Article
Biochemistry & Molecular Biology
Michell O. Almeida, Marcos R. V. Lanza, Kathia M. Honorio
Summary: The study suggests that ATEC may be a good substitute for DEHP in the production of plastics like PVC, showing the least activity in two hormone receptors.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Environmental Sciences
Lian Kang, Jiadong Chen, Junke Wang, Tianxin Zhao, Yuexin Wei, Yuhao Wu, Lindong Han, Xiangqin Zheng, Lianju Shen, Chunlan Long, Guanghui Wei, Shengde Wu
Summary: The toxic effects of DEHP on prepubertal testes were investigated, with the 500 mg/kg/day group showing significant abnormalities. RNA-seq results indicated DEHP impacts reproduction and metabolic pathways co-enrichment. DEHP exposure may cause similar damages, with two key transcriptional biomarkers identified.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Tiziana Genovese, Rosalba Siracusa, Roberta Fusco, Ramona D'Amico, Daniela Impellizzeri, Alessio Filippo Peritore, Rosalia Crupi, Enrico Gugliandolo, Rossana Morabito, Salvatore Cuzzocrea, Angela Trovato Salinaro, Marika Cordaro, Rosanna Di Paola
Summary: This study found that aged mice were more susceptible to the effects of Atrazine (ATR) compared to young mice, exhibiting more pronounced behavioral alterations and memory impairment. ATR induced oxidative stress, pro-inflammatory cytokine release, and apoptosis, with the older group showing greater sensitivity to ATR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Baek Kiook, Park Jong-Tae, Kwak Kyeongmin
Summary: The study found that urinary bisphenol S (BPS) played an important role in the diagnosis of asthma in Korean adolescent females. Compared to patients diagnosed with asthma after 60 months, high urinary BPS significantly increased the odds of lifetime asthma prevalence.
Review
Environmental Sciences
Miaoliang Wu, Fuhui Yan, Qian Liu, Ganzhong Liao, Yilin Shen, Zhi Bai, Xiaoshan Liu
Summary: Preeclampsia (PE) is a disease that occurs after 20 weeks of pregnancy and is characterized by new onset hypertension and albuminuria or other end-organ damage. It is a major complication of pregnancy that can increase morbidity and mortality in pregnant women and fetuses, causing significant social burden. Recent research suggests that exposure to environmental xenobiotic compounds, particularly endocrine disruptors, may contribute to the development of PE. However, the specific mechanisms underlying this relationship remain unclear. This paper reviews the role and potential mechanism of PE induced by exogenous chemicals and provides an outlook on the environmental etiology of PE.
Article
Environmental Sciences
Raquel Chamorro-Garcia, Nathalie Poupin, Marie Tremblay-Franco, Cecile Canlet, Riann Egusquiza, Roselyne Gautier, Isabelle Jouanin, Bassem M. Shoucri, Bruce Blumberg, Daniel Zalko
Summary: Metabolomics confirmed transgenerational obesogenic effects of environmentally relevant doses of TBT in male mice, while also showing impaired liver biotransformation capacity in females. This study demonstrates the transgenerational effects of EDC exposure and highlights the potential use of metabolomic fingerprints in identifying individuals susceptible to adverse health effects from ancestral exposure to obesogens.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Environmental Sciences
Juan P. Munoz, Tammy C. Bleak, Gloria M. Calaf
Summary: Glyphosate, a broad-spectrum herbicide introduced in 1974, has had a significant impact on the crop industry and is considered one of the most successful herbicides in history. However, recent studies have raised concerns about its safety, with conflicting opinions from international agencies regarding its effects on human health, particularly as an endocrine-disrupting chemical and carcinogen.
Article
Environmental Sciences
Niedson Correia de Lima Junior, Juliana Franco Camilo, Pamella Rodrigues do Carmo, Marcelle Novaes de Andrade, Bernardo Ferreira Braz, Ricardo Erthal Santelli, Lycia de Brito Gitirana, Andrea Claudia Freitas Ferreira, Denise Pires de Carvalho, Leandro Miranda-Alves, Glaecir Roseni Mundstock Dias
Summary: Subacute exposure to lead acetate disrupts thyroid gland function in both sexes, leading to changes in learning and memory abilities.
ENVIRONMENTAL POLLUTION
(2021)
Article
Pharmacology & Pharmacy
Huimin Wang, Xuepei Lei, Zhuo Zhang, Mohammad Mehdi Ommati, Zhongwei Tang, Jianqin Yuan
Summary: The study indicates that BPA exposure has detrimental effects on cognitive function and insulin signaling pathway in male offspring mice, potentially posing a risk for long-term neurodegeneration.
Editorial Material
Biochemistry & Molecular Biology
Borja Quiroga
Summary: BPA, a common component of plastics worldwide, has been shown to act as an endocrine disruptor with some hormonal functions. High levels of BPA are related to cardiovascular events and carcinogenesis pathways, and CKD patients have higher serum concentrations of BPA due to impaired renal function. Efforts to reduce BPA levels in these patients include developing BPA-free dialysis filters and other techniques.
