Review
Biochemistry & Molecular Biology
Evangelia Eirini Tsermpini, Anja Plemenitas Iljes, Vita Dolzan
Summary: Alcohol use disorder (AUD) is a prevalent and disabling disorder with various comorbidities. The relationship between alcohol metabolism and oxidative stress is not fully understood. Studies have shown that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration.
Article
Gastroenterology & Hepatology
Rakesh Bhatia, Christopher M. Thompson, Emalie J. Clement, Koelina Ganguly, Jesse L. Cox, Sanchita Rauth, Jawed Akhtar Siddiqui, Simran S. Mashiana, Maneesh Jain, Todd A. Wyatt, Harmeet S. Mashiana, Shailender Singh, Nicholas T. Woods, Kusum K. Kharbanda, Surinder K. Batra, Sushil Kumar
Summary: This study found that the combination of alcohol and smoking generates stable MAA-ECM adducts, increases endoplasmic reticulum stress and acinar cell death, and suppresses the expression of cell cycle regulators, leading to the development and progression of pancreatitis. Targeting aldehyde adducts might provide a new therapeutic strategy for the management of pancreatitis.
Review
Behavioral Sciences
Dorthe Gruner Nielsen, Kjeld Andersen, Anette Sogaard Nielsen, Carsten Juhl, Angelina Mellentin
Summary: Studies have shown inconsistencies between self-reported alcohol consumption and biomarkers among patients in treatment for AUD. Correlations between self-reported alcohol consumption and biological markers were strongest for intermediate-term direct markers, ranging from moderate to strong.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Andrew G. Herzog
Summary: This study found that a family history of alcohol use disorder may be a risk factor and potential clinical biomarker for catamenial epilepsy. The risk of positive AUD history was higher in women with perimenstrual and entire luteal phase patterns. However, the sensitivity of this biomarker for predicting catamenial epilepsy was relatively low.
Article
Biochemistry & Molecular Biology
Bhagyalakshmi Shankarappa, Jayant Mahadevan, Pratima Murthy, Meera Purushottam, Biju Viswanath, Sanjeev Jain, Harshad Devarbhavi, Ashok Mysore Visweswariah
Summary: The aim of this study is to evaluate the genetic and epigenetic influence at the ALDH2 locus in patients with AUD and liver complications. The study found that ALDH2 DNA methylation was lower in patients with cirrhosis compared to those without. Global DNA methylation levels were also lower in patients with cirrhosis. These findings suggest that DNA methylation could serve as a biomarker for cirrhosis and liver complications.
DNA AND CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Valeria Guidolin, Erik S. Carlson, Andrea Carra, Peter W. Villalta, Laura A. Maertens, Stephen S. Hecht, Silvia Balbo
Summary: Alcohol consumption is associated with the development of various cancers, with acetaldehyde playing a significant role in alcohol-induced carcinogenesis by generating DNA adducts. A study optimized a mass spectrometry-based approach to screen for acetaldehyde-derived DNA adducts in human DNA, identifying 22 adducts including two previously unreported ones. These new adducts, N-6-ethyldeoxyadenosine and N-4-ethyldeoxycytidine, were found in higher concentrations in oral cell DNA after alcohol exposure, confirming the genotoxic effects of alcohol.
Article
Food Science & Technology
Hua Cao, Tuoyu Zhou, Haibo Tang, Pengya Feng, Gohar Ali, Pu Liu, Xiangkai Li
Summary: The genetically modified EcN has shown effectiveness in detoxifying ethanol metabolites in liver disease models, restoring liver function, inhibiting oxidative stress, lipid peroxidation, and inflammation, as well as promoting the recovery of gut microbiota homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Environmental Sciences
Yiju Zhang, Qiao Wang, Yaoran Li, Jun Cheng, Xinyu Chen, Yu Zhang
Summary: This study developed a rapid and sensitive method for analyzing two DNA adducts induced by acrylamide exposure, and found that catechins can effectively inhibit the formation of these adducts.
Review
Physiology
Soo K. Shin, Erin E. Kaiser, Franklin D. West
Summary: Pigs, as an animal model for simulating human alcohol use disorder, exhibit similar voluntary alcohol consumption and intoxication behaviors observed in humans, along with anatomical similarities in the brain and liver, making them a promising tool for studying the complex nature of AUD and its development in humans.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Food Science & Technology
Naila Boby, Eon-Bee Lee, Muhammad Aleem Abbas, Na-Hye Park, Sam-Pin Lee, Md. Sekendar Ali, Seung-Jin Lee, Seung-Chun Park
Summary: FSC pretreatment reduces blood alcohol and acetaldehyde concentrations, modulates liver enzyme activities, increases antioxidant enzyme expression, and decreases inflammatory cytokine gene expression in the liver. Additionally, it shows no acute oral toxicity in female rats and may be beneficial for reducing alcohol-induced damage.
