Article
Virology
Jinyong Zhang, He Zhang, Wenchao Sun, Cuicui Jiao, Pengpeng Xiao, Jicheng Han, Fulong Nan, Changzhan Xie, Zhuo Ha, Zhuoxin Li, Yubiao Xie, Yuan Meng, Huijun Lu, Ningyi Jin
Summary: A novel strain of SVV, CH-GX-01-2019, was detected in swine in Guangxi Province, China, showing high similarity with other SVV isolates. Chinese SVV isolates can be divided into three clusters, predominantly distributed in south and central China. The dominant epidemic SVV isolates in China have shifted from clusters 1 and 3 to cluster 2 between 2015 and 2019.
Article
Veterinary Sciences
Xia Zhou, Wei-Fang Liang, Guang-Bin Si, Jin-Hui Li, Zhi-Fei Chen, Wei-You Cai, Dian-Hong Lv, Xiao-Hui Wen, Qi Zhai, Shao-Lun Zhai, Ming Liao, Dong-Sheng He
Summary: Pigs are the main host of Seneca Valley virus (SVV), but it has also been detected in mice and other animals, with the first report of SVV infection in a buffalo in this study, potentially expanding the host range of the virus.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Infectious Diseases
Benjamin Bennett, Constanza Urzua-Encina, Catalina Pardo-Roa, Naomi Ariyama, Claudio Lecocq, Carlos Rivera, Catalina Badia, Paulina Suarez, Michel Agredo, Carolina Aguayo, Claudia Avila, Hugo Araya, Patricio Perez, Felipe Berrios, Belen Aguero, Vanessa Mendieta, Edviges Maristela Pituco, Iassudara Garcia de Almeida, Rafael Medina, Barbara Brito, Magdalena Johow, Victor Neira Ramirez
Summary: A case of Seneca Valley virus (SVV) infection in a swine farm in Chile was reported, and epidemiological investigation and phylogenetic analyses revealed a close relationship with viruses from swine in the United States. Further studies are required to determine the risk of introduction of novel SVV and other transboundary swine pathogens to Chile.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Agriculture, Dairy & Animal Science
Tingting Zhang, Nan Liu, Lan Zhang, Wansi Jiang, Xiaole Fan, Xiuyuan Wang, Runchun Miao, Xinyu Zhai, Liangmeng Wei, Shijin Jiang, Peirong Jiao
Summary: With the expansion of duck breeding industry in China, the infection rate of duck circovirus (DuCV) and the mixed infection rate of DuCV with other diseases have significantly increased. In order to understand the epidemic status of DuCV in China, our laboratory collected 4 disease materials preliminarily diagnosed as DuCV infections. Through PCR amplification and sequence analysis, we found that these 4 viral strains belonged to the DuCV-I type and had a high homology with the German strain AY228555 (98.6%).
Article
Virology
Jun Yao, Juan Li, Lin Gao, Yuwen He, Jiarui Xie, Pei Zhu, Ying Zhang, Xue Zhang, Luoyan Duan, Shibiao Yang, Chunlian Song, Xianghua Shu
Summary: This study conducted serological and epidemiological investigations of pseudorabies virus (PRV) in pig populations in Yunnan Province, China. The results revealed that PRV posed a severe threat to the pig industry, with PRV variants being the major genotype of concern.
Article
Infectious Diseases
Weijun Zeng, Quanhui Yan, Pengfei Du, Zhongmao Yuan, Yawei Sun, Xiaodi Liu, Lihong Zhang, Xueyi Liu, Hongxing Ding, Lin Yi, Shuangqi Fan, Jinding Chen, Mingqiu Zhao
Summary: This study comprehensively analyzed the genomic sequence data of Seneca Valley virus (SVV) to gain insights into its genetic diversity, distribution patterns, and evolutionary adaptations. The results suggest that SVV has evolved into eight lineages, with the United States potentially being its source. Analysis of positive selection sites in SVV capsid proteins indicates their importance in receptor recognition, and codon preference analysis shows that natural selection has influenced SVV codon usage bias. This study highlights the significance of SVV surveillance and control measures.
