Article
Ophthalmology
Angela Lu, Yuwei Sun, Travis C. Porco, Benjamin F. Arnold, Nisha R. Acharya
Summary: The study examined the effectiveness of the recombinant zoster vaccine in preventing herpes zoster ophthalmicus in the US population, finding a high effectiveness rate of 89.1%. The low vaccination rate highlighted the need to increase vaccine utilization for public health benefit, with ophthalmologists playing a key role in recommending vaccination to eligible patients.
Review
Virology
Yasmin Marra, Fawziah Lalji
Summary: Infection with varicella zoster virus can cause either chickenpox or shingles. Two vaccines are available to prevent shingles, with the recombinant vaccine showing higher efficacy than the live vaccine. Safety data from both vaccines indicate mostly local and mild systemic reactions.
Article
Immunology
Ruth Harbecke, Jeffrey Cohen, Michael N. Oxman
Summary: Herpes zoster is a common virus that affects many people, and vaccines for preventing HZ and PHN are important for older adults. Clinical trials and real-world studies have shown that the vaccines are safe and effective in preventing these conditions.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Yizhou Ye, Baoguo Jiang, Sudhakar Manne, Peter L. Moses, Cristina Almansa, Dimitri Bennett, Paul Dolin, Alexander C. Ford
Summary: Through analysis of the CPRD database, it was found that the standardized prevalence of gastroparesis in 2016 was 13.8 per 100,000 persons, while the standardized incidence increased from 1.5 per 100,000 person-years in 2004 to 1.9 in 2016. Diabetic gastroparesis and idiopathic gastroparesis were the most common disease etiologies, with diabetic gastroparesis patients having a significantly higher risk of mortality after diagnosis compared to idiopathic gastroparesis patients.
Article
Health Care Sciences & Services
James F. Mbinta, Alex X. Wang, Binh P. Nguyen, Janine Paynter, Prosper Mandela A. Awuni, Russell Pine, Andrew A. Sporle, Colin R. Simpson
Summary: A study in New Zealand assessed the 'real-world' effectiveness of the zoster vaccine live (ZVL) against herpes zoster (HZ) and postherpetic neuralgia (PHN). The study found that the vaccine significantly reduced the risk of hospitalisation from HZ and PHN.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Biotechnology & Applied Microbiology
Tara C. Anderson, Jessica W. Leung, Rafael Harpaz, Kathleen L. Dooling
Summary: This study utilized two large national data sources to conduct a self-controlled case series analysis, which found a significantly increased risk of Guillain-Barre syndrome (GBS) following herpes zoster (HZ).
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Review
Biotechnology & Applied Microbiology
Nikolaos Giannelos, Cheryl Ng, Desmond Curran
Summary: This study critically reviewed the cost-effectiveness of the recombinant zoster vaccine (RZV) against herpes zoster (HZ). The review found that RZV vaccination is cost-effective in the prevention of HZ.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Review
Immunology
Yue Xia, Xue Zhang, Liuren Zhang, Chuanxi Fu
Summary: The study found that both recombinant zoster vaccine (RZV) and zoster vaccine live (ZVL) can reduce the risk of herpes zoster in both immunocompetent and immunocompromised subjects. RZV was more effective than ZVL in immunocompetent subjects, while it was superior to placebo in immunocompromised subjects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
James F. Mbinta, Binh P. Nguyen, Prosper Mandela A. Awuni, Paul E. Eme, Colin R. Simpson
Summary: This review aims to evaluate the effectiveness of zoster vaccines against incident HZ and postherpetic neuralgia in adults 50 years and older, using key information sources such as MEDLINE, Embase, Cochrane libraries, and CINAHL. The study will search for postlicensure observational studies published between 2006 and 2020 to assess the effectiveness of HZ/zoster vaccines in adults 50 years and older, and will include critical appraisal, data extraction, and statistical analyses using a random-effect model.
