Article
Pharmacology & Pharmacy
Tao Zheng, Qibin Wang, Fang Bian, Yan Zhao, Weidong Ma, Yonghong Zhang, Wei Lu, Pan Lei, Lulu Zhang, Xincai Hao, Li Chen
Summary: This study found that salidroside alleviates diabetic neuropathic pain by activating AMPK, inhibiting NLRP3 inflammasome activation, improving insulin resistance, and relieving oxidative stress. In vitro experiments also showed that salidroside regulated the AMPK-NLRP3 inflammasome axis in HG-treated DRGs. AMPK inhibition in vivo or silencing in vitro abolished the beneficial effects of salidroside on diabetic neuropathic pain.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mehboob Ali, Mehak Gupta, Abubakar Wani, Ankita Sharma, Mohd Abdullaha, Dilpreet Kour, Sushil Choudhary, Sandip B. Bharate, Gurdarshan Singh, Ajay Kumar
Summary: Aberrant activation of NLRP3 inflammasome is associated with inflammatory diseases, and autophagy is a primary mechanism regulating NLRP3 activity. The synthetic compound IIIM-941 inhibits ATP-induced NLRP3 inflammasome activity by inducing autophagy through the AMPK pathway, while showing no inhibitory effect on LPS-induced pro-inflammatory cytokines. This compound downregulates NLRP3 expression and prevents ASC oligomerization, thereby exerting its anti-NLRP3 inflammasome effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Carol M. Artlett
Summary: Fibrosis is the end result of chronic inflammation, characterized by excessive extracellular matrix deposition. The NLRP3 inflammasome plays a significant role in the pathogenesis of fibrotic disease and its activation leads to the secretion of pro-inflammatory cytokines and the formation of fibrotic tissue. The activation of NLRP3 is controlled by multiple activators and involves complex regulatory mechanisms.
Review
Immunology
Frederic Bornancin, Carien Dekker
Summary: This review focuses on the regulation of the NLRP3 inflammasome by phosphorylation and dephosphorylation, and discusses the kinases and phosphatases that have been reported to modulate NLRP3 activity. The aim is to integrate the current understanding and highlight potential gaps for further studies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zhiquan Zhang, Qing Ma, Ravikanth Velagapudi, William E. Barclay, Ramona M. Rodriguiz, William C. Wetsel, Ting Yang, Mari L. Shinohara, Niccolo Terrando
Summary: This study developed an orthopedic mouse model to study the impact of surgery on the vulnerable brain and found that neuroinflammation plays a crucial role in perioperative neurocognitive disorders. They also discovered the neuroprotective effects of a biomimetic peptide derived from Annexin-A1, providing a new target for the treatment of these disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Alvaro Gonzalez-Dominguez, Raul Montanez, Beatriz Castejon-Vega, Jessica Nunez-Vasco, Debora Lendines-Cordero, Chun Wang, Gabriel Mbalaviele, Jose M. Navarro-Pando, Elisabet Alcocer-Gomez, Mario D. Cordero
Summary: This study showed increased expression of NLRP3 inflammasome components in HGPS skin fibroblasts and lymphoblasts, as well as in hearts and livers of Zmpste24(-/-) mice. Inhibiting the NLRP3 inflammasome with MCC950 improved cellular phenotype, extended lifespan of progeroid animals, and reduced inflammation, suggesting a potential therapeutic approach for HGPS.
EMBO MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yineng Han, Qiaolin Yang, Yiping Huang, Pengfei Gao, Lingfei Jia, Yunfei Zheng, Weiran Li
Summary: Compressive force regulates orthodontic tooth movement by activating the NLRP3 inflammasome and inhibiting autophagy.
Article
Biochemistry & Molecular Biology
Ji Ma, Maoru Li, Tingting Yang, Yang Deng, Yadong Ding, Tiantian Guo, Jing Shang
Summary: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease with a global prevalence of 25%. The NLRP3 inflammasome plays a crucial role in inflammatory responses and steatohepatitis. Isoquercitrin (IQ), a quercetin glycoside, has shown inhibitory effects on oxidative stress and various diseases. This study demonstrated that IQ can alleviate NAFLD by suppressing the activated NLRP3 inflammasome through down-regulation of HSP90 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Do-Wan Shim, Hyo-Joung Cho, Inhwa Hwang, Taek-Yeol Jung, Hyun-Seok Kim, Ju Hee Ryu, Je-Wook Yu
Summary: The depletion of NAD(+) affects the innate immune potential of macrophages and has an impact on NLRP3 activation. FK866 facilitates NLRP3 activation by promoting perinuclear clustering of mitochondria, while supplementation with NAD(+) can counteract the FK866-induced caspase-1 cleavage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dahlia Palevski, Gil Ben-David, Yehonatan Weinberger, Rabeei Haj Daood, Jose A. Fernandez, Ivan Budnik, Sarina Levy-Mendelovich, Gili Kenet, Yael Nisgav, Dov Weinberger, John H. Griffin, Tami Livnat
Summary: 3K3A-APC has been shown to have anti-inflammatory properties and may be a novel treatment for retinal diseases associated with inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Umeharu Ohto, Yukie Kamitsukasa, Hanako Ishida, Zhikuan Zhang, Karin Murakami, Chie Hirama, Sakiko Maekawa, Toshiyuki Shimizu
Summary: This study reveals the cryo-electron microscopy structure of the dodecameric form of NLRP3 and its binding site with the inhibitor MCC950. It provides insights into the role of NLRP3 in membrane association and activation, offering potential targets for drug development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Li-Zhen Liao, Zhi-Chong Chen, Sui-Sui Wang, Wen-Bin Liu, Chang-Lin Zhao, Xiao-Dong Zhuang
Summary: The activation of NLRP3 inflammasome plays a role in the pathogenesis of cardiocytes aging, potentially through the generation of reactive oxygen species (ROS). This study suggests that targeting NLRP3 inflammasome or inhibiting ROS generation could be strategies to attenuate cardiocytes aging.
Article
Pharmacology & Pharmacy
Lijun Kong, Hewei Zhang, Chaosheng Lu, Keqing Shi, Hongjian Huang, Yushu Zheng, Yongqiang Wang, Dan Wang, Hongwei Wang, Wei Huang
Summary: AICAR activation of AMPK significantly ameliorates PALI, with hepatic AMPK activation playing a crucial protective role in PALI. AICAR-induced AMPK activation protects rats from PALI by regulating hepatic antioxidant capacity through Nrf2 and inhibiting NLRP3 inflammasome activation.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tan Zhang, Shuzhe Ding, Ru Wang
Summary: NLRP3 is a crucial pattern recognition receptor in the innate immune system, with mitochondria playing a key role in inflammasome activation. Exercise is considered an important intervention to regulate immune responses, with different types of training impacting NLRP3 inflammasome activation differently.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Alexander N. R. Weber
Summary: The NLRP3 inflammasome plays a crucial role in human diseases, and recent research has explored the potential of targeting NLRP3 via BTK, providing a new approach for inflammatory treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