INFECTION GENETICS AND EVOLUTION
(2023)
Article
Virology
Lei Hou, Xinxin Tong, Yang Pan, Ruihan Shi, Changzhe Liu, Jinshuo Guo, Yongyan Shi, Xiaoyu Yang, Yong Wang, Xufei Feng, Jianwei Zhou, Jue Liu
Summary: Entry of virus into cells is crucial for a successful infection. This study investigated the entry process of Seneca Valley virus (SVV) into cells and identified key factors involved. SVV was found to enter PK-15 cells through caveolae-mediated endocytosis and macropinocytosis, dependent on low pH, dynamin, Rab5, and Rab7. Understanding the entry mechanisms of SVV provides insights for preventing and controlling SVV infection and contributes to the knowledge of Picornaviridae family.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Shaofei Li, Tian Jing, Fang Zhu, Yiming Chen, Xiaoting Yao, Xidian Tang, Chenxiang Zuo, Mingjie Liu, Yanfei Xie, Yuecai Jiang, Yunpeng Wang, Dengliang Li, Lulu Li, Shikong Gao, Dekun Chen, Huiying Zhao, Wentao Ma
Summary: Contagious ecthyma (CE) is caused by orf virus (ORFV) and leads to lesions and economic losses in livestock. Two ORFV strains, FX and LX, were isolated from China and their genetic data revealed the epidemiology and evolution of ORFV. The study identified hotspots in East and South Asia for ORFV transmission and predicted viral epitopes for potential vaccine design.
Article
Veterinary Sciences
Dongjie Chen, Di Wang, Fang Wei, Yufang Kong, Junhua Deng, Xiangmei Lin, Shaoqiang Wu
Summary: An AKAV strain TJ2016 was isolated from cattle sera in China, and a reverse genetic platform for AKAV genome manipulation was established. This system provides a powerful tool for further research on AKAV pathogenesis and vaccine studies.
BMC VETERINARY RESEARCH
(2021)
Article
Virology
Xu Wang, Jianjun Hu, Fanyan Meng, Yiheng Cao, Zijie Wang, Qianyi Zhang, Qian Zhang, Xingxing Zhang, Mengli Han, Tongzhong Wu, Fagang Zhong, Xin Huang
Summary: This study isolated and sequenced two genotypes (B and C) of bovine parainfluenza virus 3 (BPIV3) from Chinese cattle herds. The genomes of the isolates had different lengths and multiple amino acid changes in major antigenic proteins. These findings contribute to tracing the origin of BPIV3, understanding genotype differences, and supporting vaccine development.
Article
Virology
Zekai Zhao, Lin Cao, Zixian Sun, Wenqiang Liu, Xiangmin Li, Kui Fang, Xianfei Shang, Junjie Hu, Huanchun Chen, Zhiyong Lou, Ping Qian
Summary: Two novel SVV mutants, SVV-S177A and SVV-S177A/P60S, modified based on structural biology and reverse genetics, significantly prolonged the median overall survival (mOS) from 11 days to 23 days in the NSCLC-bearing athymic mouse model, providing a direction for improving the oncolysis effect of SVV.
JOURNAL OF VIROLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Shuqi Xu, Xinhao Mu, Xin Xu, Congying Bi, Jun Ji, Yunchao Kan, Lunguang Yao, Yingzuo Bi, Qingmei Xie
Summary: This study analyzed 23 complete genomes of Chinese strains of duck hepatitis B virus (DHBV) and predicted and analyzed their recombinant events. These data aid in understanding the intergenotypic recombination of HBV and are expected to promote further research on the epidemiology and evolution of DHBV.
Article
Veterinary Sciences
Nina Wang, Lichao Yang, Guohui Li, Xu Zhang, Jianwei Shao, Jun Ma, Shouyi Chen, Quan Liu
Summary: The study detected and characterized Wenzhou virus (WENV) in rodents in Guangzhou, China, showing high genetic diversity and emphasizing the importance of surveillance for this emerging mammarenavirus in both natural reservoirs and humans.