Review
Behavioral Sciences
Otto T. Holbrook, Brandon Molligoda, Kristen N. Bushell, Kyle L. Gobrogge
Summary: Previous research on Alcohol Use Disorder (AUD) has mainly focused on the behavioral or chemical consequences following ethanol intake, but these areas have rarely been studied together. Unlike other abused drugs, ethanol has a unique metabolic pathway that produces downstream metabolites, which can form biologically active products. These metabolites can affect various behavioral responses associated with AUD. This review examines preclinical and chemical research on these downstream products and proposes a chemobehavioral model of AUD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Public, Environmental & Occupational Health
Shannon E. Cusack, Anna W. Wright, Ananda B. Amstadter
Summary: This scoping review examined the relationship between individual, trait-level resilience and alcohol use outcomes in adults over the age of 21 in the United States. Findings suggest resilience as a protective factor against various outcomes, though methodological limitations should be considered. The review implies the clinical implications of resilience in prevention and intervention programming for alcohol use outcomes.
PREVENTIVE MEDICINE
(2023)
Article
Neurosciences
Maria Flores-Lopez, Nuria Garcia-Marchena, Pedro Araos, Nerea Requena-Ocana, Oscar Porras-Perales, Sandra Torres-Galvan, Juan Suarez, Nieves Pizarro, Rafael de la Torre, Gabriel Rubio, Juan Jesus Ruiz-Ruiz, Fernando Rodriguez de Fonseca, Antonia Serrano, Francisco Javier Pavon-Moron
Summary: The study investigated the concentrations of LPA in patients with substance use disorder, finding that women had higher LPA concentrations than men and SUD patients had lower LPA concentrations. LPA species could potentially serve as biomarkers for SUD in both women and men.
Article
Plant Sciences
Zixia Hu, Yanjia Zhao, Yi Yang, Wei Li, Rong Tan, Linhua Zhao, Xiaolin Tong, Ying Peng, Jiang Zheng
Summary: In this study, a mechanism-based biomarker based on plasma protein adduction was developed to determine the exposure to Dioscorea bulbifera L. (DBL) and predict DBL-induced hepatotoxicity. The results showed that the adduction of DBL metabolite to plasma proteins correlated well with the exposure of DBL in rats, making it a potential biomarker for diagnosing DBL-induced liver injury and an indicator for DBL medication plans.
Article
Substance Abuse
Zhanzhang Wang, Shanqing Huang, Lu Li, Yuguan Wen, Dewei Shang
Summary: This systematic review and meta-analysis aimed to assess the differences in kynurenine metabolites between individuals with alcohol use disorder (AUD) and controls. The results showed that kynurenine levels and the ratio of kynurenine and tryptophan were higher in individuals with AUD, while kynurenic acid levels were reduced. The peripheral blood levels of tryptophan and the ratio of kynurenic acid and kynurenine were unaffected.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Medical Laboratory Technology
Yun Wu, Annabel W. Chen, Candida L. Goodnough, Yao Lu, Ye Zhang, Eric R. Gross
Summary: The findings suggest that only IcyHot topical analgesic cream can reduce myocardial infarct size, while other creams do not have this effect. The release of methyl salicylate from IcyHot can trigger remote cardioprotection through a TRPA1-dependent mechanism.
TRANSLATIONAL RESEARCH
(2021)
Editorial Material
Anesthesiology
Vanessa O. Zambelli, Queren A. Alcantara, Eric R. Gross
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Letter
Anesthesiology
Candida L. Goodnough, Yun Wu, Eric R. Gross
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Editorial Material
Anesthesiology
Elizabeth L. Whitlock, Eric R. Gross, C. Ryan King, Michael S. Avidan
Summary: The study found that targeting deep anesthesia in patients undergoing major noncardiac surgery was not associated with significantly increased postoperative death or major morbidity, but it significantly increased delirium incidence. The findings may be affected by subpopulation-based differences in patients.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Medicine, Research & Experimental
Mandy Otto, Laura Brabenec, Melanie Mueller, Sebastian Kintrup, Katharina E. M. Hellenthal, Richard Holtmeier, Sophie Charlotte Steinbuch, Ole Sonken Karsten, Heorhii Pryvalov, Jan Rossaint, Eric R. Gross, Nana-Maria Wagner
Summary: The study suggests that 12-HETE may serve as a biomarker for endothelial dysfunction and HFpEF in patients with type 2 diabetes. Antagonizing 12-HETE is a potent way to control the development and progression of HFpEF in type 2 diabetes by preserving vascular function.
Article
Engineering, Environmental
Bin Wang, Chengfan Wu, Shufang He, Yaguang Wang, Di Wang, Hui Tao, Chenchen Wang, Xiaoxi Pang, Fei Li, Yue Yuan, Eric R. Gross, Gaolin Liang, Ye Zhang
Summary: In this study, a new supramolecular hydrogel V1-Cal/NapFFY was developed, which significantly enhanced the therapeutic effects of V1-Cal on myocardial infarction and improved cardiac function. The hydrogel demonstrated sustained release of V1-Cal for more than two weeks and effectively reduced TRPV1 expression, apoptosis, and inflammatory factors in vivo experiments.