Article
Immunology
Yuwei Sun, Eric Kim, Christina L. Kong, Benjamin F. Arnold, Travis C. Porco, Nisha R. Acharya
Summary: This study evaluated the effectiveness of the recombinant zoster vaccine in preventing herpes zoster in a real-world setting and found that its effectiveness remains high outside of a clinical trial setting, suggesting that it can effectively prevent herpes zoster.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Geriatrics & Gerontology
Pierre-Olivier Lang, Richard Aspinall
Summary: Current vaccination policy in high-income countries is aimed at countering the decline in cell-mediated immunity to varicella zoster virus. This review discusses the effectiveness, cost effectiveness, and precautions of using the live attenuated HZ vaccine and the recently approved recombinant HZ vaccine especially for older adults.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Review
Dermatology
Hideo Asada
Summary: Herpes zoster is a disease caused by reactivation of the latent varicella-zoster virus and is more common among the elderly. In Japan, the incidence of herpes zoster has been steadily increasing and is expected to further rise. In recent years, new antiviral drugs with novel pharmacological effects and a new subunit vaccine have been introduced, leading to a new era in the treatment of herpes zoster.
JOURNAL OF DERMATOLOGY
(2023)
Review
Immunology
Desmond Curran, T. Mark Doherty, Nicolas Lecrenier, Thomas Breuer
Summary: Populations are ageing worldwide, putting pressure on healthcare budgets. Vaccination can help prevent diseases in older adults and promote healthy ageing. Herpes zoster (HZ) and its complications can cause severe pain and health problems. Vaccines to prevent HZ can reduce disease burden, maintain functioning and quality of life, supporting healthy ageing.
Article
Biotechnology & Applied Microbiology
Michele A. Kohli, Michael Maschio, Joaquin F. Mould-Quevedo, Michael Drummond, Milton C. Weinstein
Summary: In the UK, the potential cost-effectiveness of vaccinating adults aged 65 years and above with MF59-adjuvanted quadrivalent influenza vaccine (aQIV) compared with high-dose quadrivalent influenza vaccine (QIV-HD) is similar, with QIV-HD needing to be priced similarly to aQIV in order to achieve cost-effectiveness.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Alemnew F. Dagnew, Nicola P. Klein, Caroline Herve, George Kalema, Emmanuel Di Paolo, James Peterson, Bruno Salaun, Anne Schuind
Summary: The study found that the adjuvanted recombinant zoster vaccine (RZV) induced strong humoral and polyfunctional cell-mediated immune responses in adults aged >= 65 years, regardless of prior vaccination with the live-attenuated herpes zoster vaccine (ZVL). The safety profile of RZV was not affected, and no confirmed herpes zoster cases were reported.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Lucy Pembrey, Collin Brooks, Harriet Mpairwe, Camila A. Figueiredo, Aida Y. Oviedo, Martha Chico, Hajar Ali, Irene Nambuya, Pius Tumwesige, Steven Robertson, Charlotte E. Rutter, Karin van Veldhoven, Susan Ring, Mauricio L. Barreto, Philip J. Cooper, John Henderson, Alvaro A. Cruz, Jeroen Douwes, Neil Pearce
Summary: This study compared asthma inflammatory phenotypes between low-and middle-income countries (LMICs) and high-income countries (HICs), and found a lower prevalence of eosinophilic asthma in LMICs. This has significant implications for global asthma prevention and management.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Dermatology
Ketaki Bhate, Kathryn E. Mansfield, Sarah-Jo Sinnott, David J. Margolis, Elizabeth Adesanya, Nick Francis, Clemence Leyrat, Susan Hopkins, Richard Stabler, Laura Shallcross, Sinead M. Langan, Rohini Mathur
Summary: This study investigated the use of oral antibiotics for moderate-to-severe acne vulgaris using primary care data. It was found that 44.5% of individuals received long-term oral antibiotic treatment, with a median of four continuous courses per person. Further research is needed to understand the consequences of using antibiotics for shorter periods.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Elizabeth Adesanya, Julian Matthewman, Yochai Schonmann, Joseph F. Hayes, Alasdair Henderson, Rohini Mathur, Amy R. Mulick, Catherine H. Smith, Sinead M. Langan, Kathryn E. Mansfield
