Article
Veterinary Sciences
Nariman Shahhosseini, Christina Frederick, Marie-Pierre Letourneau-Montminy, Benoit-Biancamano Marie-Odile, Gary P. Kobinger, Gary Wong
Summary: The study determined the genomic organization and phylogenetic relationships of TTsusV and PCV in Canadian pig samples, showing high positivity rates of TTsusV1 and TTsusV2, and the presence of PCV1 in some samples. Despite geographical distance, similarities between Canadian and Chinese strains suggest pig trade as a possible explanation.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Chaoliang Leng, Yujing Ma, Zhiqiao Yuan, Hongyue Zhai, Yushan Ding, Yin Bao, Huimin Li, Camilo Ayra-Pardo, Hongfei Shi, Reng Qiu, Hongliang Zhang, Ke Chen, Yunchao Kan, Lunguang Yao, Zhijun Tian
Summary: The study analyzed the complete genomes of two newly emerged TTSuV isolates from a large-scale pig farm in China, finding that they belong to the TTSuV1a subtype. Further analysis revealed that these viruses were generated through recombination in the TTSuV1a genome and could replicate in cells for multiple passages.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Virology
Jun Zeng, Yangming Tang, Tao Lin, Turun Song
Summary: Torque teno virus (TTV) has the potential to be a novel marker for evaluating acute rejection (AR) and posttransplant infection in kidney transplant recipients. The diagnostic accuracy of TTV for AR is modest, but it performs poorly in discriminating posttransplant infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Microbiology
Francesco Righi, Sara Arnaboldi, Virginia Filipello, Giovanni Ianiro, Ilaria Di Bartolo, Stefania Calo, Silvia Bellini, Tiziana Trogu, Davide Lelli, Alessandro Bianchi, Silvia Bonardi, Enrico Pavoni, Barbara Bertasi, Antonio Lavazza
Summary: This study investigated the presence of potentially zoonotic TTSuV in wild animals in Northern Italy and evaluated their role as reservoirs. The results revealed the occurrence and distribution of TTSuV in wild boars and wild ruminants, with different prevalence rates in different areas.
Article
Infectious Diseases
L. Schmidt, B-E O. Jensen, A. Walker, V Keitel-Anselmino, V di Cristanziano, M. Boehm, E. Knops, E. Heger, R. Kaiser, A. de Luca, M. Oette, D. Haeussinger, J. Timm, A. Fuchs, N. Luebke
Summary: This study analyzed TTV DNA in plasma samples of 301 therapy-naive HIV-1-infected patients to evaluate its use as a predictor of the course of immune recovery. TTV plasma concentration was significantly correlated with baseline CD4(+) cell count and indicative of the immune recovery process in HIV-1-infected patients with severe immunodeficiency.
Article
Virology
Irene Goerzer, Frederik Haupenthal, Fabrizio Maggi, Fanny Gelas, Dorian Kulifaj, Ludovic Brossault, Elisabeth Puchhammer-Stoeckl, Gregor Bond
Summary: This study demonstrates that quantification of TTV load using a commercial PCR can be used to predict the risk of graft rejection and infection post kidney transplantation. The commercial PCR showed a high correlation with the in-house PCR, but there was a slight difference in results. The results showed that for every 1 log10 increase in TTV load, the risk of graft rejection decreased by 25% and the risk of infection increased by 6%. Therefore, quantification of TTV load using a commercial PCR is of significant value for risk stratification of graft rejection and infection in the first year post kidney transplantation.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Endocrinology & Metabolism
Carsten T. Herz, Oana C. Kulterer, Dorian Kulifaj, Fanny Gelas, Bernhard Franzke, Frederik Haupenthal, Gerhard Prager, Felix B. Langer, Rodrig Marculescu, Alexander R. Haug, Florian W. Kiefer, Gregor Bond
Summary: Obese individuals have higher TTV load, potentially indicating compromised immune function and serving as a risk stratification factor for unfavorable outcomes in infectious diseases including COVID-19 among this population. Further analysis of TTV-based risk assessment in obese individuals in the context of infectious disease outcomes is warranted based on our data.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Virology
Antonin Bal, Gregory Destras, Marina Sabatier, Maxime Pichon, Hadrien Regue, Guy Oriol, Yves Gillet, Bruno Lina, Karen Brengel-Pesce, Laurence Josset, Florence Morfin
Summary: This study analyzed respiratory samples from children with acute respiratory infections of unknown etiology and found a high prevalence of Torque teno mini virus (TTMV) in these samples, as well as in samples with respiratory syncytial virus (RSV) or influenza infection. Larger studies are needed to explore the role of TTMV in childhood respiratory diseases.