Article
Environmental Sciences
David A. Geier, Mark R. Geier
Summary: A study using NHANES data found that 82% of the tested individuals in the United States had detectable concentrations of glyphosate in their urine. There was a significant inverse correlation between glyphosate concentrations and total testosterone and total estradiol concentrations, but no correlation with sex hormone binding globulin concentrations.
Article
Food Science & Technology
Camila Helena Facina, Silvana Gisele Pegorin Campos, Thalles Fernando Rocha Ruiz, Rejane Maira Goes, Patricia Simone Leite Vilamaior, Sebastiao Roberto Taboga
Summary: Curcumin and piperine can mitigate the detrimental effects of BPA on the prostate gland, reducing nuclear atypia and maintaining the homeostasis of prostate epithelial cells. The protective action of these phytotherapeutic agents is associated with weight loss, anti-inflammatory potential, and control of prostate epithelial cell homeostasis.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Dongmin Yu, Dawei Zhu, Xufeng Wang, Ben Li, Jinghang Li, Peng Lu, Yumeng Ji, Xiaowei Wang
Summary: Maternal environmental sanitation during pregnancy plays a crucial role in fetal development. Exposure to DEHP is associated with potential risks to fetal heart development. The study investigated the molecular mechanisms of DEHP-induced cardiotoxicity in fetal mice.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Susana Santos, Chalana M. Sol, Charissa Van Zwol-Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W. V. Jaddoe, Leonardo Trasande
Summary: Exposure to phthalates during pregnancy may lead to fetal growth restriction and preterm birth. Different trimester-specific exposures to phthalates may have varying effects on fetal growth and birth outcomes.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Pallavi Gautam, Anand Kumar Pandey, Suresh Kumar Dubey
Summary: The widely used insecticide, imidacloprid, has caused serious environmental concerns due to its residual presence. A study on soil microcosms investigated the biodegradation potential of Agrobacterium sp. InxBP2, which achieved 88% degradation of imidacloprid within 20 days. The findings of this study provide important insights into the mechanistic link between imidacloprid degradation genes/enzymes and Agrobacterium sp. InxBP2, and have implications for soil remediation strategies.
ENVIRONMENTAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yayao Ma, Youngjae Lee, Catherine Best-Popescu, Liang Gao
Summary: The study introduces a high-resolution, high-speed fluorescence lifetime imaging microscopy based on a compressed sensing scheme, allowing for recording of fluorescence decay in a large field of view and reducing factors affecting image quality, with demonstrated utility in imaging transient dynamics at the microscopic scale.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Optics
Neha Goswami, Yuchen R. He, Yu-Heng Deng, Chamteut Oh, Nahil Sobh, Enrique Valera, Rashid Bashir, Nahed Ismail, Hyunjoon Kong, Thanh H. Nguyen, Catherine Best-Popescu, Gabriel Popescu
Summary: Efforts to combat the COVID-19 crisis have emphasized the importance of fast, accurate, and scalable testing for curbing the current impact and future pandemics. This study proposes an optical method combined with deep learning to directly image unlabeled viral particles and classify them with high accuracy, demonstrating the potential for extremely rapid virus identification. Unique nanoscale sensitivity in the input data allows for efficient detection of viruses, including distinguishing SARS-CoV-2 with high accuracy, within a short inference time.
LIGHT-SCIENCE & APPLICATIONS
(2021)
Review
Developmental Biology
CheMyong J. Ko, Yoon Min Cho, Eugene Ham, Joseph A. Cacioppo, Chan Jin Park
Summary: This review describes the role and regulatory mechanisms of the endothelin system in the ovulation process, highlighting its significance in diagnosing and treating infertility, identifying contraceptive targets, and developing novel contraception methods.
Article
Reproductive Biology
Yuna Lee, Saniya Rattan, Radwa Barakat, Zane Inman, Kathy M. De La Torre, Daryl D. Meling, Marcia H. Monaco, Joseph M. Irudayaraj, Isaac K. Cann, Chemyong J. Ko, Sharon M. Donovan, Jodi A. Flaws, Genoa R. Warner
Summary: DEHP, a commonly used chemical, is found in many consumer products. Research has shown that neonatal exposure to DEHP in pigs leads to sex-specific disruption of the reproductive system, affecting both ovaries and testes.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Environmental Sciences
Karen K. Chiu, Shah Tauseef Bashir, Ahmed M. Abdel-Hamid, Lindsay V. Clark, Mary J. Laws, Isaac Cann, Romana A. Nowak, Jodi A. Flaws
Summary: This study examines the impact of DiNP exposure on the gut microbiota and immune-related factors, revealing that DiNP exposure can alter the composition of the gut microbiota and that the gut contains microbes capable of degrading DiNP.
Review
Obstetrics & Gynecology
Chan Jin Park, Ji-Eun Oh, Jianan Feng, Yoon Min Cho, Huanyu Qiao, CheMyong Ko
Summary: Female mammals are born with an excessive number of oocytes, which decreases throughout their lifetime until nearly all are lost. In humans, the number of oocytes decreases significantly after birth and is influenced by various intrinsic and extrinsic factors, such as inflammation caused by ovulation.
