Article
Chemistry, Multidisciplinary
Luiza Izabela Jinga, Gianina Popescu-Pelin, Gabriel Socol, Sorin Mocanu, Madalina Tudose, Daniela C. Culita, Andrei Kuncser, Petre Ionita
Summary: In this study, gold nanoparticles were deposited on titanium dioxide nanoparticles and the material was found to effectively degrade methylene blue dye in the presence of hydrogen peroxide. Longer exposure time and higher oxidant content led to up to 90% degradation of the dye. The material showed promising reusability without loss of activity.
Article
Chemistry, Analytical
Xiaoyan Yang, Rong Huang, Lulu Xiong, Feng Chen, Wei Sun, Ling Yu
Summary: A novel colorimetric aptasensor was developed to detect ochratoxin A (OTA) by utilizing charge effect-assisted silver enhancement. Gold nanoparticles (AuNPs) were used as carriers of aptamers tagged with a positively charged tetramethylrhodamine (TAMRA), which catalyzed silver reduction and deposition. The TAMRA attracted and retained the silver lactate around the AuNPs due to the attraction between positive and negative charges, increasing the chance of AuNP-catalyzed silver reduction. The charge effect-assisted silver enhancement was confirmed by tagging aptamers of different base pair lengths with TAMRA. The as-prepared OTA aptasensor exhibited a working range of 1 x 10(2)-1 x 10(6) pg mL(-1) and a detection limit of 28.18 pg mL(-1). It was successfully applied to determine OTA in actual samples with satisfactory results.
Article
Food Science & Technology
Shraddha Rahi, Vikram Lanjekar, Vandana Ghormade
Summary: In this study, a rapid and user-friendly dot-blot assay for the detection of ochratoxin A was developed using peptide conjugated gold nanoparticles as a detection agent. The assay exhibited high binding affinity towards ochratoxin A and had a low limit of detection. The dot-blot assay showed comparable results with the conventional high performance liquid chromatography in the detection of ochratoxin A in wheat samples. This portable and easy-to-use assay has the potential for application at different stages of food production and distribution to ensure safe and healthy food.
Article
Spectroscopy
Xiaolong Zheng, Yanan Zhao, Yan Zhang, Yuanhua Zhu, Junxiang Zhang, Die Xu, Hualin Yang, Yu Zhou
Summary: In this study, a feasible, sensitive, and selective fluorescence method was developed for the detection of OTA. The method utilized alkaline phosphatase-triggered gold nanoclusters as a fluorescent probe, and showed good linearity and low detection limit.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Chemistry, Analytical
Wang Chen, Xingping Zhang, Qian Zhang, Guohao Zhang, Shixiang Wu, Hualin Yang, Yu Zhou
Summary: A dual-readout immunoassay based on Ce4+ oxidizing TMB and Ce3+ inducing AIE of AuNCs was developed for the detection of OTA in corn samples. The LODs were as low as 0.62 ng/mL for fluorescent assay and 0.81 ng/mL for colorimetric assay, with the recoveries of OTA ranging from 94.4% to 107.7% in the fluorescent mode and 93.7% to 106.9% in the colorimetric mode.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Applied
Yiwen Wang, Longyingzi Xie, Lanrui Ma, Qi Wu, Zhixia Li, Yanlin Liu, Qiyang Zhao, Yaohai Zhang, Bining Jiao, Yue He
Summary: Currently, developing efficient mycotoxins detection methods, especially using portable devices for readout, is challenging. In this study, a photothermal enzyme-linked immunosorbent assay (ELISA) based on gold nanostars (AuNSs) was proposed for the first time to detect ochratoxin A (OTA) using a thermometer. AuNSs with photothermal conversion capacity were prepared using an ascorbic acid (AA)-mediated in situ growth method. Quantification was achieved by converting OTA concentration to the amount of in situ synthesized AuNSs and readout was straightforward through temperature. With a tyramine signal amplification strategy, a detection limit of 0.39 ng mL-1 and satisfactory recoveries in grape juice and maize samples spiked with OTA were obtained. This method shows great potential for on-site OTA detection in food safety.
