Article
Veterinary Sciences
Yanting Yang, Tong Xu, Jianhua Wen, Luyu Yang, Siyuan Lai, Xiangang Sun, Zhiwen Xu, Ling Zhu
Summary: This study investigated the prevalence and genetic diversity of PCV2 and PCV3 in 257 pig samples from 23 different pig farms in southwest China. The results showed high prevalence rates of PCV2 and PCV3, with an increasing co-infection rate. Whole genome sequences of PCV2 and PCV3 strains were obtained, and PCV2d was found to be the predominant genotype in the southwest of China. Phylogenetic analysis of PCV3 showed high nucleotide homology and revealed three mutations associated with viral immune escape. This study enhances our understanding of the molecular epidemiology and evolution of PCV2 and PCV3.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Virology
Yangyang Pan, Shantong Qiu, Rui Chen, Tiantian Zhang, Linfeng Liang, Meng Wang, Abdul Rasheed Baloch, Libin Wang, Qian Zhang, Sijiu Yu
Summary: The study revealed the prevalence of PCV3 in Tibetan pigs in high-altitude regions of China, with higher rates of PCV3a and PCV3b subtypes in samples from diarrheic pigs. Genetic analysis showed high nucleotide identity in Cap protein sequences of different PCV3 strains, with specific amino acid sequence mutations identified in different subtypes. Further research on the evolution and pathogenicity mechanisms of PCV3 in Tibetan pigs living in this unique environment is recommended.
Article
Veterinary Sciences
Meng Ge, Jie Ren, Yi-Lin Xie, Dun Zhao, Fang-Cheng Fan, Xiao-Qin Song, Man-Xiang Li, Chao-Ting Xiao
Summary: The study conducted epidemiological and serological investigations of PCV3 in clinically healthy pigs from different regions of China. The results showed a high prevalence and genetic divergence of PCV3 among Chinese pig herds, raising concerns about the potential impact of PCV3 on the pig industry.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Xianglong Yu, Kuipeng Gao, Molin Pi, Huizi Li, Wenxia Zhong, Baojian Li, Zhangyong Ning
Summary: PCV3, a highly contagious virus causing severe dermatitis and nephropathy syndrome, has a worldwide distribution and significant economic impact on the swine industry. The phylogenetic analysis showed dispersed Rep genes in PCV3a and clustered Cap genes into distinct clades by genotypes. The study revealed a bias in codon usage and suggested natural selection as the main force influencing the pattern in PCV3.
VETERINARY RESEARCH COMMUNICATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Xifeng Hu, Zheng Chen, Yu Li, Zhen Ding, Qinghua Zeng, Tong Wan, Huansheng Wu
Summary: An epidemiological investigation in Jiangxi province, China, found that wild boar were exposed to porcine circoviruses (PCVs) including PCV2. The prevalence of PCVs, especially PCV2, highlights the need for preventing contact between livestock and wild boar to reduce the risk of PCV infection. PCV infections are associated with several disorders that have a significant negative economic impact on pig production.
