Article
Infectious Diseases
Mohamad Fawzi Mahomoodally, Sharmeen Jugreet, Kouadio Ibrahime Sinan, Gokhan Zengin, Gunes Ak, Ramazan Ceylan, Jozsef Jeko, Zoltan Cziaky, Paola Angelini, Giancarlo Angeles Flores, Roberto Venanzoni, Simonetta Cristina Di Simone, Luigi Menghini, Giustino Orlando, Claudio Ferrante, Ouattara Katinan Etienne, Massimo Tacchini
Summary: This study quantitatively analyzed the chemical composition of Bridelia ferruginea leaf and stem bark extracts, measured their antioxidant activity and enzyme inhibition properties, and investigated their potential as anti-tumor and antimicrobial agents. The results suggest that B. ferruginea has promising pharmacological activities and could be further developed for pharmaceutical and cosmeceutical industries.
Article
Energy & Fuels
Oscar Zannou, Hojjat Pashazadeh, Mohamed Ghellam, Ilkay Koca, Abderrahmane Ait Kaddour, Francoise Leriche
Summary: This paper examined the effectiveness of a natural deep eutectic solvent (NADES) based on choline chloride and glycerol for extracting phenolic compounds from borage. The results showed that NADES was more efficient than traditional solvents and the extracted phenolic compounds exhibited great antioxidant properties and high bioavailability.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Biochemistry & Molecular Biology
Oscar Zannou, Hojjat Pashazadeh, Mohamed Ghellam, Salam A. Ibrahim, Ilkay Koca
Summary: Choline chloride and glycerol-based NADES is an efficient and eco-friendly solvent for anthocyanin extraction, and it can also improve the bioavailability of anthocyanins.
Article
Food Science & Technology
Sajed Amjadi, Venous Armanpour, Marjan Ghorbani, Mahnaz Tabibiazar, Mitra Soofi, Leila Roufegarinejad
Summary: This study aimed to determine the phenolic composition, flavonoid, and anthocyanin content, antioxidant activity, and cytotoxicity characteristics of kombucha beverages containing Echium amoenum as a fermentation substrate. The addition of E. amoenum and the increase of fermentation time significantly increased the total phenol, anthocyanin, and flavonoid content as well as the antioxidant activity of samples.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Food Science & Technology
Hakimeh Oloumi, Moj Khaleghi, Ava Dalvand
Summary: Plant biotechnology has facilitated the development of new products with enhanced disease resistance, drought and salt stress tolerance, and nutritional value. This study aimed to isolate endophytic Actinobacteria strains from medicinal plants and evaluate their bioactive potential. Fifteen Actinobacteria strains were isolated from Persian iris and Echium amoenum plants, which showed antioxidant activity. Phylogenetic analysis revealed that two strains belonged to the Streptomyces genus. Furthermore, the supernatant of a selected endophytic strain promoted root and shoot growth and increased chlorophyll content in wheat plants under salinity stress. Overall, symbiotic strains with medicinal plants are valuable sources of bioactive compounds.
FOOD SCIENCE & NUTRITION
(2023)
Article
Plant Sciences
Alessandra Acquaviva, Simonetta Cristina Di Simone, Abdelhakim Nilofar, Abdelhakim Bouyahya, Gokhan Zengin, Lucia Recinella, Sheila Leone, Luigi Brunetti, Abdullahi Ibrahim Uba, Osman Guler, Maruf Balos, Ugur Cakilcioglu, Luigi Menghini, Claudio Ferrante, Giustino Orlando, Maria Loreta Libero, Annalisa Chiavaroli
Summary: Plants from the Nepeta genus, particularly Nepeta italica, have been found to possess various pharmacological properties, including analgesic effects. The polar extracts of N. italica are rich in phenolic compounds, especially rosmarinic acid. These extracts exhibit strong scavenging/reducing and enzyme inhibition effects, as well as significant anti-inflammatory effects in mouse colon.
Article
Environmental Sciences
Zahra Ahmadabadi, Mehdi Zarei, Jafar Yasrebi, Abdolmajid Ronaghi, Reza Ghasemi, Leila Sadegh Kasmaei, Elke Bloem, Ewald Schnug
Summary: The application of RHC, RHB, and MR was found to have a significant effect on reducing the toxic effects of SDZ on plant properties and positively impacting growth attributes. The use of biofertilizers decreased the uptake of SDZ by plants, improving their growth conditions.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Mehdi Jafari Jamnani, Bjarte Holmelid, Anni Vedeler, Hoda Houshiar Parsian, Heidi Lie Andersen, Torgils Fossen
Summary: Echium amoenum leaves, an Iranian medicinal plant, have been used as tea for treating inflammation and other conditions. The nutritional value of E. amoenum tea is mainly due to its high content of water-soluble antioxidants. Previous research focused on natural products from E. amoenum flowers.
