Article
Clinical Neurology
Peter Kang, Chunwei Ying, Yasheng Chen, Andria L. Ford, Hongyu An, Jin-Moo Lee
Summary: Chronic hypoxia-ischemia in the watershed region may play a significant role in the pathogenesis of cerebral small vessel disease. Watershed OEF holds promise as an imaging biomarker to identify individuals at risk for cerebral small vessel disease progression.
Article
Clinical Neurology
Robin B. Brown, Daniel J. Tozer, Marco Egle, Anil M. Tuladhar, Frank-Erik de Leeuw, Hugh S. Markus
Summary: This study investigated the regression of white matter hyperintensity lesions (WMHs) in patients with cerebral small vessel disease (SVD). It found that only a small proportion of patients showed regression, and this regression was associated with smaller initial lesion volume and better white matter microstructural integrity.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Anna Dewenter, Mina A. Jacob, Mengfei Cai, Benno Gesierich, Paul Hager, Anna Kopczak, Davina Biel, Michael Ewers, Anil M. Tuladhar, Frank-Erik De Leeuw, Martin Dichgans, Nicolai Franzmeier, Marco Duering
Summary: Fixel-based analysis of diffusion MRI can identify changes in white matter integrity. Neurodegeneration in Alzheimer's disease affects white matter macrostructure, while cerebral small vessel disease affects white matter microstructure. Fiber density reflects the impact of cerebral small vessel disease, while fiber-bundle cross-section is primarily determined by neurodegeneration.
Article
Neurosciences
Shuyue Wang, Fan Zhang, Peiyu Huang, Hui Hong, Yeerfan Jiaerken, Xinfeng Yu, Ruiting Zhang, Qingze Zeng, Yao Zhang, Ron Kikinis, Yogesh Rathi, Nikos Makris, Min Lou, Ofer Pasternak, Minming Zhang, Lauren J. O'Donnell
Summary: The study found that abnormalities in the superficial white matter contribute significantly to processing speed in CSVD patients, with free water in the superficial white matter being a sensitive imaging marker associated with cognitive function. Furthermore, free water in the superficial white matter fully mediated the association between white matter hyperintensities volume and processing speed.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Ileana Camerino, Joanna Sierpowska, Andrew Reid, Nathalie H. Meyer, Anil M. Tuladhar, Roy P. C. Kessels, Frank-Erik de Leeuw, Vitoria Piai
Summary: White matter lesions in a core frontostriatal network are associated with executive-verbal abilities in patients with cerebral small vessel disease (SVD), independent of lesion volume and processing speed. More detailed language testing is needed to elucidate language production difficulties in SVD patients.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Jing-Yi Liu, Ming Yao, Yi Dai, Fei Han, Fei-Fei Zhai, Ding-Ding Zhang, Li-Xin Zhou, Jun Ni, Shu-Yang Zhang, Li-Ying Cui, Yi-Cheng Zhu
Summary: A study in a Chinese community-based cohort found a high frequency of rare NOTCH3 variants, with carriers of EGFr-involved variants potentially predisposed to age-related cerebral small vessel disease. These carriers of rare variants also showed higher volume of white matter hyperintensities and heavier burden of cerebral small vessel disease.
Article
Clinical Neurology
Catriona R. Stewart, Michael S. Stringer, Yulu Shi, Michael J. Thrippleton, Joanna M. Wardlaw
Summary: Cerebral small vessel disease (SVD) is a significant factor in stroke and dementia, with white matter hyperintensities (WMH) contributing to these conditions. Studies have shown that patients with lower cerebral blood flow (CBF) tend to have a heavier burden of WMH, but longitudinal associations remain inconclusive. Further research is needed to determine the role of CBF in the progression of SVD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Tingting Wang, Aoming Jin, Ying Fu, Zaiqiang Zhang, Shaowu Li, David Wang, Yilong Wang
Summary: In cognitively impaired patients with CSVD, the heterogeneity of WMH may be related to conventional imaging features and injury of penetrating arteries, serving as a hallmark for early identification and prevention of cognitive impairment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Haogeng Sun, Wanjiang Li, Chao Xia, Yutao Ren, Lu Ma, Anqi Xiao, Chao You, Xiaoyu Wang, Rui Tian, Yi Liu
Summary: Using multivariate logistic regression analysis, this study found that lacunes, white matter hyperintensities (WMH), and enlarged perivascular spaces in centrum semiovale (CSO-EPVS) were independently associated with various characteristics of moyamoya disease (MMD).
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Clinical Neurology
Juan Pablo Castello, Marco Pasi, Patryk Kubiszewski, Jessica R. Abramson, Andreas Charidimou, Christina Kourkoulis, Zora DiPucchio, Kristin Schwab, Christopher D. Anderson, M. Edip Gurol, Steven M. Greenberg, Jonathan Rosand, Anand Viswanathan, Alessandro Biffi
Summary: This study found that the severity of cerebral small vessel disease (CSVD) is associated with the diagnosis of depression, both before and after intracerebral hemorrhage (ICH). ICH survivors with cerebral amyloid angiopathy-related ICH are more likely to experience depression, both before and after ICH, compared to those with hypertensive arteriopathy-related ICH. Furthermore, these survivors are more likely to report persistent depressive symptoms and display resistance to antidepressant treatment.
Article
Clinical Neurology
Yuichiro Ii, Hidehiro Ishikawa, Akihiro Shindo, Hirofumi Matsuyama, Keita Matsuura, Kana Matsuda, Kimiko Yoshimaru, Masayuki Satoh, Ryota Kogue, Maki Umino, Masayuki Maeda, Hidekazu Tomimoto
Summary: The study found that the presence of CMIs with a high CAA-SVD score could be an indicator of more severe amyloid-associated vasculopathic changes in patients with probable CAA. CMIs were more frequently detected in the parietal and occipital lobes.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kaicheng Li, Shuyue Wang, Xiao Luo, Qingze Zeng, Xiaocao Liu, Luwei Hong, Jixuan Li, Hui Hong, Xiaopei Xu, Yao Zhang, Yeerfan Jiaerken, Ruiting Zhang, Linyun Xie, Shan Xu, Xinyi Zhang, Yanxing Chen, Zhirong Liu, Minming Zhang, Peiyu Huang
Summary: This study investigated the mechanism of white matter degeneration in Alzheimer's disease (AD) by analyzing data from 152 participants. The results showed that both amyloid-beta (Aβ) and tau, as well as small vascular disease (SVD), contribute to the degeneration of white matter. The study also found that the effects of these pathologies are specific to certain regions, fiber tracts, and disease stages.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Chaofan Sui, Hongwei Wen, Shengpei Wang, Mengmeng Feng, Haotian Xin, Yian Gao, Jing Li, Lingfei Guo, Changhu Liang
Summary: CSVD patients with cerebral microbleeds (CMBs) have extensive white matter microstructural deterioration. Using DTI-derived diffusivity and anisotropy metrics, we found that CSVD patients with CMBs showed significant FA decrease and AD, RD, and MD increases in cognitive and sensorimotor-related white matter tracts.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Byeong C. Kim, Young Chul Youn, Jee Hyang Jeong, Hyun Jeong Han, Jong Hun Kim, Jae-Hong Lee, Kee Hyung Park, Kyung Won Park, Eun-Joo Kim, Mi Sun Oh, YongSoo Shim, Jong-Min Lee, Yong-Ho Choi, Gilsoon Park, Sohui Kim, Hyun Young Park, Bora Yoon, Soo Jin Yoon, Soo-Jin Cho, Key Chung Park, Duk L. Na, Sun Ah Park, Seong Hye Choi
Summary: This study compared the effects of cilostazol and aspirin on changes in cerebral white matter in patients with cerebral small vessel disease. The results showed that there was no significant difference between the two groups in terms of white matter changes over a 2-year period. However, the aspirin group had a significantly lower peak height of mean diffusivity histogram in normal-appearing white matter compared to the cilostazol group. Additionally, cilostazol significantly reduced the risk of ischemic vascular events compared to aspirin.
