Review
Biochemistry & Molecular Biology
Agata Gabryelska, Szymon Turkiewicz, Filip Franciszek Karuga, Marcin Sochal, Dominik Strzelecki, Piotr Bialasiewicz
Summary: Obstructive sleep apnea (OSA) is a chronic condition characterized by recurrent pauses in breathing, leading to intermittent hypoxia and arousals during the night. It is associated with comorbidities in various systems, including cardiovascular, metabolic, psychiatric, and neurological complications. The disruption of the circadian clock may play a significant role in the development and progression of OSA-related complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Abass Mahamoud Ahmed, Salman Mohamud Nur, Yuan Xiaochen
Summary: Obstructive sleep apnea syndrome (OSAS) is a chronic disorder characterized by recurrent episodes of upper airway obstruction during sleep, leading to hypoxia and sleep disruption. It is commonly associated with an increased prevalence of hypertension, and the underlying mechanism is related to intermittent hypoxia. This study evaluates the association between resistant hypertension and OSAS.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Piotr Fiedorczuk, Agnieszka Polecka, Marzena Walasek, Ewa Olszewska
Summary: Obstructive sleep apnea (OSA) is a prevalent and underdiagnosed disease that has a significant impact on patients' health and wellbeing, as well as imposing a financial burden. Testing for OSA using biomarkers such as CRP, IL-6, TNF-alpha, and others can provide an easier diagnostic process and allow for earlier treatment initiation, potentially preventing serious comorbidities. However, the quality of available studies on OSA-associated biomarkers is often low and associated with a high risk of bias.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
M. Leentjens, Abdulmohsen Alterki, Mohamed Abu-Farha, P. F. N. Bosschieter, CAL. de Raaff, CEE. de Vries, Eman Al Shawaf, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Sina Kavalakatt, B. A. van Wagensveld, N. de Vries, Jehad Abubaker
Summary: This study found significantly increased levels of ANGPTL7 in both the circulation and adipose tissue of patients with OSA, which were associated with increased inflammation and OSA severity. Bariatric surgery was shown to significantly reduce ANGPTL7 levels and improve OSA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Viseslav Popadic, Milica Brajkovic, Slobodan Klasnja, Natasa Milic, Nina Rajovic, Danica Popovic Lisulov, Anica Divac, Tatjana Ivankovic, Andrea Manojlovic, Novica Nikolic, Lidija Memon, Marija Brankovic, Maja Popovic, Ana Sekulic, Jelica Bjekic Macut, Olivera Markovic, Sinisa Djurasevic, Maja Stojkovic, Zoran Todorovic, Marija Zdravkovic
Summary: In a retrospective cohort study involving 328 patients with newly diagnosed obstructive sleep apnea, significant associations were found between lipid abnormalities, inflammatory markers, and other clinically important data with the severity of obstructive sleep apnea. These findings may contribute to a better understanding of the underlying pathophysiological processes and potential therapeutic modalities.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Nicole Kye Wen Tan, Dominic Wei Ting Yap, Benjamin Kye Jyn Tan, Yao Hao Teo, Elisabeth Ker Hsuen Tan, Jason Yongsheng Chan, Haur Yueh Lee, Anna See, Song Tar Toh
Summary: Meta-analysis of the association between obstructive sleep apnea (OSA) and melanoma suggests a higher risk of melanoma in patients with OSA. Future studies should focus on exploring the differential risk of melanoma for varying severity of OSA.
Article
Clinical Neurology
Elisabet Martinez-Ceron, Raquel Casitas, Raul Galera, Begona Sanchez-Sanchez, Ester Zamarron, Aldara Garcia-Sanchez, Ana Jaureguizar, Carolina Cubillos-Zapata, Francisco Garcia-Rio
Summary: The prevalence of dyslipidemia in patients with obstructive sleep apnea (OSA) increases with the severity of the disease. In OSA patients, smoking, apnea-hypopnea index (AHI), and mean nocturnal saturation are factors independently associated with dyslipidemia. Additionally, sleep fragmentation and increased sympathetic activity may contribute to lipid dysregulation in OSA patients.
Review
Clinical Neurology
Benjamin Kye Jyn Tan, Yao Hao Teo, Nicole Kye Wen Tan, Dominic Wei Ting Yap, Raghav Sundar, Chi Hang Lee, Anna See, Song Tar Toh
Summary: By considering various traditional and novel OSA severity indices, this study found that nocturnal hypoxemia in patients with OSA is independently associated with increased risk and mortality of all cancers.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Psychiatry
Jiajia Dong, Xiao Yu, Yuxin Wang, Honglei Zhang, Rui Guo
Summary: This study used bibliometric analysis to investigate research patterns on the relationship between obstructive sleep apnea (OSA) and cognitive function. The findings suggest that current research primarily focuses on correctable aspects of OSA-related cognitive dysfunction. Future studies should explore the pathology of OSA-induced cognitive impairment for more precise therapeutic interventions.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Cinthya Pena-Orbea, Lu Wang, Puntarik Srisawart, Nancy Foldvary-Schaefer, Reena Mehra
Summary: This study found sex-specific disparities in inpatient sleep testing, with women having milder OSA and lower hypoxia levels. The predictive value of sleep study type for diagnosing OSA varied by sex and severity. The findings highlight the importance of considering sex-specific differences in sleep testing.
Review
Clinical Neurology
Gonzalo Labarca, Alexia Schmidt, Jorge Dreyse, Jorge Jorquera, Ferran Barbe
Summary: This study evaluated the efficacy of telemedicine-based intervention (TM) on CPAP adherence in patients with obstructive sleep apnea (OSA), and found that TM can significantly increase CPAP adherence, especially showing better results in the three to six month treatment period.
SLEEP MEDICINE REVIEWS
(2021)
Review
Cardiac & Cardiovascular Systems
Jin Chen, Shu Lin, Yiming Zeng
Summary: The research on obstructive sleep apnea (OSA) and its link to atherosclerosis has gained importance as OSA prevalence and mortality rates increase. Despite ongoing debates, further fundamental and clinical research is necessary to better understand the complex mechanism between OSA and atherosclerosis in order to suggest newer diagnostic and treatment options.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mohammad Badran, Shawn B. Bender, David Gozal
Summary: Obstructive sleep apnea (OSA) is associated with oxidative stress, inflammation, and fibrosis, leading to cardiovascular complications. Current treatments for OSA are not effective in improving cardiovascular outcomes. Inappropriate activation of mineralocorticoid receptor (MR) in cardiovascular tissues is implicated in various cardiovascular diseases. However, the causal involvement of MR signaling in OSA-related cardiovascular disease has not been studied extensively. This article suggests MR-targeted therapy as a potential approach to mitigate the adverse cardiovascular consequences of OSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Lydia Ann, Chang-Hoon Lee, Rachel Immen, Mark Eric Dyken, Kyoungbin Im
Summary: This study found that older patients are more likely to have severe positional obstructive sleep apnea (p-OSA) and suggests that clinicians should consider positional therapy as an alternative or adjunct to continuous positive airway pressure (CPAP) treatment for older patients with cognitive impairment unable to tolerate CPAP therapy.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Mahmoud I. Mahmoud, Raed K. Alotaibi, Rayyan Almusally, Hanaa Shafiek, Yasir Elamin, Ziad Alhaj, Waleed AlBaker, Alaeldin Elfaki, Hatem Qutub, Suha J. Albahrani, Fatima M. Alabdrabalnabi, Zahra A. Al Saeed, Reem Al Argan, Fatima Al Rubaish, Yousef D. Alqurashi, Noor-Ahmed Jatoi, Abdullah H. Alharmaly, Zainab Z. Almubarak, Abir H. Al Said, Nada Albahrani
Summary: This study investigated the association between glycosylated hemoglobin (HbA1c) levels and nocturnal hypoxemia and apnea-hypopnea index (AHI) in Saudi patients with obstructive sleep apnea (OSA) and diabetes mellitus (DM). The findings suggest that nocturnal hypoxemia may be an important factor affecting glycemic control in patients with OSA and DM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Sport Sciences
Andrew Haynes, Joanne McVeigh, Leanne Lester, Peter R. Eastwood, Leon Straker, Trevor A. Mori, Lawrence Beilin, Daniel J. Green
Summary: TV watching habits during childhood and adolescence have a negative impact on cardiorespiratory fitness in adulthood, but this impact can be attenuated by engaging in higher levels of physical activity in adulthood.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Clinical Neurology
Hailey Meaklim, Imogen C. Rehm, Moira F. Junge, Melissa Monfries, Gerard A. Kennedy, Romola S. Bucks, Lisa J. Meltzer, Melinda L. Jackson
Summary: This study developed a novel Sleep Psychology Workshop for graduate psychology programs and examined its potential efficacy in improving trainee psychologists' sleep knowledge and skills. The workshop was found to significantly increase trainees' sleep knowledge and self-efficacy in sleep and insomnia management. Positive feedback was received from participants, and six months after the intervention, trainees reported routinely asking clients about sleep and improvements in their own sleep.
