期刊
TETRAHEDRON LETTERS
卷 59, 期 30, 页码 2921-2929出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2018.06.035
关键词
Spiro-indenoquinoxaline pyrrolothiazoles; Quinoline dipolarophile; Thiazolidine-2-carboxylic acid; Antioxidants; Antiproliferative
资金
- SERB, New Delhi, India [YSS/2015/000037]
- UGC, New Delhi
- UGC FRP faculty award [F.4-5(94-FRP/2015(BSR)]
The 1,3-dipolar cycloaddition reactions of azomethine ylide generated in situ from indeno quinoxaline and thiazolidine-2-carboxylic acid to a series of quinoline bearing dipolarophile afforded novel spiro indeno-quinoxaline pyrrolo thiazoles in quantitative yields. The newly synthesized compounds were characterized using different spectroscopic techniques. Furthermore, the molecular structure of compound 5c was confirmed by single crystal X-ray crystallography. The synthesized compounds were screened for their in vitro antioxidant activity and in vitro cytotoxic activity against breast cancer cell line MCF-7 and adenocarcinomic cancer cell line A-549. Compound containing more electron donors in quinoline site were found to be more potent with good IC50 values. (C) 2018 Elsevier Ltd. All rights reserved.
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