Article
Biochemistry & Molecular Biology
Sabrina Lekmine, Samira Bendjedid, Ouided Benslama, Antonio Ignacio Martin-Garcia, Samira Boussekine, Kenza Kadi, Salah Akkal, Gema Nieto, Rokayya Sami, Amina A. M. Al-Mushhin, Morooj M. Baakdah, Abeer M. Aljaadi, Saif A. Alharthy
Summary: The phenolic constituents of the Astragalus armatus Willd. plant were extracted and identified using the ultrasound-assisted extraction method and LC-MS/MS analysis. The extract showed strong antioxidant activity and significant inhibitory effects against acetylcholinesterase (AChE). The identified phenolic substances, particularly rosmarinic and chlorogenic acids, highlight the significance of the A. armatus plant in cosmetics, food additives, and the pharmaceutical industry.
Article
Agriculture, Multidisciplinary
Vasileios Chasiotis, Fatemeh Nadi, Andronikos Filios
Summary: In this study, MLP and ANFIS were used to model the fluidized bed-drying process of Echium amoenum Fisch. & C. A. Mey. Different ANN topologies and membership functions in ANFIS were examined and compared. The results showed that the ANFIS model outperformed the ANN and thin-layer model in accurately describing the moisture ratio evolution.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Pharmacology & Pharmacy
Mohammad Firoznezhad, Rita Abi-Rached, Federica Fulgheri, Matteo Aroffu, Francisco-Javier Leyva-Jimenez, Maria de la Luz Cadiz Gurrea, Maria Cristina Meloni, Francesco Corrias, Elvira Escribano-Ferrer, Jose Esteban Peris, Maria Letizia Manca, Maria Manconi
Summary: In this study, an antioxidant phytocomplex was extracted from the flowers of E. amoenum and loaded into liposomes. The liposomes were enriched with different bioadhesive polymers individually or in combination. The physico-chemical properties of the prepared vesicles were measured, as well as their stability on storage. The biocompatibility and the ability of the formulations to protect keratinocytes and promote cell migration were evaluated in vitro.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Suphachai Charoensin, Suwatsak Dansakda
Summary: Oxidative stress triggers changes in cellular energy metabolism and adaptive responses, but the polyphenol antioxidant rosmarinic acid can modulate these effects induced by hydrogen peroxide (H2O2). It reduces reactive oxygen species (ROS) levels, glucose consumption, lactate production, and enhances ATP production and glutathione production through the pentose phosphate pathway. Furthermore, rosmarinic acid downregulates glycolytic enzymes and upregulates antioxidant enzymes, protecting dermal fibroblasts from oxidative damage.
Article
Plant Sciences
Rachel G. Newman, Youyoun Moon, Janet C. Tou, Terence McManus, Nicole L. Waterland
Summary: Lemon balm is commonly consumed as herbal tea, and this study investigated the use of both adult and microgreen lemon balm for tea preparation. Adult lemon balm tea had higher levels of phenolic compounds and antioxidant capacity, while microgreen tea had higher mineral content. The mineral content was not significantly affected by the brewing conditions. This study supports using dried microgreens for herbal tea.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Review
Chemistry, Medicinal
Mohaddeseh Sadat Alavi, Sahar Fanoudi, Mahboobeh Ghasemzadeh Rahbardar, Soghra Mehri, Hossein Hosseinzadeh
Summary: Rosemary and its constituents have protective effects against natural and chemical toxicities by inhibiting oxidative stress, reducing inflammatory mediators, and modulating apoptosis and signaling pathways.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Mohammad Hadi Zarei, Mahour Farzan, Ebrahim Soleiman Dehkordi, Zahra Lorigooini, Mohammad Taghi Moradi
Summary: Echium amoenum, a medicinal plant, is used in Iranian folk medicine for various purposes. Despite conflicting results from previous studies, this research aimed to investigate the toxic effects and mechanisms of E. amoenum on hepG2 cells.
