Article
Anatomy & Morphology
Nashwa S. Wahba, Assmaa O. Saliem, Enas G. Abd Allah, Maha Z. Mohammed
Summary: This study aimed to investigate the effects of chronic fluoxetine treatment on the pars distalis of rats and the potential therapeutic effect of adipose-derived mesenchymal stem cells (ADSCs). The results showed that fluoxetine treatment led to detrimental changes in the cellular architecture, size, shape, and staining characteristics of the pars distalis cells. However, treatment with ADSCs significantly improved the microscopic appearance of the cells.
Article
Dentistry, Oral Surgery & Medicine
Elham H. Ahmed, Mohammed E. Grawish, Mohamed M. Anees, Menatalla M. Elhindawy, Mohamed Abdulrahman, Mohamad E. Helal
Summary: This study aimed to demonstrate the changes induced by cadmium intoxication and the possible prophylactic and therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) in rat submandibular salivary glands. The results showed that the prophylactic and therapeutic groups had similar histological and biochemical indicators compared to the control group, indicating that BMSCs have prophylactic and therapeutic effects against cadmium-induced cytotoxicity.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Health Care Sciences & Services
Shankargouda Patil, Ahmed Alamoudi, Bassam Zidane, Khalid J. Alzahrani, Fuad M. Alzahrani, Hamsa Jameel Banjer, Rodolfo Reda, Thodur Madapusi Balaji, Shilpa Bhandi, A. Thirumal Raj, Luca Testarelli
Summary: This study investigated the effects of melatonin on the proliferation and differentiation of dental pulp stem cells (DPSCs). The results showed that melatonin at concentrations of 1 μM and 25 μM stimulated the differentiation of DPSCs into osteocytes, but had little influence on adipogenic and chondrogenic differentiation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Marwa T. Hassen, Hanaa K. Mohamed, Metwally M. Montaser, Mohamed E. El-Sharnouby, Nabil Awad, Rasha A. Ebiya
Summary: Cisplatin commonly causes testicular damage as a side effect, but the combination of bone marrow-derived stem cells and beetroot extract has been shown to reduce this damage, improving sperm count, testosterone level, and antioxidant capacity.
Article
Biology
Yuyan Liu, Yun Li, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Lu Wang, Yuan Fang, Dengfeng Ding, Feihu Zhou, Hongjun Kang
Summary: MSCs have immunomodulatory effects and can reduce multiorgan damage and mortality rate caused by heatstroke, as well as stabilize immunoglobulin levels.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Cell Biology
Balun Li, Xuedi Cheng, Aili Aierken, Jiaxin Du, Wenlai He, Mengfei Zhang, Ning Tan, Zheng Kou, Sha Peng, Wenwen Jia, Haiyang Tang, Jinlian Hua
Summary: Abundant evidence demonstrates the therapeutic effect of adipose-derived mesenchymal stem cells (ADMSCs) in treating diabetes mellitus. However, the inconsistent viability and quick senescence of ADMSCs after in vitro cell culture, along with unsatisfactory therapeutic effects, remain unresolved issues. The addition of melatonin (MLT) to ADMSC culture medium was shown to promote the cells' viability by binding to MLT receptors, activating the TGF-beta pathway, and improving cell cycle changes, potentially enhancing the effects of ADMSCs in treating T2DM symptoms such as hyperglycemia and insulin resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natalie Vallant, Bynvant Sandhu, Karim Hamaoui, Maria Prendecki, Charles Pusey, Vassilios Papalois
Summary: This study compared the paracrine effects of MSC supernatants from different age and genotype sources on macrophages, revealing distinct patterns of inflammatory marker expression. These findings are crucial for preclinical and clinical studies utilizing MSCs for inflammation and allo-response mitigation in transplant patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Lan Li, Dongqi Cheng, Xingxing An, Guangneng Liao, Ling Zhong, Jingping Liu, Younan Chen, Yujia Yuan, Yanrong Lu
Summary: The study demonstrated that MSCs treatment could reduce elevated levels of uric acid and improve kidney function in hyperuricemic nephropathy rat models. In vitro experiments also showed that MSCs could protect against uric acid-induced cell injury. These findings suggest that MSCs therapy may be a potential treatment for hyperuricemia-related renal diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dana Nir, Ivana Ribarski-Chorev, Chen Shimoni, Carmit Strauss, Jan Frank, Sharon Schlesinger
Summary: Mesenchymal stem cells (MSC) play important roles in maintaining tissue homeostasis, but heat shock can impair MSC function and induce premature senescence. Pre-exposure to antioxidants reduces reactive oxygen species and protects cells from premature senescence and cytokine release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Esraa Ali Mahmoud, Houry Moustafa Baghdadi, Rabab Hassan, Shaimaa Eliwa Ghazy
