Article
Chemistry, Medicinal
Nashwah G. M. Attallah, Fatma Alzahraa Mokhtar, Engy Elekhnawy, Selim Z. Heneidy, Eman Ahmed, Sameh Magdeldin, Walaa A. Negm, Aya H. El-Kadem
Summary: This study assessed the hepatoprotective effects of Salvinia auriculata methanol extract (SAME) against methotrexate (MTX)-induced hepatotoxicity and identified the possible mechanisms involved. The results showed that SAME effectively improved MTX-induced liver damage, suppressed inflammation, and decreased cellular apoptosis. Furthermore, SAME exhibited antibacterial activity.
Article
Food Science & Technology
Jing Wan, Peng He, Yuanshan Chen, Qiujin Zhu
Summary: A practical, efficient, and rapid method for quantifying 19 pyrethroids in tea and orange samples was developed. Out of 262 tea samples, 11 pyrethroids were detected positive with concentrations below maximum residue limits. No pyrethroid was found in 209 peeled orange samples.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Luisa Ronga, Iogann Tolbatov, Ester Giorgi, Paulina Pisarek, Christine Enjalbal, Alessandro Marrone, Diego Tesauro, Ryszard Lobinski, Tiziano Marzo, Damiano Cirri, Alessandro Pratesi
Summary: A panel of four gold(I) complexes, inspired by auranofin, were reported by the research group. These complexes showed similarities to auranofin but exhibited distinct features, such as lower log P values. Experimental and theoretical studies revealed that structural modifications on the phosphine ligand of auranofin can impact the chemical properties and biological mode of action of the derivatives.
INORGANIC CHEMISTRY
(2023)
Article
Biology
Muqeet Wahid, Fatima Saqib, Saeed Akhtar, Anam Ali, Trina Ekawati Tallei, Jesus Simal Gandara
Summary: This study aimed to investigate the regulatory role of C. melo seeds in calcium-mediated smooth muscle contraction. The quantification of phytochemicals in C. melo seeds revealed the presence of rutin, kaempferol, and quercetin. In vitro and in vivo experiments confirmed the relaxant effect of C. melo seeds on smooth muscle and its potential antidiarrheal properties. Molecular docking analysis identified key genes associated with calcium-mediated signaling that showed high binding affinity with the phytochemicals present in C. melo seeds.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biochemical Research Methods
William Craig Byrdwell, Hari K. Kotapati, Robert Goldschmidt, Pavel Jakubec, Lucie Novakova
Summary: The study demonstrates the use of split-flow two-dimensional liquid chromatography (SF-2D-LC) and quadruple parallel mass spectrometry (LC3MS4) for analyzing NIST SRM 1849a adult/infant formula, achieving successful three-dimensional chromatographic separation with optimized separation space and mass spectrometry methods.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Agricultural Engineering
Juana Rozalen, M. Mercedes Garcia, Amaya Zalacain, Horacio Lopez-Corcoles, Jorge Hurtado de Mendoza, Katrina Cornish, Manuel Carmona
Summary: Guayule, as a promising renewable source of natural rubber/latex, has resins with various activities potentially related to sesquiterpenes. By exploring different analytical methods, it was found that there may be new members of the guayulins family and the relationship in seasonal changes was identified.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Analytical
Ernesto de Jesus Zapata Flores, Nguyen Kim Ngan Bui, Sigrid Selberg, Koit Herodes, Ivo Leito
Summary: This study proposes derivatization reagents based on azobenzene, AzoB and AzoC, for LC-ESI-MS analysis of free amino acids in fermented beverages and juices. The results show that AzoB can be used for targeted and non-targeted analysis, while AzoC has advantages such as fast reaction and good reactivity with secondary amines but is affected by side products for quantitation.
