期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 98, 期 -, 页码 161-173出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2017.11.009
关键词
Parabens; Preservatives; Extraction techniques; Chromatography; Human-associated samples
资金
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT, & Future Planning [2016R1E1A1A01940995]
- R&D Center for Green Patrol Technologies through the R&D for Global Top Environmental Technologies - Ministry of Environment (MOE), Republic of Korea
Parabens are an important class of antimicrobial compounds used as preservatives. Although they are considered to be safe when used within specified concentration limits, concerns about their potential toxicity have been raised due to their presence in cancerous breast tissues and their association with estrogenic activity, various kinds of allergies, and the malfunctioning of reproductive organs. The small quantities of parabens in human samples and complex nature of biological matrices make it difficult to determine free and/or conjugated forms of parabens and their metabolites. Consequently, it is desirable to develop sophisticated approaches for their sample pretreatments and subsequent determination. This review presents recent developments in the extraction, pre-concentration, and instrumental detection methods needed for the accurate quantification of parabens in human samples. This review is thus expected to help readers assess the potential impacts of parabens on human health through proper description of their exposure routes to human. (C) 2017 Elsevier B.V. All rights reserved.
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