Bone Toolbox: Biomarkers, Imaging Tools, Biomechanics, and Histomorphometry

Comparing the incidence of bone tumors in rats chronically exposed to the selective PTH type 1 receptor agonist abaloparatide or PTH(1–34)

(2017) Jacquelin Jolette et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys

(2016) Michael S Ominsky et al.   JOURNAL OF BONE AND MINERAL RESEARCH

One Year of Abaloparatide, a Selective Activator of the PTH1 Receptor, Increased Bone Formation and Bone Mass in Osteopenic Ovariectomized Rats Without Increasing Bone Resorption

(2016) Aurore Varela et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Carcinogenicity risk assessment of romosozumab: A review of scientific weight-of-evidence and findings in a rat lifetime pharmacology study

(2016) Luc Chouinard et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Esomeprazole use is independently associated with significant reduction of BMD: 1-year prospective comparative safety study of four proton pump inhibitors

(2015) Elton Bahtiri et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period

(2014) Rogely W. Boyce et al.   BONE

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function

(2014) N.J. Peake et al.   OSTEOARTHRITIS AND CARTILAGE

Assessment of a Nonsteroidal Aromatase Inhibitor, Letrozole, in Juvenile Rats

(2013) Louise Pouliot et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

High-resolution peripheral quantitative computed tomography and finite element analysis of bone strength at the distal radius in ovariectomized adult rhesus monkey demonstrate efficacy of odanacatib and differentiation from alendronate

(2013) Antonio Cabal et al.   BONE

The Effect of Rosiglitazone on Bone Mass and Fragility Is Reversible and Can Be Attenuated With Alendronate

(2013) Sanjay Kumar et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Heterochrony and post-natal growth in mammals - an examination of growth plates in limbs

(2013) M. Geiger et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Evaluation of high-resolution peripheral quantitative computed tomography, finite element analysis and biomechanical testing in a pre-clinical model of osteoporosis: A study with odanacatib treatment in the ovariectomized adult rhesus monkey

(2012) Richa Y. Jayakar et al.   BONE

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone density and structure in healthy postmenopausal women treated with exemestane for the primary prevention of breast cancer: a nested substudy of the MAP.3 randomised controlled trial

(2012) Angela M Cheung et al.   LANCET ONCOLOGY

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor  

(2012) W. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys

(2011) Michael S. Ominsky et al.   BONE

Effects of neonatal castration and androgenization on sexual dimorphism in bone, leptin and corticosterone secretion

(2011) Wagner Garcez de Mello et al.   BONE

Simulated increases in body fat and errors in bone mineral density measurements by DXA and QCT

(2011) Elaine W Yu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

(2010) A. Michael Parfitt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

(2010) Michael S Ominsky et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cellular mechanisms of bone remodeling

(2010) Erik Fink Eriksen   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Pyridone 6, A Pan-Janus-Activated Kinase Inhibitor, Suppresses Osteoclast Formation and Bone Resorption through Down-Regulation of Receptor Activator of Nuclear Factor-κB (NF-κB) Ligand (RANKL)-Induced c-Fos and Nuclear Factor of Activated T Cells (NFAT) c1 Expression

(2009) Han Bok Kwak et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Selective Serotonin Reuptake Inhibitors and Other Antidepressants and Risk of Fracture

(2008) Peter Vestergaard et al.   CALCIFIED TISSUE INTERNATIONAL

Effects of Treatment with Parathyroid Hormone 1–84 on Quantity and Biomechanical Properties of Thoracic Vertebral Trabecular Bone in Ovariectomized Rhesus Monkeys

(2008) J. Fox et al.   CALCIFIED TISSUE INTERNATIONAL

Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis*

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Peripheral Quantitative Computed Tomography in Children and Adolescents: The 2007 ISCD Pediatric Official Positions

(2008) Babette Zemel et al.   JOURNAL OF CLINICAL DENSITOMETRY

Improved reproducibility of high-resolution peripheral quantitative computed tomography for measurement of bone quality

(2008) Joshua A. MacNeil et al.   MEDICAL ENGINEERING & PHYSICS

Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: Comparison with synchrotron radiation microcomputed tomography and ash measurements

(2008) G. J. Kazakia et al.   MEDICAL PHYSICS