Electrochemical sensor for detecting pain reliever/fever reducer drug acetaminophen based on electrospun CeBiOx nanofibers modified screen-printed electrode

A series of functional CeBiOx nanofibers (NFs) with different Ce:Bi molar ratios were successfully prepared by a facile two-step synthetic procedure including electrospinning and calcination. After systematic characterization of their morphology and structure/composition using various advanced techniques, the as-synthesized CeBiOx NFs were employed to modify screen-printed electrodes (SPEs) for the determination of fever reliever/pain reducer drug acetaminophen (AP) via both cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The results showed that the electrocatalytic activity of CeBiOx NFs was heavily dependent on Ce:Bi molar ratio and the Ce0.75Bi0.25Ox NFs resulted in the highest electro-oxidation signal for AP among all Ce:Bi molar ratios tested in this study. Moreover, the Ce0.75Bi0.25Ox NFs modified SPE showed a sensitivity of 360 mu A mM(-1)cm(-2), a low detection limit of 0.2 mu M (signal to noise ratio of 3), a wide linear range up to 130 mu M for DPV-based AP detection, and good intra- and inter-electrode reproducibility. Both the selectivity against uric acid, glucose, dopamine, ascorbic acid and the accuracy of the developed sensor for real sample analysis were also investigated using commercial paracetamol tablets and AP-spiked human serum samples. (C) 2017 Elsevier B.V. All rights reserved.