Article
Virology
Gustaf Leijonhufvud, Amanj Bajalan, Tatiany Aparecida Teixeira Soratto, Britt Gustafsson, Gordana Bogdanovic, Annelie Bjerkner, Tobias Allander, Gustaf Ljungman, Bjorn Andersson
Summary: TTV is a group of chronically persisting viruses with a wide sequence diversity, and studies suggest that it is more common than detected by conventional qPCR assays. Analysis of TTV genome sequences reveals that some strains may not be detected by qPCR designed on a conserved region of the TTV genome.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Florian Laubscher, Mary-Anne Hartley, Laurent Kaiser, Samuel Cordey
Summary: This study investigates the genomic diversity of Torque teno virus (TTV) in blood samples from febrile Tanzanian children. The results show that TTV is highly prevalent in the blood samples, with a wide variety of genotypes and species. Furthermore, the diversity of co-detected TTV was significantly associated with the age of the subjects, indicating repetitive acquisition of TTV during the first months/years of life.
Article
Veterinary Sciences
Da-Yoon Kim, Hee-Seop Ahn, Sang-Hoon Han, Hyeon-Jeong Go, Dong-Hwi Kim, Jae-Hyeong Kim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, In-Soo Choi
Summary: This study detected the incidence of Torque teno canis virus (TTCaV) in dogs in Republic of Korea and reported a new recombinant virus. Further research is required to understand the pathogenesis of TTCaV in dogs.
VETERINARY SCIENCES
(2022)
Article
Microbiology
Kwonil Jung, Linda J. Saif
Summary: The study found that co-infection with PEDV and PDCoV did not increase the severity of PEDV infection, but it may interfere or inhibit the replication of PDCoV in the gastrointestinal tract of pigs. This suggests a potential influence of PEDV on PDCoV infection in co-infected pigs.
VETERINARY MICROBIOLOGY
(2021)
Article
Virology
Morgane Solis, Ilies Benotmane, Floriane Gallais, Sophie Caillard, Samira Fafi-Kremer
Summary: Transplant recipients, especially kidney transplant recipients, show poor responses to SARS-CoV-2 mRNA vaccines. A retrospective study found that high viral load of Torque teno virus (TTV), a ubiquitous virus reflecting global immune response levels, is associated with nonresponse to two or three doses of the vaccine in kidney transplant recipients.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Teresa del Rosal, M. Luz Garcia-Garcia, Inmaculada Casas, Maria Iglesias-Caballero, Francisco Pozo, Sonia Alcolea, Blanca Bravo, Jose M. Rodrigo-Munoz, Victoria del Pozo, Cristina Calvo
Summary: The prevalence of TTV infection in children with respiratory infections was evaluated in this study, and its correlations with outcomes and immune response were analyzed. The results showed that TTV infection is common in children with respiratory infections and is associated with abnormal chest radiograph, disease severity, and changes in protein expression and release.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Lucia Canamero, Adalberto Benito-Hernandez, Elena Gonzalez, Clara Escagedo, Maria Rodriguez-Vidriales, Maria del Mar Garcia-Saiz, Rosalia Valero, Lara Belmar, Maria Angeles de Cos, Maria Victoria Francia, Juan Carlos Ruiz, Emilio Rodrigo
Summary: The study aimed to investigate the relationship between Torque Teno Virus (TTV) load and exposure to immunosuppressive drugs in kidney transplantation (KTx) patients. The results showed that TTV load was not related to the exposure to maintenance immunosuppression drugs such as mycophenolic acid (MPA) and tacrolimus. However, TTV load could be a useful marker for predicting the risk of opportunistic infections after KTx.
