Article
Immunology
L. F. van Beek, J. D. Langereis, H. B. van den Berg van Saparoea, J. Gillard, W. S. P. Jong, F. J. van Opzeeland, R. Mesman, L. van Niftrik, I. Joosten, D. A. Diavatopoulos, J. Luirink, M. I. de Jonge
Summary: Protein bodies (PBs) are insoluble, aggregated particles consisting of proteins that have the potential to be used as vaccine formulations. Studies show that PBs can provide superior protection against nasopharyngeal colonization by Streptococcus pneumoniae and elicit strong mucosal immune responses, making them a promising platform for next-generation vaccine development.
Article
Microbiology
Jessica R. Lane, Muralidhar Tata, Rahena Yasmin, Hansol Im, David E. Briles, Carlos J. Orihuela
Summary: The virulence factor PspA plays a critical role in the aggregation and protection of Streptococcus pneumoniae during colonization, while lactoferrin counters this effect. PspA forms protein complexes with mGAPDH and lactoferrin on the surface of the bacteria, and changes in the levels of these proteins may have important implications on the colonization, survival on fomites, and transmission of S. pneumoniae.
Article
Microbiology
Willem R. Miellet, Sonia T. Almeida, Krzysztof Trzcinski, Raquel Sa-Leao
Summary: Streptococcus pneumoniae causes significant morbidity and mortality among older adults. The low sensitivity of culture-based approaches and nasopharyngeal samples has hindered adult S. pneumoniae carriage studies in the past. However, qPCR-based approaches and testing of oral samples can improve the accuracy of adult carriage detection.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Adriano P. Araujo, Maria Leonor S. Oliveira, Eliane N. Miyaji
Summary: Streptococcus pneumoniae colonizes the human nasopharynx asymptomatically, but can cause various diseases. This study demonstrates the important role of PspA and PspC in nasopharyngeal colonization, although their significance may vary between different strains.
MICROBIAL PATHOGENESIS
(2023)
Article
Infectious Diseases
Leigh M. Howard, Xiang Huang, Wencong Chen, Yuhan Liu, Kathryn M. Edwards, Marie R. Griffin, Yuwei Zhu, Jorge E. Vidal, Keith P. Klugman, Ana I. Gil, Nicole R. Soper, Isaac P. Thomsen, Katherine Gould, Jason Hinds, Claudio F. Lanata, Carlos G. Grijalva
Summary: We investigated the association between nasopharyngeal pneumococcal co-colonization and pneumococcal density in young Peruvian children. Pneumococcal co-colonization was common but not associated with increased pneumococcal density.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Sudhanshu Shekhar, Heidi A. Amdal, Fernanda Cristina Petersen
Summary: Mucosal immunization with S. mitis serotype 5 protects mice against S. pneumoniae serotype 5 infection and induces Th17 and predominant serotype-specific IgG/IgA antibody responses against pneumococcal infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Sonia T. Almeida, Ana Cristina Paulo, Filipe Froes, Herminia de Lencastre, Raquel Sa-Leao
Summary: The study found that the pneumococcal carrier state in healthy adults is more dynamic than generally assumed, with frequent acquisition and often long duration of carriage. This suggests that some adults may act as reservoirs of pneumococci, impacting the potential herd effects achievable through children vaccination depending on the community's social structure. These findings are important for designing strategies to prevent pneumococcal disease in adults.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Carina Valente, Ana R. Cruz, Adriano O. Henriques, Raquel Sa-Leao
Summary: Streptococcus pneumoniae, a human pathogen causing high morbidity and mortality, can exhibit intra-species interactions in biofilms. These interactions are independent of the capsular and sequence type of the strains involved. A new experimental approach was developed to study these interactions, which can help understand the underlying mechanisms. This study provides important insights into the mixed biofilm growth of pneumococcal strains.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Jiaqi D. Zhu, Annie Abruzzo, Cindy N. Wu, Gavyn Chern Wei Bee, Alejandro A. Pironti, Gregory Putzel, Surya A. Aggarwal, Hannes Eichner, Jeffrey A. Weiser
Summary: This study investigates the impact of capsule thickness on host-pathogen interactions using genetically-modified strains of Streptococcus pneumoniae. The results show that a sufficiently thick capsule can protect the organism from recognition by host factors and benefit both invasive infection and colonization. Additionally, the study finds substantial variability in capsule thickness among different clinical isolates of S. pneumoniae.