Review
Radiology, Nuclear Medicine & Medical Imaging
Peiyu Huang, Kang Chen, Chen Liu, Zhiming Zhen, Ruiting Zhang
Summary: Cerebral small vessel disease is a significant factor in brain disorders in older adults, posing a higher risk of stroke and dementia. Diagnosis and grading of small vessel disease heavily rely on magnetic resonance imaging due to the lack of clinical and fluid biomarkers. Recent advances in high-resolution MRI techniques enable direct visualization of cerebral small vessel structures, providing valuable insights into aging-related degeneration and enhancing disease diagnosis and treatment. This article reviews the progress in these imaging techniques and their applications in aging and disease studies, while discussing challenges and future directions.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Sanaz Sedaghat, Pamela L. Lutsey, Yuekai Ji, Jean-Philippe Empana, Farzaneh Sorond, Timothy M. Hughes, Thomas H. Mosley, Rebecca F. Gottesman, David S. Knopman, Keenan A. Walker, Vilmundur Gudnason, Lenore J. Launer, Thomas T. van Sloten
Summary: Better cardiovascular health at midlife and improvement of cardiovascular health within midlife are associated with lower dementia risk.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Blossom C. M. Stephan, Denise M. Gaughan, Steven Edland, Villi Gudnason, Lenore J. Launer, Lon R. White
Summary: In this study, neuropathological-based risk scores were used to predict clinical dementia, and different models were identified for predicting neurodegenerative and vascular neuropathology. The findings suggest that there may be shared risk factors and pathways across dementia-related lesions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Peripheral Vascular Disease
Jesus D. Melgarejo, Meike W. Vernooij, M. Arfan Ikram, Zhen-Yu Zhang, Daniel Bos
Summary: Intracranial arteriosclerosis mediates the link between blood pressure and cerebral small vessel disease. Internal elastic lamina calcification, as a marker of arterial stiffness, is the main mechanism explaining this association.
Article
Neurosciences
Tyler Saunders, Ciaran Gunn, Kaj Blennow, Hlin Kvartsberg, Henrik Zetterberg, Susan D. Shenkin, Simon R. Cox, Ian J. Deary, Colin Smith, Declan King, Tara Spires-Jones
Summary: Neurogranin (Ng), a post-synaptic protein, has been investigated as a biomarker for Alzheimer's disease (AD) and aging in cerebrospinal fluid (CSF). Our study examined Ng abundance in post-mortem human brain tissue in AD, healthy aging (HA), and mid-life (ML) cohorts. Ng levels were quantified using immunohistochemistry in brain regions associated with cognitive change. The results showed significantly reduced Ng levels in AD compared to HA and ML cases, indicating loss of neurogranin in the brain. Our findings support the use of CSF Ng as a biomarker for AD and cognitive decline in healthy aging.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Di Wang, Nicolas Honnorat, Peter T. Fox, Kerstin Ritter, Simon B. Eickhoff, Sudha Seshadri, Mohamad Habes
Summary: We compared three heatmap methods derived from deep neural networks and SVM activation patterns to analyze structural MRI scans of subjects with Alzheimer's disease. Our results showed that all three heatmap methods were able to capture brain regions more accurately than SVM activation patterns, and the Integrated Gradients method had the best overlap with the independent meta-analysis.
Article
Endocrinology & Metabolism
Jacquelyn Y. Taylor, Yunfeng Huang, Wei Zhao, Michelle L. Wright, Zeyuan Wang, Qin Hui, Stephanie Potts-Thompson, Veronica Barcelona, Laura Prescott, Yutong Yao, Cindy Crusto, Sharon L. R. Kardia, Jennifer A. Smith, Yan Sun
Summary: This study found that BMI is associated with DNAm differences among women, and these differences can be confirmed in DNA extracted from salivary and peripheral blood samples in two cohorts of Black populations.
Article
Clinical Neurology
Dana Shulman, Serafima Dubnov, Tamara Zorbaz, Nimrod Madrer, Iddo Paldor, David A. Bennett, Sudha Seshadri, Elliott J. Mufson, David S. Greenberg, Yonatan Loewenstein, Hermona Soreq
Summary: Females with Alzheimer's disease (AD) experience accelerated dementia and loss of cholinergic neurons compared to males, and the underlying mechanisms may involve changes in transfer RNA fragments (tRFs) targeting cholinergic transcripts (CholinotRFs). The study found that NAc CholinotRFs of mitochondrial genome origin had reduced levels, which correlated with elevations in their predicted cholinergic-associated mRNA targets. Single-cell RNA sequencing in AD temporal cortices also indicated altered sex-specific levels of cholinergic transcripts in diverse cell types and sex-specific CholinotRF elevations in neuroblastoma cells under cholinergic differentiation. These findings suggest the involvement of CholinotRFs in cholinergic regulation and their potential role in AD sex-specific cholinergic loss and dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Endocrinology & Metabolism
Kenneth E. Westerman, Maura E. Walker, Sheila M. Gaynor, Jennifer Wessel, Daniel DiCorpo, Jiantao Ma, Alvaro Alonso, Stella Aslibekyan, Abigail S. Baldridge, Alain G. Bertoni, Mary L. Biggs, Jennifer A. Brody, Yii-Der Ida Chen, Josee Dupuis, Mark O. Goodarzi, Xiuqing Guo, Natalie R. Hasbani, Adam Heath, Bertha Hidalgo, Marguerite R. Irvin, W. Craig Johnson, Rita R. Kalyani, Leslie Lange, Rozenn N. Lemaitre, Ching-Ti Liu, Simin Liu, Jee-Young Moon, Rami Nassir, James S. Pankow, Mary Pettinger, Laura M. Raffield, Laura J. Rasmussen-Torvik, Elizabeth Selvin, Mackenzie K. Senn, Aladdin H. Shadyab, Albert V. Smith, Nicholas L. Smith, Lyn Steffen, Sameera Talegakwar, Kent D. Taylor, Paul S. de Vries, James G. Wilson, Alexis C. Wood, Lisa R. Yanek, Jie Yao, Yinan Zheng, Eric Boerwinkle, Alanna C. Morrison, Miriam Fornage, Tracy P. Russell, Bruce M. Psaty, Daniel Levy, Nancy L. Heard-Costa, Vasan S. Ramachandran, Rasika A. Mathias, Donna K. Arnett, Robert Kaplan, Kari E. North, Adolfo Correa, April Carson, Jerome I. Rotter, Stephen S. Rich, Joann E. Manson, Alexander P. Reiner, Charles Kooperberg, Jose C. Florez, James B. Meigs, Jordi Merino, Deirdre K. Tobias, Han Chen, Alisa K. Manning
Summary: This study aimed to identify gene-diet interactions (GDIs) impacting the macronutrient-glycemia relationship in genetically and culturally diverse cohorts. It was found that higher carbohydrate intake was associated with slightly lower glycemic trait values. A common African ancestry-enriched variant reached study-wide significance and replicated in the UK Biobank, suggesting that a large sample size is necessary for identifying similar macronutrient GDIs.
Article
Multidisciplinary Sciences
Gha Young Lee, Chen Yao, Shih-Jen Hwang, Jiantao Ma, Roby Joehanes, Dong Heon Lee, R. Curtis Ellison, Lynn L. Moore, Chunyu Liu, Daniel Levy
Summary: The study suggests a possible correlation between diabetes and rheumatoid arthritis, with the protein sRAGE playing a protective role in both conditions. The AGER/RAGE axis could be a potential therapeutic target for treating rheumatoid arthritis.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Stefanie Schreiber, Jose Bernal, Philipp Arndt, Frank Schreiber, Patrick Mueller, Lorena Morton, Ruediger Christian Braun-Dullaeus, Maria Del Carmen Valdes-Hernandez, Roberto Duarte, Joanna Marguerite Wardlaw, Sven Guenther Meuth, Grazia Mietzner, Stefan Vielhaber, Ildiko Rita Dunay, Alexander Dityatev, Solveig Jandke, Hendrik Mattern
Summary: Brain vascular health is crucial in preventing and slowing down the progression of amyotrophic lateral sclerosis (ALS). Impaired brain vascular health in ALS leads to decreased levels of vascular endothelial growth factor, compromised endothelial cell formation, and blood-brain barrier integrity. This review discusses the pathogenesis of impaired brain vascular health in ALS and the potential of novel magnetic resonance imaging techniques in its detection. It also highlights the importance of blood supply patterns to the motor cortex as a marker of resistance and resilience against vascular risk and events in ALS, providing insights for ALS management and understanding of the disease.
