Review
Endocrinology & Metabolism
Damilare Emmanuel Rotimi, Tomilola Debby Olaolu, Matthew Iyobhebhe, Adekemi Grace Oluwafemi, Olabisi Esther Bakare, Oluyomi Stephen Adeyemi
Summary: Male infertility is caused by interconnected endogenous mechanisms, with around 50% being of unknown cause. Both oxidative stress (OS) and inflammation are independently implicated in male infertility. Inflammation and OS are intimately connected and can initiate a vicious cycle that disrupts the testicular system. Studies have shown that ROS, facilitated by inflammatory cells, and proinflammatory gene expressions play key roles in testicular OS and dysfunction.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Andrology
Hissah Ahmed Alturki, Hany Amin Elsawy, Ademola Clement Famurewa
Summary: This study investigated the effect of silymarin (SIL) on testicular toxicity induced by acrylamide (ACR) in rats. The results showed that SIL could attenuate ACR-induced reproductive deficits, restore antioxidant balance, and maintain DNA integrity.
Article
Biochemistry & Molecular Biology
Rasha Abu-Khudir, Hayfa Habes Almutairi, Sahar S. Abd El-Rahman, Karim Samy El-Said
Summary: The study investigated the protective role of the natural antioxidant hesperidin (HSD) against lead-acetate (PbAc)-induced testicular toxicity. The results showed that HSD treatment can restore the testicular injury induced by PbAc by suppressing oxidative stress and modulating reproductive hormones.
Article
Medicine, Research & Experimental
Ajlaa Sofya Mohd Khalil, Nelli Giribabu, Suseela Yelumalai, Huma Shahzad, Eswar Kumar Kilari, Naguib Salleh
Summary: Myristic acid (MA) can protect testes against damage in diabetes mellitus (DM) by preventing oxidative stress, inflammation, and apoptosis, while maintaining steroidogenesis and spermatogenesis.
Article
Environmental Sciences
Ling-Ling Zhao, Emmanuel Ayobami Makinde, Opeyemi Joshua Olatunji
Summary: The ethyl acetate extract from Shorea roxburghii (SRE) was found to have a protective effect on diabetes-induced testicular damage, improving testicular function, reducing inflammation, and oxidative stress.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hassan Rakhshandeh, Hamed Rajabi Khasevan, Anella Saviano, Mohammad Reza Mahdinezhad, Vafa Baradaran Rahimi, Sajjad Ehtiati, Leila Etemad, Alireza Ebrahimzadeh-bideskan, Francesco Maione, Vahid Reza Askari
Summary: The study found that Portulaca oleracea extract has a protective effect on streptozotocin-induced type-I-diabetes-associated reproductive system dysfunction and inflammation in rats. It ameliorated various parameters and histopathological indexes' damage, indicating its potential use in managing diabetic-associated clinical complications.
Article
Andrology
Joana N. Simas, Talita B. Mendes, Leonardo W. Fischer, Vanessa Vendramini, Sandra M. Miraglia
Summary: The study found that resveratrol (RES) can effectively alleviate male reproductive damage caused by type 1 diabetes, improve sperm DNA integrity and reproductive outcomes. RES acts as an adjuvant against hyperglycemia by controlling oxidative stress, thus ameliorating the severe impact of diabetes on male reproductive system.
Article
Obstetrics & Gynecology
M. J. Campbell, I. E. Sucquart, A. Whittaker, H. J. Sanganee, C. L. R. Barratt, S. J. Martins da Silva
Summary: The study showed that AZD5904 can improve sperm function in an in vitro model of oxidative stress, increasing sperm penetration through viscous media and potentially offering a new treatment approach for male infertility. The study was conducted in vitro, and a clinical trial is now planned to validate these results.
HUMAN REPRODUCTION
(2021)
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Petr Slama, Shubhadeep Roychoudhury
Summary: Inflammation and oxidative stress are core causatives of male infertility, with a close connection between the two. Inflammation leads to elevated levels of proinflammatory mediators in the male reproductive tract, while oxidative stress causes oxidative damage to reproductive cells and intracellular components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Emily P. P. Evans, Jorien T. M. Scholten, Aldona Mzyk, Claudia Reyes-San-Martin, Arturo E. Llumbet, Thamir Hamoh, Eus G. J. M. Arts, Romana Schirhagl, Astrid E. P. Cantineau
Summary: Currently, 15% of couples are suffering from infertility, with 45-50% of cases attributed to male factors. Free radicals or reactive oxygen species (ROS) play a key role in the fertility process, while also serving important functions in sperm maturation. These ROS are influenced by lifestyle, age, and disease.