Article
Immunology
Beth Temple, Monica Larissa Nation, Vo Thi Trang Dai, Jemima Beissbarth, Kathryn Bright, Eileen Margaret Dunne, Jason Hinds, Pham Thi Hoan, Jana Lai, Cattram Duong Nguyen, Belinda Daniela Ortika, Thanh Phan, Ho Nguyen Loc Thuy, Nguyen Trong Toan, Doan Y. Uyen, Catherine Satzke, Heidi Smith-Vaughan, Tran Ngoc Huu, Kim Mulholland
Summary: The study found that both PCV10 and PCV13 have similar effects in reducing pneumococcal carriage, with both vaccines reducing the carriage of vaccine serotypes. In addition, the distribution of serotypes among unvaccinated participants was also described.
Article
Infectious Diseases
Rama Kandasamy, Stephanie Lo, Meeru Gurung, Michael J. Carter, Rebecca Gladstone, John Lees, Sonu Shrestha, Stephen Thorson, Sanjeev Bijukchhe, Madhav C. Gautam, Reetu Shrestha, Sunaina Gurung, Bibek Khadka, Lesley McGee, Robert F. Breiman, David R. Murdoch, Dominic F. Kelly, Shrijana Shrestha, Stephen D. Bentley, Andrew J. Pollard
Summary: Pneumococcal disease is a major cause of bacterial pneumonia and invasive bacterial disease in children globally. This study used whole-genome sequencing to analyze strains of pneumococcus collected in Kathmandu, Nepal from 2005 to 2018. The research identified a strain, GPSC9, with high disease prevalence, multidrug resistance, and the ability to switch to an unencapsulated phenotype.
Article
Immunology
Maimuna Carrim, Stefano Tempia, Deus Thindwa, Neil A. Martinson, Kathleen Kahn, Stefan Flasche, Orienka Hellferscee, Florette K. Treurnicht, Meredith L. McMorrow, Jocelyn Moyes, Thulisa Mkhencele, Azwifarwi Mathunjwa, Jackie Kleynhans, Limakatso Lebina, Katlego Mothlaoleng, Floidy Wafawanaka, Francesc Xavier Gomez-Olive, Cheryl Cohen, Anne von Gottberg, Nicole Wolter
Summary: This study conducted in high HIV prevalence settings found that pneumococcus colonization is widespread across all age groups. Children and individuals with HIV are more likely to be colonized and have higher pneumococcal loads. Carriage duration decreases with age, highlighting the importance of children in pneumococcal transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Immunology
Claire Froneman, Peter Kelleher, Ricardo J. Jose
Summary: Infections with Streptococcus pneumoniae are a common cause of morbidity and mortality worldwide, especially affecting those at the extremes of age and immunocompromised individuals. Preventing pneumococcal disease is crucial in at-risk individuals, and pneumococcal vaccination should be offered to them.
Article
Microbiology
Elissavet Nikolaou, Simon P. Jochems, Elena Mitsi, Sherin Pojar, Annie Blizard, Jesus Reine, Carla Solorzano, Edessa Negera, Beatriz Carniel, Alessandra Soares-Schanoski, Victoria Connor, Hugh Adler, Seher R. Zaidi, Caz Hales, Helen Hill, Angie Hyder-Wright, Stephen B. Gordon, Jamie Rylance, Daniela M. Ferreira
Summary: This study utilized a human challenge model to investigate host-pathogen interactions following exposure to Streptococcus pneumoniae. Results showed that nasal colonization can take up to 24 hours to become established, and two distinct bacterial clearance profiles were associated with protection. These findings are crucial for design and testing of novel vaccine candidates.