BMC VETERINARY RESEARCH
(2021)
Article
Biochemical Research Methods
Hua Wang, Xinli Ding, Wenbo Sun, Zhi Chen, Linyi Bai, Hongkun Liang, Yujie Liu, Wanli Zhang, Guisheng Wang, Guiwen Yang, Michael G. Mauk, Yuanyuan Cui, Lei Chen
Summary: This study describes the development and demonstration of a recombinase polymerase amplification (RPA) test for the rapid and accurate detection of Seneca Valley virus (SVV). The RPA test targeting the conserved regions of SVV showed good sensitivity and specificity, making it an effective tool for rapid diagnosis of SVV.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Microbiology
Jiangwei Song, Rong Quan, Dan Wang, Jue Liu
Summary: This study demonstrates that Seneca Valley virus (SVV) infection leads to cleavage, degradation, and cytoplasmic redistribution of heterogeneous nuclear ribonucleoprotein K (hnRNP K). The viral 3C(pro) protease is responsible for the degradation of hnRNP K through the caspase pathway. A cleavage fragment of hnRNP K promotes SVV replication, while hnRNP K inhibits viral replication. hnRNP K interacts with the viral 5' untranslated region (UTR) and knockdown of hnRNP K inhibits SVV replication.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Environmental Sciences
Kaizhao Zhang, Xiaotong Tan, Ying Li, Guan Liang, Zhangyong Ning, Yongjiang Ma, Yugu Li
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2018)
Article
Biochemistry & Molecular Biology
Hao Cui, Jianxin Liu, Guming Xu, Xujiao Ren, Zhenbiao Li, Ying Li, Zhangyong Ning
BIOCHEMICAL GENETICS
(2019)
Article
Virology
Jianxin Liu, Zhenbiao Li, Xujiao Ren, Huizi Li, Rong Lu, Yuan Zhang, Zhangyong Ning
ARCHIVES OF VIROLOGY
(2019)
Letter
Virology
Jianxin Liu, Yunfeng Zha, Huizi Li, Yanwei Sun, Fuguang Wang, Rong Lu, Zhangyong Ning
Article
Infectious Diseases
Jianxin Liu, Huizi Li, Boyang Liu, Bingqian Zhao, Pengtao Zhang, Xianglong Yu, Zhangyong Ning
TRANSBOUNDARY AND EMERGING DISEASES
(2020)
Article
Genetics & Heredity
Jianxin Liu, Qianju Guo, Huizi Li, Xianglong Yu, Boyang Liu, Bingqian Zhao, Zhangyong Ning
Article
Biochemistry & Molecular Biology
Xianglong Yu, Jianxin Liu, Huizi Li, Boyang Liu, Bingqian Zhao, Zhangyong Ning
Summary: The study revealed that APPV genomes exhibit a relatively unstable change and a slight low codon usage bias. Results showed that both mutation pressure and natural selection impact the codon usage bias of APPV, with natural selection having a more significant influence on the E2 gene.
BIOCHEMICAL GENETICS
(2021)
Article
Virology
Jianxin Liu, Pengtao Zhang, Yongjie Chen, Wenxia Zhong, Baojian Li, Molin Pi, Zhangyong Ning
Summary: Researched prepared VLPs of APPV and evaluated VLPs vaccine in BALB/c mice. Results showed strong antibody responses induced by VLPs, reducing viral load, and BALB/c mice are suitable as a laboratory model for APPV.
ARCHIVES OF VIROLOGY
(2021)
Article
Veterinary Sciences
Xianglong Yu, Kuipeng Gao, Molin Pi, Huizi Li, Wenxia Zhong, Baojian Li, Zhangyong Ning
Summary: PCV3, a highly contagious virus causing severe dermatitis and nephropathy syndrome, has a worldwide distribution and significant economic impact on the swine industry. The phylogenetic analysis showed dispersed Rep genes in PCV3a and clustered Cap genes into distinct clades by genotypes. The study revealed a bias in codon usage and suggested natural selection as the main force influencing the pattern in PCV3.
VETERINARY RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Bingqian Zhao, Huizi Li, Suilan Cao, Wenxia Zhong, Baojian Li, Weixin Jia, Zhangyong Ning
Summary: The study highlights the role of anti-inflammatory regulators PTX3, Del-1, and GDF-15 in the inflammatory response caused by H5N1 and H9N2 AIV infections in birds and mammals. The findings show that overexpression of these factors can inhibit the expression of inflammatory cytokines, offering insights into potential host-specific anti-inflammatory agents for combating avian influenza viruses.
Article
Microbiology
Huizi Li, Cunhao E. Lin, Wenbao Qi, ZhenZhen E. Sun, Zhenxin Xie, Weixin E. Jia, Zhangyong Ning
Summary: Senecavirus A (SVA)-induced porcine idiopathic vesicular disease has caused significant economic losses worldwide. This study reveals that SVA infection induces glycolysis and lactate production to facilitate virus replication, while inhibiting type I interferons mainly through attenuating the interaction between MAVS and RIG-I. These findings provide a new perspective on the relationship between metabolism and innate immunity in SVA infection, suggesting that targeting glycolysis or lactate production may be effective strategies against the virus.
Article
Virology
Xianglong Yu, Jianxin Liu, Huizi Li, Boyang Liu, Bingqian Zhao, Zhangyong Ning
Summary: The study analyzed the codon usage bias of PEDV, revealing its existence in the genome. Principal component analysis, ENC plot, and PR2 plot showed that mutation pressure and natural selection influenced the codon usage bias of PEDV genomes.
ARCHIVES OF VIROLOGY
(2021)
Article
Veterinary Sciences
Kaizhao Zhang, Pan Tao, Jianxin Liu, Qingnan Wang, Shikun Ge, Zhangyong Ning
ACTA VETERINARIA HUNGARICA
(2017)
