Article
Medicine, Research & Experimental
Jin Luo, Yaqin Wang, Qianrong Qi, Yan Cheng, Wangmin Xu, Jing Yang
Summary: The study found that SIN treatment has a therapeutic effect on pregnancy outcomes of recurrent spontaneous abortion mice, possibly through regulating the balance of Th1/Th2 in maternal circulation and decidual tissues.
MEDICAL SCIENCE MONITOR
(2021)
Article
Immunology
Ying Qian, Yue Pei, Wei Jiang, Caihong Zheng
Summary: This study found that astilbin has a therapeutic effect on rats with RSA by regulating the balance of Th1/Th2 in maternal circulation and likely in decidual tissue.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiaoqing Li, Xiaomin Xu, Wenhuan Wang, Congcong Sun, Hai Wang, Jiayong Zheng
Summary: This study aimed to investigate the mechanism of lymphocyte immunotherapy (LIT) in the treatment of unexplained recurrent spontaneous abortion (URSA). The results showed that the proportion of Th1 cells increased significantly after LIT and the Th1/Th2 balance decreased significantly. Additionally, the proportion of Th1 and Th2 cells was significantly higher in patients with successful pregnancies, while the Th17/Treg balance decreased in successful pregnancy after LIT.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Immunology
Alla Arefieva, Marina Nikolaeva, Elena Stepanova, Lubov Krechetova, Elena Golubeva, Nana Tetruashvili, Gennady Sukhikh
Summary: The study found that the intensity of CD200 expression and the Th1/Th2 cytokine ratios after LIT were significant predictors of pregnancy establishment. Elevated CD200 expression on allogeneic lymphocytes is likely to suppress the pro-inflammatory Th1-type immunity needed for successful embryo implantation.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Review
Immunology
Qiu-Yan Zhao, Qing-Hui Li, Yao-Yao Fu, Chun-E Ren, Ai-Fang Jiang, Yu-Han Meng
Summary: This study aims to explore the connection between decidual macrophages and RSA by analyzing their phenotypes and functions. The findings contribute to understanding the mechanisms of RSA and have significant implications for its prevention and management.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yumei Zhou, Linhan Hu, Honglei Zhang, Haiyun Zhang, Juntong Liu, Xiaoshan Zhao, Ji Wang, Qi Wang
Summary: The study found that GMK achieves a similar effect as dexamethasone in controlling symptoms of allergic asthma and inhibiting inflammation, reconstructs the immune balance of Th1/Th2 and Treg/Th17 cells, and impacts asthma treatment by altering gut microbiota. Metabolome results reveal specific substances associated with Th1/Th2 and Treg/Th17 cell balance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Natasha Kashyap, Anjuma Begum, Chandana Ray Das, Ratul Datta, Mohit Kumar Verma, Anita Dongre, Syed Akhtar Husain, Luqman Ahmad Khan, Purabi Deka Bose
Summary: Recurrent pregnancy loss (RPL) refers to the spontaneous loss of two or more consecutive pregnancies before 20 weeks of gestation, with a prevalence rate of 1% in the reproductive-age population. This study found that mRNA expression of progesterone receptor isoform B (PR-B) was downregulated in RPL cases, and a single nucleotide polymorphism (SNP) rs1372000 in the PIBF gene was associated with lower serum PIBF levels and increased IL-12 expression, while IL-10 expression decreased. It suggests that progesterone, through PIBF, modulates the immune state of pregnancy to be Th1-biased in RPL, which is unfavorable for a healthy pregnancy.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Immunology
Heng Gu, Longyu Li, Mengxuan Du, Hang Xu, Mengge Gao, Xiaohua Liu, Xiangcai Wei, Xingming Zhong
Summary: This study investigated the differential expression of immunoregulatory genes in unexplained recurrent spontaneous abortion (URSA), identifying specific genes associated with immune cell functions and pathways related to URSA. The findings suggest a potential link between abnormal expression of immunoregulatory genes and URSA, with IFNG playing a key role in regulating maternal immune response. Further research is needed to validate these results and provide insights into the pathogenesis of recurrent spontaneous abortion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Yang Li, Yaxuan Li, Weidong Liu, Baorui Wang, Ping Wang, Yanwei Qi
Summary: The study aimed to evaluate the relationship between Th2/Th1 cytokine imbalance and recurrent intussusception, providing a theoretical basis for a comprehensive treatment strategy. The results showed that Th2/Th1 cytokine imbalance was closely related to the incidence of recurrent intussusception, which might be a potential risk factor and more likely to occur in children between the ages of 2 and 3. Future research is needed to target the Th2/Th1 cytokine imbalance and develop a reasonable treatment plan to prevent recurrence.
Article
Endocrinology & Metabolism
Xiaofeng Xu, Jing Wang, Damin Zhu, Jiaqian Yin, Jinxian Liu, Xiao Wu, Wenjuan Yang, Qian Hu, Yu Ren, Zhiguo Zhang, Ping Zhou, Zhaolian Wei, Huijuan Zou, Yunxia Cao
Summary: This study found that the levels of HMGB1 were significantly higher in URSA patients, and low-dose aspirin can decrease the concentrations of HMGB1 and IFN-γ, providing a protective effect.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Obstetrics & Gynecology
Dan Li, Lianwen Zheng, Donghai Zhao, Ying Xu, Yeling Wang
Summary: Recurrent spontaneous abortion (RSA) affects 1-2% of women of childbearing age, with unknown etiology likely linked to immune aberrancy. Research shows a connection between various immune cells and RSA, highlighting the importance of understanding their interactions for preventing RSA.