Article
Environmental Sciences
Jerusa Maria de Oliveira, Graziela Domingues de Almeida Lima, Ana Luiza Fonseca Destro, Suellen Condessa, Jener Alexandre Sampaio Zuanon, Mariella Bontempo Freitas, Leandro Licursi de Oliveira
Summary: Research shows that exposure to DTM has harmful effects on the reproductive function of Neotropical fruit-eating bats, potentially leading to cell degeneration. This has important implications for seed dispersal and reforestation in the Neotropical forests.
Article
Pharmacology & Pharmacy
Dalia Ibrahim, Nadia Abozied, Samar Abdel Maboud, Ahmad Alzamami, Norah A. Alturki, Mariusz Jaremko, Maram Khalil Alanazi, Hayaa M. Alhuthali, Asmaa Seddek
Summary: Cancer is characterized by abnormal cell proliferation and chemotherapy, specifically using cyclophosphamide, is a common treatment technique. However, cyclophosphamide has serious side effects including testicular damage and infertility. This study explored the potential protective effects of mesenchymal stem cell transplantation on testicular tissues damaged by cyclophosphamide. The results showed that transplantation of mesenchymal stem cell mitigated the harmful effects of cyclophosphamide, improving testicular function and spermatogenesis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Toxicology
Zhang Qian, Chuwei Li, Wei Zhao, Zhaowanyue He, Mengqi Xue, Shuxian Wang, Xi Cheng, Rujun Ma, Xie Ge
Summary: In this study, we examined the toxic effects of short chain chlorinated paraffins (SCCPs) on the testis in mice treated with SCCPs by gavage. The results showed that SCCPs exposure significantly reduced sperm parameters and caused disorderly arranged seminiferous epithelium and increased apoptotic cells in the testes. Oxidative stress induced by SCCPs exposure and dysfunction of the NRF2 signaling pathway were identified as key factors in the testicular toxicity. Resveratrol, an NRF2 activator, was found to alleviate the damage caused by SCCPs on the male reproductive system. Oxidative stress and NRF2 could be potential targets for clinical treatment of reproductive toxicity induced by SCCPs.
TOXICOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Na Li, Xinyi Dong, Sen Fu, Xiaoyan Wang, Huaibiao Li, Ge Song, Donghui Huang
Summary: This study analyzes the effect of C-type natriuretic peptide (CNP) on sperm motility in asthenozoospermia, and explores the mechanism of CNP on the reproductive system and sperm motility. The concentration of CNP in asthenospermia patients' semen is lower than in normal people, and CNP significantly improves sperm motility through the NPR-B/cGMP pathway. CNP also alleviates tissue damage in the reproductive system and increases testosterone levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Luciana Dalazen dos Santos, Tugstenio Lima de Souza, Gabriel Ian da Silva, Mateus Francescon Ferreira de Mello, Jeane Maria de Oliveira, Marco Aurelio Romano, Renata Marino Romano
Summary: The increased prevalence of male reproductive disorders and infertility in humans is believed to be caused by exposure to chemical endocrine disruptors. Acrylamide, a compound found in some foods consumed by children and adolescents, has been found to reduce sperm production and functionality when exposed to during the prepubertal period. This reduction is attributed to oxidative stress, which is known to negatively impact sperm quality and quantity.
ENVIRONMENTAL POLLUTION
(2023)
Article
Obstetrics & Gynecology
Hossein Hosseinirad, Marefat Ghaffari Novin, Sedighe Hosseini, Hamid Nazarian, Zahra Safaei, Teibeh Hashemi, Shahrokh Paktinat, Zahra Shams Mofarahe
Summary: The study found a significant decrease in PR mRNA expression and phospho-Ser294 PR protein level in RIF patients compared to the control group. These results suggest impaired expression of PR and its phosphorylated form in RIF patients for the first time.
