Combining ligand-based and structure-based drug design approaches to study the structure-activity relationships of a β-carboline derivative series

Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma

(2013) Huailei Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer

(2013) Hao Zhang et al.   PHYTOMEDICINE

The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype

(2013) Lei Zhao et al.   PeerJ

Harmine induces apoptosis in HepG2 cells via mitochondrial signaling pathway

(2012) Ming-Rong Cao et al.   Hepatobiliary & Pancreatic Diseases International

Studies on Anti-metastatic and Anti-invasive Effects of Harmine Using Highly Metastatic Murine B16F-10 Melanoma Cells

(2012) T. P. Hamsa et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Novel Trisubstituted Harmine Derivatives with Original in Vitro Anticancer Activity

(2012) Raphaël Frédérick et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Series of Beta-Carboline Derivatives Inhibit the Kinase Activity of PLKs

(2012) Xiaomin Han et al.   PLoS One

A Natural Small Molecule Harmine Inhibits Angiogenesis and Suppresses Tumour Growth through Activation of p53 in Endothelial Cells

(2012) Fujun Dai et al.   PLoS One

Quantitative structure–activity relationship of antitumor and neurotoxic β-carbolines alkaloids: nine harmine derivatives

(2012) F. Lamchouri et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Inhibitory Effects of Herbal Alkaloids on the Tumor Necrosis Factor-α and Nitric Oxide Production in Lipopolysaccharide-Stimulated RAW264 Macrophages

(2011) Yoshimitsu Yamazaki et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents

(2011) Zhiyong Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma

(2011) Thayele Hamsa et al.   Chinese Medicine

Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)

(2010) Tatyana Adayev et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents

(2010) Rihui Cao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of model predictive ability by external validation techniques

(2010) Viviana Consonni et al.   JOURNAL OF CHEMOMETRICS

Best Practices for QSAR Model Development, Validation, and Exploitation

(2010) Alexander Tropsha   Molecular Informatics

Synthesis and antiviral activity of β-carboline derivatives bearing a substituted carbohydrazide at C-3 against poliovirus and herpes simplex virus (HSV-1)

(2009) Anelise S. Nazari Formagio et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

(2009) Nora Göckler et al.   FEBS Journal

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Quinoline alkaloids as intercalative topoisomerase inhibitors

(2009) Kendall G. Byler et al.   JOURNAL OF MOLECULAR MODELING