Article
Infectious Diseases
Meiji Soe Aung, Thida San, Noriko Urushibara, Nilar San, Myat Su Hlaing, Pan Ei Soe, Wut Hmone Win Htut, Ingin Moe, Win Lei Yi Mon, Zar Chi Nyein Chan, Nobumichi Kobayashi
Summary: The study revealed the prevalence and clonal diversity of MRSA/MSSA in children in Myanmar, with MRSA accounting for 19.7% of isolates and Panton-Valentine leukocidin (PVL) genes detected in 61.5% of all isolates. ST239 MRSA isolates exhibited the highest resistance rates to antimicrobials, and quinolone resistance was found in the dominant MRSA clones and some MSSA lineages.
MICROBIAL DRUG RESISTANCE
(2022)
Article
Microbiology
Masako Osada, Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Mina Hirose, Nobumichi Kobayashi
Summary: This study investigated the prevalence, antimicrobial resistance, and genetic determinants of Staphylococcus/Mammaliicoccus species in retail ground meat in Japan. The findings revealed the presence of resistant and diverse strains, as well as the potential plasmid transmission mechanism.
Article
Infectious Diseases
Haiyang Yu, Maria Karla Gonzalez Molina, Yenisel Carmona Cartaya, Marcia Hart Casares, Meiji Soe Aung, Nobumichi Kobayashi, Dianelys Quinones Perez
Summary: This study conducted surveillance on carbapenem-resistant Enterobacterales in 10 hospitals in Havana, Cuba over a six-year period. The most common carbapenemase-producing Enterobacterales (CPE) species was Klebsiella pneumoniae, and urinary tract infections were the most prevalent source of infection.
Article
Infectious Diseases
Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Kenji Kudo, Masahiko Ito, Satoshi Habadera, Nobumichi Kobayashi
Summary: This study identified novel penicillin binding protein (PBP) profiles and mutations associated with penicillin nonsusceptibility in nonencapsulated Streptococcus pneumoniae (NESp). The results revealed that the PBP profiles 13-16-ne1 and 13-7-ne4, as well as PBP1a type-13 and-131, PBP2b type-7,-ne1, and-ne2 were closely associated with penicillin nonsusceptibility in NESp.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Virology
Kerry Gainor, Yussaira Castillo Fortuna, Angeline Steny Alakkaparambil, Wendy Gonzalez, Yashpal Singh Malik, Souvik Ghosh
Summary: This study reports high detection rates of PCV2 in diarrheic pigs from three pig farms in the Dominican Republic, with PCV2d identified as the predominant genotype. Additionally, other related viruses were identified, highlighting the need for further research on the epidemiology and biology of these novel viruses.
Article
Infectious Diseases
Win Kalayar Kyaw, Meiji Soe Aung, Thida San, Win Win Maw, Khin Khin Mu, Win Lei Yee Mon, Mie Mie Than, Nilar San, Cho Cho Than, Noriko Urushibara, Nobumichi Kobayashi
Summary: A study conducted at Yangon General Hospital in Myanmar analyzed 226 clinical isolates of Staphylococcus aureus/Staphylococcus argenteus to investigate antimicrobial resistance and genetic features. It was found that methicillin-resistant S. aureus (MRSA) accounted for 19% of the isolates, with mostly SCCmec type IV or V. The detection rate of Panton-Valentine leukocidin genes was higher in methicillin-susceptible S. aureus (39%) than in MRSA (22%).