REPRODUCTIVE SCIENCES
(2021)
Article
Obstetrics & Gynecology
Zahra Mehraban, Marefat Gaffari Novin, Mohammad Ghasem Golmohammadi, Hamid Nazarian
Summary: The study showed that Ceratonia siliqua L. extract can improve sperm parameters and DNA fragmentation in male mice treated with cyclophosphamide (CP). The extract reduced the negative effects of CP on sperm count, viability, abnormal sperm, MDA levels, and DNA damage.
REPRODUCTIVE SCIENCES
(2021)
Article
Cell Biology
Sanaz Ziaeipour, Abbas Piryaei, Abbas Aliaghaei, Hamid Nazarian, Parvaneh Naserzadeh, Vahid Ebrahimi, Shabnam Abdi, Farshad Shahi, Hosein Ahmadi, Fatemeh Fadaei Fathabadi, Mohammad-Amin Abdollahifar
Summary: Chronic scrotal hyperthermia significantly impacts testicular tissue structure, sperm parameters, and oxidative stress in adult mice, leading to decreased sperm count and testis weight, as well as an increase in oxidative stress levels.
Article
Obstetrics & Gynecology
Shahrokh Paktinat, Sahar Esfandyari, Amin Karamian, Ameneh Koochaki, Ali Asadirad, Marefat Ghaffari Novin, Samira Mohammadi-Yeganeh, Saghar Salehpour, Seyed Mahmoud Hashemi, Hamid Nazarian
Summary: The study demonstrated that CM derived from SEV-exposed eSC induced secretion of the pro-inflammatory cytokines IL-1 alpha and IL-6 by macrophages, while reducing the secretion of the anti-inflammatory cytokine IL-10.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Hamid Nazarian, Marefat Ghaffari Novin, Sara Khaleghi, Bahare Habibi
Summary: The failure of embryo implantation is a significant limitation in assisted reproduction and pregnancy. MicroRNAs have attracted attention for their important role in human embryo implantation. Recent studies have shown that microRNAs can act as non-invasive biomarkers, improving embryo selection and predicting endometrial receptivity, while also providing new information for implantation studies.
CURRENT MOLECULAR MEDICINE
(2022)
Review
Obstetrics & Gynecology
Sara Khaleghi, Rouhollah Fathi, Farideh Eivazkhani, Ashraf Moini, Marefat Ghaffari Novin, Bita Ebrahimi, Hamid Nazarian
Summary: Ovarian tissue cryopreservation offers hope for women who have lost fertility due to diseases like cancer, with scientists at the Royan Institute in Tehran conducting studies to find the best way to extract mature oocytes. The various research conducted in this area by researchers at the Royan Institute over the past 20 years is collated in this review to provide an overview of the current status of fertility preservation.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Fereshteh Safian, Mohammad Bayat, Vahid Jajarmi, Mohammad-Amin Abdollahifar, Hamid Nazarian, Zahra Shams Mofarahe, Mahsa Ghaffari Novin, Mahsa Kazemi, Pourya Raee, Sufan Chien, Marefat Ghaffari Novin
Summary: The study aimed to evaluate the effects of photobiomodulation (PBM) on sperm parameters before and after cryopreservation. Results showed that pre-freezing PBM therapy improved total sperm motility and progressive sperm motility, reduced DNA fragmentation and lipid peroxidation levels, as well as decreased apoptotic/necrotic cells in normozoospermic men. Additionally, no significant differences were observed in the expression levels of certain genes related to sperm quality among the study groups.
REPRODUCTIVE SCIENCES
(2022)
Article
Neurosciences
Pariya Khodabakhsh, Maryam Bazrgar, Fatemeh Mohagheghi, Siavash Parvardeh, Abolhassan Ahmadiani
Summary: The role of miR-140-5p inhibition in promoting Pin1 expression and the therapeutic potential of AntimiR-140-5p in an A beta oligomer-induced Alzheimer's disease rat model were investigated. The results showed that miR-140-5p inhibitors markedly improved spatial learning and memory deficits induced by A beta O and suppressed the expression of inflammatory mediators and phosphorylation of tau protein. This study suggests that miR-140-5p inhibitors may be a promising agent for the treatment of Alzheimer's disease.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Kamran Rezaei, Mohammad-Abbas Sheikholeslami, Ebrahim Salimi-Sabour, Ensieh Lotfali, Siavash Parvardeh
Summary: The study found that Ganoderma lucidum extract significantly reduced symptoms in morphine-dependent mice, including jumps, leanings, and diarrhea. This suggests that G. lucidum extract has the potential to mitigate morphine dependence and inhibit withdrawal syndrome symptoms in mice.
JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS
(2022)
Article
Andrology
Pourya Raee, Zahra Shams Mofarahe, Hamid Nazarian, Mohammad-Amin Abdollahifar, Mahsa Ghaffari Novin, Shahin Aghamiri, Marefat Ghaffari Novin
Summary: Obesity is associated with sperm telomere shortening and aberrant autophagy-related mRNA expression. It also affects semen parameters, sperm apoptosis, and oxidative stress levels.
BASIC AND CLINICAL ANDROLOGY
(2023)
Article
Obstetrics & Gynecology
Zahra Kuroshli, Marefat Ghaffari Novin, Hamid Nazarian, Mohammad-Amin Abdollahifar, Shahrzad Zademodarres, Maryam Pirani, Farideh Arab Jahvani, Fatemeh Fadaei Fathabady, Zahra Shams Mofarahe
Summary: This study evaluated the effects of vitamin D on the expression and protein levels of related genes in endometrial cells of women with recurrent implantation failure (RIF). The results showed that RIF patients with vitamin D deficiency had lower levels of these genes and proteins compared to RIF patients without deficiency.
REPRODUCTIVE SCIENCES
(2023)
Article
Engineering, Biomedical
Sanaz Ziaeipour, Mohsen Norouzian, Hojjat-Allah Abbaszadeh, Abbas Aliaghaei, Hamid Nazarian, Amin Karamian, Faraj Tabeie, Parvaneh Naserzadeh, Shabnam Abdi, Mohammad-Amin Abdollahifar, Shahrokh Paktinat
Summary: Testicular heat stress impairs spermatogenesis, and the mechanism underlying this vulnerability to heat-induced injury remains unclear. Photobiomodulation therapy (PBMT) has recently been used to improve sperm quality and fertility. This study aimed to evaluate the effect of PBMT on spermatogenesis in mouse models of hyperthermia-induced azoospermia. The results showed that PBMT at a lower intensity increased enzyme activity and antioxidant levels, reduced oxidative stress markers, and restored spermatogenesis in the azoospermia model. The findings suggest that PBMT has a significant therapeutic effect in heat-induced azoospermia mouse models.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Obstetrics & Gynecology
Mohammadhosssein Kargar Godaneh, Saleh Rahimi, Marzieh Abizadeh, Shiva Motamedi, Ali Younesi, Hamid Nazarian, Ahmadreza Gholshan, Azadeh Kargar Godaneh, Abbas Aliaghaei, Shabnam Abdi, Sima Inanlu, Sanaz Ziaeipour, Mohammad-Amin Abdollahifar, Vahid Ebrahimi
Summary: This study investigated the effect of insulin on gene expression, hormonal status, and histological aspects of the ovary in a PCOS animal model. The results showed that insulin treatment improved hormonal balance, follicle development, and insulin resistance in the ovaries of PCOS mice.
INTERNATIONAL JOURNAL OF FERTILITY & STERILITY
(2023)
Article
Biotechnology & Applied Microbiology
Bahareh Habibi, Marefat Ghaffari Novin, Saghar Salehpour, Mahsa Ghaffari Novin, Samira Mohammadi Yeganeh, Hamid Nazarian
Summary: This study found that CAMK1D expression and overexpression of miR-34-5p and miR-26-5p could be considered as markers of successful pregnancy. Additionally, the results suggest that normal FF treatment of RIF patients may result in the production of high-quality embryos.
BIOMEDICAL AND BIOTECHNOLOGY RESEARCH JOURNAL
(2022)
Article
Anatomy & Morphology
Sara Dadras, Mohammad Bayat, Marefat G. Novin, Hamid Nazarian, Amir Raoofi, Shabnam Abdi, Sina Sadeghzadeh, Faezeh Tajari, Mohammad-Amin Abdollahifar
Summary: The study investigated the effects of diabetes mellitus on sperm parameters in mice. Results showed a decrease in sperm count and motility in diabetic mice compared to the control group, as well as significant differences in volume and length of sperm components between the two groups.
EUROPEAN JOURNAL OF ANATOMY
(2021)
