期刊
SYNTHESIS-STUTTGART
卷 50, 期 8, 页码 1699-1710出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1591884
关键词
aryloxypyridine; diaryliodonium salt; O-arylation; 2-pyridone; substituent effects
An efficient transition-metal-free strategy to synthesize 2-aryloxypyridine derivatives has been developed by a selective O-arylation of 2-pyridones with diaryliodonium salts. The reaction was compatible with a series of functional groups for 2-pyridones and diaryliodonium salts such as halides, nitro, cyano, and ester groups. The substituents at the C6-position of 2-pyridones favored O-arylation products because of steric hindrance. The reaction was easily performed on a gram-scale and 6-chloro-2-pyridone was a good precursor to access various unsubstituted 2-aryloxypyridines by dehalogenation. A P2Y(1) lead compound analogue could be prepared in good yield over two steps.
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