Review
Geriatrics & Gerontology
Birgit Weinberger
Summary: Maintaining good health in old age is crucial for alleviating societal, economic, and healthcare challenges caused by aging populations. Preventing infections through vaccination is an important measure to ensure healthy aging and preserve quality of life for older adults. Ongoing research is focused on improving vaccines, developing universal vaccines, and increasing awareness for life-long vaccination to protect the vulnerable older age group.
Correction
Oncology
Alexander B. Olawaiye, James J. Java, Thomas C. Krivak, Michael Friedlander, David G. Mutch, Gretchen Glaser, Melissa Geller, David M. O'Malley, Robert M. Wenham, Roger B. Lee, Diane C. Bodurka, Thomas J. Herzog, Michael A. Bookman
GYNECOLOGIC ONCOLOGY
(2019)
Article
Obstetrics & Gynecology
Peter G. Rose, Janzes J. Java, Ritu Salani, Melissa A. Geller, Angeles Alvarez Secord, Krishnansu S. Tewari, David P. Bender, David G. Mutch, Michael L. Friedlander, Linda Van Le, Michael W. Method, Chad A. Hamilton, Roger B. Lee, Robert M. Wenham, Saketh R. Guntupalli, Maurie Markman, Franco M. Muggia, Deborah K. Armstron, Michael A. Bookman, Robert A. Burger, Lally J. Copeland
OBSTETRICS AND GYNECOLOGY
(2019)
Article
Pediatrics
Mary T. Caserta, Hongmei Yang, Sanjukta Bandyopadhyay, Xing Qiu, Steven R. Gill, James Java, Andrew McDavid, Ann R. Falsey, David J. Topham, Jeanne Holden-Wiltse, Kristin Scheible, Gloria Pryhuber
JOURNAL OF PEDIATRICS
(2019)
Article
Oncology
Katherine C. Fuh, James J. Java, John K. Chan, Daniel S. Kapp, Bradley J. Monk, Robert A. Burger, Robert C. Young, David S. Alberts, William P. McGuire, Maurie Markman, Jeffrey Bell, Robert F. Ozols, Deborah K. Armstrong, Carol Aghajanian, Michael A. Bookman, Robert S. Mannel
GYNECOLOGIC ONCOLOGY
(2019)
Article
Health Care Sciences & Services
Jennifer R. Mammen, James J. Java, Jill Halterman, Marc N. Berliant, Amber Crowley, Sean M. Frey, Marina Reznik, Jonathan M. Feldman, Judith D. Schoonmaker, Kimberly Arcoleo
Summary: This study describes the development of a smartphone telemedicine program for adults with asthma and its results from proof-of-concept testing. The program incorporated symptom monitoring, telemedicine visits, and self-management training, resulting in improved asthma control, quality of life, and FEV1 percent predicted. Healthcare utilization and prescriptions also increased significantly. Careful attention to systems capabilities and stakeholder acceptability is necessary for successful integration into practice.
JOURNAL OF TELEMEDICINE AND TELECARE
(2021)
Article
Oncology
D. P. Mysona, L. K. H. Tran, P. M. H. Tran, P. A. Gehrig, L. Van Le, S. Ghamande, B. J. Rungruang, J. Java, A. K. Mann, J. Liao, D. S. Kapp, Bruno dos Santos, J. X. She, J. K. Chan
GYNECOLOGIC ONCOLOGY
(2020)
Article
Allergy
Jennifer R. Mammen, Kelsey Turgeon, Ashley Philibert, Judith D. Schoonmaker, James Java, Jill Halterman, Marc N. Berliant, Amber Crowley, Marina Reznik, Jonathan M. Feldman, Robert J. Fortuna, Kimberly Arcoleo
Summary: The study revealed issues with asthma management and treatment among young adults, including incorrect self-management behaviors and misconceptions about medication. Enhancing asthma education and support for young adults is crucial to improve their adherence to care and quality of life.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Allergy
Jennifer R. Mammen, Judith D. Schoonmaker, James Java, Jill Halterman, Marc N. Berliant, Amber Crowley, Marina Reznik, Jonathan M. Feldman, Robert J. Fortuna, Sean M. Frey, Kelsey Turgeon, Ashley Philibert, Kimberly Arcoleo
Summary: This study evaluated the efficacy, feasibility, and acceptability of a multi-component smartphone-telemedicine program (TEAMS) in delivering remote asthma care and improving patient outcomes. The results showed that TEAMS significantly improved asthma control, quality of life, provider adherence to guidelines, and patient adherence to medication. Both participants and providers reported high acceptability of the program.
