Reversible stapling of unprotected peptides via chemoselective methionine bis-alkylation/dealkylation

Unique arginine array improves cytosolic localization of hydrocarbon-stapled peptides

(2018) Kim Quach et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Reversibly switching the conformation of short peptide through in-tether chiral sulfonium auxiliary

(2018) Xiaodong Shi et al.   CHINESE CHEMICAL LETTERS

Structural Basis of Inhibition of ERα-Coactivator Interaction by High-Affinity N-Terminus Isoaspartic Acid Tethered Helical Peptides

(2017) Mingsheng Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Double quick, double click reversible peptide “stapling”

(2017) Claire M. Grison et al.   Chemical Science

Achieving enhanced cell penetration of short conformationally constrained peptides through amphiphilicity tuning

(2017) Yuan Tian et al.   Chemical Science

Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization

(2016) Ziqing Qian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer

(2016) Mareike M. Wiedmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide

(2016) Kuan Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction

(2016) Thomas E. Speltz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effect of Preorganized Charge-Display on the Cell-Penetrating Properties of Cationic Peptides

(2016) Yvonne A. Nagel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crosslinked Aspartic Acids as Helix-Nucleating Templates

(2016) Hui Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Investigation of Cellular Uptakes of the In-Tether Chiral-Center-Induced Helical Pentapeptides

(2016) Kuan Hu et al.   BIOCONJUGATE CHEMISTRY

An in-tether sulfilimine chiral center induces helicity in short peptides

(2016) Huacan Lin et al.   CHEMICAL COMMUNICATIONS

A proline-derived transannular N-cap for nucleation of short α-helical peptides

(2016) Yuan Tian et al.   CHEMICAL COMMUNICATIONS

Constructing thioether-tethered cyclic peptides via on-resin intra-molecular thiol-ene reaction

(2016) Bingchuan Zhao et al.   JOURNAL OF PEPTIDE SCIENCE

A real-time fluorometric method for the simultaneous detection of cell death type and rate

(2016) Sasker Grootjans et al.   Nature Protocols

An in-tether sulfilimine chiral center induces β-turn conformation in short peptides

(2016) Huacan Lin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stapling of unprotected helical peptides via photo-induced intramolecular thiol–yne hydrothiolation

(2016) Yuan Tian et al.   Chemical Science

Connecting two proteins using a fusion alpha helix stabilized by a chemical cross linker

(2016) Woo Hyeon Jeong et al.   Nature Communications

Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity

(2016) Qingzhou Zhang et al.   Scientific Reports

Hydrocarbon Stapled Peptides as Modulators of Biological Function

(2015) Philipp M. Cromm et al.   ACS Chemical Biology

Intracellular Delivery of Peptidyl Ligands by Reversible Cyclization: Discovery of a PDZ Domain Inhibitor that Rescues CFTR Activity

(2015) Ziqing Qian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling

(2015) Naila Assem et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Situ Conjugation of Dithiophenol Maleimide Polymers and Oxytocin for Stable and Reversible Polymer–Peptide Conjugates

(2015) Jennifer Collins et al.   BIOCONJUGATE CHEMISTRY

Synthesis of Side-Chain Modified Polypeptides

(2015) Timothy J. Deming   CHEMICAL REVIEWS

Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions

(2015) Teresa A. F. Cardote et al.   ChemMedChem

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Fluorescence Correlation Spectroscopy Reveals Highly Efficient Cytosolic Delivery of Certain Penta-Arg Proteins and Stapled Peptides

(2015) Jonathan R. LaRochelle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins in Vitro and in Vivo

(2015) Margie Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptide/Protein Stapling and Unstapling: Introduction of s-Tetrazine, Photochemical Release, and Regeneration of the Peptide/Protein

(2015) Stephen P. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Towards understanding cell penetration by stapled peptides

(2015) Qian Chu et al.   MedChemComm

Constrained Peptides with Target-Adapted Cross-Links as Inhibitors of a Pathogenic Protein-Protein Interaction

(2014) Adrian Glas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cover Picture: Excellent Stability of a Lithium-Ion-Conducting Solid Electrolyte upon Reversible Li+/H+Exchange in Aqueous Solutions (Angew. Chem. Int. Ed. 1/2015)

(2014) Cheng Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploration of the Design Principles of a Cell-Penetrating Bicylic Peptide Scaffold

(2014) Rike Wallbrecher et al.   BIOCONJUGATE CHEMISTRY

Modulators of Protein–Protein Interactions

(2014) Lech-Gustav Milroy et al.   CHEMICAL REVIEWS

Phage Selection of Photoswitchable Peptide Ligands

(2014) Silvia Bellotto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Influence of Macrocyclization on Allosteric, Juxtamembrane-Derived, Stapled Peptide Inhibitors of the Epidermal Growth Factor Receptor (EGFR)

(2014) Julie K.-L. Sinclair et al.   ORGANIC LETTERS

Functionalised staple linkages for modulating the cellular activity of stapled peptides

(2014) Yu Heng Lau et al.   Chemical Science

Reversible chemoselective tagging and functionalization of methionine containing peptides

(2013) Jessica R. Kramer et al.   CHEMICAL COMMUNICATIONS

Future directions for peptide therapeutics development

(2013) Allan A. Kaspar et al.   DRUG DISCOVERY TODAY

A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Convergent diversity-oriented side-chain macrocyclization scan for unprotected polypeptides

(2013) Yekui Zou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeting protein–protein interactions as an anticancer strategy

(2013) Andrei A. Ivanov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Determination of biothiols by a novel on-line HPLC-DTNB assay with post-column detection

(2012) Mustafa Özyürek et al.   ANALYTICA CHIMICA ACTA

Preparation of Multifunctional and Multireactive Polypeptides via Methionine Alkylation

(2012) Jessica R. Kramer et al.   BIOMACROMOLECULES

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

Arginine Topology Controls Escape of Minimally Cationic Proteins from Early Endosomes to the Cytoplasm

(2012) Jacob S. Appelbaum et al.   CHEMISTRY & BIOLOGY

Flexible or fixed: a comparative review of linear and cyclic cancer-targeting peptides

(2012) Áron Roxin et al.   Future Medicinal Chemistry

Development of α-Helical Calpain Probes by Mimicking a Natural Protein–Protein Interaction

(2012) Hyunil Jo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of oncogenic Wnt signaling through direct targeting of  -catenin

(2012) T. N. Grossmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and Structure of Stapled Peptides Binding to Estrogen Receptors

(2011) Chris Phillips et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoreactive Stapled BH3 Peptides to Dissect the BCL-2 Family Interactome

(2010) Craig R. Braun et al.   CHEMISTRY & BIOLOGY

Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

(2010) Mark E. B. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

(2010) Michelle L Stewart et al.   Nature Chemical Biology

Solid-phase synthesis of short α-helices stabilized by the hydrogen bond surrogate approach

(2010) Anupam Patgiri et al.   Nature Protocols

Suppression of Side Reactions During Final Deprotection Employing a Strong Acid in Boc Chemistry: Regeneration of Methionyl Residues from Their Sulfonium Salts

(2009) Misako Taichi et al.   International Journal of Peptide Research and Therapeutics

Inhibition of Hypoxia Inducible Factor 1—Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix

(2009) Laura K. Henchey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE