Review
Ophthalmology
Alex Jia Yang Cheong, Sean Kang Xuan Wang, Chang Yi Woon, Ki Han Yap, Kevin Joo Yang Ng, Flora Wen Xin Xu, Uri Alkan, Adele Chin Wei Ng, Anna See, Shaun Ray Han Loh, Tin Aung, Song Tar Toh
Summary: In this meta-analysis, OSA was found to be associated with a higher risk of glaucoma. After adjusting for confounding factors, patients with OSA had a 40% higher odds of developing glaucoma.
Article
Respiratory System
Thomas Gaisl, Protazy Rejmer, Maurice Roeder, Patrick Baumgartner, Noriane A. Sievi, Sandra Siegfried, Simon F. Staempfli, Robert Thurnheer, John R. Stradling, Felix C. Tanner, Malcolm Kohler
Summary: This study found that OSA may be a modest but independent risk factor for faster TAA expansion, potentially contributing to life-threatening complications in aortic disease. There was no association between OSA severity and aortic events in the participants.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Review
Physiology
Jian Sun, Jie He, Zongan Liang
Summary: This meta-analysis explored the association between ocular surface alterations and disease severity in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). The prevalence of floppy eyelid syndrome (FES) and dry eye syndrome was found to be high in OSAHS patients. They also exhibited lower Schirmer 1 value and tear break-up time, as well as higher OSDI scores, corneal staining scores, and meibomian gland loss rates compared to healthy controls. Moreover, there were negative correlations between Schirmer 1 value/tear break-up time and apnea-hypopnea index (AHI), and a positive association between OSDI and AHI.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Clinical Neurology
Hiwa Mohammadi, Ardalan Aarabi, Mohammad Rezaei, Habibolah Khazaie, Serge Brand
Summary: The study found that individuals with OSAS have significantly lower spindle density in N3 and shorter spindle duration in N2 compared to healthy controls. Furthermore, individuals with mild OSAS showed sleep spindle characteristics more similar to healthy controls, unlike those with moderate and severe OSAS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Respiratory System
Jean-Benoit Martinot, Nhat-Nam Le-Dong, Atul Malhotra, Jean-Louis Pepin
Summary: Respiratory effort is a main feature of obstructive sleep apnoea (OSA), and is associated with sympathetic overactivity. This study found that the percentage of total sleep time spent with increased respiratory effort (REMOV,%TST), measured by mandibular jaw movements, can predict the prevalence of hypertension in adults with OSA.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Clinical Neurology
Pan Liu, Weiguo Kong, Caijing Fang, Kangxu Zhu, Xiaohua Dai, Xiangming Meng
Summary: This study evaluated the efficacy and adverse effects of hypoglossal nerve stimulation in adolescents with down syndrome and obstructive sleep apnea. The results showed that hypoglossal nerve stimulation significantly reduces apnea-hypopnea index and improves the quality of life.
FRONTIERS IN NEUROLOGY
(2022)
Review
Medicine, General & Internal
Marta Stelmach-Mardas, Beata Brajer-Luftmann, Marta Kusnierczak, Halina Batura-Gabryel, Tomasz Piorunek, Marcin Mardas
Summary: A meta-analysis of multiple studies found that weight reduction significantly influences the apnea-hypopnea index, total cholesterol, triglycerides, fasting insulin, and blood pressure in obstructive sleep apnea patients, highlighting the importance of lifestyle modification in managing cardio-metabolic risk factors.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Analytical
Wen-Te Liu, Shang-Yang Lin, Cheng-Yu Tsai, Yi-Shin Liu, Wen-Hua Hsu, Arnab Majumdar, Chia-Mo Lin, Kang-Yun Lee, Dean Wu, Yi-Chun Kuan, Hsin-Chien Lee, Cheng-Jung Wu, Wun-Hao Cheng, Ying-Shuo Hsu
Summary: Obstructive sleep apnoea is a major global health concern, with discrepancies between home-based and hospital-based PSG measurements. The percentage of supine sleep time in home assessments correlates with OSA indices. High supine sleep time may lead to an overestimation of OSA indices in hospital examinations.