Article
Chemistry, Multidisciplinary
Chunqing Fu, Keyu Zhang, Manyuan Wang, Feng Qiu
Summary: This study developed a method for analyzing the active components of Artemisia annua extract in rat plasma. The absorption, metabolism, and impact on drug metabolism of different components were investigated. The results provide a foundation for understanding the mechanism of action of Artemisia annua in the body.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Agricultural Engineering
Sainan Ma, Ruchang Hu, Jieyu Ma, Jinwan Fan, Feifei Wu, Yang Wang, Linkai Huang, Guangyan Feng, Dandan Li, Gang Nie, Xinquan Zhang
Summary: Anthocyanin and proanthocyanidin are natural plant products beneficial to human and livestock health. Comparative transcriptomics and metabolomics analyses revealed differentially expressed genes and potential metabolites involved in anthocyanin and proanthocyanidin biosynthesis in white clovers. The findings provide a molecular genetic basis for future validation of candidate genes and breeding of high-proanthocyanidin white clover cultivars.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Applied
Marie Bagge Jensen, Petra Loznjak Svarc, Jette Jakobsen
Summary: Growing evidence of the importance of vitamin K in human health beyond blood coagulation and bone health necessitates further research. A method for extraction, lipase treatment, clean-up, and detection and quantification of various forms of vitamin K was developed and validated in a single laboratory. Deuterium labelled MK-7 can be used as an internal standard for MK-9, showing the potential for accurate quantification.
Article
Plant Sciences
Muqeet Wahid, Fatima Saqib
Summary: This study used network pharmacology and molecular docking techniques to investigate the multi-target mechanism of watermelon seeds against asthma and diarrhea, and confirmed its antispasmodic and bronchodilator abilities through biological tests.
Article
Pharmacology & Pharmacy
Kohei Kawabata, Miya Kohashi, Shiori Akimoto, Hiroyuki Nishi
Summary: In this study, the photostability of felodipine (FL) medicine and its altered forms was evaluated. The residual amounts of FL after 24 h of UV irradiation were measured and two photoproducts were identified. The chemical structures of the photoproducts were determined using mass spectrometry analysis. The generation rates of the photoproducts were found to be dependent on the presence of aqueous media.
Article
Food Science & Technology
Yufeng Zhou, Yuanxiao Cao, Jiaxun Li, Osman Tuncay Agar, Colin Barrow, Frank Dunshea, Hafiz A. R. Suleria
Summary: In this study, different parts (pulp, peel, and seed) of two varieties of papaya (yellow-and red-fleshed) at different stages of ripeness (unripe and ripe) were characterized for their phenolic compounds using LC-ESI-QTOF-MS/MS. The results showed that yellow-fleshed unripe papaya seed had the highest total phenolic content, red-fleshed ripe papaya peel exhibited the highest level of total tannin content, while red-fleshed unripe peel had the highest total flavonoid content. The experiment also identified 118 phenolic compounds in total, indicating that all parts of the papaya fruit are potential sources of phenolic compounds, especially the peel.
Article
Horticulture
Anjali Rai, Khushboo Kumari, Sung Soo Han
Summary: Victoria Amazonica is a plant with ornamental, medicinal, and functional food value. Polyphenols are bioactive compounds abundant in this plant and have been studied using high-performance liquid chromatography coupled with electrospray ionization mass spectrometry. More than 108 phenolic substances were identified, of which 101 compounds have never been documented before in V. Amazonica. The plant parts showed potential utilization in the food, cosmetics, and pharmaceutical industries due to its high antioxidant activity and phenolic content.
SCIENTIA HORTICULTURAE
(2023)
Article
Pharmacology & Pharmacy
Ying Xia, Jia-Yi Long, Meng-Yuan Shen, Na Dong, Hong-Li Guo, Ya-Hui Hu, Xiao-Peng Lu, Xuan-Sheng Ding, Feng Chen, Jin-Chun Qiu
Summary: The study compared the accuracy of two methods, EMIT assay and LC-ESI-MS/MS, in measuring plasma VPA concentrations for pediatric patients with epilepsy. Results showed a significant correlation between the two methods but with EMIT assay overestimating VPA levels compared to LC-ESI-MS/MS method. Further studies are needed to confirm the optimal therapeutic range for VPA monitoring in clinical practice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Nerea Uri-Carreno, Per H. Nielsen, Krist V. Gernaey, Qian Wang, Ulla Gro Nielsen, Marta Nierychlo, Susan H. Hansen, Lisette Thomsen, Xavier Flores-Alsina
Summary: Membrane-Aerated Biofilm Reactors (MABRs) are an effective alternative for wastewater treatment plants (WWTP) with enhanced nitrogen removal capacity and reduced energy consumption. This study demonstrates the impact of oxidation-reduction potential (ORP) on the performance of MABRs, showing that low ORP conditions can hinder nitrification. By increasing ORP and replacing/cleaning membranes, nitrification rates and the abundance of nitrifying organisms were significantly improved. The study also suggests that low ORP conditions promote the reduction of iron and sulfur compounds, leading to deposition in the biofilm and inhibiting nitrifiers growth.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Computer Science, Interdisciplinary Applications
Simon B. Lindahl, Deenesh K. Babi, Krist V. Gernaey, Guerkan Sin
Summary: This paper proposes a methodology for setting up and solving integrated capacity and production planning problems. It utilizes mixed-integer linear programming problems to determine whether capacity levels should be changed. The methodology is applied to case studies from pharmaceutical manufacturing and demonstrates its ability to solve problems of industrial scale and relevance.
