Article
Chemistry, Applied
Lin Gu, Jingru Zhang, Guangxin Yang, Yunyu Tang, Xuan Zhang, Xuanyun Huang, Wenlei Zhai, Essy Kouadio Fodjo, Cong Kong
Summary: A green and facile hydrothermal synthesis approach was used to prepare nitrogen-doped carbon quantum dots using wolfberry, which were developed as a highly sensitive fluorescent 'on-off-on' switch sensor for the detection of Fe3+ and L-ascorbic acid (AA). The N-CQDs displayed superior fluorescence characteristics and a quantum yield up to 22%, showing potential for effective and efficient nanosensor applications. The N-CQDs demonstrated selective reaction with Fe3+ and fluorescence recovery with the addition of AA, establishing a promising strategy for the detection of Fe3+ and AA with low-cost, green synthesis.
Article
Chemistry, Analytical
Jianlin Pu, Chang Liu, Bin Wang, Pei Liu, Yanzi Jin, Jiucun Chen
Summary: The study has successfully constructed orange red-emitting carbon dots with a high quantum yield, demonstrating unique properties and applications in the presence of Fe3+. These CDs have shown potential for detecting Fe3+ in water due to their distinct color changes and fluorescence emission characteristics.
Article
Chemistry, Multidisciplinary
Xiaokai Chen, Xiaodong Zhang, Fu-Gen Wu
Summary: Green fluorescent carbon nanodots synthesized in this work exhibit high quantum yield and acidotropic effect, making them promising for lysosome imaging with minimal impact on lysosomal morphology and excellent biocompatibility in cell models.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Physical
Zheng Yang, Tiantian Xu, Shaobing Zhang, Hui Li, Yali Ji, Xiaodan Jia, Jianli Li
Summary: This study presents a fluorescent sensor based on carbon dots, which can selectively quantify Fe3+ and ascorbic acid. The quenching and recovery of fluorescence in the sensor are achieved through coordination and redox reactions, providing high selectivity, sensitivity, and interference immunity. The sensor can be used for monitoring and removal of Fe3+ and AA in environmental solutions and solid samples.
Article
Environmental Sciences
Natarajan Architha, Murugesan Ragupathi, Chellappan Shobana, Thangasamy Selvankumar, Ponnuchamy Kumar, Yun Sung Lee, Ramakrishnan Kalai Selvan
Summary: Biomass-derived carbon quantum dots synthesized from Mexican Mint leaves via microwave-assisted reflux method exhibited strong fluorescence properties and high sensitivity to Fe3+ ions, allowing for the construction of logic gates and effective application in cell imaging.
ENVIRONMENTAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Guili Ge, Lin Li, Mingjian Chen, Xu Wu, Yuxin Yang, Dan Wang, Sicheng Zuo, Zhaoyang Zeng, Wei Xiong, Can Guo
Summary: A green, economical and effective method for synthesizing fluorescent nitrogen-doped carbon dots (N-CDs) was successfully developed using fresh tea leaves and urea as carbon and nitrogen sources. The N-CDs exhibited bright blue fluorescence and showed excellent biocompatibility, high photostability, and low detection limit.
Article
Chemistry, Inorganic & Nuclear
Jianbin Zhang, Guoshuang Zheng, Yan Tian, Chenghong Zhang, Yuting Wang, Mingjie Liu, Dongze Ren, Huijun Sun, Weiting Yu
Summary: In this study, carbon dots were synthesized using natural siberian elm seeds as carbon source by hydrothermal method. The obtained carbon dots exhibited excellent fluorescence properties, pH stability, and photostability, and could be selectively quenched by Fe3+. MTT assay confirmed their good biocompatibility and effective cell labeling.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Bing Liu, Junting Tao, Jiaqi Pan, Chaorong Li, Fu Li, Yingying Zheng
Summary: Green-emitting nitrogen-doped carbon dots (CDs) were prepared by one-step solvothermal method, showing uniform particle size and excellent fluorescence performance. They exhibited low cytotoxicity and good biocompatibility in water, and showed good selectivity towards detecting Fe3+ ions.
