Article
Chemistry, Multidisciplinary
Jiali Zhai, Lei Bao, Anna K. K. Walduck, Brendan P. P. Dyett, Xudong Cai, Miaosi Li, Zeyad Nasa, Calum J. J. Drummond
Summary: This study reports a nanocomposite formulation consisting of nanosized C-dots encapsulated in lipid nanoparticles. The encapsulation enhances the cellular uptake efficiency and fluorescent properties of C-dots, thereby improving their bioimaging potential.
Article
Chemistry, Multidisciplinary
Thibaut Blondy, Julien Poly, Camille Linot, Joanna Boucard, Emilie Allard-Vannier, Steven Nedellec, Phillipe Hulin, Celine Henoumont, Lionel Larbanoix, Robert N. Muller, Sophie Laurent, Elena Ishow, Christophe Blanquart
Summary: The surface chemistry of nanoparticles has a significant impact on their cellular uptake, and the residual groups of chain transfer agents (CTAs) introduced in the main chain can modulate the cell uptake of nanoparticles. This study demonstrates that the cellular internalization of functionalized nanoparticles can be controlled by the compaction of the PEG comb-like shell incorporating CTAs with a long alkyl chain, without changing the overall surface potential.
Article
Chemistry, Multidisciplinary
Wencheng Zhong, Kangqiang Liang, Wenfeng Liu, Li Shang
Summary: In this study, a new design of Forster resonance energy transfer-based dual-color photoswitchable fluorescent nanoparticles (DPF NPs) was reported by using ligand-protected gold nanoclusters (AuNCs). The ultrasmall-sized AuNCs act as the FRET donors and also regulate the properties of spiropyran through ligand-spiropyran interactions. These DPF NPs exhibit high fluorescence on/off ratios for both green and red fluorescence emission, and show good reversibility during cycled photo-stimulation. Cell imaging experiments demonstrated that DPF NPs can specifically accumulate in lipid droplets and enable photoswitchable dual-color imaging in living cells.
Article
Chemistry, Physical
Chunyan Liu, Sirong Li, Di Fang, Xiangshuang Cong, Feizhen Zhu, Yan Zhang, Yen Wei, Mei Tian
Summary: This study presents a large-area, transparent, and ultra-stable free-standing fluorescent silica-based film with color-tunable emissions. The film is prepared using an amphiphilic aggregation-induced emission (AIE) luminogen as both a structure-directing agent and a light-emitting source. The films exhibit variable excitation-dependent emission colors and dual-center emission characteristics.
SURFACES AND INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Elias A. Halabi, Ralph Weissleder
Summary: Highly multiplexed, cyclic fluorescence imaging has improved our understanding of human diseases. However, current cyclic methods have limitations such as long quenching times and extensive wash steps. This study presents a new series of fluorochromes that can be efficiently inactivated by a single light pulse, allowing for fast and controllable quenching without the need for washing or additional chemicals.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Analytical
Mengyun Wang, Xiaojing Han, Xiaopeng Yang, Jianfei Liu, Xiangzhi Song, Weimin Zhu, Yong Ye
Summary: The article introduces a new AIE fluorescent probe QM-ClO for detecting HClO, providing an effective tool for studying apoptosis-related diseases.
Article
Chemistry, Multidisciplinary
Vitalii Tkachenko, Philippe Kunemann, Jean Pierre Malval, Tatiana Petithory, Laurent Pieuchot, Loic Vidal, Abraham Chemtob
Summary: Self-assembled block copolymer nanoparticles with high stability and uniformity were successfully prepared using photomediated RAFT polymerization-induced self-assembly method. The nanoparticles show potential for bioimaging applications due to their high stability and high yield.