Article
Clinical Neurology
Chia-Feng Juang, Chih-Yu Wen, Kai-Ming Chang, Yu-Hsuan Chen, Ming-Feng Wu, Wei-Chang Huang
Summary: The study aimed to propose a self-estimation method for predicting obstructive sleep apnea-hypopnea syndrome (OSAHS) using easy-to-obtain physiological features, and the results showed that the explainable fuzzy neural network (EFNN) was the preferred method for predicting moderate-to-severe OSAHS.
Article
Medicine, General & Internal
Andras Bikov, Martina Meszaros, Laszlo Kunos, Alina Gabriela Negru, Stefan Marian Frent, Stefan Mihaicuta
Summary: Patients with OSA had higher AIP and triglyceride, and lower HDL-C levels. AIP was significantly correlated with the Epworth Sleepiness Scale score, the apnoea-hypopnoea index, and oxygen desaturation index, but not with markers of sleep quality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Suhan Wang, Hailin Xiong, Longlong Wang, Guo Pei, Miaochan Lao, Yanxia Xu, Linjiong Liu, Siqi Luo, Yunquan Zhang, Qiong Ou
Summary: This study investigated the association of residential greenness with obstructive sleep apnoea (OSA) indexes in adults in Guangdong Province, Southern China. The results showed a significant association between residential greenness levels and OSA indexes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Respiratory System
Winfried J. Randerath, Simon Herkenrath, Marcel Treml, Ludger Grote, Jan Hedner, Maria Rosaria Bonsignore, Jean Louis Pepin, Silke Ryan, Sophia Schiza, Johan Verbraecken, Walter T. McNicholas, Athanasia Pataka, Pawel Sliwinski, Ozen K. Basoglu
Summary: Recent research indicates that the Baveno classification system, which incorporates symptoms and comorbidities, offers a more effective stratification of obstructive sleep apnoea (OSA) patients and provides better guidance for treatment decisions.
Review
Clinical Neurology
Jie He, Chunmao Wang, Wancheng Li
Summary: This study conducted a meta-analysis to evaluate the prevalence of laryngopharyngeal reflux (LPR) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). The results showed that the prevalence of LPR in OSAHS patients was 49%, with a higher likelihood of LPR in European and American patients and in obese individuals and those with severe OSAHS. The study also found that LPR-positive OSAHS patients had higher apnea-hypopnea index (AHI) and body mass index (BMI), as well as positive correlations between reflux symptom index (RSI) scores and AHI.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Clinical Neurology
Le Wang, Dong-hui Wei, Jing Zhang, Jie Cao
Summary: The aim of this study was to investigate the distribution of the percentage of cumulative time with oxygen saturation below 90% in total sleep time (T90) in obstructive sleep apnea (OSA) patients with similar severity and evaluate its relationship with hypertension. The study found that OSA patients with similar severity of apnea hypopnea index (AHI) may have different T90 values, especially in severe cases. After adjusting for traditional risk factors, a higher T90 was independently associated with an increased risk of hypertension in patients with severe OSA.
NATURE AND SCIENCE OF SLEEP
(2022)
Review
Endocrinology & Metabolism
Chaoyu Wang, Zhiping Zhang, Zhenzhen Zheng, Xiaojuan Chen, Yu Zhang, Chunhe Li, Huimin Chen, Huizhao Liao, Jinru Zhu, Junyan Lin, Hongwei Liang, Qiuying Yu, Riken Chen, Jinhua Liang
Summary: This study found significant differences in the incidence of osteoporosis, lumbar spine bone mineral density, and T-score between the OSAHS group and the control group. Therefore, attention should be paid to the treatment and management of adult OSAHS and active sleep intervention to reduce the risk of osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Luyao Qiu, Wanyuan Xia, Wendao Li, Jing Ping, Songtao Ding, Handeng Liu
SCIENTIFIC REPORTS
(2019)
Article
Biotechnology & Applied Microbiology
Jun Duan, Wanyuan Xia, Kai Yang, Xuelei Li, Feng Zhang, Jie Xu, Ying Jiang, Jia Liang, Bing Li
Summary: This study evaluated the efficacy of twin-block appliance in the treatment of pediatric obstructive sleep apnea. The results showed that twin-block therapy significantly decreased AHI and significantly increased lowest SaO(2), suggesting that it may be an effective method for treating pediatric OSA.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.