Article
Spectroscopy
Urosa Latief, Shafi ul Islam, Zubair M. S. H. aKhan, Mohd Shahid Khan
Summary: This study reported an economical, easy, greener, and non-toxic synthesis method of water-soluble carbon quantum dots (CQDs), which exhibit strong blue fluorescence under UV lamp and show a sensitive response to Fe3+ ions. TEM measurements confirmed their spherical morphology and varying sizes in the range of 0.5-5 nm, with a detection limit of 0.2 μM.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Environmental Sciences
Prakash Krishnaiah, Raji Atchudan, Suguna Perumal, El-Sayed Salama, Yong Rok Lee, Byong-Hun Jeon
Summary: This study utilized waste biomass to synthesize nitrogen-doped carbon dots (NCDs) through hydrothermal method, demonstrating their fluorescence properties and potential for detecting metal ions in aqueous media with good sensitivity and selectivity. The synthesized NCDs showed strong cyan-blue fluorescence upon UV-light irradiation and exhibited a linear quenching rate with the concentration of Fe3+ and Mn2+ ions. The limit of detection for Fe3+ and Mn2+ ions were calculated to be 1.4 and 1.2 μM, respectively. These findings lay the groundwork for the development of NCDs as fluorescence sensors in aqueous environments.
Article
Chemistry, Inorganic & Nuclear
Shuang Ding, Ying Gao, Binshan Ni, Xiaodong Yang
Summary: This study reports the environmentally friendly synthesis of Carbon Quantum Dots (CQDs) using various typical crop biomasses as carbon sources. The resulting CQDs exhibit strong fluorescence and good dispersion in water, making them suitable as fluorescent probes for the selective and sensitive detection of Fe3+ ions.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Zishan Sun, Yuping Zhou, Weiying Zhou, Jiabao Luo, Ruiyuan Liu, Xinguo Zhang, Liya Zhou, Qi Pang
Summary: Green-emitting carbon dots (G-CDs) were synthesized using a green hydrothermal method with betaine hydrochloride and sulfadiazine as carbon and nitrogen sources. G-CDs exhibit excellent luminescence stability and can detect Pb(ii) concentrations, making them suitable for zebrafish and cell imaging applications. The results suggest that G-CDs have potential as multifunctional probes in various biological studies.
Article
Chemistry, Analytical
Min Na, Yangxia Han, Yonglei Chen, Sudai Ma, Juanjuan Liu, Xingguo Chen
Summary: A new style of fluorescent SiNPs as a pH-sensitive probe was designed and prepared in this study for real-time monitoring of pH changes in living cells, showing a positive correlation between SiNPs fluorescence intensity and pH value in solutions, with excellent biocompatibility demonstrated.