Review
Chemistry, Multidisciplinary
Wei Li, Gabriele S. Kaminski Schierle, Bingfu Lei, Yingliang Liu, Clemens F. Kaminski
Summary: Super-resolution imaging techniques have become popular for visualizing cellular structures with nanometric resolution. This review focuses on the use of fluorescent nanoparticles (NPs) as bright and photostable probes for super-resolution imaging. The review provides an overview of different super-resolution methods, discusses their demands on the properties of fluorescent NPs, and reviews the features, strengths, and weaknesses of each NP class. The future outlook and opportunities in material science for the development of probes for multiplexed subcellular imaging with nanometric resolution are also discussed.
Article
Chemistry, Multidisciplinary
Lulu Huang, Xiuhai Mao, Jie Li, Qian Li, Jianlei Shen, Mengmeng Liu, Chunhai Fan, Yang Tian
Summary: By designing dual-emissive gold nanoparticles with varying spikiness, the interactions between spiky nanoparticles and cells were investigated. It was found that the nanospikes regulated myosin IIA recruitment at the cell membrane, enhancing cellular uptake efficiency. Moreover, the spiky nanoparticles facilitated endocytosis dynamics. These findings provide insights into the intracellular fate of nanoparticles and the development of theranostic nanocarriers.
Review
Biotechnology & Applied Microbiology
Maja van Hees, Sofie Slott, Anders Hojgaard Hansen, Heon Seok Kim, Hanlee P. Ji, Kira Astakhova
Summary: This article introduces new approaches for improving cellular uptake and endosomal escape of CRISPR-Cas9, with a focus on non-viral carriers. It also discusses the use of peptide and nanoparticle-based systems as platforms for in vivo CRISPR-Cas9 delivery.
Article
Chemistry, Analytical
Shihua Li, Nangen Yang, Qiuping Ma, Shijie Li, Shufen Tong, Jiewei Luo, Xiaorong Song, Huanghao Yang
Summary: This study investigates the oxidation responsiveness of near-infrared II (NIR-II) luminescent AuNCs and finds that AuNCs capped with different ligands have different oxidation properties in the presence of peroxynitrite anions (ONOO-). N-acetylcysteine-capped AuNCs are more easily oxidized and aggregate into large-sized assemblies, while macromolecular mercapto-beta-cyclodextrin-capped AuNCs do not show this behavior. Furthermore, N-acetylcysteine-capped AuNCs are demonstrated to be effective for sensitive NIR-II PL imaging of mice acute kidney injury (AKI), thanks to the synergistic effect of in situ AuNC aggregation and decreased glomerular filtration rate (GFR) in the injured kidney, surpassing methods solely based on decreased GFR.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Federica Vurro, Ylenia Jabalera, Silvia Mannucci, Giulia Glorani, Alberto Sola-Leyva, Marco Gerosa, Alessandro Romeo, Maria Grazia Romanelli, Manuela Malatesta, Laura Calderan, Guillermo R. Iglesias, Maria P. Carrasco-Jimenez, Concepcion Jimenez-Lopez, Massimiliano Perduca
Summary: MamC-expressed BMNPs have advantages in stable functionalization and molecule release, but face challenges in cell internalization. Encapsulation with PLGA and functionalization with TAT peptide enhance internalization without compromising cell viability.