COMPUTERS & CHEMICAL ENGINEERING
(2023)
Article
Environmental Sciences
Xavier Flores-Alsina, Nerea Uri-Carreno, Per H. Nielsen, Krist V. Gernaey
Summary: Membrane Aerated Biofilm Reactors (MABR) are increasingly accepted in wastewater treatment processes. This study tests the prediction capabilities of an integrated modelling approach using full-scale data from a wastewater treatment plant. Results show a 10% mismatch between predictions and measurements, but the model provides valuable insights into biofilm structure and microbial activity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Morteza Zadkarami, Ali Akbar Safavi, Krist V. Gernaey, Pedram Ramin, Oscar A. Prado-Rubio
Summary: In recent years, water reclaim has become more relevant due to population increase and the number of industrial sites. Dynamic membrane filtration systems play an important role in water reuse. However, process monitoring of these systems is challenging due to intentional disturbances and input fluctuations, making fault detection and optimal operation difficult. This study presents a fault detection framework using classification methods applied to a pilot-scale dynamic ultrafiltration process. The results show that the Multilayer Perceptron Neural Network classifier has the highest detection accuracy and low false alarms. This framework is significant for digitalization and automated surveillance strategies for membrane system monitoring.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
Review
Engineering, Environmental
Yiqi Liu, Pedram Ramin, Xavier Flores-Alsina, Krist. Gernaey
Summary: Recent advances in AI and DA offer opportunities for fault management and decision-making in urban wastewater treatment systems (UWS). However, the complexity and size of UWS, variations in instrumentation, and poor data quality pose challenges for AI and DA applications. This review critically analyzes previous work on AI-based data-driven methodologies for system-wide fault detection and management, addressing process and instrumentation faults, and explores the interplay among UWS, data, and AI. It provides insights into the strengths and weaknesses of different approaches and discusses opportunities and challenges.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
Article
Biotechnology & Applied Microbiology
Gisela Nadal-Rey, John M. Kavanagh, Benny Cassells, Sjef Cornelissen, David F. Fletcher, Krist V. Gernaey, Dale D. McClure
Summary: This study used the particle lifeline approach to quantify the effect of reactor design on industrial organisms. The results showed that cells in the stirred tank reactor experienced longer fluctuations of starvation and overflow metabolism compared to those in the bubble column, due to differences in mixing between the two designs. These findings are important for optimizing large-scale reactor designs and developing scale down systems.
BIOCHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Nikolaus I. Vollmer, Carina L. Gargalo, Krist V. Gernaey, Stig I. Olsen, Guerkan Sin
Summary: This study conducted a detailed life cycle assessment of an integrated xylitol biorefinery that utilizes wheat straw as feedstock. Through optimization and techno-economic analysis, the environmental impacts of the biorefinery were evaluated and compared to the current chemical production processes of xylitol. The results showed lower impacts compared to standard chemical production but slightly higher impacts compared to a proprietary production process.
INTERNATIONAL JOURNAL OF LIFE CYCLE ASSESSMENT
(2023)
Article
Engineering, Environmental
Sebastian O. N. Topalian, Pedram Ramin, Kasper Kjellberg, Christian Kazadi Mbamba, Damien J. Batstone, Krist V. Gernaey, Xavier Flores-Alsina
Summary: In this study, a dynamic polymer dosing strategy is developed for an industrial centrifuge system that receives highly variable rates and quality of feed solids from a wastewater treatment plant. The strategy includes data extraction, data wrangling, model development, and model analysis, using partial least squares and random forest models to predict polymer dosages. The approach has the potential to save operators a significant amount of time and improve efficiency.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Education, Scientific Disciplines
Fiammetta Caccavale, Carina L. Gargalo, Krist V. Gernaey, Ulrich Kruhne
Summary: In times of educational disruption, significant advances have been made in adopting digitalization strategies. It is important for chemical engineers to be adequately educated to face the challenges of Industry 4.0 and acquire new skills. This study establishes a pedagogical framework to teach Python to chemical engineers, with courses covering topics such as chemical reaction engineering and machine learning. The students found the course to be useful and achieved practical problem-solving using Python.