Article
Psychology, Biological
Iain Mathieson, Felix R. Day, Nicola Barban, Felix C. Tropf, David M. Brazel, Ahmad Vaez, Natalie van Zuydam, Barbara D. Bitarello, Eugene J. Gardner, Evelina T. Akimova, Ajuna Azad, Sven Bergmann, Lawrence F. Bielak, Dorret Boomsma, Kristina Bosak, Marco Brumat, Julie E. Buring, David Cesarini, Daniel Chasman, Jorge E. Chavarro, Massimiliano Cocca, Maria Pina Concas, George Davey Smith, Gail Davies, Ian J. Deary, Tonu Esko, Jessica D. Faul, Oscar Franco, Andrea Ganna, Audrey J. Gaskins, Andrea Gelemanovic, Eco J. C. de Geus, Christian Gieger, Giorgia Girotto, Bamini Gopinath, Hans Joergen Grabe, Erica P. Gunderson, Caroline Hayward, Chunyan He, Diana van Heemst, W. David Hill, Eva R. Hoffmann, Georg Homuth, Jouke Jan Hottenga, Hongyang Huang, Elina Hyppoenen, M. Arfan Ikram, Rick Jansen, Magnus Johannesson, Zoha Kamali, Sharon L. R. Kardia, Maryam Kavousi, Annette Kifley, Tuomo Kiiskinen, Peter Kraft, Brigitte Kuehnel, Claudia Langenberg, Gerald Liew, Penelope A. Lind, Jian'an Luan, Reedik Magi, Patrik K. E. Magnusson, Anubha Mahajan, Nicholas G. Martin, Hamdi Mbarek, Mark McCarthy, George McMahon, Sarah E. Medland, Thomas Meitinger, Andres Metspalu, Evelin Mihailov, Lili Milani, Stacey A. Missmer, Paul Mitchell, Stine Mollegaard, Dennis O. Mook-Kanamori, Anna Morgan, Peter van der Most, Renee de Mutsert, Matthias Nauck, Ilja M. Nolte, Raymond Noordam, Brenda W. J. H. Penninx, Annette Peters, Patricia A. Peyser, Ozren Polasek, Chris Power, Ajka Pribisalic, Paul Redmond, Janet W. Rich-Edwards, Paul M. Ridker, Cornelius A. Rietveld, Susan M. Ring, Lynda M. Rose, Rico Rueedi, Vallari Shukla, Jennifer A. Smith, Stasa Stankovic, Kari Stefansson, Doris Stoeckl, Konstantin Strauch, Morris A. Swertz, Alexander Teumer, Gudmar Thorleifsson, Unnur Thorsteinsdottir, A. Roy Thurik, Nicholas J. Timpson, Constance Turman, Andre G. Uitterlinden, Melanie Waldenberger, Nicholas J. Wareham, David R. Weir, Gonneke Willemsen, Jing Hau Zhao, Wei Zhao, Yajie Zhao, Harold Snieder, Marcel den Hoed, Ken K. Ong, Melinda C. Mills, John R. B. Perry
Summary: Identifying genetic determinants of reproductive success can reveal the mechanisms underlying fertility and identify genes that are currently under natural selection. A genome-wide association study on individuals of European ancestry identified 43 genomic loci associated with the number of children ever born or childlessness. These loci are involved in various aspects of reproductive biology, such as puberty timing, age at first birth, sex hormone regulation, endometriosis, and age at menopause. Additionally, missense variants in ARHGAP27 were found to be associated with higher number of children ever born but shorter reproductive lifespan, suggesting a trade-off at this locus. Other genes, including PIK3IP1, ZFP82, and LRP4, were also implicated by coding variants, and a new role for the melanocortin 1 receptor (MC1R) in reproductive biology was suggested. Furthermore, integration with data from historical selection scans revealed an allele in the FADS1/2 gene locus that has been undergoing selection for thousands of years. These findings highlight the diverse biological mechanisms contributing to reproductive success.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Cell Biology
Fanny M. Elahi, Suvarna Alladi, Sandra E. Black, Jurgen A. H. R. Claassen, Charles DeCarli, Timothy M. Hughes, Justine Moonen, Nicholas M. Pajewski, Brittani R. Price, Claudia Satizabal, Elizabeth Shaaban, Narlon C. B. S. Silva, Heather M. Snyder, Lukas Sveikata, Jeff D. Williamson, Frank J. Wolters, Atticus H. Hainsworth
Summary: The SPRINT-MIND study found that intensive blood pressure reduction in older adults can reduce the risk of cognitive impairment. In this perspective, recommendations are made for clinical practice and future trials. Future trials should include cognitive endpoints suitable for the participant group and use adaptive designs to ensure robust answers. Reliable data from diverse populations, including the oldest-old, will maximize the global implementation of trial findings.
