Article
Chemistry, Multidisciplinary
Diogo A. Galico, Rayan Ramdani, Muralee Murugesu
Summary: This study demonstrates molecular upconversion of Ho-III ions using a specially designed molecular cluster-aggregate (MCA), showing distinct Ho-III green and red UC emissions along with conventional near-infrared emission.
Article
Chemistry, Multidisciplinary
Richard C. Knighton, Lohona K. Soro, Alexandre Lecointre, Guillaume Pilet, Alexandra Fateeva, Laurie Pontille, Laura Frances-Soriano, Niko Hildebrandt, Loic J. Charbonniere
Summary: Nonanuclear lanthanide complexes represent a new class of solution-state upconversion (UC) molecules, showing a very efficient UC phenomenon with Tb luminescence in the visible region upon 980 nm NIR excitation of Yb. These new molecular complexes exhibit an unprecedented UC efficiency of 1.0 x 10(-7) at only 2.86 W cm(-2), up to 26 times more efficient than current molecular systems, and UC can be observed down to a concentration of 10 nM.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Abdur Raheem Aleem, Rihui Chen, Tonghua Wan, Wei Song, Chuyan Wu, Xue Qiu, Qiuqiang Zhan, Kuncheng Xu, Xin Gao, Tianci Dong, Xiang Chen, Lin Yu, Hongli Wen
Summary: This study proposes highly water-soluble and biocompatible nanoprobes for ratiometric detection of multiple antibiotics. The nanoprobes exhibit excellent sensitivity and selectivity, achieving satisfactory results in detecting real samples.
Article
Engineering, Environmental
Yi Zhang, Da Luo, Yin Zhang, Qi-Hai Zhang, Qing-Yuan Ji, Shi-Kang Zhou, Shan Huang, Li-li Li, Feng Lu, Wei-Feng Yao, Fang -Fang Cheng, Jun-Jie Zhu, Li Zhang
Summary: A highly sensitive and efficient LRET-based nanosensor integrating confined emission effect and cycling amplification strategy has been developed for the detection of miR-21. This method involves the electrostatic absorption of 8-17 DNAzyme-BHQ1 and CPT-aDNA3 onto UCNPs, forming an energy donor-acceptor pair (UCNPs-BHQ1) to capture miR-21. The proposed approach enables sensitive detection of miR-21 in vitro, real-time intracellular detection in HeLa cells, and in vivo monitoring of miR-21 expression in tumor-bearing mice.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Optics
Yongjun Meng, Dingxin Huang, Hong Li, Xia Feng, Feng Li, Qianyi Liang, Tianzi Ma, Jiahao Han, Jianwei Tang, Guanying Chen, Xue-Wen Chen
Summary: Stable nanocrystals can be utilized in various fields through plasmonic coupling to achieve high brightness upconversion luminescence, and the saturation of plasmonic enhancement in this phenomenon is demonstrated. Researchers have improved the upconversion luminescence of nanocrystals by optimizing their material properties and surface structures through plasmonic coupling. These findings are of great significance for developing ultrabright upconversion nanomaterials for multiple applications.
Article
Chemistry, Multidisciplinary
Mingkai Wang, Hanlin Wei, Shuai Wang, Chuanyu Hu, Qianqian Su
Summary: This study focused on developing lanthanide-doped nanocrystals with efficient ultraviolet emission for applications in drug release, photocatalysis, photodynamic therapy, and solid-state lasing. By using a dye-sensitized, heterogeneous core-multishelled lanthanide nanoparticle, the researchers were able to significantly enhance ultraviolet upconversion. Their findings demonstrated a promoted multiphoton upconversion and provided insights into the energy transfer pathway for future developments in ultraviolet-emissive nanohybrids.
Article
Optics
Aleksandra Pilch-Wr, Karolina Ledwa, Agata Kotulska, Artur Bednarkiewicz
Summary: In this study, Yb^3+ and Tm^3+ doped NaYF4 nanoparticles codoped with optically active Ce^3+ ions were synthesized and investigated. The relative emission intensity ratios of the nanoparticles were found to be significantly dependent on external stimuli such as temperature and excitation pulse length. The results showed potential applications for tuning emission and thermal properties in practical uses.