Article
Chemistry, Organic
Ismail Celik, Meryem Erol, Ozlem Arpaci, Fatma Senol, Ilkay Orhan
Summary: This study evaluated the in vitro inhibitory activity of benzoxazole derivatives with p-tert-butyl at position 2 and acetamide bridged 4-substituted piperazine/piperidine at position 5 against important targets in reducing the adverse effects of Alzheimer's disease. The most active compound, 1 g, inhibited BChE by 54 +/- 0.75% at a concentration of 50 mu M. Molecular docking studies showed that Schrodinger docking scores were more consistent. The compounds exhibited compatible ADME profiles and bioactivity scores with Lipinski and other limiting rules.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Review
Chemistry, Medicinal
Ilkay Erdogan Orhan, Abdur Rauf, Muhammad Saleem, Anees Ahmed Khalil
Summary: This review summarizes the potential therapeutic applications of natural plant extracts and their bioactive constituents as PDE inhibitors. The most promising class of compounds with PDE-inhibiting property belongs to phenolics, including flavonoids, while other plant compounds like coumarins, saponins, lignans, terpenes, anthraquinones, and alkaloids have also shown inhibitory effects. Further clinical studies exploring the synergistic use of different therapies are recommended to achieve multi-targeted results.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Serena Fiorito, Francesco Epifano, Lorenzo Marchetti, Lucia Palumbo, Ilkay Erdogan Orhan, Majid Sharifi-Rad, Salvatore Genovese
Summary: This comprehensive review explores the pharmacological activities and modulatory properties of O-Prenylcoumarins and their potential to regulate lipid and sugar metabolism. The study highlights their presence in common fruits and vegetables, emphasizing their nutraceutical role in promoting health.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Abdur Rauf, Muslim Raza, Muhammad Humayun Khan, Hassan A. Hemeg, Yahya S. Al-Awthan, Omar Bahattab, Sami Bawazeer, Saima Naz, Faika Basoglu, Muhammad Saleem, Majid Khan, Hosseini Seyyedamirhossein, Mohammad S. Mubarak, Ilkay Erdogan Orhan
Summary: This study focused on the isolation, in vitro and in silico studies of two natural bio-active flavonoids (1 & 2) isolated from Euphorbia pulcherrima bark for the first time. The chemical structures of the isolated compounds were confirmed, and their bioactivity was evaluated. The results showed promising inhibitory potential against urease and tyrosinase enzymes, as well as anti-glycation and phosphodiesterase inhibitory activities. Docking study indicated the structural features of the compounds are in accordance with their bioactivity.
ANNALS OF MEDICINE
(2022)
Article
Chemistry, Applied
Hasya Nazli Gok, Simon Vlad Luca, Saadet Tugrul Ay, Lukasz Komsta, Ramin Ekhteiari Salmas, Ilkay Erdogan Orhan, Krystyna Skalicka-Wozniak
Summary: The ethanol extracts of five Origanum species showed significant cholinesterase inhibition and antioxidant effects, with the phytochemical composition of 60 extracts analyzed. The study also identified a correlation between certain compounds and bioactivity. Additionally, molecular docking data suggested that caffeoylarbutin had the lowest binding energy against both AChE and BChE.
Article
Biochemistry & Molecular Biology
Banu Kaskatepe, Sinem Aslan Erdem, Sukran Ozturk, Zehra Safi Oz, Eldan Subasi, Mehmet Koyuncu, Josipa Vlainic, Ivan Kosalec
Summary: This study investigated and compared the antifungal activity and essential oil composition of naturally growing and cultivated samples of marjoram. The results showed that both samples of marjoram essential oil exhibited strong antifungal activity against Candida spp. Additionally, the essential oils showed inhibition of biofilm formation and germ-tube formation, which are virulence factors of Candida albicans.
Article
Chemistry, Medicinal
Serkan Yigitkan, Abdulselam Ertas, Ramin Ekhteiari Salmas, Mehmet Firat, Ilkay Erdogan Orhan
Summary: This study investigated the HMG-CoA reductase inhibitory potential of extracts from the roots and aerial parts of Salvia multicaulis Vahl. and identified 7-acetoxyhorminone as the most effective inhibitory compound.
Article
Medicine, Research & Experimental
Shynggys Sergazy, Anastassiya Vetrova, Ilkay Erdogan Orhan, Fatma Sezer Senol Deniz, Ahmet Kahraman, Jian-Ye Zhang, Mohamad Aljofan
Summary: This study is the first to report the potential antiproliferative effects of ethanol extracts of several Geraniaceae species. Four of the tested species showed potential antitumor action against all the tumor cells used, by inducing cellular defense mechanisms called autophagy and apoptosis.
Article
Biochemistry & Molecular Biology
Milena Polumackanycz, Pawel Konieczynski, Ilkay Erdogan Orhan, Nurten Abaci, Agnieszka Viapiana
Summary: The study compared the chemical composition and biological activity of water and hydromethanolic extracts of R. rosea commercial samples. The hydromethanolic extracts were found to be rich in phenolic compounds and exhibited higher antioxidant and neurobiological activity, while the water extracts contained higher levels of determined elements.
