A Multifunctional Biomimetic Nanoplatform for Relieving Hypoxia to Enhance Chemotherapy and Inhibit the PD-1/PD-L1 Axis

In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

(2018) Chao Wang et al.   Science Translational Medicine

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

(2017) Jianqin Lu et al.   Nature Communications

Carbon-Dot-Decorated Carbon Nitride Nanoparticles for Enhanced Photodynamic Therapy against Hypoxic Tumor via Water Splitting

(2016) Di-Wei Zheng et al.   ACS Nano

Cancer Cell Membrane-Coated Gold Nanocages with Hyperthermia-Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer

(2016) Huiping Sun et al.   ADVANCED FUNCTIONAL MATERIALS

An O2Self-Sufficient Biomimetic Nanoplatform for Highly Specific and Efficient Photodynamic Therapy

(2016) Hong Cheng et al.   ADVANCED FUNCTIONAL MATERIALS

Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy

(2016) Guosheng Song et al.   ADVANCED MATERIALS

Intelligent Albumin-MnO2Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

(2016) Qian Chen et al.   ADVANCED MATERIALS

Cancer Cell Membrane-Coated Upconversion Nanoprobes for Highly Specific Tumor Imaging

(2016) Lang Rao et al.   ADVANCED MATERIALS

Effects of adenosine metabolism in astrocytes on central nervous system oxygen toxicity

(2016) Chen Yu-liang et al.   BRAIN RESEARCH

Chemotherapy and immunotherapy: mapping the road ahead

(2016) Alistair M Cook et al.   CURRENT OPINION IN IMMUNOLOGY

High co-expression of PD-L1 and HIF-1α correlates with tumour necrosis in pulmonary pleomorphic carcinoma

(2016) Yih-Leong Chang et al.   EUROPEAN JOURNAL OF CANCER

PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma

(2016) Melanie Ruf et al.   INTERNATIONAL JOURNAL OF CANCER

One-pot Synthesis of Metal–Organic Frameworks with Encapsulated Target Molecules and Their Applications for Controlled Drug Delivery

(2016) Haoquan Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of HIF in immunity and inflammation

(2016) Eoin P. Cummins et al.   MOLECULAR ASPECTS OF MEDICINE

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

(2016) S Chouaib et al.   ONCOGENE

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

The hypoxia-inducible factor (HIF) couples immunity with metabolism

(2016) Doug N. Halligan et al.   SEMINARS IN IMMUNOLOGY

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

(2016) Shohei Koyama et al.   Nature Communications

Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

(2016) Chunbai He et al.   Nature Communications

Core-Shell Upconversion Nanoparticle@Metal-Organic Framework Nanoprobes for Luminescent/Magnetic Dual-Mode Targeted Imaging

(2015) Yantao Li et al.   ADVANCED MATERIALS

Releasing the Brakes on Cancer Immunotherapy

(2015) Dan R. Littman   CELL

Cell membrane-camouflaged nanoparticles for drug delivery

(2015) Brian T. Luk et al.   JOURNAL OF CONTROLLED RELEASE

A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy

(2015) Samuel G. Awuah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules

(2015) Kang Liang et al.   Nature Communications

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

(2014) Ronnie H. Fang et al.   NANO LETTERS

PD-L1 Expression Correlates with Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy in Breast Cancer

(2014) H. Wimberly et al.   Cancer Immunology Research

Ablation of Hypoxic Tumors with Dose-Equivalent Photothermal, but Not Photodynamic, Therapy Using a Nanostructured Porphyrin Assembly

(2013) Cheng S. Jin et al.   ACS Nano

Inhibition of p-STAT3 Enhances IFN-  Efficacy against Metastatic Melanoma in a Murine Model

(2010) L. Y. Kong et al.   CLINICAL CANCER RESEARCH