期刊
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY
卷 30, 期 172, 页码 SE41-SE50出版社
GAKUSHIN PUBL CO
DOI: 10.4052/tigg.1731.1SE
关键词
carbohydrate recognition domain; oligosaccharide; prototype galectin; tandem-repeat type galectin; X-ray crystal structure
资金
- Japan Society for the Promotion of Science (JSPS) [23370054]
- fund for Characteristic Prior Research from Kagawa University
The galectins are a family of beta-galactoside-specific animal lectins that contain a conserved carbohydrate recognition domain (CRD) with approximately 140 amino acid residues. There are 14 members in the mammalian galectin family (galectin-1-10, and 1115), and they have different specificities for oligosaccharides. X-ray structures of the galectin CRD in complexes with oligosaccharides have provided important clues about the oligosaccharide-recognition mechanisms of galectins giving the different specificities. Galectin is divalent in glycan binding due to the association of two CRDs that crosslink with oligosaccharides. The spatial arrangement of the two CRDs is very important for elucidating the biological functions of galectins. Several different spatial arrangements of CRDs are found in X-ray structures of galectins. I herein examined the three-dimensional structures of galectins relevant for biological functions, based on the protein-ligand interactions related with oligosaccharide-specificity, the cross-linking structure by galectin and oligosaccharides, and the spatial arrangements of CRDs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据