Article
Multidisciplinary Sciences
Aurelien Mercier, Thomas Obadia, Davide Carraretto, Enkelejda Velo, Gaelle Gabiane, Silvia Bino, Marie Vazeille, Giuliano Gasperi, Catherine Dauga, Anna R. Malacrida, Paul Reiter, Anna-Bella Failloux
Summary: The invasive mosquito Ae. albopictus can transmit CHIKV and DENV, and temperature is a key factor in limiting their transmission. Local transmissions of these viruses have been reported in southern Europe, but it is uncertain how far north transmission could occur.
SCIENTIFIC REPORTS
(2022)
Article
Parasitology
Daniel Chieh-Ding Lin, Shih-Che Weng, Po-Nien Tsao, Justin Jang Hann Chu, Shin-Hong Shiao
Summary: Co-infection of dengue virus and Zika virus in Aedes aegypti mosquitoes enhance viral replication and suggest that the NS5 protein is a potential target for vector control.
PARASITES & VECTORS
(2023)
Article
Multidisciplinary Sciences
Mary E. Petrone, Rebecca Earnest, Jose Lourenco, Moritz U. G. Kraemer, Robert Paulino-Ramirez, Nathan D. Grubaugh, Leandro Tapia
Summary: This study analyzed the temporal and spatial patterns of chikungunya, Zika, and dengue outbreaks reported in the Dominican Republic between 2012 and 2018. The research found that emerging disease outbreaks were robust to the climatological and spatio-temporal constraints defining seasonal dengue outbreak dynamics, indicating the need for constant surveillance to prevent future health crises.
NATURE COMMUNICATIONS
(2021)
Review
Parasitology
Eric P. Caragata, Heverton L. C. Dutra, Pedro H. F. Sucupira, Alvaro G. A. Ferreira, Luciano A. Moreira
Summary: The review discusses the strategy of controlling arbovirus transmission by exploiting the Wolbachia-mosquito relationship, which has led to significant decreases in dengue virus incidence through releasing Wolbachia-infected mosquitoes. It also mentions that external factors can modulate Wolbachia density and transmission.
TRENDS IN PARASITOLOGY
(2021)
Editorial Material
Cell Biology
Rafael K. Campos, Shannan L. Rossi, Robert B. Tesh, Scott C. Weaver
Summary: Emerging zoonotic mosquito-borne viruses pose increasing health threats and require global preparedness to effectively mitigate the impacts in terms of health, society, and economy.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Meng Zou, Chunyan Su, Tingting Li, Jing Zhang, Daiying Li, Ning Luan, Dehong Ma, Jiansheng Liu, Qiangming Sun, Xiaozhong Peng, Hongqi Liu
Summary: This study reports the co-infection of CHIKV during the DENV epidemic in Xishuangbanna, China in 2019. Molecular epidemiology revealed that the CHIKV identified in this study belongs to the Asian lineage, with lineage-specific mutations and some reported adaptive mutations, distinguishing it from the recently reported East/Central/South African CHIKV in Ruili.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Shan-Ko Tsai, Yu-Lin Hsu, Der-Jiang Chiao, Pei-Yun Shu, Hui-Tsu Lin, Shu-Fen Chang, Hui-Chung Lin, Shih-Hsin Huang, Chun-Hsiung Wang, Chia-Chu Hsiung, Chang-Chi Lin, Tzong-Yuan Wu, Szu-Cheng Kuo
Summary: This study describes the production of novel CHIKV virus-like particles (VLPs) from mosquitoes using a Baculovirus/Mosquito system. The VLPs showed potential as an antigen for serological detection and vaccine development against CHIKV infection, as they were able to induce neutralizing antibody responses and specific antibody production in mice.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Immunology
Zhiwei Huang, Yuxuan Zhang, Hongyu Li, Jiajie Zhu, Wanchen Song, Keda Chen, Yanjun Zhang, Yongliang Lou
Summary: Mosquito-borne viral diseases, such as Dengue, Zika, and Chikungunya viruses, have become significant public health concerns. Currently, there are no effective vaccines available for these viruses, except for the licensed Dengue vaccine. Efforts to control the spread of COVID-19 have somewhat limited the transmission of mosquito-borne viral diseases. Various vaccine platforms, including inactivated, viral-vector, live attenuated, protein, and nucleic acid vaccines, are being developed to combat these viruses. This review provides valuable insights for responding to potential outbreaks.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Emergency Medicine
Aleem Azal Ali, Belinda Bajric, Carmen L. Isache, Ravindra P. Maharaj
Summary: Chikungunya is an arboviral infection characterized by acute viral illness and inflammatory arthritis. First described in Tanzania in 1952, outbreaks had been limited to Africa, Asia, Europe, and the Indian and Pacific Oceans until 2013. The disease spread to the Caribbean in late 2013 and subsequently to Central and South America. In the United States, there have been travel-associated cases of Chikungunya reported, with the first case acquired in Florida without international travel history.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Constantino Carreto, Roxana Gutierrez-Romero, Tania Rodriguez
Summary: This study analyzes the temporal and spatial dynamics of dengue, chikungunya, and Zika in Mexico and evaluates the impact of seasonal climatological variability on the transmission risk of these mosquito-borne diseases. The results show a strong correlation between the transmission risk index and the incidence of these diseases, indicating that the index is a valuable tool for surveillance in settings with varied climates and limited capacity.
INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS
(2022)
Review
Multidisciplinary Sciences
Guan-Hong Wang, Stephanie Gamez, Robyn R. Raban, John M. Marshall, Luke Alphey, Ming Li, Jason L. Rasgon, Omar S. Akbari
Summary: This review explores the latest developments in pathogen-blocking Wolbachia and genome engineering approaches to mosquito-borne disease control, discussing their similarities and critical distinctions, as well as their potential future applications.
NATURE COMMUNICATIONS
(2021)
Article
Plant Sciences
Sze Mun Chan, Kong Soo Khoo, Shamala Devi Sekaran, Nam Weng Sit
Summary: The study evaluated 132 extracts from 21 medicinal plants for anti-chikungunya virus activity, identifying several plant extracts with potential to inhibit viral infection.
Review
Virology
Yuan Fang, Emad I. M. Khater, Jing-Bo Xue, Enas H. S. Ghallab, Yuan-Yuan Li, Tian-Ge Jiang, Shi-Zhu Li
Summary: This systematic review examines the prevalence of mosquito-borne viruses (MBVs) in Egypt. The study finds that dengue virus (DENV) and West Nile virus (WNV) have shown an increase in seropositivity rates, and spillover events have been recorded. The surveillance system for MBVs in Egypt has deficiencies and calls for the establishment of an early warning system and a joint system for medical care and public health.
Article
Medicine, General & Internal
A. Utarini, C. Indriani, R. A. Ahmad, W. Tantowijoyo, E. Arguni, M. R. Ansari, E. Supriyati, D. S. Wardana, Y. Meitika, I. Ernesia, I. Nurhayati, E. Prabowo, B. Andari, B. R. Green, L. Hodgson, Z. Cutcher, E. Rances, P. A. Ryan, S. L. O'Neill, S. M. Dufault, S. K. Tanamas, N. P. Jewell, K. L. Anders, C. P. Simmons
Summary: The cluster-randomized trial in Indonesia showed that deploying mosquitoes infected with the wMel strain of Wolbachia pipientis led to a reduction in symptomatic, virologically confirmed dengue infections and hospitalizations among residents.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Chemistry, Medicinal
Kseniya N. Sedenkova, Victoria I. Uvarova, Anna A. Nazarova, Aleksandra V. Peisikova, Evgeny V. Khvatov, Maksim V. Sukhorukov, Vasilisa S. Frolenko, Alexander S. Goryashchenko, Ivan S. Kholodilov, Yuri K. Grishin, Viktor B. Rybakov, Marat T. Makenov, Evgeny S. Morozkin, Lyudmila S. Karan, Liubov I. Kozlovskaya, Aydar A. Ishmukhametov, Dmitry I. Osolodkin, Elena B. Averina
Summary: A series of tetrahydroquinazoline N-oxides were synthesized and their antiviral activity against flaviviruses such as TBEV, YFV, and WNV was assessed. Most of the compounds showed activity against TBEV and WNV, and a few also demonstrated inhibitory activity against YFV. The mechanism of action of these compounds appears to affect the early stages of viral replication cycle after cell entry.
