期刊
TRANSPLANT INFECTIOUS DISEASE
卷 20, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/tid.12850
关键词
haploidentical transplantation; post-transplantation cyclophosphamide; progressive multifocal leukoencephalopathy
A 52-year-old man suffered from progressive multifocal leukoencephalopathy (PML) after human leukocyte antigen (HLA)-haploidentical transplantation with post-transplantation cyclophosphamide (PTCY). Mirtazapine, mefloquine, and cytarabine failed to improve his symptoms, and he finally died 4.5months after PML onset. This is the first case report of a patient with PML after HLA-haploidentical transplantation with PTCY. Although T-cell replete HLA-haploidentical transplantation with PTCY has enabled early immune reconstitution, PML should be considered if a patient's mental condition deteriorates.
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