Article
Immunology
Alex Grier, Ann L. Gill, Haeja A. Kessler, Anthony Corbett, Sanjukta Bandyopadhyay, James Java, Jeanne Holden-Wiltse, Ann R. Falsey, David J. Topham, Thomas J. Mariani, Mary T. Caserta, Edward E. Walsh, Steven R. Gill
Summary: The study reveals the dysbiosis of nasal microbiota in infants with RSV infection, which may be associated with the progress of the disease. The temporal dynamics of microbiota provide indicators of disease risk and insights into the impact of RSV infection on microbiota composition.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Ferralita S. Madere, Michael Sohn, Angelina K. Winbush, Breona Barr, Alex Grier, Cal Palumbo, James Java, Tracy Meiring, Anna-Lise Williamson, Linda-Gail Bekker, David H. Adler, Cynthia L. Monaco
Summary: The female reproductive tract microbiome plays a crucial role in maintaining vaginal health, with viruses being key regulators. However, the impact of the female reproductive tract viruses, particularly bacteriophages, on health and dysbiosis is not well understood. This study suggests that bacterial vaginosis (BV) is associated with altered phageome diversity, transkingdom interplay, and specific bacteriophage taxa.
Article
Oncology
Omali Pitiyarachchi, Michael Friedlander, James J. Java, John K. Chan, Deborah K. Armstrong, Maurie Markman, Thomas J. Herzog, Bradley J. Monk, Floor Backes, Angeles Alvarez Secord, Albert Bonebrake, Peter G. Rose, Krishnansu S. Tewari, Samuel S. Lentz, Melissa A. Geller, Larry J. Copeland, Robert S. Mannel
Summary: This study reported the proportion of patients with Stage III epithelial ovarian cancer (EOC) who were long-term disease-free survivors (LTDFS >=10 years) after receiving intraperitoneal or intravenous chemotherapy. It also identified the predictors of LTDFS.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Eva Culakova, Supriya G. Mohile, Luke Peppone, Erika Ramsdale, Mostafa Mohamed, Huiwen Xu, Megan Wells, Rachael Tylock, Jim Java, Kah Poh Loh, Allison Magnuson, Leah Jamieson, Victor Vogel, Paul R. Duberstein, Benjamin P. Chapman, William Dale, Marie Anne Flannery
Summary: Providing a geriatric assessment summary with management recommendations to oncologists reduces clinician-rated toxicity in older patients with advanced cancer receiving treatment. A GA intervention for older patients with advanced cancer reduces patient-reported symptomatic toxicity in the presence of a high baseline symptom burden.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Eva Culakova, Supriya Gupta Mohile, Mostafa Refaat Mohamed, Erika E. Ramsdale, Rachael Tylock, Megan Wells, Zhihong Zhang, James Java, Kah Poh Loh, Allison Magnuson, Luke Joseph Peppone, Marie Anne Flannery
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Critical Care Medicine
R. Misra, J. Java, G. Bandyopadhyay, S. Bhattacharya, C. Poole, H. Huyck, G. Deutsch, T. J. Mariani, G. S. Pryhuber
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
J. R. Mammen, J. Halterman, M. N. Berliant, K. Turgeon, A. Philibert, J. Java, M. Reznik, J. M. Feldman, R. Fortuna, J. D. Schoonmaker, A. Crowley, S. M. Frey, K. J. Arcoleo
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)