CLINICAL AND EXPERIMENTAL REPRODUCTIVE MEDICINE-CERM
(2022)
Article
Environmental Sciences
Diana C. Pacyga, Brad A. Ryva, Romana A. Nowak, Serdar E. Bulun, Ping Yin, Zhong Li, Jodi A. Flaws, Rita S. Strakovsky
Summary: This study investigated the association between phthalates and fibroids and found that each two-fold increase in sigma DEHP or sigma AA was associated with a 13% and 16% greater risk of prior fibroid diagnosis in women. These associations were strongest in women who were overweight/obese and in those diagnosed with fibroids within 5 years before phthalate assessment.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Environmental Sciences
Endia J. Fletcher, Ramses Santacruz-Marquez, Vasiliki E. Mourikes, Alison M. Neff, Mary J. Laws, Jodi A. Flaws
Summary: This review discusses the effects of phthalate mixtures on the female reproductive system. Phthalates have been found to target the ovaries, disrupting normal reproductive function and potentially affecting folliculogenesis and steroidogenesis. Additionally, phthalates can cross the placental barrier and impact fetal development. However, the specific effects of phthalate mixtures on the ovary and female reproduction are still not well understood.
Article
Developmental Biology
Radwa Barakat, Clyde A. Campbell, Raquel Espin-Palazon
Summary: In this study, we developed a protocol to perform CUT&RUN experiments in zebrafish and provided a detailed workflow for the identification of predicted TF binding sites in any animal species. Our strategy will greatly contribute to the research in the zebrafish community, improving the epigenetic resolution achievable in this model organism.
Review
Biochemistry & Molecular Biology
Nitya Shree, Zehuan Ding, Jodi Flaws, Mahua Choudhury
Summary: The prevalence of poor metabolic health is increasing exponentially worldwide, with exposure to environmental chemicals, such as endocrine-disrupting chemicals (EDCs), gaining attention as a contributing factor. Recent reports suggest that non-coding RNAs, specifically microRNAs (miRs), may play a vital role in this phenomenon.
Article
Biochemistry & Molecular Biology
Yee Ming Khaw, Shehata Anwar, Jinyan Zhou, Tasuku Kawano, Po-Ching Lin, Ashley Otero, Radwa Barakat, Jenny Drnevich, Tomoko Takahashi, CheMyong Jay Ko, Makoto Inoue
Summary: Estrogen through estrogen receptor alpha (ER alpha) is involved in disease modification in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). However, the exact mechanisms of ER alpha signaling in disease pathogenesis remain unclear. Our study shows that deletion of ER alpha in dendritic cells (DCs) leads to severe neurodegeneration in a mouse EAE model and resistance to interferon beta (IFN beta), a first-line treatment for MS. Estrogen derived from extragonadal sources plays a crucial role in controlling disease phenotypes.
Review
Environmental Sciences
Xing Zhang, Jodi A. Flaws, Michael J. Spinella, Joseph Irudayaraj
Summary: Endocrine disrupting chemicals (EDCs) are exogenous substances that can alter the endocrine function of an organism, leading to adverse effects on growth, development, metabolism, and reproductive function. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in both animals and humans. This review discusses the renal accumulation of specific EDCs, such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and explores how exposure to these EDCs can result in renal lesions and diseases, including cancer. The regulation of target genes and activation of related pathways by typical EDCs are also summarized.
Article
Environmental Sciences
Vasiliki E. Mourikes, Ramses Santacruz Marquez, Ashley Deviney, Alison M. Neff, Mary J. Laws, Jodi A. Flaws
Summary: Imidacloprid is a neonicotinoid pesticide used in agriculture, gardening, and veterinary medicine. It has the potential to accumulate in the environment and harm non-targeted species. Imidacloprid and its metabolite desnitro-imidacloprid have different effects on follicle growth and steroidogenesis. These compounds also alter the expression of genes related to hormone regulation and apoptosis.
Article
Veterinary Sciences
Mohamed Zeineldin, Radwa Barakat
Summary: This study analyzed 16S rRNA gene datasets from various domestic animals to identify host-specific signatures of respiratory microbiota. Cattle and pigs exhibited higher diversity and variety of respiratory microbiota compared to other animals. The study also found that individual study, health status, and sampling sites significantly influenced the composition and diversity of respiratory microbiota.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Genetics & Heredity
Clotilde Maurice, Mathieu Dalvai, Romain Lambrot, Astrid Deschenes, Marie-Pier Scott-Boyer, Serge McGraw, Donovan Chan, Nancy Cote, Ayelet Ziv-Gal, Jodi A. Flaws, Arnaud Droit, Jacquetta Trasler, Sarah Kimmins, Janice L. Bailey
Summary: The study found that paternal exposure to POPs pollutants can impact the development and pregnancy outcomes of offspring, with this effect potentially explained by sperm DNA methylation. Experimental results suggest that the paternal methylome is sensitive to the environment, with some perturbations persisting for at least two subsequent generations.