BEHAVIORAL SLEEP MEDICINE
(2023)
Article
Anesthesiology
Mon Ohn, Sarah Salerno, Julie Nguyen, David Sommerfield, Hayley Herbert, Paul Bumbak, David Hillman, Ramzan Nazim Khan, Kathleen J. Maddison, Jennifer H. Walsh, Peter R. Eastwood, Britta S. Von Ungern-Sternberg
PEDIATRIC ANESTHESIA
(2023)
Article
Pediatrics
David Balfour, Phillip E. Melton, Joanne A. McVeigh, Rae-Chi Huang, Peter R. Eastwood, Sian Wanstall, Amy C. Reynolds, Sarah Cohen-Woods
Summary: This study aimed to investigate the association between childhood measures of sleep health and epigenetic age acceleration in late adolescence. The results showed no evidence for a relationship between parent-reported sleep trajectories and epigenetic age acceleration. However, there was a positive cross-sectional relationship between self-reported sleep problems and intrinsic epigenetic age acceleration, which was attenuated after controlling for depressive symptom score. This finding may suggest that adolescents with higher depressive symptoms have greater overtiredness and intrinsic epigenetic age acceleration. Mental health should be considered as a potential confounding variable in future research on sleep and epigenetic age acceleration, especially when using subjective sleep measures.
Article
Clinical Neurology
Michelle Olaithe, Cele Richardson, Melissa Ree, Kasey Hartung, Tricia Wylde, Romola Bucks
Summary: This study systematically reviewed meta-analyses and systematic reviews on the factors affecting sleep in young people and evaluated the quality of published literature. The results showed that factors such as electronic media use, type of day, sex, age, culture/geographical location, substance use, family environment, and evening light exposure were negatively associated with sleep in young people. The study also found that cognitive and/or behavioral interventions of at least 2 x 1-hr sessions improved sleep.
BEHAVIORAL SLEEP MEDICINE
(2023)
Article
Critical Care Medicine
Ross J. Marriott, Bhajan Singh, Nigel McArdle, Ellie Darcey, Stuart King, Daniela Bond-Smith, Ayesha Reynor, William Noffsinger, Kim Ward, Sutapa Mukherjee, David R. Hillman, Gemma Cadby
Summary: The severity of obstructive sleep apnea (OSA) is associated with cancer prevalence and incidence, although this association seems to be secondary to other risk factors for cancer development. Nocturnal hypoxemia is independently associated with prevalent cancer, but AHI is not independently associated with cancer prevalence.