REPRODUCTIVE SCIENCES
(2021)
Article
Cell Biology
Yuan Zhang, Jiuli Zhang, Jun Bao, Chaohua Tang, Ziwei Zhang
Summary: The study found that selenium deficiency can lead to necroptosis, inflammatory responses, and abnormal expression of cytokines in swine intestine tissues, potentially causing damage to the digestive system.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Medicinal
Xudong Hu, Bing Luo, Qing Wu, Qingbiao Chen, Penghui Lu, Jie Huang, Xiaoxia Liang, Cheng Ling, Yiqun Li
Summary: This study compared the effects of dezocine and sufentanil on postoperative pain and Th1/Th2 balance in breast cancer patients undergoing surgery, with dezocine found to maintain Th1/Th2 balance more stable.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Immunology
Hossein Ansariniya, Fateme Zare, Nariman Mosaffa, Farah Idali, Mahdi Shabani, Hossein Hadinedoushan
Summary: This review discusses the role of the immune system in mouse models of RSA. Research has shown that immune system alterations contribute to the development of RSA. These findings offer new possibilities for preventing RSA from an immunological perspective.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Toxicology
Miho Sakakibara, Yosuke Maeda, Kazuichi Nakamura
Summary: We found that changes in the Th1/Th2 cell ratio and the percentage of Treg cells can have an impact on the maintenance of pregnancy. Adjusting the Th1/Th2 balance and the percentage of Treg cells can reduce fetal death rates.
JOURNAL OF TOXICOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shabanali Khodashenas Limoni, Mehdi Forouzandeh Moghadam, Seyed Mohammad Moazzeni, Hosna Gomari, Fatemeh Salimi
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2019)
Review
Cell Biology
Bahman Yousefi, Majid Eslami, Abdolmajid Ghasemian, Parviz Kokhaei, Amir Salek Farrokhi, Narges Darabi
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Cell Biology
Amir Salek Farrokhi, Narges Darabi, Bahman Yousefi, Rafee Habib Askandar, Mansoreh Shariati, Majid Eslami
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Immunology
Atefeh Yaftiyan, Maryam Eskandarian, Amir Hossein Jahangiri, Nazanin Atieh Kazemi Sefat, Seyed Mohammad Moazzeni
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2019)
Review
Engineering, Multidisciplinary
Shirin Nour, Nafiseh Baheiraei, Rana Imani, Navid Rabiee, Mohammad Khodaei, Akram Alizadeh, Seyed Mohammad Moazzeni
JOURNAL OF BIONIC ENGINEERING
(2019)
Review
Cell Biology
Bahman Yousefi, Maryam Mohammadlou, Maryam Abdollahi, Amir Salek Farrokhi, Mohsen Karbalaei, Masoud Keikha, Parviz Kokhaei, Saeid Valizadeh, Alireza Rezaiemanesh, Vahid Arabkari, Majid Eslami
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Oncology
Mohammad Reza Javan, Arezou Khosrojerdi, Seyed Mohammad Moazzeni
FRONTIERS IN ONCOLOGY
(2019)
Review
Engineering, Biomedical
Shirin Nour, Nafiseh Baheiraei, Rana Imani, Mohammad Khodaei, Akram Alizadeh, Navid Rabiee, S. Mohammad Moazzeni
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2019)
Article
Cell Biology
Fatemeh Rezaei Kahmini, Shahab Shahgaldi, Seyed Mohammad Moazzeni
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Allergy
Fatemeh Ghasemi Sakha, Amirreza Azimi Saeen, Seyed Mohammad Moazzeni, Farnaz Etesam, Gholamhassan Vaezi
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2020)
Article
Developmental Biology
Amir Salek Farrokhi, Amir-Hassan Zarnani, Fatemeh Rezaei Kahmini, Seyed Mohammad Moazzeni
Summary: This study demonstrated that the administration of MSCs significantly reduced the abortion rate in abortion-prone mice by inducing Tregs expansion and upregulating Treg-related genes, establishing an immune-privileged microenvironment to protect the fetus against detrimental maternal immune responses.
Article
Biochemistry & Molecular Biology
Maryam Ajami, Mahboobeh Nazari, Habibollah Mahmoodzadeh, Seyed Mohammad Moazzeni
Summary: CD137, a key T cell costimulatory molecule, interacts with its ligand to activate both T lymphocytes and antigen presenting cells. Recombinant CD137-Fc shows promise in treating cancers, autoimmune disorders, viral infections, and potentially in managing coronavirus infections. Its production and application in cell-based immunotherapy is notable during the current Covid-19 pandemic.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Immunology
Mohammad Reza Javan, Azam Rahimpour, Seyed Mohammad Moazzeni
Summary: Simultaneous overexpression of A20 and BTLA genes in DCs resulted in the development of tolerogenic DCs with enhanced potential in inducing Treg cells. These DCs showed remarkable stability after inflammatory stimulation, offering a promising potential in treating autoimmune and inflammatory disorders.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Amirhossein Jahangiri, Rana Ezzeddini, Nazanin Zounemat Kermani, Fariborz Bahrami, Amir Salek Farrokhi
Summary: Breast cancer is the most common cancer diagnosed in women. Herceptin can block the effects of HER-2 and tumor cell growth. However, there are still failures and resistances in the treatment of HER-2(+) invasive breast cancer. STAT3, which is persistently activated in breast cancer, is associated with immune suppression and tumor cell proliferation. We investigated whether inhibiting STAT3 could improve the impact of Herceptin on reducing immune checkpoint inhibitors and promoting a protective immune response.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Meeting Abstract
Immunology
M. Eskandarian, S. M. Moazzeni
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)