期刊
TETRAHEDRON
卷 74, 期 38, 页码 4994-4999出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.06.051
关键词
Nanaomycin A; de novo asymmetric synthesis; Sharpless asymmetric dihydroxylation; Pyranonaphthoquinone; Oxa Pictet-Spengler reaction
资金
- NSF [CHE-1565788]
The de novo asymmetric total synthesis of (-)-nanaomycin A is described. The entirely linear route required only 13 steps from commercially available starting materials (3% overall yield). Key transformations include a Claisen rearrangement, an asymmetric dihydroxylation, a regioselective tosylation, a diastereoselective intramolecular Friedel-Crafts alkylation and a nitrile hydrolysis. As the route relies on a Sharpless asymmetric dihydroxylation it is equally amenable for the synthesis of (+)-nanaomycin A. (C) 2018 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据