Article
Materials Science, Biomaterials
Lijie Li, Qi Zhan, Kaikai Yi, Ning Chen, Xueping Li, Shixue Yang, Xin Hou, Jin Zhao, Xubo Yuan, Chunsheng Kang
Summary: By engineering liposomes with lysophosphatidylcholine (LPC), the cellular uptake efficiency of liposomes was improved, leading to enhanced antitumor activity. In animal experiments, LPC-engineered liposomes showed better tumor growth inhibition without significant side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Chemistry, Multidisciplinary
Huiyu Niu, Junwei Liu, Helen M. O'Connor, Thorfinnur Gunnlaugsson, Tony D. James, Hua Zhang
Summary: Typical PeT-based fluorescent probes are multi-component systems that utilize a fluorophore connected to a recognition/activating group through an unconjugated linker. These probes have been widely used in cell imaging and disease diagnosis due to their low background fluorescence and significant fluorescence enhancement towards the target. This review summarizes the research progress made in the past five years on PeT-based fluorescent probes targeting cell polarity, pH, and various biological species, emphasizing molecular design strategies, mechanisms, and applications. By providing guidance and promoting the development of new and improved PeT-based fluorescent probes, this review aims to promote the use of PeT-based systems for sensing, imaging, and disease therapy.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Junling Yin, Ling Huang, Luling Wu, Jiangfeng Li, Tony D. James, Weiying Lin
Summary: The microenvironment within specific organelles plays a vital role in cellular processes and physiological functions. Monitoring and understanding the variations in the microenvironment is essential for identifying disease development. Progress has been made in developing fluorescent probes to study the microenvironment within specific cellular regions, but comprehensive research on small-molecule fluorescent chemosensors for cellular microenvironments is still needed.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Yite Li, Liqian Liu, Tian Meng, Lei Wang, Zhigang Xie
Summary: An ionic ZIF-8@iCOF nanocomposite was designed as a sunlight-driven photocatalytic filter, which achieved improved visible light absorption and enhanced ROS generation, resulting in antibacterial efficiency of 99.99999%. Furthermore, the combination of the material with a commercial polymer formed fibrous membranes with high interception efficiency, good biocompatibility, and strong bacteria elimination under sunlight conditions.
Article
Materials Science, Biomaterials
Yawei Li, Wei Zhang, Naiyuan Shi, Wenqing Li, Junxia Bi, Xianmin Feng, Nianqiu Shi, Wenhe Zhu, Zhigang Xie
Summary: By utilizing the self-assembly of DHA, carrier-free nanoparticles with high drug encapsulation efficiency and on-demand drug release behavior were synthesized. These DHA nanodrugs exhibited superior therapeutic efficacy in cancer treatment in both in vitro and in vivo experiments, with the p53 signaling pathway playing a crucial role. This work provides theoretical support for developing pure nanodrugs via self-assembly and for the clinical usage of DHA.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Chengjian Mou, Xinyuan Wang, Yanchao Liu, Zhigang Xie, Min Zheng
Summary: Developing highly effective antibacterial films for wound healing is a challenge. Homogeneous and flexible CDs-PVA composite films were constructed by doping CDs into PVA. PVA(5) and PVA(8) showed excellent antibacterial performance against both Gram-negative and Gram-positive bacteria, and could be easily processed into band-aid type dressings for wound healing.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Guocui Pan, Zhiyuan Wu, Zhaoyang Liu, Bin Xu, Wenjing Tian
Summary: In this study, we achieved in situ fluorescence switching in molecular aggregates of thianaphthene-dioxide derivatives through topological [2+2] photocycloaddition, providing a promising approach for regulating molecular stacking and altering photophysical processes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yude Wei, Runqing Yang, Guangzhen Cui, Shuting Dai, Guocui Pan, Jing Wang, Haoxuan Ren, Wenyue Ma, Zijian Gu, Chenchen Zhang, Guangming Li, Zhaoyang Liu, Bin Xu, Wenjing Tian
Summary: Sensing of low-pressure signals is crucial for cutting-edge technologies. In this study, a highly sensitive piezochromic fluorescent switching under low-pressure regimes has been achieved using tetraphenylethylene-anthraquinone (TPE-AQ) based on controlled molecular design and polymorphic phase strategy. The influence of intramolecular conformation effect and variations of intermolecular stacking modes on the piezochromic property of TPE-AQ is explored. The underlying mechanism of the low-pressure sensitive piezochromic fluorescence switching is found to be related to the loosely packed molecular orientation.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Hongxin Liu, Zhigang Xie, Min Zheng
Summary: Cancer immunotherapy is a popular area of research, and carbon dots have shown potential as nanovectors to enhance its efficacy.