ANALYTICAL CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Yongchao Du, Yaxi Li, Yunliang Liu, Naiyun Liu, Yuanyuan Cheng, Qiuzhong Shi, Xiang Liu, Zhimin Tao, Yumeng Guo, Jianguo Zhang, Najmeh Askaria, Haitao Li
Summary: The research developed a carbon dot sensor using corn stalk powder as a carbon precursor, which can be used for the detection of Fe3+ ions and biological cell imaging. The sensor showed high selectivity and sensitivity towards Fe3+ ions, while also exhibiting low cytotoxicity and good biocompatibility.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Ru Fan, Jianxing Xiang, Peipei Zhou, He Mei, Yanyan Li, Huili Wang, Xiaodong Liu, Xuedong Wang
Summary: Myrica rubra-based N-doped carbon dots (MN-CDs) were fabricated by a green hydrothermal method. They exhibited differences in fluorescence intensities and had excellent anti-photobleaching and anti-salt capacity. The MN-CDs-based switch probe showed high sensitivity and visual detection capability for Fe3+ and AA.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Maryam Besharati, Mahmoud Amouzadeh Tabrizi, Fatemeh Molaabasi, Reza Saber, Mojtaba Shamsipur, Javad Hamedi, Saman Hosseinkhani
Summary: Two biosensing methods utilizing NAD(P)H-dependent TetX2 enzyme activity and thionine were developed to detect tetracycline in milk. The methods showed great potential for being portable instruments for on-site TC measurements.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zahra Gharehdaghi, Rahmatollah Rahimi, Seyed Morteza Naghib, Fatemeh Molaabasi
Summary: In this study, two types of Cu-MOF-based nanocomposites, GO/Cu-TCPP and Fe3O4@Cu-3(BTC)(2), were investigated for loading and pH-sensitive release of doxorubicin (DOX). It was found that GO/Cu-TCPP had a higher adsorption capacity for DOX compared to Fe3O4@Cu-3(BTC)(2). The release of DOX from both nanocomposites was pH-sensitive, with GO/Cu-TCPP releasing a higher percentage of DOX at pH 5 than at pH 7.4. The difference in drug release between the two nanocomposites was attributed to their differences in drug loading capacity. The results indicate that both GO/Cu-TCPP and Fe3O4@Cu-3(BTC)(2) nanocomposites have low toxicity and good biocompatibility.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Soroush Moasses Ghafary, Elnaz Rahimjazi, Hadiseh Hamzehil, Sayed Mostafa Modarres Mousavi, Maryam Nikkhah, Saman Hosseinkhani
Summary: There is a need for a novel targeted drug delivery system to overcome the drawbacks of conventional chemotherapy. In this study, nano-carriers based on MiRGD peptides and graphene quantum dots were used for targeted delivery of two different drug models. The results indicate that the prepared nano-composites are suitable for targeted drug delivery and tracking in cancer cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Review
Chemistry, Physical
Yasaman-Sadat Borghei, Saman Hosseinkhani, Mohammad Reza Ganjali
Summary: This review provides a guideline for physicist/chemist/biologist/physician in the introduction of metallic nanocluster applications in biomedicine. It introduces the physicochemical properties of metallic nanoclusters and the potential biomedical opportunities, guiding researchers in developing new scaffolds for biomedical engineering.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2022)
Article
Biochemistry & Molecular Biology
Yasaman-Sadat Borghei, Saman Hosseinkhani
Summary: DNA-functionalized gold nanoparticles hold great promise in biomedical applications. A novel approach of in-situ synthesis of gold nanoparticles on polyguanine strands is reported, leading to the formation of polyvalent DNA-functionalized gold nanoparticles. This method demonstrates general applicability and shows higher attractiveness in biomedical diagnosis and specific sequence detection.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Toxicology
Jalil Mehrzad, Taghi Zahraei Salehi, Alireza Khosravi, Saman Hosseinkhani, Yaser Tahamtani, Ensiyeh Hajizadeh-Saffar, Maedeh Moazenchi, Amir Mohammad Malvandi
Summary: This study analyzed the effects of aflatoxins on rat pancreatic islet cells, finding that these environmental toxins can impair the quality and function of the cells, potentially leading to endocrine disorders such as type-2 diabetes.
