Article
Chemistry, Analytical
Haifeng Yang, Chengmei Liu, Yu Mei, Peng Zhang, Qian Zhang, Caifeng Ding
Summary: A novel near-infrared fluorescent probe P1 was developed for ratiometric monitoring of esterase activity. It showed high sensitivity and selectivity for esterase, and achieved precise quantitative analysis and imaging in living cells and in vivo.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Yaru Sun, Ruifei Wang, Jingxian Wang, Hua Wei, Qingxian Chen, Yue Wang, Baoli Dong
Summary: A ratiometric two-photon fluorescent probe, NAB, was developed for the precise detection of peroxynitrite (ONOO-) in living cells and brain tissues. NAB showed highly sensitive response and excellent selectivity to ONOO-, and could selectively locate at the endoplasmic reticulum (ER). The probe NAB demonstrated the capability of detecting exogenous and endogenous ONOO- in living cells and brain tissues.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Junshuai Tang, Pingzhu Zhang, Zimeng Li, Yuehua Zhang, Hua Chen, Xiaoliu Li, Chao Wei
Summary: A simple ratiometric two-photon fluorescent probe RTFP was designed and synthesized for effective monitoring of carbon monoxide (CO) in living systems. The probe showed excellent selectivity and sensitivity towards CO, and successfully imaged endogenous CO in living cells and zebrafish.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xianzhe Wei, Juan Li, Xiaofeng Yang, Baoli Dong, Bing Geng, Zengjun Li, Xiaoxiao Hu, Biyan Ding, Jing Zhang, Mei Yan
Summary: This paper presents the design of an enzyme-activated two-photon fluorescent probe (RN-GLU) for rapid and selective detection of beta-glucuronidase (GLU) in colon cancer. The probe exhibits good lysosome targetability and penetration ability, making it a potential method for evaluating GLU functions in colon cancer diagnosis and complex biosystems.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Xiaohua Chen, Qi Chen, Man Chen, Wenjuan Wang, Chuan Sun, Xinru Wang, Peng Ning, Liling Hou, Yan Feng, Xiangming Meng
Summary: The level of apoptosis is closely related to the occurrence of cancer and other diseases. Real-time monitoring of apoptosis in living cells has potential for early disease diagnosis, therapeutic evaluation, and drug screening. A two-photon fluorescent probe Lyso-PCE was developed for pH detection and lysosome-targeting, demonstrating applications in monitoring pH changes, apoptosis, and evaluating apoptotic drugs like bpV(phen).
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Shuoshuo Wang, Jipeng Yao, Bei Wang, Xiang Liu
Summary: Developing an effective fluorescent probe for detecting hydrogen peroxide is urgently needed. Probe Z, constructed with naphthimide as the fluorophore and phenylboronic acid pinacol esters as the recognition group, shows higher sensitivity, lower detection limit, higher selectivity, and broad pH applicability. It has low cytotoxicity and can be used to detect exogenous hydrogen peroxide in HeLa cells, making it a potential tool for studying hydrogen peroxide in physiological activities.
Article
Spectroscopy
Wenjun Bai, Yixuan Li, Li Zhao, Ruxin Li, Jiahou Geng, Yang Lu, Yufen Zhao, Jinhui Wang
Summary: In this study, a ratiometric fluorescent probe based on extended 7C-7C conjugation of a triphenylamine unit was designed for the detection of NTR and lysosomes imaging. The probe showed high selectivity, rapid response, and a wide pH range towards NTR. It also exhibited low cytotoxicity in both normal and tumor cells, as well as excellent lysosomes colocalization.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Zixuan Zhan, Li Chai, Qian Lei, Xinglong Zhou, Yuxi Wang, Hui Deng, Yi Lv, Weimin Li
Summary: Acute lung injury is a pulmonary inflammatory disease with high morbidity and mortality rates, posing challenges in diagnosis and treatment. The development of a two-photon ratiometric fluorescent probe TPRS-HOCl shows potential for early diagnosis and treatment guidance for ALI.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Xianghua Wu, Yuxun Lu, Bo Liu, Yu Chen, Junfeng Zhang, Ying Zhou
Summary: Hydrogen sulfide (H2S) serves as a crucial signaling molecule in biological systems and can be utilized as a trigger for new drug release, benefiting cancer bio-imaging and therapy. The designed fluorescent theranostic prodrug compound can specifically react with H2S, releasing active therapeutic components, showing potential for cancer treatment.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Inorganic & Nuclear
Hong Wang, Changli Zhang, Zhiyong Jiang, Li Xu, Zhipeng Liu
Summary: In this study, phenothiazine-fused boron complexes were identified as promising scaffolds for ratiometric fluorescent hypochlorite probes. The synthesized complexes demonstrated ultrafast and ratiometric absorption/fluorescence changes for hypochlorite. Additionally, an endoplasmic reticulum-targeting probe was developed and showed excellent real-time imaging ability for both endogenous and exogenous hypochlorite in living cells.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Analytical
Ya-Nan Wei, Bo Lin, Yang Shu, Jian-Hua Wang
Summary: A novel fluorescent probe ANET was designed to target mitochondria for detecting Cys, showing advantages of ratiometric fluorescence, high selectivity, and a large Stokes shift. Imaging of Cys was confirmed in HepG2 cells using this probe.
