期刊
TRENDS IN IMMUNOLOGY
卷 39, 期 7, 页码 515-522出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.04.003
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资金
- NIAID NIH HHS [T32 AI007180, T32 AI100853] Funding Source: Medline
Antiself antibodies are most commonly associated with autoimmune disorders, but a large body of evidence indicates that they are also present in numerous infectious diseases. These autoimmune antibodies appear transiently during infection with a number of viruses, bacteria, and parasites and in some cases have been associated with the development of autoimmune disorders that develop after infection has been cleared. Traditionally these infection-associated autoantibodies are considered an erroneous byproduct of a legitimate immune response, but their possible role in the clearance of microbes and infected cells or inhibition of host-cell invasion suggests that they may be present because of their beneficial protective role against various infections.
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