Article
Multidisciplinary Sciences
Ryan J. J. Ward, Sophie M. M. Wuerger, Maliha Ashraf, Alan Marshall
Summary: This study investigates the role of physicochemical features of odors in explaining olfactory crossmodal correspondences. The findings show a 49% similarity between perceptual and physicochemical spaces, and significant predictors for various crossmodal correspondences.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Carl E. Schoonover, Sarah N. Ohashi, Richard Axel, Andrew J. P. Fink
Summary: The study found that although activity in the primary olfactory cortex could discriminate between odorants at any time, the odor-evoked responses drifted over days to weeks. Daily exposure to the same odorant slowed the rate of drift, but when exposure was halted the rate increased again. This instability may be related to the unstructured connectivity of the piriform cortex.
Article
Biochemical Research Methods
Lior Lebovich, Michael Yunerman, Viviana Scaiewicz, Yonatan Loewenstein, Dan Rokni
Summary: This study explores the interference mechanisms of background odors in odor detection tasks. The results show that background odors decrease mouse performance but paradoxically also decrease reaction times, indicating an increase in noise in the decision-making process. By fitting the drift diffusion model to behavioral data, it was found that background odors affect both the signal and noise, leading to a paradoxical relationship between trial difficulty and decision speed.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Diogo Manoel, Melanie Makhlouf, Charles J. Arayata, Abbirami Sathappan, Sahar Da'as, Doua Abdelrahman, Senthil Selvaraj, Reem Hasnah, Joel D. Mainland, Richard C. Gerkin, Luis R. Saraiva
Summary: This study generated the most comprehensive mouse olfactory ethological atlas to date, revealing the diverse behavior of mice in response to different odorants. Three fundamental properties were identified in both mouse and human odor perception: odor valence parameters, physicochemical properties of odorants, and the impact of odorant concentration on olfactory perception. These results provide insights into mouse olfactory behavior and its comparison to human odor perception.
Article
Multidisciplinary Sciences
Diogenes Diego de Carvalho Bispo, Pedro Renato de Paula Brandao, Danilo Assis Pereira, Fernando Bisinoto Maluf, Bruna Arrais Dias, Hugo Rafael Paranhos, Felipe von Glehn, Augusto Cesar Penalva de Oliveira, Alexandre Anderson de Sousa Munhoz Soares, Maxime Descoteaux, Neysa Aparecida Tinoco Regattieri
Summary: This study aimed to investigate changes in olfactory bulb volume and brain network in the white matter (WM) in patients with persistent olfactory disfunction (OD) following COVID-19. A cross-sectional study evaluated 38 participants with OD after mild COVID-19 and 24 controls. The results showed that patients with OD after COVID-19 had relevant WM network dysfunction with increased connectivity in the parietal sensory cortex.
SCIENTIFIC REPORTS
(2023)
Article
Otorhinolaryngology
Ran Lu, N. Ahmad Aziz, Martin Reuter, Tony Stocker, Monique M. B. Breteler
Summary: This study revealed that olfactory bulb volume was independently correlated with odor identification function and mediated the age-related association between volumes of central olfactory structures and olfactory function.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2021)
Article
Cell Biology
Mary R. Schreck, Liujing Zhuang, Emma Janke, Andrew H. Moberly, Janardhan P. Bhattarai, Jay A. Gottfried, Daniel W. Wesson, Minghong Ma
Summary: The central gating mechanism for olfactory processing during sleep remains uncertain. This study found increased neural activity in the olfactory pathway during sleep compared to wakefulness, suggesting a lack of central gating. Additionally, slower and shallower breathing during sleep may suggest a partial peripheral gating mechanism.
Article
Neurosciences
Behzad Iravani, Artin Arshamian, Mikael Lundqvist, Leslie M. Kay, Donald A. Wilson, Johan N. Lundstrom
Summary: Neuronal oscillations facilitate bidirectional information flow between the olfactory bulb (OB) and piriform cortex (PC) in healthy humans, aiding in odor perception. Data demonstrate that odor identity can be decoded from neural oscillations as early as 100 ms after odor onset.
Article
Multidisciplinary Sciences
Agnieszka Sabiniewicz, Leonie Hoffmann, Antje Haehner, Thomas Hummel
Summary: Improvement in olfactory performance corresponds with a decrease in depression severity, particularly in dysosmic patients.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Antonie Louise Bierling, Ilona Croy, Thomas Hummel, Gianaurelio Cuniberti, Alexander Croy
Summary: The research explores the link between physicochemical odor space and perception, revealing significant differences in individual perception of pleasantness and intensity. It also highlights the importance of understanding the interactions between odor quality and perception, as well as emphasizing the correlation between structure and perception in a non-expert group.
Article
Neurosciences
Debanjan Dasgupta, Tom P. A. Warner, Andrew Erskine, Andreas T. Schaefer
Summary: This study used in vivo extracellular and intracellular electrophysiological recordings in the mouse olfactory bulb to investigate how temporal odor features are encoded by the olfactory system. The results showed that mice are able to discriminate odor stimuli based on their temporal structure, and that mitral cells and tufted cells can encode dominant temporal frequencies up to 20 Hz. The study also found that the coupling of membrane potential with odor stimuli was invariant to odor identity, and pharmacological blocking of inhibitory circuitry modulated frequency coupling.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Seth R. Odell, David Clark, Nicholas Zito, Roshni Jain, Hui Gong, Kendall Warnock, Ricardo Carrion-Lopez, Coral Maixner, Lucia Prieto-Godino, Dennis Mathew
Summary: A study found that starving crawling insects exhibit reduced head wavings and straighter tracks when searching for food. By using Drosophila melanogaster larva as the research subject, it was revealed that the flexibility in insect navigation strategy might arise during early olfactory processing, with Keystone-LN, an inhibitory local neuron, playing a critical role in implementing head-sweep behavior. Insulin signaling is likely involved in mediating starvation-induced changes in the magnitude of head-sweeps and shaping the larva's odor-guided movement.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Anna Athanassi, Marine Breton, Laura Chalencon, Jerome Brunelin, Anne Didier, Kevin Bath, Nathalie Mandairon
Summary: Experiencing chronic stress increases the risk for depression and affects the quality of life. Odorants play a crucial role in social interactions and behavior, and a decrease in olfactory function is associated with depression symptoms. The hedonic value of odorants is encoded by granule cells in the olfactory bulb, which can be affected by chronic mild stress. This study explores the link between olfactory hedonics, neurogenesis, and stress-associated depression.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Applied
Pedram Shoa, Seyed Ahmad Mireei, Abbas Hemmat, Sara W. Erasmus, Saskia M. van Ruth
Summary: This study analyzed Iranian natural salts using the BARDS method and investigated the compositions and crystalline structures of the samples. By visualizing the salt types using nonlinear dimensionality reduction methods, the potential of BARDS in characterizing natural edible salts was demonstrated.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Neurosciences
Han Xu, Chi Geng, Xinzhong Hua, Penglai Liu, Jinshan Xu, Anan Li
Summary: By recording odor-evoked Ca2+ and electrophysiological signals simultaneously in awake, head-fixed mice, researchers found that Ca2+ signals were most closely correlated with beta-band power in the LFP. The study provided new insights into the relationship between different types of neural signals and their performance in odor classification.
NEUROSCIENCE BULLETIN
(2021)
Article
Food Science & Technology
Wenchuan Guo, Liang Shang, Xinhua Zhu, Stuart O. Nelson
FOOD AND BIOPROCESS TECHNOLOGY
(2015)
Article
Agriculture, Multidisciplinary
Wenchuan Guo, Jingsi Gu, Dayang Liu, Liang Shang
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2016)
Article
Chemistry, Analytical
Liang Shang, Chuanjun Liu, Masashi Watanabe, Bin Chen, Kenshi Hayashi
SENSORS AND ACTUATORS B-CHEMICAL
(2017)
Article
Food Science & Technology
Liang Shang, Wenchuan Guo, Stuart O. Nelson
FOOD ANALYTICAL METHODS
(2015)
Article
Chemistry, Multidisciplinary
Liang Shang, Chuanjun Liu, Bin Chen, Kenshi Hayashi
Article
Engineering, Electrical & Electronic
Bin Chen, Chuanjun Liu, Lingpu Ge, Liang Shang, Hao Guo, Kenshi Hayashi
Summary: Gold nano-urchins (AuNUs) were synthesized and deposited on indium tin oxide (ITO) glass in this study. The study compared the influence of the resistance of ITO glass and the deposition density of NUs on refractive index sensitivity (RIS) of these ITO substrates. It was found that ITO glass with a resistance of 8-12 /sq and substrates with many AuNU dimers gave the highest RIS. Additionally, the study proposed the use of AuNU substrate for heparin detection through Au etching, achieving a linear range of 0.05 to 5 μg/mL with a detection limit of 8 ng/mL.
IEEE SENSORS JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Bin Chen, Chuanjun Liu, Liang Shang, Hao Guo, Jiongming Qin, Lingpu Ge, Chun Ju Jing, Changhao Feng, Kenshi Hayashi
JOURNAL OF MATERIALS CHEMISTRY C
(2020)
Article
Chemistry, Analytical
Liang Shang, Chuanjun Liu, Yoichi Tomiura, Kenshi Hayashi
ANALYTICAL CHEMISTRY
(2017)
Meeting Abstract
Behavioral Sciences
Liang Shang, Chuanjun Liu, Yoichi Tomiura, Kenshi Hayashi
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)