Article
Chemistry, Multidisciplinary
Wanjun Gong, Lingdong Jiang, Yanxia Zhu, Mengna Jiang, Danyang Chen, Zhaokui Jin, Shucun Qin, Zhiqiang Yu, Qianjun He
Summary: A catalytic hydrogenation strategy was proposed to design and synthesize a ratiometric fluorescent probe, enabling in vitro and in vivo fluorescence imaging of hydrogen molecules. The developed probe exhibits high sensitivity, rapid responsivity, high selectivity, and low detection limit, allowing for rapid and real-time detection of hydrogen molecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Analytical
Dongmei Wang, Jiajia He, Junyong Sun
Summary: The thiolysis of NBD-A enables specific detection of H2S and real-time imaging in living organisms. The NBD@PFO probes, constructed with ratiometric mode and two-photon excitation, show high selectivity, fast response, and are successfully applied for monitoring H2S concentration in living cells and zebrafish. This work demonstrates the potential of polymer nanoparticles to enhance the imaging capability of an organic small molecular probe.
Article
Chemistry, Analytical
Yong-Peng Yang, Fu-Jian Qi, Ya-Long Zheng, De-Chen Duan, Xia-Zhen Bao, Fang Dai, Shengxiang Zhang, Bo Zhou
Summary: This study developed a fast imaging probe for mitochondrial TrxR2 and visualized the increased activity of TrxR2 in cancer cells, as well as the decreased activity in Parkinson's disease and ischemic stroke.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Vinayak Juvekar, Hyo Won Lee, Dong Joon Lee, Hwan Myung Kim
Summary: Two-photon microscopy is an important tool for deep-tissue imaging, providing high-resolution fluorescence images beyond millimeter depths. Recent research has focused on developing innovative strategies and probes for quantitative analysis using two-photon fluorescence.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Editorial Material
Gastroenterology & Hepatology
Jin Roh, Choong-Kyun Noh
Article
Oncology
Choong-Kyun Noh, Chang Su Lim, Gil Ho Lee, Myung Ki Cho, Hyo Won Lee, Jin Roh, Young Bae Kim, Eunyoung Lee, Bumhee Park, Hwan Myung Kim, Sung Jae Shin
Summary: In this study, we used two-photon microscopy with fluorescent probes to visualize and measure enzyme activity in gastric cancer. The results showed significant differences in beta-gal and CES activity between normal tissue and cancer, indicating the potential of this novel method for gastric cancer diagnosis. The method enabled visual differentiation and quantitative depth profiling of gastric cancer, showing promising diagnostic capabilities.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Hyo Won Lee, Dong Joon Lee, Chang Su Lim
Summary: Imaging and photodynamic therapy through two-photon excitation can be applied to medical application of deep inside the tissue by minimizing light absorption by the tissue. To maximize image realization and treatment effectiveness, a photosensitizer with high fluorescence quantum yields must be developed.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Hyo Won Lee, Vinayak Juvekar, Dong Joon Lee, Sun Mi Kim, Hwan Myung Kim
Summary: Researchers have developed a highly stable red-emissive ratiometric fluorescent probe (CCGal1) for quantitatively monitoring beta-gal enzyme activity in live cells and tissues, showing fast emission color change and high enzyme reaction efficacy with minimized cytotoxicity.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Dong Joon Lee, Vinayak Juvekar, Hyo Won Lee, Eun Seo Kim, Choong-Kyun Noh, Sung Jae Shin, Hwan Myung Kim
Summary: In this study, a two-photon photosensitizer ACC-B was designed for real-time cancer therapy, which triggered highly selective cancer ablation through photodynamic therapy and enabled real-time imaging differentiation between normal and cancer tissues using fluorescence microscopy images.