MICROBIAL DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Mina Hirose, Kenji Kudo, Naoyuki Tsukamoto, Masahiko Ito, Nobumichi Kobayashi
Summary: This study investigated the prevalence of virulence factors, drug resistance and its genetic determinants, and clonal lineages of E. faecalis and E. faecium clinical isolates in northern Japan. The results showed that E. faecalis isolates had a higher prevalence of virulence factors promoting bacterial colonization compared to E. faecium. There were evident differences in resistance to certain antibiotics and its determinants between the two species. Additionally, the first identification of optrA gene in ST480 E. faecalis in Japan was reported.
Article
Infectious Diseases
Noriko Urushibara, Meiji Soe Aung, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Nobumichi Kobayashi
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Masachika Saeki, Shinya Nirasawa, Meiji Soe Aung, Mayumi Ono, Noriko Urushibara, Nobumichi Kobayashi, Satoshi Takahashi
Summary: This study retrospectively analyzed 100 cases of positive blood cultures for Staphylococcus aureus, and the Xpert MRSA/SA BC assay was used to detect MRSA and MSSA. The results showed that this assay accurately identified MRSA and MSSA, but over half of the MSSA isolates showed positive results for the orfX-associated region, which may cause confusion in the identification of MRSA.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Article
Microbiology
Fardousi Akter Sathi, Meiji Soe Aung, Shyamal Kumar Paul, Syeda Anjuman Nasreen, Nazia Haque, Sangjukta Roy, Salma Ahmed, Mohammad Monirul Alam, Shahed Khan, Mohammad Arif Rabbany, Joy Prokas Biswas, Nobumichi Kobayashi
Summary: In this study, the existing multilocus sequence typing (MLST) scheme for Candida auris was modified and MLST schemes were developed for Candida blankii and Kodamaea ohmeri. These schemes were successfully applied to clinical isolates from Bangladesh in 2021, revealing the clonal diversity of these three fungal species.
Article
Infectious Diseases
Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Mina Hirose, Yuuki Kimura, Kenji Kudo, Masahiko Ito, Nobumichi Kobayashi
Summary: This study collected a total of 279 MRSA isolates from patients with bloodstream infection in northern Japan. The major lineages identified were CC5-MRSA-IIa and CC1-MRSA-IVa, with a lower prevalence of CC8-MRSA-IVa. Compared to previous studies, there was an increased proportion of CC1-MRSA-IVa and the emergence of a novel variant of the USA300 clone.
MICROBIAL DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Norifumi Matsuda, Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Kenji Taniguchi, Kenji Kudo, Masahiko Ito, Nobumichi Kobayashi
Summary: This study investigated the molecular epidemiology of hvKp and hvKv in northern Japan, revealing that 25% of K. pneumoniae and 1% of K. variicola carried virulence genes. The hvKp were mainly classified into certain clonal groups with specific sequence types.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Letter
Infectious Diseases
Satoshi Hirakawa, Toshihiko Mori, Yasuo Ohkoshi, Meiji Soe Aung, Nobumichi Kobayashi
NEW MICROBES AND NEW INFECTIONS
(2022)
Article
Infectious Diseases
Fardousi Akter Sathi, Shyamal Kumar Paul, Salma Ahmed, Mohammad Monirul Alam, Syeda Anjuman Nasreen, Nazia Haque, Arup Islam, Sultana Shabnam Nila, Sultana Zahura Afrin, Meiji Soe Aung, Nobumichi Kobayashi
Summary: This study aimed to determine the prevalence of different Candida species and their susceptibility to antifungal drugs in a tertiary care hospital in Bangladesh. The results showed that C. albicans was the most common species, and NAC isolates exhibited higher resistance to fluconazole.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Infectious Diseases
Thida San, Meiji Soe Aung, Nilar San, Myat Myint Zu Aung, Win Lei Yi Mon, Thin Ei Thazin, Nobumichi Kobayashi
Summary: This study investigated the prevalence of bacterial species and their susceptibility to antimicrobials among pediatric patients in a tertiary-care hospital in Myanmar. The results showed that Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus were the most frequently recovered species, with high rates of resistance observed in Escherichia coli and Klebsiella pneumoniae. Additionally, most bacterial species exhibited fluoroquinolone resistance.
INFECTIOUS DISEASE REPORTS
(2022)