Summary: Evidence suggests a possible association between atopic eczema or psoriasis and mental illness, but the factors associated with mental illness are still unclear. This review identified several factors associated with depression and anxiety among adults with psoriasis, but there is limited research on factors associated with mental illness among adults with atopic eczema or psoriasis.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Katrina Abuabara, Sinead M. Langan
Summary: Atopic dermatitis is a common chronic inflammatory skin disease that can occur at any age and has variable patterns of disease activity over time. Genetic factors and parental history of atopy are consistent predictors of more persistent disease. Age-related differences in molecular markers are being studied, although there is a lack of longitudinal data. Preventive measures such as breastfeeding, probiotics, and emollients have shown inconsistent long-term benefits in randomized trials. Future research should focus on disease activity beyond early adulthood and the impact of treatments on long-term outcomes.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Kate Greenwell, Katy Sivyer, Laura Howells, Mary Steele, Matthew J. Ridd, Amanda Roberts, Amina Ahmed, Sandra Lawton, Sinead M. Langan, Julie Hooper, Sylvia Wilczynska, Paul Leighton, Gareth Griffiths, Tracey Sach, Paul Little, Hywel C. Williams, Kim S. Thomas, Lucy Yardley, Miriam Santer, Ingrid Muller
Summary: This study aimed to explore the views and experiences of individuals who have used the Eczema Care Online interventions, in order to understand their effectiveness and identify influencing factors. The findings suggest that the interventions are easy to use and trustworthy, and can help individuals manage their eczema by improving their understanding and confidence in eczema management, reducing treatment concerns, and enhancing treatment adherence and management of irritants/triggers.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Sophia Quirke-McFarlane, John Weinman, Emma S. Cook, Zenas Z. N. Yiu, Nick Dand, Sinead M. Langan, Katie Bechman, Teresa Tsakok, Kayleigh J. Mason, Helen McAteer, Freya Meynell, Bolaji Coker, Alexandra Vincent, Dominic Urmston, Amber Vesty, Jade Kelly, Camille Lancelot, Lucy Moorhead, Ines A. Barbosa, Herve Bachelez, Francesca Capon, Claudia R. Contreras, Claudia De La Cruz, Paola Di Meglio, Paolo Gisondi, Denis Jullien, Jo Lambert, Luigi Naldi, Lluis Puig, Phyllis Spuls, Tiago Torres, Richard B. Warren, Hoseah Waweru, James B. Galloway, Christopher E. M. Griffiths, Jonathan N. Barker, Sam Norton, Catherine H. Smith, Satveer K. Mahil
Summary: This study investigated the nonadherence to immune-modifying therapy in individuals with psoriasis during the COVID-19 pandemic and its association with mental health. The most common reason for nonadherence was concerns about immunity. After adjusting for potential confounders, the association between anxiety and nonadherence to immune-modifying therapy became weaker and no longer significant. This study highlights the importance of clear and adequate communication with patients during a pandemic.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Education & Educational Research
Neisha Sundaram, Tanya Abramsky, William E. Oswald, Sarah Cook, Katherine E. Halliday, Patrick Nguipdop-Djomo, Joanna Sturgess, Georgina Ireland, Shamez N. Ladhani, Punam Mangtani, Sinead M. Langan, James R. Hargreaves, Chris Bonell
Summary: This study examined the implementation of COVID-19 preventive measures in 128 schools in England and their association with staff well-being. The findings showed that there were challenges in implementing the measures, but staff reported high adherence to measures such as wearing face coverings and regular handwashing. Higher adherence to measures was associated with lower burnout among school leaders and teaching staff. These findings highlight the need to support teacher well-being and improve the implementation of preventive measures.