Summary: This study aimed to evaluate and compare the reparative role of bone marrow-mesenchymal stem cells (BM-MSCs) and platelet-rich plasma (PRP) against irradiation-induced submandibular gland damage. The results showed that both BM-MSCs and PRP can effectively treat the damage, with the combined therapy recommended.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tarek Khamis, Adel Abdelkhalek, Hussein Abdellatif, Nourelden Dwidar, Ahmed Said, Rama Ahmed, Kerolos Wagdy, Rowina Elgarhy, Rawan Eltahan, Hisham Mohamed, Eman Said Amer, Maria Hanna, Tarek Ragab, Abdallah Kishk, Judy Wael, Eyad Sarhan, Linda Saweres, Mohamed Reda, Sara Elkomy, Abdalah Mohamed, Abdullah Samy, Ateya Khafaga, Youliana Shaker, Hamdy Yehia, Asma Alanazi, Mohammed Alassiri, Emil Tirziu, Iulia Maria Bucur, Ahmed Hamed Arisha
Summary: This study indicates that BM-MSCs may have therapeutic potential for the treatment of DN and provide important insights into their potential use as a novel therapeutic approach for DN.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Chao Gu, Quan Zhou, Xiayu Hu, Xiaoyang Ge, Mingzhuang Hou, Wenhao Wang, Hao Liu, Qin Shi, Yong Xu, Xuesong Zhu, Huilin Yang, Xi Chen, Tao Liu, Fan He
Summary: Osteoporotic bone defects are a severe complication of osteoporosis. This study found that melatonin has the potential to enhance the repair of osteoporotic bone defects by restoring the mitochondrial function of bone marrow-derived mesenchymal stem cells (BMMSCs). In vitro experiments showed that melatonin improved the mitochondrial function of BMMSCs and reduced the level of mitochondrial superoxide. In animal experiments, silk fibroin scaffolds loaded with melatonin partially restored the mitochondrial energy metabolism and osteogenic differentiation of BMMSCs.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Cell & Tissue Engineering
Yen-Ta Chen, Fei-Chi Chuang, Chih-Chao Yang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Chi-Ruei Huang, Kuan-Hui Huang, Hon-Kan Yip
Summary: The combined use of melatonin and adipose-derived mesenchymal stem cells effectively protects the testis against acute testicular torsion-induced ischemia-reperfusion injury.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Michiko Horiguchi, Yuko Okada, Yuya Turudome, Kentaro Ushijima
Summary: Type 1 diabetes mellitus leads to degeneration of organelles in adipose-derived stem cells, with the main characteristic being prominent enlarged spherical vesicles. The exosomes of T1DM ADSCs are found to be enlarged, reduced in number, and increased in the percentage positive for tetraspanin CD9, providing insight into the characteristics of stem cells in patients with type 1 diabetes mellitus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anatomy & Morphology
W. A. Nasr El-Din, N. Nooreldin, A. S. Essawy
Summary: This study compared the healing effect of intravenous (IV) versus subconjunctival (SC) BM-MSCs on rats' corneas subjected to UVB-irradiation, finding that local SC injection of BM-MSCs had remarkable regenerative efficacy on corneal injury compared to the systemic IV route.
FOLIA MORPHOLOGICA
(2022)
Article
Immunology
Sahar Sobhy Abd Elhalem, Nawal Zakaria Haggag, Nashwa Ahmed El-Shinnawy
Article
Biochemistry & Molecular Biology
Nashwa Ahmed El-Shinnawy, Sahar Sobhy Abd Elhalem, Nawal Zakaria Haggag, Gamal Badr
Article
Toxicology
Shadia M. Kadry, Mai H. El-Dakdoky, Nawal Z. Haggag, Laila A. Rashed, Marwa T. Hassen
TOXICOLOGY MECHANISMS AND METHODS
(2018)
Article
Developmental Biology
Mennatallah H. Abdelaziz, Eman Y. Salah EL-Din, Mai H. El-Dakdoky, Tawfik A. Ahmed
BIRTH DEFECTS RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Sahar S. Abd-Elhalem, Nashwa A. El-Shinnawy, Ehab E. Abu-El Magd, Waleed K. El Zawawy, Nawal Z. Haggag
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Agriculture, Dairy & Animal Science
Marwa T. Hassen, Hanaa K. Mohamed, Metwally M. Montaser, Mohamed E. El-Sharnouby, Nabil Awad, Rasha A. Ebiya
Summary: Cisplatin commonly causes testicular damage as a side effect, but the combination of bone marrow-derived stem cells and beetroot extract has been shown to reduce this damage, improving sperm count, testosterone level, and antioxidant capacity.
Article
Chemistry, Applied
Nawal S. Hassan, Nora E. M. Shaheen, Nawal Z. Haggag, Marwa T. Hassen
Summary: This study examined the effects of OTC and MSCs on CPF-induced lung toxicity in rats. The results showed significant improvements in lung toxicity, anti-inflammatory activity, and restoration of lung tissue structure and function.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
Article
Biology
Nawal Zakaria Haggag, Nashwa Ahmed El-Shinnawy, Sahar Sobhy Abd-Elhalem, Laila Ahmed Rashed
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2019)