期刊
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
卷 62, 期 3, 页码 982-989出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2014.2377197
关键词
Conformable; liquid crystal polymer (LCP); monolithic fabrication; neural prosthesis; retinal prosthesis
资金
- Public Welfare and Safety research program through the National Research Foundation of Korea - Ministry of Science, ICT and Future Planning [2011-0020987]
- Pioneer Research Center Program through the National Research Foundation of Korea - Ministry of Science, ICT and Future Planning [2009-0082961]
- Brain Korea 21 Plus Project, the Department of Electrical and Computer Engineering, Seoul National University
- National Research Foundation of Korea [2011-0007411]
- National Research Foundation of Korea [2009-0082961, 2010-0020851] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A novel retinal prosthetic device was developed using biocompatible liquid crystal polymer (LCP) to address the problems associated with conventional metal- and polymer-based devices: the hermetic metal package is bulky, heavy, and labor-intensive, whereas a thin, flexible, and MEMS-compatible polymerbased system is not durable enough for chronic implantation. Exploiting the advantageous properties of LCP such as a low moisture absorption rate, thermobonding, and thermoforming, we fabricate a small, light-weight, long-term reliable retinal prosthesis that can be conformally attached on the eye-surface. A LCP fabrication process using monolithic integration and conformal deformation was established enabling miniaturization and a batch manufacturing process as well as eliminating the need for feedthrough technology. The functionality of the fabricated device was tested through wireless operation in saline solution. Its efficacy and implantation stability were verified through in vivo animal tests by measuring the cortical potential and monitoring implanted dummy devices for more than a year, respectively.
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