Article
Veterinary Sciences
Yu-Rong Wei, Wen-Ge Ma, Ping Wang, Wen Wang, Xiao-Hui Su, Xue-Yun Yang, Xiao-Yun Mi, Jian-Yong Wu, Jiong Huang
Summary: This study characterizes the comparative genomic evolution of the LSDV strain from its first outbreak in China, revealing a common ancestor with LSDV strains from China and Vietnam. The findings provide additional genomic data for the tracking and control of LSDV in China and neighboring countries.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Infectious Diseases
Cheng-Yao Hou, Liu-Hui Zhang, Yuan-Hang Zhang, Jian-Tao Cui, Li Zhao, Lan-Lan Zheng, Hong-Ying Chen
Summary: Porcine circovirus 4 (PCV4), a novel circovirus, was first discovered in Hunan Province of China in April 2019. PCV4 infection has been detected in China and South Korea. Research in Henan Province of China from 2011 to 2021 found that PCV4 has been circulating for at least 10 years, with genomic identity ranging from 98.2% to 98.8% among different strains.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Infectious Diseases
Tong Xu, Yuan-Hang Zhang, Run-Bo Tian, Cheng-Yao Hou, Xin-Sheng Li, Lan-Lan Zheng, Lin-Qing Wang, Hong-Ying Chen
Summary: PCV2 and PCV3 are prevalent in pig populations in China, with PCV2d being the predominant PCV2 genotype in central China, and high nucleotide identity (>98%) among PCV3 sequences obtained in this study and reference sequences.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Virology
Monica Resendiz-Sandoval, Veronica A. Vazquez-Garcia, Kenneth Contreras-Vega, Edgar A. Melgoza-Gonzalez, Veronica Mata-Haro, Luis Gimenez-Lirola, Jesus Hernandez
Summary: This study investigated the presence of PCV3 in samples collected in Mexico and found that PCV3 has been circulating in the region since 2008. The virus has a higher prevalence in pigs with clinical manifestations of diseases.
Article
Biochemical Research Methods
Yunfei Jia, Qianlei Zhu, Tong Xu, Ximeng Chen, Hongxuan Li, Mengyao Ma, Yibei Zhang, Zejun He, Hongying Chen
Summary: PCV2 is a economically important viral agent in swine worldwide. PCV3 has been frequently reported and co-infection of PCV2 and PCV3 is common in China. This study investigated the distribution, epidemiology, and genetic diversity of PCV2 and PCV3 in Henan province of China. A total of 1,760 clinical tissue samples were collected and screened. The positive rates of PCV2 and PCV3 were 72.90% and 5.17% respectively, with a co-infection rate of 3.64%. Furthermore, complete genomes of PCV2 and PCV3 strains were obtained.
MOLECULAR AND CELLULAR PROBES
(2022)
Article
Agriculture, Dairy & Animal Science
Wenke Lv, Lihua Cao, Lulu Yang, Nina Wang, Zhili Li, Shujian Huang, Feng Wen, Jinyue Guo
Summary: This study provides valuable insights into the prevalence and genetic characteristics of PCV2 and PCV3 in Guangdong province, China from 2017 to 2023. The study found a high prevalence of PCV2 and PCV3, with no detection of PCV4. Co-infections of PCV2 with other pig viruses were common. Analysis of PCV2 and PCV3 isolates identified high-frequency mutation sites.
Article
Agriculture, Multidisciplinary
Deng-feng Wang, Xue-yun Yang, Yu-rong Wei, Jian-jun Li, Hongduzi Bolati, Xiao-xiao Meng, Gunuer Tuerxun, Nuerbaiheti Nuerdan, Jian-yong Wu
Summary: This study isolated and sequenced five suspected caprine arthritis-encephalitis virus (CAEV) strains from different provinces in China. It found that these Chinese CAEV strains had a genome similarity of 58-93% to strains outside of China, and belonged to subgenotype B1. These Chinese CAEV strains isolated from different provinces over five years still showed high homology and contained unique ancestral population components, indicating a different origin from other known strains. These findings provide important genomic data for future epidemiological investigations and CAEV eradication programs.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)
Article
Veterinary Sciences
Menghang Wang, Ying Yu, Jianan Wu, Shujie Wang, Luis G. Gimenez-Lirola, Pablo Pineyro, Yu Wang, Hongliang Cui, Xijun He, Jeffrey J. Zimmerman, Yabin Tu, Xuehui Cai, Gang Wang
Summary: In this study, researchers isolated and characterized the PCV3-DB-1 strain in PK-15 cells. They observed PCV-like particles through electron microscopy and confirmed the replication of PCV3 in PK-15 cell culture using in situ hybridization RNA analysis. Phylogenetic analysis placed PCV3-DB-1 in the PCV3a clade based on its Cap protein characteristics.