Review
Pharmacology & Pharmacy
Qing Pei, Bowen Jiang, Dengyuan Hao, Zhigang Xie
Summary: Chemotherapy plays a critical role in cancer treatment, especially for advanced and metastatic tumors. However, the therapeutic effect of Paclitaxel-based formulations is limited by off-target toxicity and drug resistance. Self-assembled PTX nanoparticles have shown promise in enhancing therapeutic index. This study summarizes the self-assembly strategy of PTX nanodrugs and outlines the advancements in tumor therapy, including mono chemotherapy, combination therapy, and theranostics.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Multidisciplinary
Xuanhang Wang, Bin Xu, Wenjing Tian
Summary: This article introduces the recent progress in the development of solid-state luminescent molecular photoswitches, mainly focusing on molecular design strategy, switchable luminescence, and potential applications. The researchers successfully realized solid-state photoinduced luminescence switching and reversible three-color fluorescence switching using flexible covalent coupling strategy and increasing molecular distortion. Furthermore, they investigated the relationship between molecular structure and optical properties, and explored the potential applications of luminescent photoswitches in advanced anticounterfeiting, optical memory, information encryption, and super-resolution imaging.
ACCOUNTS OF MATERIALS RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Tingting Sun, Jiaxiang Guo, Hui Wen, Qing Pei, Qihang Wu, Dengyuan Hao, Chuandong Dou, Zhigang Xie
Summary: This study reports the photothermal conversion behaviors of a boron-containing organic diradicaloid (BOD), which can assemble with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) to form rodlike nanoparticles (BOD NPs). These BOD NPs show high photothermal conversion capability and stability, and possess morphological superiority for effective photothermal therapy of tumors. This work demonstrates the promise of organic diradicaloids as efficient photothermal agents for biomedical applications.
Review
Chemistry, Multidisciplinary
Yuxuan Song, Guocui Pan, Chenchen Zhang, Can Wang, Bin Xu, Wenjing Tian
Summary: Solid-state luminescence of organic & pi;-conjugated molecules has attracted considerable attention as an international forefront research area. The interactions between transition dipoles of adjacent molecules are found to be closely associated with the optical properties in the aggregate state. Therefore, by manipulating the intermolecular interactions and stacking modes, the luminescent properties of organic crystals can be efficiently modulated. This review presents recent studies on the molecular packing structures and optical properties in & pi;-conjugated organic luminescent crystals, as well as their applications in stimuli response, amplified spontaneous emission, and organic solid-state lasers. Furthermore, the development and future prospects of this research field are discussed, providing insights for the specific design of organic luminescent molecules with desired optoelectronic properties in the aggregate states.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Materials Science, Biomaterials
Wentao Lei, Qihang Wu, Hui Wen, Yulin Wang, Wenhai Lin, Tingting Sun, Zhigang Xie
Summary: Amino acids are fundamental building blocks of life in biological systems, and their modification can add interesting properties to key molecules. In this study, BDP was modified with l-aspartic acid (Asp) and d-Asp to produce BDP-LAsp and BDP-DAsp, respectively. The synthesized BDPs can self-assemble into uniform nanoparticles (NPs) due to the hydrophilicity of Asp. We discovered that BDP-LAsp NPs exhibited higher photodynamic therapeutic efficacy against cancer cells and bacteria compared to BDP-DAsp NPs. This presents a simple design strategy for modifying photosensitizers in the field of biomedicine.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Wenyue Ma, Zijian Gu, Canran Wang, Liangyu Dong, Zhaoyang Liu, Leijing Liu, Bin Xu, Wenjing Tian
Summary: Functionalized covalent organic frameworks (COFs) with hydrazine-linkage were prepared from imine-linkage nanosphere via linker exchange. The COFs exhibited good crystallinity, porosity, stability, and luminescent properties, making them promising fluorescent sensors for the detection of Cu2+.