CHEMICAL ENGINEERING JOURNAL
(2022)
Editorial Material
Biochemistry & Molecular Biology
Freeborn Rwere, Xuan Yu, Che-Hong Chen, Eric R. Gross
Letter
Anesthesiology
Austin D. Le, Yuemeng Li, Alicia Zhu, Jaiveer Singh, Jane Y. Xu, Malathi Srinivasan, Latha P. Palaniappan, Jin Long, Eric R. Gross
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Biochemistry & Molecular Biology
Xuan Yu, Xiaocong Zeng, Feng Xiao, Ri Chen, Pritam Sinharoy, Eric R. Gross
Summary: The study found that individuals carrying the ALDH2*2 genetic variant may be more susceptible to increased cardiovascular oxidative stress caused by e-cigarette aerosol exposure.
Article
Cardiac & Cardiovascular Systems
Chao Wu, Rongrong Liu, Zhaofei Luo, Meiyan Sun, Muge Qile, Shijin Xu, Shiyun Jin, Li Zhang, Eric R. Gross, Ye Zhang, Shufang He
Summary: This study reveals the functional role of spinal astrocytes in myocardial I/R injury and provides a potential therapeutic approach targeting spinal cord astrocytes for the prevention of cardiac injury.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Editorial Material
Anesthesiology
Andrew Owen, Creed M. Stary, Eric R. Gross
Summary: Perioperative organ injury is a common and significant complication in the approximately 240 million individuals who undergo surgery worldwide each year. Ischaemic preconditioning, a technique that reduces organ injury in experimental models, has faced challenges when translated to clinical practice. However, utilizing isolated preconditioned exosomes, secreted vesicles containing cell-survival mediators, offers a potential solution to overcome these hurdles and prevent perioperative organ injury.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Cell Biology
Hongchao Guo, Xuan Yu, Yu Liu, David T. Paik, Johanne Marie Justesen, Mark Chandy, James W. S. Jahng, Tiejun Zhang, Weijun Wu, Freeborn Rwere, Shane Rui Zhao, Suman Pokhrel, Rabindra V. Shivnaraine, Souhrid Mukherjee, Daniel J. Simon, Amit Manhas, Angela Zhang, Che-Hong Chen, Manuel A. Rivas, Eric R. Gross, Daria Mochly-Rosen, Joseph C. Wu
Summary: The common ALDH2*2 variant affects around 8% of the global population and is associated with a severe loss of ALDH2 enzymatic activity and an increased risk of CAD. Empagliflozin, an SGLT2 inhibitor, has been shown to improve EC dysfunction caused by ALDH2*2, suggesting a potential preventive measure against CAD.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Meena Easwaran, Chloe Santa Maria, Joshua D. Martinez, Barbara Hung, Xuan Yu, Joanne Soo, Akari Kimura, Eric R. Gross, Elizabeth Erickson-DiRenzo
Summary: This study examines the short-term effects of e-cigarette inhalation on the mouse larynx and finds minimal cellular and inflammatory changes. Flavor and region-specific changes were observed after long-term exposure.
Article
Cardiac & Cardiovascular Systems
Chun Liu, Mengcheng Shen, Wilson L. W. Tan, Ian Y. Chen, Yu Liu, Xuan Yu, Huaxiao Yang, Angela Zhang, Yanxia Liu, Ming-Tao Zhao, Mohamed Ameen, Mao Zhang, Eric R. Gross, Lei S. Qi, Nazish Sayed, Joseph C. Wu
Summary: In this study, the researchers found that simvastatin improves endothelial cell function by reducing chromatin accessibility and regulating the YAP-SOX9 signaling pathway. This discovery offers new therapeutic strategies for cardiovascular disease protection.
NATURE CARDIOVASCULAR RESEARCH
(2023)
Review
Cell Biology
Robert Tarran, R. Graham Barr, Neal L. Benowitz, Aruni Bhatnagar, Hong W. Chu, Pamela Dalton, Claire M. Doerschuk, M. Bradley Drummond, Diane R. Gold, Maciej L. Goniewicz, Eric R. Gross, Nadia N. Hansel, Philip K. Hopke, Robert A. Kloner, Vladimir B. Mikheev, Evan W. Neczypor, Kent E. Pinkerton, Lisa Postow, Irfan Rahman, Jonathan M. Samet, Matthias Salathe, Catherine M. Stoney, Philip S. Tsao, Rachel Widome, Tian Xia, DaLiao Xiao, Loren E. Wold
Summary: E-cigarettes have become increasingly popular, particularly among young people, in recent years. Research on the health effects of e-cigarettes is still in its early stages, with some suggesting that they may pose less of a health risk compared to traditional combustible cigarettes.