VETERINARY SCIENCES
(2023)
Article
Infectious Diseases
Meng Ge, Wen-Qin Hu, Ke-Ming Ning, Shuang-Yin Li, Chao-Ting Xiao
Summary: PCV4 is the fourth porcine circovirus identified in China and can be detected in both diseased and healthy pigs. An indirect anti-PCV4 IgG ELISA based on Rep protein was developed and used to investigate the seroprevalence of PCV4 in pig herds in China, revealing an overall seroprevalence of 43.97%, with the highest rates detected in sows.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Veterinary Sciences
Liang Cao, Ziping Yu, Haiqiang He, Xiaofang Guo, Chun Wei, Xuancheng Zhang, Junduo Bao, Chenghui Li, Hongning Zhou, Jialiang Xin, Fulong Nan
Summary: Since 2013, there has been a dengue epidemic in Yunnan, China and neighboring countries. However, the number of cases decreased significantly after the COVID-19 pandemic in 2019. A retrospective study analyzed the epidemiological and genetic diversity of dengue viruses (DENV) isolated in Yunnan between 2017 and 2018. The outbreak was mainly caused by DENV1 and DENV2, with a significant correlation between imported and local cases.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Infectious Diseases
F. Bao, S. Mi, Q. Luo, H. Guo, C. Tu, G. Zhu, W. Gong
TRANSBOUNDARY AND EMERGING DISEASES
(2018)
Article
Infectious Diseases
Huijuan Wang, Jinyan Gu, Gang Xing, Xiaohuo Qiu, Shuting An, Yuexia Wang, Cheng Zhang, Changming Liu, Wenjie Gong, Changchun Tu, Shuo Su, Jiyong Zhou
TRANSBOUNDARY AND EMERGING DISEASES
(2019)
Article
Infectious Diseases
Chaonan Xing, Zongji Lu, Jianfeng Jiang, Liangzong Huang, Jialun Xu, Desheng He, Zelin Wei, Haijie Huang, Hongren Zhang, Cangyao Murong, Changchun Tu, Wenjie Gong
INFECTION GENETICS AND EVOLUTION
(2019)
Article
Microbiology
Wenjie Gong, Junhui Li, Zunbao Wang, Jiumeng Sun, Shijiang Mi, Zongji Lu, Jian Cao, Zhihua Dou, Yanjun Sun, Pengjiang Wang, Ke Yuan, Liying Zhang, Xubin Zhou, Sun He, Changchun Tu
VETERINARY MICROBIOLOGY
(2019)
Article
Virology
Xiaofeng Zhai, Jiumeng Sun, Ziqing Yan, Jie Zhang, Jin Zhao, Zongzheng Zhao, Qi Gao, Wan-Ting He, Michael Veit, Shuo Su
JOURNAL OF VIROLOGY
(2020)
Article
Infectious Diseases
Chaonan Xing, Jianfeng Jiang, Zongji Lu, Shijiang Mi, Biao He, Changchun Tu, Xiufan Liu, Wenjie Gong
TRANSBOUNDARY AND EMERGING DISEASES
(2020)
Review
Biochemistry & Molecular Biology
Jiumeng Sun, Wan-Ting He, Lifang Wang, Alexander Lai, Xiang Ji, Xiaofeng Zhai, Gairu Li, Marc A. Suchard, Jin Tian, Jiyong Zhou, Michael Veit, Shuo Su
TRENDS IN MOLECULAR MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Jiumeng Sun, Wen Zhao, Ruyi Wang, Wenyan Zhang, Gairu Li, Meng Lu, Yuekun Shao, Yichen Yang, Ningning Wang, Qi Gao, Shuo Su
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Virology
Shijiang Mi, Shibang Guo, Chaonan Xing, Chaoting Xiao, Biao He, Bin Wu, Xianzhu Xia, Changchun Tu, Wenjie Gong
Summary: This study reported the first successful isolation of a porcine astrovirus 5 (PAstV5) strain, as well as the coinfection mechanism of porcine circovirus type 2 (PCV2) and PAstV5 with CSFV, which significantly enhanced the replication of PAstV5 by suppressing interferon response.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Biao He, Wenjie Gong, Xiaomin Yan, Zihan Zhao, Ling'en Yang, Zhizhou Tan, Lin Xu, Aiwei Zhu, Jianing Zhang, Jihong Rao, Xinglong Yu, Jianfeng Jiang, Zongji Lu, Yifang Zhang, Jianmin Wu, Yong Li, Yuxiang Shi, Qing Jiang, Xiwen Chen, Changchun Tu
Summary: Pigs are a major meat source worldwide and a pillar of Chinese animal husbandry. A comprehensive study has been conducted to delineate the pig virome, establishing a viromic baseline for disease prevention and control. The viromic strategy developed in this study has the potential to revolutionize surveillance measures for pathogenic viruses in animal species.
