期刊
CHEMICAL SCIENCE
卷 9, 期 22, 页码 5082-5086出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8sc01476k
关键词
-
资金
- NSF [CHE-1624216]
- NIH [R01-GM102554]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM102554] Funding Source: NIH RePORTER
A new C-C bond formation strategy based on enantioselective radical alkylation of C(sp(3))-H bonds via Co(II)-based metalloradical catalysis has been demonstrated for stereoselective synthesis of chiral indolines. The Co(II)-based system enables activation of aryldiazomethanes as radical precursors at room temperature for enantioselective intramolecular radical alkylation of broad types of C-H bonds, constructing 2-substituted indolines in high yields with excellent enantioselectivities. In addition to chemoselectivity and regioselectivity, this Co(II)-catalyzed alkylation features tolerance to functional groups and compatibility with heteroaryl substrates. Detailed mechanistic studies provide insight into the underlying stepwise radical pathway.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据