期刊
SYNTHETIC COMMUNICATIONS
卷 48, 期 10, 页码 1206-1212出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2018.1439176
关键词
1,2,3-Triazoles; CTAB; CuAAC; phase transfer catalyst; water
A practical, straightforward, and highly efficient CuI mediated green protocol for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazole was developed using cetyltrimethylammonium bromide as a cheap additive in good to excellent yields. Low catalyst loadings, environmentally friendly solvent, wide substrate scope and short reaction times at room temperature make this strategy more accessible and safe. [GRAPHICS] .
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