EDUCATION FOR CHEMICAL ENGINEERS
(2023)
Article
Education, Scientific Disciplines
Isuru A. Udugama, Martin Atkins, Christoph Bayer, James Carson, Duygu Dikicioglu, Krist Gernaey, Jarka Glassey, Matthew Taylor, Brent R. Young
Summary: Educators in chemical engineering have a history of using digital tools for solving engineering problems, but it can be challenging to determine which tool is best for teaching specific concepts. A survey of department heads and committee members in IChemE institutions found that Microsoft Excel (VBA), commercial simulators, and scripting tools were ideal for teaching core subjects, while 3D models and Virtual/Augmented Reality were suited for teaching process design, safety, and sustainability. Non-technical factors such as simplicity, maintenance, and cost also play a role in tool adoption.
EDUCATION FOR CHEMICAL ENGINEERS
(2023)
Proceedings Paper
Automation & Control Systems
Marcus Krogh Nielsen, Jens Dynesen, Jess Dragheim, Ib Christensen, Sten Bay Jorgensen, Jakob Kjobsted Huusom, Krist V. Gernaey, John Bagterp Jorgensen
Summary: In this paper, a novel kinetic growth model for Methylococcus capsulatus (Bath) is presented, which incorporates growth and pH coupling. The model is applied to a laboratory-scale continuous stirred tank reactor for single-cell protein production. The simulation method ensures non-negativity in state and algebraic variables, and introduces linear scaling for numerical stability. A numerical experiment of economic optimal control for single-cell protein production is conducted, demonstrating non-trivial input profiles for biomass growth and pH tracking.
2023 EUROPEAN CONTROL CONFERENCE, ECC
(2023)
Article
Chemistry, Analytical
Isabella Jul-Jorgensen, Krist V. Gernaey, Christian A. Hundahl
Summary: Cleaning Validation is a critical process in pharmaceutical manufacturing, ensuring that cross-contamination levels remain within acceptable limits. The recent development of handheld Fourier-Transform IR (FTIR) spectroscopy provides a feasible solution for real-time release in pharmaceutical manufacturing plants. This paper addresses the challenges of model development for multi-product plants without complete traceability, utilizing a partial least squares discriminant analysis model based on total organic carbon (TOC) measurements to determine cleanliness. The model is tested on artificial samples printed with a chemical printer for multiple products, incorporating different surface roughness spectra, and evaluated based on sensitivity, specificity, and class error.
Review
Environmental Sciences
Elham Ramin, Lourenco Faria, Carina L. Gargalo, Pedram Ramin, Xavier Flores-Alsina, Maj M. Andersen, Krist V. Gernaey
Summary: This study presents the first global review of water innovation practices in industrial symbiosis cases, proposing six categories of practices and highlighting regional variations and knowledge gaps, emphasizing the need for further research.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2024)
Article
Computer Science, Interdisciplinary Applications
Carina L. Gargalo, Haoshui Yu, Nikolaus Vollmer, Ahmad Arabkoohsar, Krist Gernaey, Guerkan Sin
Summary: With the increasing concern for climate change, renewable and sustainable energy production has attracted considerable attention. Life cycle assessment (LCA) is an effective tool for comparing environmental impacts. However, there are differences in the choice of LCA methods, detail sharing, and sensitivity analysis among different studies, making it difficult to compare results.
COMPUTERS & CHEMICAL ENGINEERING
(2024)
Article
Engineering, Chemical
Jesper Frandsen, Jakob K. Huusom, Krist V. Gernaey, Jens Abildskov
Summary: This paper presents a method for the design and verification of isocratic and gradient simulated moving bed (SMB) chromatography based on the triangle theory. The method is applicable to a wide range of isotherms and multicomponent systems, and explores the influence of modifier concentrations on gradient SMB performance.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)