Article
Multidisciplinary Sciences
Amir Amiri-Sadeghan, Ali Dinari, Soheila Mohammadi, Tayebeh Zohrabi, Reza Khodarahmi, Saman Hosseinkhani, Jungwon Yoon
Summary: The photo-physical properties of metal nano clusters are sensitive to their surrounding medium, and this sensitivity, combined with the unique properties of self-assembled structures, opens up new opportunities for sensing applications.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yasaman-Sadat Borghei, Saman Hosseinkhani, Mohammad Reza Ganjali
Summary: This review focuses on the basic physicochemical properties of plasmonic nanoparticles and their applications in biomedical and tissue engineering. It aims to provide a comprehensive and authoritative overview to the scientific community. The review introduces the fundamental characteristics of nanomaterials and illustrates their applications in the field through selected case studies.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Soroush Moasses Ghafary, Paula M. Soriano-Teruel, Shima Lotfollahzadeh, Monica Sancho, Eva Serrano-Candelas, Fatemeh Karami, Stephen J. Barigye, Ivan Fernandez-Perez, Rafael Gozalbes, Maryam Nikkhah, Mar Orzaez, Saman Hosseinkhani
Summary: This study identified QM380 and QM381 as inhibitors of NLRP3(PYD) homo-oligomerization, which interfere with the formation of inflammasomes and reduce inflammatory responses. Spectroscopic techniques and computational docking analyses confirmed the experimental results and predicted possible mechanisms underlying the inhibition of NLRP3(PYD) homo-interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Optics
Yasaman-Sadat Borghei, Saman Hosseinkhani
Summary: This review focuses on the physico-chemical basis of semiconductor quantum dots in various medical applications, emphasizing more on the strategy and method rather than the target molecules.
JOURNAL OF LUMINESCENCE
(2022)
Article
Multidisciplinary Sciences
Shima Lotfollahzadeh, Elaheh Sadat Hosseini, Hooman Mahmoudi Aznaveh, Maryam Nikkhah, Saman Hosseinkhani
Summary: This study successfully fabricated a promising nanohybrid system to improve the therapeutic efficacy of TRAIL. By conjugating TRAIL with graphene quantum dots, the study demonstrated enhanced functional stability and effective anticancer activity.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Y-S Borghei, S. Hosseinkhani, M. R. Ganjali
Summary: Magnetic nanoparticles (MNPs) have biomedical applications that can be classified based on their unique properties in the presence or removal of an external magnetic field. Magnetite nanoparticles, with their unique physicochemical and catalytic properties, have gained increasing attention in medical fields for diagnosis, imaging, therapy, and cellular/tissue engineering.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Maryam Hosseini, Zahed Ahmadi, Amirhosein Kefayat, Fatemeh Molaabasi, Anita Ebrahimpour, Yousef Naderi Khojasteh Far, Mehdi Khoobi
Summary: In this study, a helical structure of gold nanoparticles was engineered using Spirulina platensis as a biotemplate for the treatment and diagnosis of cancer. The biohybrid showed excellent imaging performance and tumor suppression effects, as well as biodegradability and good biocompatibility.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Fatemeh Molaabasi, Amirhosein Kefayat, Abbas Ghasemzadeh, Mojdeh Amandadi, Mojtaba Shamsipur, Mozhgan Alipour, Seyyed Ebrahim Moosavifard, Maryam Besharati, Saman Hosseinkhani, Ramin Sarrami-Forooshani
Summary: A label-, antibody-, enzyme-, and amplification-free ratiometric fluorescent biosensor has been developed for the rapid and low-cost diagnosis of COVID-19. The biosensor exhibits high sensitivity and specificity, and can detect the virus using isolated RNA samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Mojtaba Shamsipur, Elaheh Babaee, Mohammad-Bagher Gholivand, Fatemeh Molaabasi, Farimah Mousavi, Ali Barati, Behnam Hajipour Verdom, Behnaz Shojaedin-Givi, Hossein Naderi-Manesh
Summary: In this study, a new fluorescence probe based on insulin-capped gold nanoclusters (Ins/Au-NCs) was developed for selective detection of Cu2+ ions and glutathione (GSH). The probe showed high sensitivity and stability. Cu2+ ions caused fluorescence quenching of Ins/Au-NCs, which could be recovered in the presence of GSH. The probe had low detection limits and broad linear ranges for Cu2+ ions and GSH. It also showed promising application in detecting low levels of Cu2+ ions and GSH in water and human serum samples.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).