Article
Biochemistry & Molecular Biology
Maria Fuentes-Baile, Elizabeth Perez-Valenciano, Pilar Garcia-Morales, Camino de Juan Romero, Daniel Bello-Gil, Victor M. Barbera, Alvaro Rodriguez-Lescure, Jesus M. Sanz, Cristina Alenda, Miguel Saceda
Summary: CLytA-DAAO immobilized in magnetic nanoparticles increases enzyme stability and prolongs action time. The gradual generation of reactive oxygen species by CLytA-DAAO is more effective in inducing cytotoxicity compared to direct addition of H2O2. Preliminary studies suggest that CLytA-DAAO immobilized in magnetic nanoparticles could be an effective anti-cancer therapy for pancreatic and colorectal carcinoma and glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Xiaoyuan Ji, Qian Lu, Xuhao Sun, Liyun Zhao, Yuhan Zhang, Jinshui Yao, Xian Zhang, Hui Zhao
Summary: As a nanozyme, Au@PNIPAm nanoparticles exhibit advantages such as stable structure, adjustable catalytic activity, multifunctionality, and recyclability. They show high affinity for 3,3,5,5-tetramethylbenzidine (TMB), hydrogen peroxide (H2O2), and glucose, and can be used for the detection of H2O2 or glucose. Additionally, Au@PNIPAm nanozymes have the ability to decompose intracellular H2O2 and protect cells from oxidative stress damage.
Article
Chemistry, Applied
Liangwen Hao, Jing Chen, Xirui Chen, Tongtong Ma, Xiaoxia Cai, Hong Duan, Yuankui Leng, Xiaolin Huang, Yonghua Xiong
Summary: A novel bifunctional magneto-gold nanohybrid was integrated into lateral flow immunoassay for simultaneous magnetic separation and colorimetric target sensing, achieving ultrasensitive detection of ochratoxin A in grape juice. The method demonstrated excellent selectivity and comparability to liquid chromatography coupled with mass spectrometry, and is readily extendable to other small molecule detection in food samples.
Article
Chemistry, Multidisciplinary
Hao Fang, Yaofeng Zhou, Yanbing Ma, Qi Chen, Weipeng Tong, Shengnan Zhan, Qian Guo, Yonghua Xiong, Ben Zhong Tang, Xiaolin Huang
Summary: This study presents a highly sensitive quantitative detection strategy for low-abundance target analytes by utilizing the synergistic combination of M13 phage-mediated leverage effect and GISG-amplified light scattering signal modulation. The strategy achieves ultrasensitive and rapid quantification of target analytes and displays about 4 orders of magnitude enhancement in sensitivity compared to traditional methods.
Article
Chemistry, Analytical
Hongshuai Zhu, Chuanhe Liu, Xinxin Liu, Zhu Quan, Weipeng Liu, Yingju Liu
Summary: A multi-colorimetric immunosensor based on the mimetic enzyme etching of gold nanobipyramids was established to detect ochratoxin A. The method showed high sensitivity and specificity, indicating its potential for OTA detection in real samples.
Article
Chemistry, Analytical
Jie Zhang, Yuheng Lu, Wei Gao, Peng Yang, Nansheng Cheng, Yanwen Jin, Junbo Chen
Summary: In this study, a recognition-triggered structure switching-based element spectrometric assay was developed for ultrasensitive and highly specific detection of Ochratoxin A (OTA). The OTA aptamer was used to form a locked hairpin primer, which was then attached to magnetic beads. Upon binding of OTA to its aptamer, the primer was released, allowing for spontaneous structure-switching. Rolling circle amplification was used to produce repeated sequences by designing a dumbbell structure template. A DNA-AuNP tag was prepared to hybridize with the repeated sequences, enabling the formation of a detectable signal. This method allows for amplified detection of OTA at femtomolar concentrations and has potential applications in food safety inspection.
MICROCHEMICAL JOURNAL
(2023)
Article
Food Science & Technology
Magdalena Cuciureanu, Cristina Tuchilus, Anca Vartolomei, Bogdan Ionel Tamba, Lorena Filip
Summary: Ochratoxins, known for their nephrotoxicity, hepatotoxicity, and carcinogenicity, contaminate plant and animal foods, reaching body fluids upon ingestion. A validated competitive direct enzyme immunoassay method was used to determine ochratoxin A in colostrum and cow's milk, showing linearity and high recovery. This method is recommended for detecting micro-pollutants in foods and biological fluids.