ARCHIV DER PHARMAZIE
(2023)
Review
Biochemistry & Molecular Biology
Ramesh Kumar, Divya Mehta, Nimisha Mishra, Debasis Nayak, Sujatha Sunil
Summary: Viruses depend on host cells for replication and survival, utilizing post-translational modifications (PTMs) to control viral replication. Host proteins use PTMs to inhibit viral protein synthesis, eliminate viruses, while PTMs of viral proteins can increase their solubility and virulence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
M. Ratheesh, Sujatha Sunil, S. Sheethal, Svenia P. Jose, S. Sandya, Oriparambil Sivaraman Nirmal Ghosh, Sony Rajan, Tariq Jagmag, Jayesh Tilwani
Summary: The study aims to demonstrate the anti-viral and anti-inflammatory effects of a novel polyherbal formulation called Imusil. Chemical characterizations of Imusil were conducted, and the results showed that Imusil significantly inhibited the replication of SARS-CoV-2 and reduced the production of inflammatory mediators.
INFLAMMOPHARMACOLOGY
(2022)
Article
Microbiology
Juthamas Phadungsombat, Hisham A. Imad, Emi E. Nakayama, Pornsawan Leaungwutiwong, Pongrama Ramasoota, Wang Nguitragool, Wasin Matsee, Watcharapong Piyaphanee, Tatsuo Shioda
Summary: The study reveals the lineage and spread of the Indian Ocean Lineage (IOL) of the chikungunya virus (CHIKV) in the past decade. It finds that the virus originated in Kenya and spread through the Indian ocean and the Indian subcontinent, before expanding through Southeast Asia. The virus carries a mutation that enhances replication in Aedes albopictus mosquitoes. However, recent outbreaks in different countries lacked this mutation but carried other mutations. The study also investigates the phylogenetic relationships and shows the dynamics of the IOL sub-lineages in different regions.
Article
Virology
Rummana Rahim, Abu Hasan, Juthamas Phadungsombat, Nazmul Hasan, Nikhat Ara, Suma Mita Biswas, Emi E. Nakayama, Mizanur Rahman, Tatsuo Shioda
Summary: Dengue virus (DENV) infections can result in varying clinical outcomes, from mild symptoms to severe and fatal disease. The severity of dengue infection is influenced by the replacement of circulating DENV serotypes and genotypes. A study conducted in Bangladesh revealed a shift in the dominant serotype from DENV2 to DENV3 and the replacement of DENV2 genotypes from clades B and C to clade C. DENV3 genotype I was the only one in circulation and was associated with a high incidence of severe cases in 2019.
Review
Microbiology
Emi E. Nakayama, Tatsuo Shioda
Summary: Antibody-dependent enhancement (ADE) is the phenomenon where antibodies produced after infection or vaccination can enhance subsequent viral infections in vitro and in vivo. This is due to the production of antibodies with low neutralizing activity, antigen-antibody complexes causing inflammation, or an overabundance of T-helper 2 cells. This article describes the three types of ADE and their relationship to vaccination and natural infection, as well as the possible involvement of ADE in COVID-19 pathogenesis.
Article
Microbiology
Juthamas Phadungsombat, Huong Thi Thu Vu, Quynh Thi Nguyen, Ha Thi Van Nguyen, Ha Thi Nhu Nguyen, Bich Thi Dang, Emi E. Nakayama, Azumi Ishizaki, Hiroshi Ichimura, Tatsuo Shioda, Thach Ngoc Pham
Summary: The study conducted molecular characterization of dengue patients' samples in northern Vietnam collected in 2019-2020, revealing the circulating serotypes as DENV-1 and DENV-2, with DENV-2 being the predominant strain. The current Asian-Pacific lineage of the cosmopolitan virus is closely related to recent outbreaks in Southeast Asian countries and China. Multiple introductions of the virus occurred in 2016-2017, possibly from maritime Southeast Asia, mainland Southeast Asia, or China, rather than an expansion of localized Vietnamese cosmopolitan strains.
Article
Virology
Abu Hasan, Rummana Rahim, Emi E. Nakayama, Kazuko Uno, Nazmul Hasan, Mizanur Rahman, Tatsuo Shioda
Summary: This study evaluated 130 COVID-19 patients and found increased IL-6 production in severe cases. The anti-N antibody played a crucial role in inducing IL-6 production. Uncontrolled IL-6 production exacerbated disease severity and mortality. Targeting the N protein could be a therapeutic strategy for severe cases.
