. Seth Horne
Summary: By studying the folding kinetics and mechanism of the BdpA sequence, researchers found that altering the backbone connectivity can affect protein folding. This suggests that protein mimetic chains have a significant degree of plasticity in transitioning between unfolded and folded states.
Article
Chemistry, Multidisciplinary
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
Summary: This study presents the first direct spectroscopic evidence of a cyclic seven-membered iminoborane. Compared to linear amino-iminoboranes, this cyclic iminoborane exhibits weakened bond strength and lower Lewis acidity value. The study suggests that the reduced ring strain of cyclic iminoborane prevents nitrogen fixation but allows facile (2 + 2) cycloaddition reaction with C2H4.
Article
Chemistry, Multidisciplinary
Renny Mathew, Aniruddha Mazumder, Praveen Kumar, Julie Matula, Sharmarke Mohamed, Petr Brazda, Mahesh Hariharan, Brijith Thomas
Summary: This study reveals the packing arrangement of partially disordered nitro-perylenediimide (NO2-PDI) using a synergistic approach that combines 3D ED, ssNMR, and DFT techniques. By overcoming these challenges, this methodology opens up new avenues for material characterization, driving exciting advancements in the field.