Review
Chemistry, Analytical
Xiaoqian Tang, Jiasi Zuo, Cheng Yang, Jun Jiang, Qi Zhang, Jianfeng Ping, Peiwu Li
Summary: Biotoxins, including mycotoxins, marine toxins, and bacterial food toxins, pose significant threats in various fields such as food, feed, seafood, and medicine due to their potential harmful effects on humans. The increased consumption of fast food and prepared food without considering associated toxins is a critical issue. Therefore, the development of effective methods for monitoring biotoxins is crucial. In recent years, biosensors have been widely used for biotoxin detection due to their simplicity, quick detection procedure, low cost, and other advantages. This study provides a comprehensive overview of the application of biosensors in biotoxin detection, focusing on optical, electrochemical, piezoelectric, and photothermal applications. Additionally, the integration of different detection platforms as multimodal combination biosensors is discussed to meet the demand for highly accurate technologies. Major challenges faced by biosensors are examined, and novel insights for improving food safety technology are provided.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Haruki Inoue, Shin-ichi Naya, Atsunobu Akita, Hisashi Sugime, Hiroaki Tada
Summary: Gold nanoparticles of different sizes were formed on antimony-doped tin oxide nanocrystals using temperature-varied deposition-precipitation method. These nanoparticles showed strong absorption in the near-infrared region and exhibited thermally activated catalytic activity for a specific oxidation reaction.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Analytical
Hong Duan, Xirui Chen, Yuhao Wu, Yuankui Leng, Xiaolin Huang, Yonghua Xiong
Summary: This study demonstrates that controlling the size of nanobeads within a certain range can enhance the sensitivity of sandwich immunochromatographic assay, and selecting a membrane aperture that matches the nanobead size can also help improve detection efficiency.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Juan Li, Xiaolin Huang, Xu Zhao, Li-Jian Chen, Xiu-Ping Yan
Summary: In this study, green-emitting Zn2GeO4:Mn2+,Pr3+ nanoparticles were synthesized via a one-pot hydrothermal method, showing regular shape, uniform size, and good afterglow luminescent performance. The pH stimuli-responsive luminescent behavior and possible mechanism of these nanoparticles were explored. Leveraging the pH-responsive persistent luminescence, they were used as autofluorescence-free probes for biosensing and high-level information encryption.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Rui Chen, Xirui Chen, Yaofeng Zhou, Tong Lin, Yuankui Leng, Xiaolin Huang, Yonghua Xiong
Summary: A three-in-one multifunctional catalytic colorimetric nanohybrid was developed as promising signal reporters for ultrasensitive immunochromatographic disease diagnostics.
Article
Chemistry, Multidisciplinary
Jing Chen, Liangwen Hao, Jiaqi Hu, Kang Zhu, Yu Li, Sicheng Xiong, Xiaolin Huang, Yonghua Xiong, Ben Zhong Tang
Summary: A universal boronate-affinity crosslinking-amplified DLS immunoassay was developed for point-of-care glycoprotein detection, achieving ultrasensitive and rapid quantitative assay within 15 minutes. This approach combines antibody-coated magnetic nanoparticles for target capture and DLS signal transduction with phenylboronic acid-based boronate-affinity materials as crosslinking amplifiers, making it a promising strategy for extending DLS technique to detect glycoproteins even in challenging environments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Analytical
Tong Lin, Xiaolin Huang, Liang Guo, Shu Zhou, Xiangmin Li, Yuanjie Liu, Jing Hu, Xirui Chen, Yonghua Xiong
Summary: The study presents a novel method for preparing immunoprobes that improves antibody orientation and biological activity, resulting in significant enhancement in lateral flow immunoassay performance.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Bao Gao, Tongtong Ma, Lin Feng, Xiaolin Huang, Xuelan Chen, Yonghua Xiong
Summary: In this study, a novel immunosensor using the light scattering intensity of silver and gold alloy as a signal transducer was developed to enhance the sensitivity and linearity for quantitative detection of Cronobacter muytjensii. The developed method showed high sensitivity with a low detection limit, wide dynamic range, and acceptable accuracy for quantitative detection of C. muytjensii in real PIF samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Medicine, Research & Experimental
Xirui Chen, Lu Ding, Xiaolin Huang, Yonghua Xiong
Summary: This article introduces the application of engineered noble metal nanoparticles in improving immunoassay sensitivity. By modulating the physical parameters of nanoparticles, including size, shape, composition, and external structure, the performance of immunoassay can be improved. Engineered nanoparticles have a wide range of applications in trace analysis.