Review
Endocrinology & Metabolism
Janis D. Harse, Ross J. Marriott, Kun Zhu, Kevin Murray, Romola S. Bucks
Summary: Low levels of vitamin D are associated with poorer cognition in adults, while the relationship with high levels is mixed. A systematic review and meta-analysis was conducted to investigate the dose-response associations between 25-hydroxyvitamin D (25OHD) levels and cognitive performance in community-dwelling adults. The findings suggest a nonlinear association between baseline 25OHD levels and global cognition, memory, and executive function. Poorer cognitive performance is related to low 25OHD levels, while significant improvement is observed at levels up to 60-70 nM/L. These findings highlight the importance of maintaining vitamin D levels of at least 60 nM/L for better cognitive function during aging.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Editorial Material
Clinical Neurology
David R. Hillman
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Clinical Neurology
Hailey Meaklim, Lisa J. Meltzer, Imogen C. Rehm, Moira F. Junge, Melissa Monfries, Gerard A. Kennedy, Romola S. Bucks, Marnie Graco, Melinda L. Jackson
Summary: This study evaluated the effectiveness of an online sleep education workshop in disseminating sleep and insomnia knowledge to graduate psychology students. The workshop was successful in improving students' sleep knowledge and self-efficacy to manage sleep disturbances using cognitive behavioral therapy for insomnia (CBT-I). Feedback from students was positive, and 83% of students reported using the sleep knowledge/skills learned in the workshop in their clinical practice after 12 months.
Article
Public, Environmental & Occupational Health
Alexandra P. Metse, Peter Eastwood, Melissa Ree, Adrian Lopresti, Joseph J. Scott, Jenny Bowman
Summary: This article reports on the sleep health characteristics of young Australian adults and examines the associations with measures of physical and mental health. The study found that satisfaction with sleep and daytime alertness were significantly associated with better physical and mental health.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH
(2023)
Article
Anesthesiology
Mon Ohn, David Sommerfield, Julie Nguyen, Daisy Evans, R. Nazim Khan, Neil Hauser, Hayley Herbert, Paul Bumbak, Andrew C. Wilson, Peter R. Eastwood, Kathleen J. Maddison, Jennifer H. Walsh, Britta S. von Ungern-Sternberg
Summary: This study investigated the utility of pharyngeal closing pressure (PCLOSE) for predicting obstructive sleep apnoea (OSA) and perioperative respiratory adverse events. The results showed that PCLOSE can reliably identify moderate or severe OSA, but cannot predict perioperative respiratory adverse events.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Medicine, General & Internal
Amy C. Reynolds, Pieter Coenen, Bastien Lechat, Leon Straker, Juliana Zabatiero, Kath J. Maddison, Robert J. Adams, Peter Eastwood
Summary: This study examined the associations between three clinically significant sleep disorders and workplace productivity losses among young Australian adults. The results showed that insomnia was a risk factor for workplace productivity loss in young workers.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Clinical Neurology
Hideki Shimamoto, Peter Eastwood, Martin Anderson, Koh Mizuno
Summary: As lifestyles have changed to prioritize nighttime activities, daytime sleepiness has become a common issue among Japanese university students, with an overall prevalence of 57%. Factors associated with excessive daytime sleepiness (EDS) include female sex, exercise habits, long commuting times, later wake-up times, and shorter sleep duration. Interventions, such as educational programs promoting strategies to increase sleep duration and delay wake-up time, should be considered to reduce the risk of EDS among university students.
SLEEP AND BIOLOGICAL RHYTHMS
(2023)
Article
Clinical Neurology
Michelle Olaithe, Erica W. Hagen, Jodi H. Barnet, Peter R. Eastwood, Romola S. Bucks
Summary: There is currently no way to estimate the duration of obstructive sleep apnoea (OSA) in a person. The 'age of OSA onset' algorithm was developed to address this issue and was tested in two study cohorts. The algorithm was found to estimate the duration of OSA with a mean absolute error of 6.6 to 7.8 years.
Review
Medicine, General & Internal
Jessica A. Kerr, Alanna N. Gillespie, Meredith O'Connor, Camille Deane, Rohan Borschmann, S. Ghazaleh Dashti, Elizabeth A. Spry, Jessica A. Heerde, Holger Moller, Rebecca Ivers, Joseph M. Boden, James G. Scott, Romola S. Bucks, Rebecca Glauert, Stuart A. Kinner, Craig A. Olsson, George C. Patton
Summary: This article aims to identify intervention targets for premature mortality through systematic reviews, evaluate the quality and risk of bias in the reviews, and compare and evaluate the findings of each review and their relevant primary studies to identify existing evidence gaps.