Article
Virology
Zhe Yang, Biao He, Zongji Lu, Shijiang Mi, Jianfeng Jiang, Zhongdi Liu, Changchun Tu, Wenjie Gong
Summary: A novel porcine virus, porcine birnavirus (PBRV), was unexpectedly identified from classical swine fever virus-infected pigs by viral metagenomic analysis. PBRV strains were found in diseased pigs from nine provinces/autonomous regions in China spanning 21 years, showing replication in the pigs. Genome-based sequence comparison revealed genetic distance from existing members within the Birnaviridae family, with PBRVs forming an independent genotype separated from other genera. Phylogenetic analysis suggested the classification of PBRVs into two or three subgenotypes (PBRV-A1-2 and PBRV-B1-3) based on nucleotide sequences.
Article
Biochemistry & Molecular Biology
Wan-Ting He, Xin Hou, Jin Zhao, Jiumeng Sun, Haijian He, Wei Si, Jing Wang, Zhiwen Jiang, Ziqing Yan, Gang Xing, Meng Lu, Marc A. Suchard, Xiang Ji, Wenjie Gong, Biao He, Jun Li, Philippe Lemey, Deyin Guo, Changchun Tu, Edward C. Holmes, Mang Shi, Shuo Su
Summary: This study conducted a transcriptomic analysis of game animals in China and identified numerous potentially high-risk viruses for humans and domestic animals. Civets were found to carry the highest number of these high-risk viruses. The study also revealed the transmission pathways of coronaviruses between different species.
Review
Cell Biology
Jin Tian, Jiumeng Sun, Dongyan Li, Ningning Wang, Lifang Wang, Chang Zhang, Xiaorong Meng, Xiang Ji, Marc A. Suchard, Xu Zhang, Alexander Lai, Shuo Su, Michael Veit
Summary: This article mainly introduces the taxonomy, geographic distribution, and unique traits of bats as virus reservoirs, as well as the origin, intermediate hosts, and interspecies transmission mechanisms of Middle East respiratory syndrome coronavirus, severe acute respiratory syndrome coronavirus, SARS-CoV-2, and other viruses associated with bats. The molecular interactions between viral surface proteins and host cell receptors are also studied, comparing these interactions in humans, intermediate hosts, and bats.
Article
Microbiology
Jin Zhao, Jiumeng Sun, Xinxin Li, Gang Xing, Yifang Zhang, Alexander Lai, Guy Baele, Xiang Ji, Shuo Su
Summary: Paramyxoviridae is a rapidly growing family of viruses, and it is difficult to predict the harm of newly emerging viruses to humans and animals. By analyzing the genomes of porcine parainfluenza virus (PPIV), a new species named PPIV-2 was discovered, and a revision of the species classification criteria for the Respirovirus genus was proposed. Recombination events and high genetic diversity were found in PPIV-1, indicating the importance of recombination in the diversity of the Respirovirus genus.
MICROBIOLOGY SPECTRUM
(2022)
Editorial Material
Public, Environmental & Occupational Health
Zhiwen Jiang, Jiumeng Sun, Letian Zhang, Shiyu Yan, Dongyan Li, Chang Zhang, Alexander Lai, Shuo Su
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)