Article
Multidisciplinary Sciences
Naira Nayeem, Syed Mohammed Basheeruddin Asdaq, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Yahya Mohzari, Ahmed A. Alrashed, Norah Alotaibi, Aseel S. Aalhathal, Mansour A. Alharbi, Norah N. Aldhawyan, Mohammed Asad, Faisal Mohammad Ali Abdalla, Saeed Y. Najmi
Summary: The study demonstrated the potential of methanolic and chloroform extracts of Dodonaea viscosa as effective wound healing agents in animal models, indicating the healing potency of the extracts.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Polymer Science
Cristiana M. P. Yoshida, Murilo S. Pacheco, Mariana A. de Moraes, Patricia S. Lopes, Patricia Severino, Eliana B. Souto, Classius F. da Silva
Summary: The study found that the inclusion of aloe vera altered the color parameters, barrier properties, and mechanical properties of the films. While the concentration of aloe vera did not significantly change film properties, it did increase the stability of the films at lower temperatures. This suggests a crosslinking/complexation between chitosan and aloe vera, providing suitable properties for wound dressing materials.
Article
Materials Science, Multidisciplinary
Yi Li, Hangqi Luo, Yue Li, Peipei Huang, Jie Xu, Jian Zhang, Peihan Cai, Huacheng He, Jiang Wu, Xiaokun Li
Summary: Functional degradable sutures with controlled release of basic fibroblast growth factor (bFGF) were developed to enhance wound healing. The suture showed prolonged bFGF release, improved cell adhesion and proliferation, accelerated wound closure, and facilitated skin mechanical restoration.
MATERIALS & DESIGN
(2023)
Review
Pharmacology & Pharmacy
Hooi Leong Loo, Bey Hing Goh, Learn-Han Lee, Lay Hong Chuah
Summary: With the increasing prevalence of impaired wound healing, there has been a growing interest in the development of novel wound dressings with enhanced healing functions. Nanoparticle-based delivery systems, particularly chitosan-based nanoparticles, have emerged as promising candidates due to their non-toxicity, biocompatibility, and bioactivity. This review focuses on the application of chitosan-based nanoparticle systems in wound treatment, discussing their properties, mechanisms, and potential for improving wound healing. The results show that chitosan-based nanoparticles exhibit superior wound healing effects, either alone or as drug delivery vehicles. Overall, there are great opportunities and potentials for the use of chitosan nanoparticles in wound healing.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gan Xu, Na Xu, Tingjie Ren, Changyou Chen, Jiangfeng Li, Liangping Ding, Yang Chen, Guoqiang Chen, Zheng Li, Yunlong Yu
Summary: A multifunctional chitosan/silver/tannic acid cryogel has been prepared for hemostasis and wound healing. The cryogel exhibits stability, compressibility, and good antibacterial ability. It can scavenge free radicals and promote cell proliferation, significantly enhancing wound repair.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Environmental
Caihong Yang, Xiaoya Ding, Chaoyu Yang, Luoran Shang, Yuanjin Zhao
Summary: In this study, marine polymer composite microcapsules were prepared using microfluidic electrospray for wound healing. The microcapsules, composed of an alginate (ALG) core and a chitosan (CS) shell, showed excellent biocompatibility and antibacterial capacity. Vascular endothelial growth factor (VEGF) could also be loaded and sustainably released from the microcapsules. The microcapsules demonstrated their potential clinical applications by inhibiting bacterial growth and promoting angiogenesis during wound closure.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Integrative & Complementary Medicine
Manasi Varadkar, Chhaya Gadgoli
Summary: The study found that encapsulating crocetin into vesicles can increase its stability and has good wound healing activity.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)
Article
Chemistry, Applied
Pengpeng Deng, Lichao Yao, Juanjuan Chen, Zhigang Tang, Jinping Zhou
Summary: AC hydrogels can accelerate wound healing, with self-healing, low swelling rate, biocompatibility, and excellent hemostatic effect. They also show outstanding antibacterial activity and can be used for designing multifunctional dressings.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Lubomir Petrov, Olya Stoilova, Georgi Pramatarov, Hristiyana Kanzova, Elina Tsvetanova, Madlena Andreeva, Almira Georgieva, Dimitrinka Atanasova, Stanislav Philipov, Albena Alexandrova
Summary: The study aimed to investigate the effect of the combined application of chitosan and diosgenin on a mouse skin wound model. The results showed that the combined application significantly reduced wound area and maintained high levels of total glutathione in wound tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Esmaeel Sharifi, Rezvan Jamaledin, Fatemeh Familsattarian, Fereshteh Nejaddehbashi, Mitra Bagheri, Mohammad Chehelgerdi, Ehsan Nazarzadeh Zare, Omid Akhavan
Summary: This research evaluated the potential of bioactive chitosan@poly (ethylene oxide)@CuFe2O4 (CS@PEO@CF) nanofibers in wound healing. The nanoparticles showed antibacterial and antioxidant properties and did not adversely affect fibroblast cell viability. The nanofibrous mats promoted cell migration and growth at the wound edge, leading to enhanced wound healing and regeneration of sebaceous glands and hair follicles within the skin.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Meng Zhang, Guohui Wang, Dong Wang, Yuqi Zheng, Yanxin Li, Wenqiao Meng, Xin Zhang, Feifan Du, Shaoxiang Lee
Summary: This study successfully prepared a bilayer composite dressing for wound healing, with the upper layer possessing antibacterial activity and the lower layer having biocompatibility, the combination of which showed synergistic antibacterial effects and could accelerate wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nanoscience & Nanotechnology
Jinfeng Cao, Ping Wu, Qianqian Cheng, Chen He, Yun Chen, Jinping Zhou
Summary: A new type of injectable CMCh hydrogel wound dressing with self-healing properties is constructed using coordination bonds and alkali/urea aqueous solutions. The hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability, significantly accelerating skin tissue regeneration and wound closure. It has great potential in tissue engineering applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Ziqiang Zhou, Xuejuan Zhang, Lijun Xu, Huangjie Lu, Yuying Chen, Chuanbin Wu, Ping Hu
Summary: In this study, a novel hydrogel was designed as a wound dressing material for diabetic wounds. The hydrogel showed good biocompatibility and enhanced wound healing in diabetic rats.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Chih-Hsin Wang, Juin-Hong Cherng, Chuan-Chieh Liu, Tong-Jing Fang, Zhi-Jie Hong, Shu-Jen Chang, Gang-Yi Fan, Sheng-Der Hsu
Summary: Chitosan dressing demonstrated excellent antimicrobial and procoagulant properties, accelerating wound healing by protecting against microbial infection and promoting the growth of beneficial microbiota. The dressing exhibited good biocompatibility and outstanding blood absorption ability, inhibiting bacterial growth up to 8 days post-surgery. These findings suggest that chitosan dressing provides a suitable environment for beneficial microbiota and is effective in promoting wound repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
M. C. Linju, M. R. Rekha
Summary: The present study developed a L-proline conjugated chitosan scaffold for wound healing. The scaffold was characterized by various tests and showed no cytotoxicity. In vitro experiments demonstrated that the modified scaffold promoted wound closure and collagen deposition. These findings suggest that the L-proline conjugated scaffold has potential as a wound dressing to improve wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)