Article
Immunology
Ramon Cortez, Luana N. Moreira, Marina Padilha, Mariana D. Bibas, Ricardo K. Toma, Gilda Porta, Carla R. Taddei
Summary: Studies have shown that the composition of intestinal microbiome in pediatric patients with primary sclerosing cholangitis (PSC) is influenced by disease, age, and disease activity status, highlighting significant differences in microbiome between PSC patients. Specific genera Veillonella and Megasphaera have increased relative abundance depending on age at diagnosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Gastroenterology & Hepatology
Mahasish Shome, Lusheng Song, Stacy Williams, Yunro Chung, Vel Murugan, Jin G. Park, William Faubion, Shabana F. Pasha, Jonathan A. Leighton, Joshua LaBaer, Ji Qiu
Summary: By analyzing the anti-microbial antibody response in patients with inflammatory bowel disease (IBD), we have identified antibody signatures for Crohn's disease (CD) and ulcerative colitis (UC), as well as discovered the associated microorganisms. These findings contribute to our understanding of the role specific microorganisms play in the pathogenesis of IBD and could potentially aid in early and accurate diagnosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Samantha Gonzalez Delgado, Idalia Garza-Veloz, Fabiola Trejo-Vazquez, Margarita L. Martinez-Fierro
Summary: This study aims to integrate scientific data on the role of the intestinal microbiota in regulating gut serotonin signaling and reuptake and its involvement in the pathogenesis of IBD. It is found that the use of selective serotonin reuptake inhibitors as an adjuvant therapy can improve disease activity and extraintestinal manifestations in IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Adelaide Teofani, Irene Marafini, Federica Laudisi, Daniele Pietrucci, Silvia Salvatori, Valeria Unida, Silvia Biocca, Giovanni Monteleone, Alessandro Desideri
Summary: This study investigated the impact of lifestyle and dietary habits on the intestinal microbiota diversity and relative abundance in patients with IBD, identifying specific confounders and covariates that influence the association between certain bacterial taxa and disease status. The results suggest that variables related to an IBD-associated lifestyle and dietary habits play a role in modulating the gut microbiota in IBD patients compared to healthy controls.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Haya Abbas-Egbariya, Yael Haberman, Tzipi Braun, Rotem Hadar, Lee Denson, Ohad Gal-Mor, Amnon Amir
Summary: This study reveals a common non-specific response of the gut microbiome in a wide array of diseases, which may cause confusion in disease classification. A universal dysbiosis index is developed to prioritize fecal samples and donors across different diseases. Additionally, specific bacteria associated with inflammatory bowel disease are identified as potential biomarkers and intervention targets.
Article
Microbiology
Sang-Bum Kang, Hyeonwoo Kim, Sangsoo Kim, Jiwon Kim, Soo-Kyung Park, Chil-Woo Lee, Kyeong Ok Kim, Geom-Seog Seo, Min Suk Kim, Jae Myung Cha, Ja Seol Koo, Dong-Il Park
Summary: This study identified distinct oral microbiome patterns in patients with inflammatory bowel disease (IBD), and found significantly reduced richness in the microbiome of IBD patients compared to healthy controls. The study also showed that the oral microbiome patterns were highly accurate in distinguishing between IBD and healthy controls, as well as between Crohn's disease (CD) and ulcerative colitis (UC).
Article
Immunology
Bin Liu, Ding Ye, Hong Yang, Jie Song, Xiaohui Sun, Yingying Mao, Zhixing He
Summary: This study used two-sample Mendelian randomization analyses to investigate the potential causal associations between gut microbial genera and inflammatory bowel disease (IBD), ulcerative colitis (UC), or Crohn's disease (CD). The results showed that six bacterial genera were associated with the risk of IBD, UC, or CD. Specifically, Eubacterium ventriosum group was associated with a lower risk of IBD and UC, whereas Coprococcus 2 was associated with a higher risk. Oxalobacter was positively associated with IBD and CD, and Ruminococcaceae UCG014 was positively associated with IBD and CD. Enterorhabdus and Lachnospiraceae UCG001 showed negative associations with IBD and CD. No reverse causation was found in the analysis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Immunology
Jianxiang Xue, Jessica A. Dominguez Rieg, Linto Thomas, James R. White, Timo Rieg
Summary: This study investigates the importance of intestinal NHE3 for gut microbiota homeostasis and its relationship with inflammatory bowel disease (IBD) using metagenome shotgun sequencing. The results show that NHE3 deficiency leads to significant changes in the gut microbiome, favoring the competitive advantage of pro-inflammatory species. These findings provide a deeper understanding of the interactions between NHE3, dysbiosis, and IBD.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kaline Arnauts, Padhmanand Sudhakar, Sare Verstockt, Cynthia Lapierre, Selina Potche, Clara Caenepeel, Bram Verstockt, Jeroen Raes, Severine Vermeire, Joao Sabino, Catherine Verfaillie, Marc Ferrante
Summary: Microbial dysbiosis is a known phenomenon in patients with inflammatory bowel disease, but the exact mechanism behind host-microbial interactions remains unclear. This study found that the transcriptional response of epithelial cells was not different between patients with ulcerative colitis (UC) and non-IBD controls following exposure to microbiota. However, UC microbiota exposure led to a significant decrease in epithelial barrier integrity, regardless of the origin of the epithelial cells. Furthermore, UC microbiota induced stress responses in all epithelial cells, while responses to healthy volunteer (HV) microbiota were milder.
Review
Biochemistry & Molecular Biology
Ellen Cristina Souza de Oliveira, Ana Elisa Valencise Quaglio, Daniela Oliveira Magro, Luiz Claudio Di Stasi, Ligia Yukie Sassaki
Summary: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder characterized by an overactive immune response to environmental factors, including gut microbiota and dietary components. MicroRNAs (miRNAs) have been associated with various physiological processes and play a role in the regulation of inflammatory pathways. Differences in miRNA profiles can be used as a diagnostic and prognostic marker in IBD. The interaction between miRNAs and intestinal microbiota is still not fully understood, but recent studies have shown their role in modulating intestinal homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Amy L. Lightner, Sarah Vogler, John McMichael, Xue Jia, Miguel Regueiro, Taha Qazi, Scott R. Steele
Summary: While UC patients were more likely to have neoplasia detected during colonoscopy, the rates of progression from LGD and HGD to adenocarcinoma were equivalent in UC and CD, suggesting consistent endoscopic surveillance strategies for all IBD patients.
JOURNAL OF CROHNS & COLITIS
(2021)
