Designing interactions by control of protein–ligand complex conformation: tuning arginine–arene interaction geometry for enhanced electrostatic protein–ligand interactions

Fluorine Scan of Inhibitors of the Cysteine Protease Human Cathepsin L: Dipolar and Quadrupolar Effects in the π-Stacking of Fluorinated Phenyl Rings on Peptide Amide Bonds

(2016) Maude Giroud et al.   ChemMedChem

Glycobiology simplified: diverse roles of glycan recognition in inflammation

(2016) Ronald L. Schnaar   JOURNAL OF LEUKOCYTE BIOLOGY

Protein Flexibility in Drug Discovery: From Theory to Computation

(2015) Rosa Buonfiglio et al.   ChemMedChem

Thermodynamics of Ion Pair Formations Between Charged Poly(Amino Acid)s

(2015) Vytautas Petrauskas et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer

(2012) Gabriel A. Rabinovich et al.   IMMUNITY

The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

(2011) Kadhirvel Saraboji et al.   BIOCHEMISTRY

When Galectins Recognize Glycans: From Biochemistry to Physiology and Back Again

(2011) Santiago Di Lella et al.   BIOCHEMISTRY

Arene-Anion Based Arginine-Binding Motif on a Galactose Scaffold: Structure-Activity Relationships of Interactions with Arginine-Rich Galectins

(2011) Christopher T. Öberg et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mutational Tuning of Galectin-3 Specificity and Biological Function

(2010) Emma Salomonsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Medicinal Chemist’s Guide to Molecular Interactions

(2010) Caterina Bissantz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

(2010) Carl Diehl et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Double Affinity Amplification of Galectin–Ligand Interactions through Arginine–Arene Interactions: Synthetic, Thermodynamic, and Computational Studies with Aromatic Diamido Thiodigalactosides

(2008) Ian Cumpstey et al.   CHEMISTRY-A EUROPEAN JOURNAL

Arginine Binding Motifs: Design and Synthesis of Galactose-Derived Arginine Tweezers as Galectin-3 Inhibitors

(2008) Christopher T. Öberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Drug Design: Exploring the Proper Filling of Apolar Pockets at Enzyme Active Sites

(2008) Martina Zürcher et al.   JOURNAL OF ORGANIC CHEMISTRY