Article
Infectious Diseases
Hisham Ahmed Imad, Ploi Lakanavisid, Phimphan Pisutsan, Kentaro Trerattanavong, Thundon Ngamprasertchai, Wasin Matsee, Watcharapong Piyaphanee, Pornsawan Leaungwutiwong, Wang Nguitragool, Emi E. Nakayama, Tatsuo Shioda
Summary: Fever and rash, also known as febrile exanthem, are commonly caused by infection by microorganisms. While viruses are frequently responsible, bacteria can also cause rashes. Some microbes may exhibit distinctive features during illness, but coinfections can make clinical diagnosis challenging.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Infectious Diseases
Abu Hasan, Tadahiro Sasaki, Juthamas Phadungsombat, Ritsuko Koketsu, Rummana Rahim, Nikhat Ara, Suma Mita Biswas, Riku Yonezawa, Emi E. Nakayama, Mizanur Rahman, Tatsuo Shioda
Summary: Through genetic analysis of influenza virus samples from patients in Evercare Hospital Dhaka, Bangladesh, we identified the presence of H1N1pdm influenza subtype, which had spread rapidly without acquiring oseltamivir resistance.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Infectious Diseases
Ahmed Miqdhaadh, Hisham Ahmed Imad, Aminath Fazeena, Thundon Ngamprasertchai, Wang Nguitragool, Emi E. Nakayama, Tatsuo Shioda
Summary: This study presented a case of multisystem inflammatory syndrome in adults (MIS-A) during COVID-19 outbreaks, detailing the clinical presentation, laboratory findings, diagnosis, and treatment process. The article highlighted the importance of clinicians remaining vigilant in identifying cases of MIS-A during the pandemic.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Infectious Diseases
Hisham Ahmed Imad, Aishath Azna Ali, Mariyam Nahuza, Rajan Gurung, Abdulla Ubaid, Aishath Maeesha, Sariu Ali Didi, Rajib Kumar Dey, Abdullah Isneen Hilmy, Aishath Hareera, Ibrahim Afzal, Wasin Matsee, Wang Nguitragool, Emi. E. Nakayama, Tatsuo Shioda
Summary: Scrub typhus, a neglected tropical disease mainly found in Asia, is caused by a bacterium transmitted by larvae of mites. This study reviewed a case of a 23-year-old woman who presented with worsening abdominal pain, jaundice, and positive findings for scrub typhus. Additional tests also suggested the possibility of an alternative cause for acute acalculous cholecystitis. Treatment with doxycycline was recommended for patients in endemic regions before serological confirmation.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Infectious Diseases
Hisham A. Imad, Juthamas Phadungsombat, Emi E. Nakayama, Lapakorn Chatapat, Phimphan Pisutsan, Wasin Matsee, Watcharapong Piyaphanee, Wang Nguitragool, Tatsuo Shioda
Summary: Dengue fever is a neglected tropical disease transmitted primarily by mosquitoes, leading to a spectrum of clinical manifestations. With increased global travel and tourism, individuals naive to dengue viruses are at risk of infection.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Infectious Diseases
Kanaporn Poltep, Juthamas Phadungsombat, Emi E. Nakayama, Nathamon Kosoltanapiwat, Borimas Hanboonkunupakarn, Witthawat Wiriyarat, Tatsuo Shioda, Pornsawan Leaungwutiwong
Summary: The study revealed that diverse genotypes and clades of dengue viruses are circulating in Bangkok, Thailand, with DENV-1 being the most prevalent and DENV-2 and DENV-4 having multiple genotypes and clades. Additionally, a cluster of genotype I DENV-3 viruses rarely reported in Thailand was observed. Continued investigation of DENV is necessary to understand its relationship within Thailand and neighboring countries in Southeast Asia and Asia.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Love Panchariya, Wajahat Ali Khan, Shobhan Kuila, Kirtishila Sonkar, Sibasis Sahoo, Archita Ghoshal, Ankit Kumar, Dileep Kumar Verma, Abdul Hasan, Mohd Azeem Khan, Niyati Jain, Amit Kumar Mohapatra, Shubhashis Das, Jitendra K. Thakur, Souvik Maiti, Ranjan Kumar Nanda, Rajkumar Halder, Sujatha Sunil, Arulandu Arockiasamy
Summary: Research shows that zinc can inhibit the SARS-CoV-2 main protease and viral replication, increasing antiviral potency. The crystal structure of the complex formed by zinc and Mpro provides important structural basis for further study of viral replication.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Ankitha George, M. S. Amrutha, Priyanshu Srivastava, Sujatha Sunil, V. V. R. Sai, Ramanathan Srinivasan
Summary: This study presents a novel plasmonic fiber optic sandwich immunobiosensor for the detection of chikungunya virus. It demonstrates high sensitivity and specificity for CHIKV-nsP3, illustrating the potential for direct and sensitive point-of-care detection of the chikungunya viral disease.