Article
Chemistry, Multidisciplinary
Wei Zhang, Wenhai Lin, Zhensheng Li, Tingting Sun, Zhigang Xie
Summary: Photothermal therapy (PTT) is an effective tumor therapeutic method, but the overexpression of heat shock proteins (HSPs) and the self-repair mechanism of malignant tumors may limit its efficacy. A nanoplatform (IBDDP&GOx NPs) integrating PTT, starvation therapy, and oxidation therapy was developed using a conjugated polymer (IBDDP) and glucose oxidase (GOx). This nanoplatform effectively combines the photothermal properties of IBDDP and the biological catalytic activity of GOx, resulting in enhanced inhibitory effects on tumor cell survival and proliferation.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Materials Science, Biomaterials
Huafeng Geng, Wenhai Lin, Junbao Liu, Qing Pei, Zhigang Xie
Summary: Phototheranostics, integrating optical imaging and phototherapy, has received widespread attention. Achieving nanophototherapeutics with near infrared (NIR)-light synchronously triggered photodynamic therapy (PDT) and photothermal therapy (PTT) is challenging. In this study, a multifunctional theranostic nanoplatform was developed by co-assembling NIR boron dipyrromethene (BODIPY) with a cooperative D-pi-A structure of a thiophene-BODIPY core and benzene-diethylamino, and a choline phosphate lipid. The resulting nanoparticles exhibited desirable NIR absorption, uniform spherical morphology, and good colloidal stability. The elaborate molecular design and supramolecular assembly endowed these nanoparticles with desirable PDT and PTT activities.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Materials Science, Multidisciplinary
Yanting Shi, Yutao Zou, M. Shahnawaz Khan, Mengge Zhang, Jiang Yan, Xiaohua Zheng, Weiqi Wang, Zhigang Xie
Summary: Metal-organic frameworks (MOFs) are highly ordered self-assembled structures with large surface areas, nanoporosity, and tunable size and shape, making them ideal candidates for sensor applications. This review explores the structural features of MOFs for biological sensing and the MOF-analyte interaction, as well as the state-of-the-art progress in MOF-based sensors for healthcare, food safety, environmental monitoring, and pharmaceutics. The review also discusses the possible applications of MOF-based materials in identifying high performance and detecting food freshness, gas leakage, and medical diagnostics, and highlights the current limitations in sensing performance.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Alexander M. Prophet, Kritanjan Polley, Gary J. Van Berkel, David T. Limmer, Kevin R. Wilson
Summary: The oxidation kinetics of iodide by ozone at the air-water interface is studied in single microdroplets. Molecular simulations and kinetic modeling are used to understand the underlying multiphase mechanism.
Article
Chemistry, Multidisciplinary
Rong Zhang, Jiajing Lan, Fei Wang, Shumei Chen, Jian Zhang
Summary: By utilizing 1,1'-ferrocene dicarboxylic acid as a chelating and surface protection ligand, we have synthesized multi-nuclear indium oxide clusters with varying nuclear sizes, including heptanuclear and thirteen-nuclear clusters. These clusters possess labile coordination sites, allowing for structural modification and self-assembly, resulting in the formation of various cluster structures.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Chemistry, Multidisciplinary
Chang-Hee Lee, Sookil Park, Sanggil Kim, Ji Young Hyun, Hyun Soo Lee, Injae Shin
Summary: The epidermal growth factor receptor (EGFR) is a cell-surface glycoprotein involved in cell proliferation and tumor development. This study used a fluorescently labeled EGFR to investigate its time-dependent endocytosis in live cells and found that appended glycans affect EGFR internalization. Additionally, the study detected sialic acid residues attached to EGFR on the live cell surface using FRET-based imaging. This research provides valuable insights into the cellular functions of EGFR.