JOURNAL OF SCHOOL HEALTH
(2023)
Article
Dermatology
Loes M. Hollestein, Morgan Ya Fang Ye, Ky-Leigh Ang, Harriet Forbes, Kathryn E. Mansfield, Katrina Abuabara, Liam Smeeth, Sinead M. Langan
Summary: This study found an association between atopic eczema and decreased lymphocyte count, which increased with the severity of eczema. The lymphocyte count was lower in patients with atopic eczema, regardless of immunosuppressive drug use. Further research is needed to investigate the broader health implications of lower lymphocyte count in patients with severe eczema.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Obstetrics & Gynecology
Paul Madley-Dowd, Jessica Rast, Viktor H. H. Ahlqvist, Caichen Zhong, Florence Z. Z. Martin, Neil M. M. Davies, Kristen Lyall, Craig Newschaffer, Torbjorn Tomson, Cecilia Magnusson, Dheeraj Rai, Brian K. K. Lee, Harriet Forbes
Summary: This study examined the prescription of antiseizure medication (ASM) during pregnancy and found an increase in prescription rates, especially among women with indications other than epilepsy. Continuous use of ASMs during pregnancy was more common in women with epilepsy. Factors associated with discontinuation included age ≥35, higher social deprivation, frequent contact with the GP, and prescription of antidepressants or antipsychotics.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Infectious Diseases
Patrick Nguipdop-Djomo, William E. Oswald, Katherine E. Halliday, Sarah Cook, Joanna Sturgess, Neisha Sundaram, Charlotte Warren-Gash, Paul E. M. Fine, Judith Glynn, Elizabeth Allen, Taane G. Clark, Benjamin Ford, Alison Judd, Georgina Ireland, John Poh, Chris Bonell, Fiona Dawe, Emma Rourke, Ian Diamond, Shamez N. Ladhani, Sinead M. Langan, James Hargreaves, Punam Mangtani
Summary: This study investigated risk factors for SARS-CoV-2 infections in school students and staff. It found that student infections were related to the percentage of students eligible for free school meals and the use of public transports. Contact patterns between students and staff were not associated with infection risk. Household infections were the strongest risk factor for both students and staff. The study suggests that the school-based mitigation measures implemented in England in 2020/2021 helped reduce transmission risk in schools.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Annabel A. Powell, Georgina Ireland, Rebecca Leeson, Andrea Lacey, Ben Ford, John Poh, Samreen Ijaz, Justin Shute, Peter Cherepanov, Richard Tedder, Christian Bottomley, Fiona Dawe, Punam Mangtani, Peter Jones, Patrick Nguipdop-Djomo, Shamez N. Ladhani, Shazaad Ahmad, Frances Baawuah, Joanne Beckmann, Andrew Brent, Bernadette Brent, Joanna Garstang, Ifeanyichukwu O. Okike, Kevin Brown, Mary Ramsay, Chris Bonell, Sarah Cook, Charlotte Warren-Gash, Jody Phelan, James Hargreaves, Sinead Langan, Neisha Sundaram, Elliot McClenaghan, Gillian McKay, John Edmunds, Paul Fine
Summary: This study aimed to estimate the national and regional prevalence of SARS-CoV-2 antibodies in primary and secondary school children in England. The results showed that the national prevalence of SARS-CoV-2 antibodies in unvaccinated primary school students was 40.1%, while in unvaccinated secondary school students it was 82.4%. These findings highlight the importance of seroprevalence studies in estimating prior exposure to the virus.
JOURNAL OF INFECTION
(2023)
Article
Medicine, General & Internal
Alasdair D. D. Henderson, Elizabeth Adesanya, Amy Mulick, Julian Matthewman, Nhung Vu, Firoza Davies, Catherine H. H. Smith, Joseph Hayes, Kathryn E. E. Mansfield, Sinead M. Langan
Summary: This study found that people with eczema and psoriasis have an increased risk of common mental disorders (anxiety, depression), and sleep quality may be an important factor leading to anxiety and depression in eczema patients.
Article
Public, Environmental & Occupational Health
Julian Matthewman, Kathryn E. Mansfield, Joseph F. Hayes, Elizabeth Adesanya, Catherine H. Smith, Amanda Roberts, Sinead M. Langan, Alasdair Henderson
Summary: This study investigated the associations between eczema and psoriasis and anxiety and depression using different methods of data collection. The findings show a consistent association between these skin disorders and mental health issues, but poor agreement between different data sources.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Neisha Sundaram, Nerissa Tilouche, Lucy Cullen, Paniz Hosseini, Patrick Nguipdop-Djomo, Sinead M. Langan, James R. Hargreaves, Chris Bonell
Summary: This study investigated the implementation of Covid-19-prevention measures in schools in England during the 2020-2021 school year. The research found that school leaders quickly responded to government guidance, developed prevention plans, and disseminated them to staff, parents, and students. However, conflicts between the measures and the schools' mission, as well as staff burnout and absence, posed challenges to implementation.
SSM-QUALITATIVE RESEARCH IN HEALTH
(2023)