JOURNAL OF LUMINESCENCE
(2022)
Article
Nanoscience & Nanotechnology
Huin-Ning Huang, Shan-Yu Wang, Wei-Hung Chiang
Summary: The study presents a new method for the selective and label-free SERS detection of dopamine using microplasma synthesis of Ag/graphene oxide nanoribbon nanocomposites. The synthesized Ag/GONR nanocomposites exhibit superior SERS performance for sensitive detection of dopamine with low limit of detection and broad linear detection range. The exceptional performance is attributed to the synergistic effect of Ag-induced electromagnetism and GONR-assisted chemical enhancement mechanism.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Feiyi Sun, Hanchen Shen, Qinghu Yang, Zhaoyue Yuan, Yuyang Chen, Weihua Guo, Yu Wang, Liang Yang, Zhantao Bai, Qingqing Liu, Ming Jiang, Jacky W. Y. Lam, Jianwei Sun, Ruquan Ye, Ryan T. K. Kwok, Ben Zhong Tang
Summary: Researchers have developed PT-UCNP-B/G nanoparticles that can modulate neuronal activities through both light and heat stimulation, addressing the issues of invasive brain implants and thermal effects in optogenetics.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Qiujun Lu, Lingling Xie, Shuhang Yin, Feng Chen, Cuiyan Wu, Meiling Liu, Haitao Li, Youyu Zhang
Summary: A novel luminescent nanosensor for ultrasensitive detection of miRNA-10b has been developed, which shows great promise for early diagnosis of hepatocellular carcinoma (HCC) due to its high sensitivity and selectivity.
Article
Chemistry, Multidisciplinary
Mikkel Baldtzer Liisberg, Satu Lahtinen, Ane Beth Sloth, Tero Soukka, Tom Vosch
Summary: The frequency encoded upconversion (FE-UPCON) widefield microscopy allows for multiplexed signal recovery in imaging by separating luminescence from spectrally and spatially overlapping trivalent lanthanide ions in upconversion nanoparticles. This technique utilizes periodic coexcitation with a secondary light source modulated at a chosen frequency to enhance the luminescence of the lanthanide ions of interest, enabling selective imaging and single UCNP detection without compromising sensitivity. FE-UPCON introduces a new dimension (frequency space) for multiplexed imaging with UCNPs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Mengyuan Hou, Lele Ma, Huaixia Yang, Fuchun Si, Yanju Liu
Summary: In this study, surface-modified upconversion nanomaterials (UCNPs) were used for the first time to achieve sensitive detection of CYFRA21-1. The combination of UCNPs and ATRP amplifies the detection signal and improves sensitivity. The proposed upconversion fluorescent platform shows excellent selectivity and can be used for screening potential lung cancer patients.
Article
Chemistry, Analytical
Yao-Yao Fan, Jun Li, Li Fan, Jie Wen, Jing Zhang, Zhi-Qi Zhang
Summary: A label-free dual-emission aptasensor based on FRET was developed for the detection of AFB1. By utilizing two fluorescent probes and a chimeric aptamer in this system, AFB1 can be quantitatively detected with high sensitivity and a low detection limit. This convenient and reliable method could be widely used for the rapid detection of other mycotoxins in complex food samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Weitao Ying, Xuemei Fan, Jianmin Gu, Shiqing Xu, Shimin Liu
Summary: In this study, a combinational upconversion (UC) all-optical logic system based on glass-ceramic material is developed. It enables the control of logic gates and logic operations through optical signals. By utilizing dual-wavelength excitation and upconversion emission, the system achieves high luminescence intensity and color adjustment, providing insights for the development of future optical computing technologies.
CELL REPORTS PHYSICAL SCIENCE
(2022)
Article
Optics
Jinchang Yin, Hongting Zheng, Wuji Zhang, Lu Shen, Ruiran Lai, Li Tian, Fuli Zhao, Yuanzhi Shao
Summary: This study developed a multifunctional molecular optical nanoprobe capable of emitting NIR-IIb luminescence and visible light for tumor imaging and photodynamic therapy. By adjusting the doping ratios of rare-earth ions, optimal emission and upconversion efficiency were achieved. The nanoprobe showed synergistic therapeutic effects, excellent tumor imaging capabilities, and potential as a new type of therapeutic agent for tumors.
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).