ANALYTICAL CHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Gil Ho Lee, Eunyoung Lee, Bumhee Park, Jin Roh, Sun Gyo Lim, Sung Jae Shin, Kee Myung Lee, Choong-Kyun Noh
Summary: By comparing the clinical outcomes of ESD and surgery in patients with UD intramucosal EGC, it was found that the ESD group had a shorter hospital stay, but inferior RFS and local recurrence were observed.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Gil Ho Lee, Sun Gyo Lim, Bumhee Park, Sung Jae Shin, Jae Youn Cheong, Kee Myung Lee
Summary: This study evaluated the association between regular endoscopic screening and interval cancer detection in the Korean National Cancer Screening Program. The results showed that regular screening can reduce the risk of interval cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Jingjing Han, Hyo Won Lee, Yahui Chen, Haidong Li, Hwan Myung Kim, Juyoung Yoon
Summary: The study presents a new fluorogenic probe for detecting dynamic changes and aberrant polarity of lipid droplets, which could potentially be beneficial for clinical diagnosis and tracking the origin of lipid droplets and monitoring polarity-related subcellular organelles.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Editorial Material
Gastroenterology & Hepatology
Gil Ho Lee, Choong-Kyun Noh
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hyo Won Lee, In-Jeong Lee, Soo-Jin Lee, Yu Rim Kim, Hwan Myung Kim
Summary: Lipid droplets (LDs) are lipid-abundant organelles that play important roles in cellular metabolic processes and are associated with various diseases related to lipid regulation. Researchers have developed a highly selective fluorescent tracker LD1 to monitor LD dynamics in live samples.
Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Bumhee Park, Sung Soo Ahn
Summary: The presence of faecal haemoglobin, even in the absence of gastrointestinal bleeding, may indicate systemic inflammation and be linked to the development of immune-mediated inflammatory diseases (IMIDs). Positive faecal immunochemical test (FIT) is associated with an increased risk of rheumatoid arthritis (RA) in the general population.
Article
Biochemistry & Molecular Biology
Chang-Gun Lee, Soo-Jin Lee, Seokho Park, Sung-E Choi, Min-Woo Song, Hyo Won Lee, Hae Jin Kim, Yup Kang, Kwan Woo Lee, Hwan Myung Kim, Jong-Young Kwak, In-Jeong Lee, Ja Young Jeon
Summary: This study evaluated the effect of MS-275, an HDAC1/3 inhibitor, on the degradation of hepatic lipid droplets (LDs) and oxidation of free fatty acids (FFAs) in high-fat diet-induced NAFLD mice. The results showed that MS-275 improved hepatic metabolic alterations by increasing the dynamic degradation of LDs and promoting FFAs oxidation in the fatty liver. The lipolysis and autophagy pathways were activated, while de novo lipogenesis was reduced in MS-275 treated mouse liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Choong-Kyun Noh, Woohyun Jung, Min Jae Yang, Wook Hwan Kim, Jae Chul Hwang
Summary: The gut microbiome of patients with gallstones differs from that of healthy controls, but the microbiome does not change significantly three months after cholecystectomy. Our data revealed specific taxa associated with postcholecystectomy diarrhea (PCD), highlighting the potential for symptom relief through restoration of the gut microbiome.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Immunology
Eunyoung Lee, Gil Ho Lee, Bumhee Park, Sung Soo Ahn, Choong-Kyun Noh
Summary: This study investigated the association between abnormal FIT results and the onset of inflammatory bowel disease (IBD). The results indicated that a positive FIT result was associated with a higher risk of IBD. These findings suggest that abnormal FIT results could be a preceding sign of incident IBD in the general population, and regular screening for early disease detection might be beneficial for individuals with positive FIT results and suspected IBD symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Bumhee Park, Sun Gyo Lim, Sung Jae Shin, Kee Myung Lee, Gil Ho Lee
Summary: This study investigated the long-term effect of Helicobacter pylori eradication on the prevention of metachronous gastric neoplasm after endoscopic submucosal dissection (ESD) of gastric adenoma. The results showed that eradication of H. pylori did not increase the risk of metachronous gastric neoplasm after ESD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