CELL REPORTS MEDICINE
(2023)
Article
Environmental Sciences
Arce Domingo-Relloso, Roby Joehanes, Zulema Rodriguez-Hernandez, Lies Lahousse, Karin Haack, M. Daniele Fallin, Miguel Herreros-Martinez, Jason G. Umans, Lyle G. Best, Tianxiao Huan, Chunyu Liu, Jiantao Ma, Chen Yao, Allan Jerolon, Jose D. Bermudez, Shelley A. Cole, Dorothy A. Rhoades, Daniel Levy, Ana Navas-Acien, Maria Tellez-Plaza
Summary: This study investigated the role of DNA methylation in mediating the association between smoking and lung cancer. Differential methylation sites related to smoking and lung cancer were identified through blood DNA methylation analysis. The findings were validated in another study and showed downregulated gene expression related to cancer. Therefore, the association between smoking and lung cancer can be partly explained by differences in baseline blood DNA methylation.
ENVIRONMENTAL POLLUTION
(2023)
Article
Genetics & Heredity
Andrea R. V. R. Horimoto, Lisa A. Boyken, Elizabeth E. Blue, Kelsey E. Grinde, Rafael A. Nafikov, Harkirat K. Sohi, Alejandro Q. Nato, Joshua C. Bis, Luis I. Brusco, Laura Morelli, Alfredo Ramirez, Maria Carolina Dalmasso, Seth Temple, Claudia Satizabal, Sharon R. Browning, Sudha Seshadri, Ellen M. Wijsman, Timothy A. Thornton
Summary: This study conducted a genome-wide analysis of Alzheimer's disease (AD) in a Caribbean Hispanic (CH) population and identified three loci associated with reduced risk of AD, driven by Native American ancestry. The findings highlight the importance of leveraging genetic ancestry diversity in admixed populations for genetic mapping of AD.
HUMAN GENETICS AND GENOMICS ADVANCES
(2023)
Article
Clinical Neurology
Luigi Lorenzini, Silvia Ingala, Lyduine E. Collij, Viktor Wottschel, Sven Haller, Kaj Blennow, Giovanni Frisoni, Gael Chetelat, Pierre Payoux, Pablo Lage-Martinez, Michael Ewers, Adam Waldman, Joanna Wardlaw, Craig Ritchie, Juan Domingo Gispert, Henk J. M. M. Mutsaerts, Pieter Jelle Visser, Philip Scheltens, Betty Tijms, Frederik Barkhof, Alle Meije Wink
Summary: Amyloid-beta accumulation in highly connected brain regions is associated with functional connectivity alterations in the early stages of Alzheimer's disease. Dynamic functional connectivity variations indicate increased regional flexibility and promote functional integration. This study investigates the associations between abnormal cerebrospinal fluid amyloid and static and dynamic properties of functional hubs, and their relationship with cognitive performance in non-demented participants. The results suggest that dynamic eigenvector centrality is an early biomarker of Alzheimer's disease pathology and cognitive decline.
BRAIN COMMUNICATIONS
(2023)