期刊
TRENDS IN IMMUNOLOGY
卷 39, 期 7, 页码 577-590出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.04.009
关键词
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类别
资金
- Associazione Italiana per la Ricerca sul Cancro (AIRC): Special Project 5x1000 [9962]
- AIFA (Agenzia Italiana del Farmaco) [2016-02364631]
- [IG 2015Id. 17200]
- [IG2014Id. 15704]
- [IG2017Id. 20312]
- [IG2014Id. 15283]
- [IG2017Id. 19920]
- [IG2015Id. 16764]
Natural killer (NK) cells are involved in innate defenses against viruses and tumors. Their function is finely tuned by activating and inhibitory receptors. Among the latter, killer immunoglobulin-like receptors and CD94/NKG2A recognize human leukocyte antigen (HLA) Class I molecules, allowing NK cells to discriminate between normal and aberrant cells, as well as to recognize allogeneic cells, because of their ability to sense HLA polymorphisms. This latter phenomenon plays a key role in HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for high-risk acute leukemia patients transplanted from an NK-alloreactive donor. Different haplo-HSCT settings have been developed, either T depleted or T replete-the latter requiring graft versus-host disease prophylaxis. A novel graft manipulation, based on depletion of T cells and B cells, allows infusion of fully mature, including alloreactive, NK cells. The excellent patient clinical outcome underscores the importance of these innate cells in cancer therapy.
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