Article
Chemistry, Multidisciplinary
Subhankar Sahu, Lokesh Kumar, Sumita Das, Dipti Gupta, Ruchi Anand
Summary: This study proposes a strategy that combines organic electronics with biosensor scaffolds to create a compact device for monitoring environmental aromatic pollution. By coupling biosensing protein MopR with an organic electrochemical transistor (OECT), a sensor module capable of efficient detection of phenol was designed. Exclusive phenol detection with minimal loss of sensitivity could be achieved in complex pollutant mixtures and real environmental samples.
Review
Chemistry, Multidisciplinary
Changseok Lee, Hyung-Joon Kang, Sungwoo Hong
Summary: The formation of C-N bonds through hydroamination reactions catalyzed by nickel hydrides has been a topic of recent interest. This approach offers a way to efficiently transform a variety of alkene and alkyne substrates into compounds enriched with C-N bonds. The review provides a concise overview of the underlying reaction mechanisms and aims to stimulate further progress in NiH-catalytic techniques and catalyst design.
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Dmitry L. Lipilin, Mikhail O. Zubkov, Mikhail D. Kosobokov, Alexander D. Dilman
Summary: This article describes a direct photocatalytic method for the thiolation of unprotected acids, which was previously challenging. By using a thionocarbonate reagent with an N-O bond, the efficient conversion of carboxylic acids to thiols is achieved.
Article
Chemistry, Multidisciplinary
Jason Malenfant, Lucille Kuster, Yohann Gagne, Kouassi Signo, Maxime Denis, Sylvain Canesi, Mathieu Frenette
Summary: Raman microscopy can reveal compound-specific vibrational fingerprints without sample preparation. The combination of efficient theoretical calculations and a user-friendly software can accurately predict peak positions and provide match scores to assist with structure determination.
Article
Chemistry, Multidisciplinary
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
Summary: Essential trace metals play crucial roles in the survival and virulence of bacterial pathogens. Helicobacter pylori requires nickel for colonization and persistence in the stomach, and NixA is an essential nickel transporter in this process. This study characterizes the selectivity and electrogenic nature of NixA-mediated nickel transport.
Article
Chemistry, Multidisciplinary
Tarali Devi, Kuheli Dutta, Jennifer Deutscher, Stefan Mebs, Uwe Kuhlmann, Michael Haumann, Beatrice Cula, Holger Dau, Peter Hildebrandt, Kallol Ray
Summary: This study emphasizes the importance of subtle electronic changes and secondary interactions in the stability of biologically relevant metal-dioxygen intermediates. It also shows that the role of the chloride ligand in stabilizing the Fe-III-(OOBu)-Bu-t moiety can extend to other anions, including the thiolate ligand.
Article
Chemistry, Multidisciplinary
Jacqueline R. Santhouse, Jeremy M. G. Leung, Lillian T. Chong, W. Seth Horne
Summary: By studying the folding kinetics and mechanism of the BdpA sequence, researchers found that altering the backbone connectivity can affect protein folding. This suggests that protein mimetic chains have a significant degree of plasticity in transitioning between unfolded and folded states.
Article
Chemistry, Multidisciplinary
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
Summary: This study presents the first direct spectroscopic evidence of a cyclic seven-membered iminoborane. Compared to linear amino-iminoboranes, this cyclic iminoborane exhibits weakened bond strength and lower Lewis acidity value. The study suggests that the reduced ring strain of cyclic iminoborane prevents nitrogen fixation but allows facile (2 + 2) cycloaddition reaction with C2H4.
Article
Chemistry, Multidisciplinary
Renny Mathew, Aniruddha Mazumder, Praveen Kumar, Julie Matula, Sharmarke Mohamed, Petr Brazda, Mahesh Hariharan, Brijith Thomas
Summary: This study reveals the packing arrangement of partially disordered nitro-perylenediimide (NO2-PDI) using a synergistic approach that combines 3D ED, ssNMR, and DFT techniques. By overcoming these challenges, this methodology opens up new avenues for material characterization, driving exciting advancements in the field.