Article
Education, Scientific Disciplines
H. Turan Akkoyun, Sevinc Aydin, Mahire Bayramoglu Akkoyun, Aydin Sukru Bengu, Suat Ekin, Sinem Aslan Erdem
Summary: This study investigates the effects of arbutin on the erythrocyte and serum fatty acid profiles in rats exposed to potassium bromate. The results suggest that arbutin affects fatty acid metabolism enzymes and alters fatty acid amounts.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
H. Turan Akkoyun, Ahmet Uyar, Mahire Bayramoglu Akkoyun, Aydin Sukru Bengu, Sule Melek, Fatma Karagozoglu, Sevinc Aydin, Suat Ekin, Sinem Aslan Erdem
Summary: This study aimed to investigate the protective effects of arbutin against brain injury induced by potassium bromate in rats. The results showed that arbutin can effectively reduce brain tissue damage caused by potassium bromate by regulating the levels of malondialdehyde, superoxide dismutase, and catalase.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Environmental Sciences
Nurten Abaci, F. Sezer Senol Deniz, Ramin Ekhteiari Salmas, Fatma Uysal Bayar, Kenan Turgut, Ilkay Erdogan Orhan
Summary: The ethanol extracts of Salvia fruticosa Mill.'s leaves from two new cultivars, Uysal-SFU and Turgut-SFT, were found to be promising inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) relevant to Alzheimer's disease. The extracts showed IC50 values of 30.62 +/- 3.27 and 32.97 +/- 2.33 μg/mL against AChE for SFU and SFT, respectively, and IC50 values of 69.91 +/- 1.08 and 86.55 +/- 1.26 μg/mL against BChE. The essential oils in the extracts exhibited weak inhibition against AChE and no inhibition against BChE. Additionally, the extracts showed strong DPPH radical scavenging activity and ferric-reducing antioxidant power.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Review
Chemistry, Medicinal
Abdulselam Ertas, Serkan Yigitkan, Ilkay Erdogan Orhan
Summary: Salvia species, particularly hydroalcoholic extracts and essential oils of S. officinalis and S. lavandulaefolia leaves, have shown positive effects on cognitive dysfunction in patients with mild to moderate Alzheimer's disease in clinical studies. However, further long-term clinical studies with larger sample sizes and standardized sage preparations are needed to validate these effects.
Article
Biology
Merve Tunca Koyun, Seda Sirin, Sinem Aslan Erdem, Belma Aslim
Summary: This study aimed to find a pigment of bacterial origin with protective and preventive activity against neurological injury and carcinogenesis. The pigment, called pyocyanin, extracted from Pseudomonas aeruginosa, was found to have inhibitory effects on AChE, antioxidant activities, and affected cell proliferation and cytotoxicity. The results suggest that pyocyanin could be used as a natural food additive or an active drug ingredient. More advanced molecular studies are needed to confirm its effectiveness.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2022)
Meeting Abstract
Physiology
Ahmet Onur Dastan, Okan Arihan, Asli San Dagli Gul, Gulderen Yilmaz, Aysen Erdem
Article
Plant Sciences
Anaswara Rani, Sneha Asha, Minsa Mini, Pooja P. Rajan, Merin Tomy, Ashita Jose, Xavier Ts, Praveen Kumar
Summary: This study focuses on the eco-friendly synthesis of copper oxide nanoparticles using Centra-therum punctatum leaf extract. The synthesized nanoparticles showed potent antimicrobial activity and effectively inhibited biofilm formation by Pseudomonas aeruginosa. These findings demonstrate the potential of copper oxide nanoparticles for environmentally friendly synthesis and applications.
SOUTH AFRICAN JOURNAL OF BOTANY
(2024)
Article
Plant Sciences
Bruno Fagundes dos Santos, Talita Oliveira de Arauja, Camilla Oliveira Rios, Advanio Inacio Siqueira-Silva, Eduardo Gusmao Pereira
Summary: This study investigated the interaction between iron excess and phosphorus deficiency in Paspalum densum. The results showed that iron excess decreased phosphorus concentration in roots, while phosphorus deficiency increased iron concentration in leaves. Stomatal limitation was the main cause of decreased photosynthesis due to iron excess. Phosphorus deficiency contributed to higher phosphorus use efficiency and biomass.
SOUTH AFRICAN JOURNAL OF BOTANY
(2024)