Article
Biotechnology & Applied Microbiology
Jiaqi Hu, Lu Ding, Jing Chen, Jinhua Fu, Kang Zhu, Qian Guo, Xiaolin Huang, Yonghua Xiong
Summary: A new dynamic light scattering (DLS) immunosensing technology was reported for rapid and sensitive detection of NT-proBNP. Boronate affinity recognition was used to amplify nanoparticle aggregation for highly sensitive DLS transduction. The developed DLS immunosensor showed ultrahigh sensitivity, fast response time, and small sample consumption.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biophysics
Kang Zhu, Jing Chen, Jiaqi Hu, Sicheng Xiong, Lifeng Zeng, Xiaolin Huang, Yonghua Xiong
Summary: This study introduces an innovative BAR-enhanced DLS biosensor for ultra-sensitive PCT detection, showing high sensitivity and specificity. The sensor offers quick total detection time, low sample consumption, and applicability for a broader range of patients and urgent cases.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Food Science & Technology
Xujing Guo, Xirui Chen, Rui Chen, Yujie Tu, Tianying Lu, Yuqian Guo, Liang Guo, Yonghua Xiong, Xiaolin Huang, Ben Zhong Tang
Summary: In this study, a paper-based smart sensing chip was developed for real-time monitoring of food freshness. By detecting color and fluorescence changes, ammonia vapors can be sensitively detected, demonstrating the feasibility of the paper chip for evaluating food spoilage degree.
Article
Food Science & Technology
Weipeng Tong, Hanpeng Xiong, Hao Fang, Yuhao Wu, Haichuan Li, Xiaolin Huang, Yuankui Leng, Yonghua Xiong
Summary: In order to achieve high-throughput analysis of mycotoxins, there is a great need for point-of-care (POC) methods that do not require expensive instruments or specialized technicians. The conventional enzyme-linked immunosorbent assay (ELISA), which is widely used for screening, has low sensitivity and is affected by competing antigens. In this study, we developed a plasmonic-photothermal ELISA that uses color-temperature dual-modal signals for highly sensitive detection of ochratoxin A (OTA), with the signal amplified by a bifunctional M13 phage. Under optimal conditions, the colorimetric and photothermal signals showed good dynamic linearity for quantitative OTA detection, with detection limits of 12.1 and 8.6 pg mL(-1), respectively. Additionally, the proposed ELISA could be visually determined with a cutoff limit of 78 pg mL(-1) based on a distinct color change from deep blue to red. The method also showed high accuracy and robustness when applied to OTA-spiked corn samples. Overall, this strategy provides a promising method for eco-friendly and sensitive POC screening of OTA, and can be easily adapted for other analytes by changing the specific mimotope sequence.
Article
Food Science & Technology
Hanpeng Xiong, Ping Chen, Xirui Chen, Xuanang Shen, Xiaolin Huang, Yonghua Xiong, Yu Su
Summary: In this study, a novel aggregation-induced emission (AIE)-based sandwich lateral flow immunoassay (LFIA) was introduced for the sensitive detection of Staphylococcal enterotoxin A (SEA) using red-emissive AIE nanoparticles (AIENPs) as the fluorescent nanoprobe. The ultrasensitive detection of SEA in pasteurised milk was achieved within 20 min with a limit of detection of 0.04 ng mL(-1). The proposed PBA-AIENP-LFIA platform shows promise as a potent tool for the identification of additional compounds in food samples as well as an ideal test method for on-site detections.
Article
Food Science & Technology
Ge Xu, Xiaojing Fan, Xirui Chen, Zilong Liu, Guoxin Chen, Xiaxia Wei, Xiangmin Li, Yuankui Leng, Yonghua Xiong, Xiaolin Huang
Summary: In this study, ultrabright fluorescent microbeads (AIEMBs) were developed by encapsulating a green-emitting fluorophore with aggregation-induced emission (AIE) characteristic in polymer nanoparticles. The AIEMBs were then used as signal reporters in a competitive LFIA for the highly sensitive screening of fumonisin B1 (FB1) in corn samples. The AIE-LFIA demonstrated high sensitivity, excellent selectivity, good accuracy, and high reliability, indicating a promising platform for FB1 screening.
Article
Chemistry, Analytical
Wenchao Zhan, Yu Su, Xirui Chen, Hanpeng Xiong, Xiaxia Wei, Xiaolin Huang, Yonghua Xiong
Summary: A hydrogel probe encapsulating aggregation-induced emission luminogen (AIEgen) was developed for ultrasensitive detection of Hg2+, with improved sensitivity through the use of hydrophilic hydrogels and spatial networks. The probe exhibited high specificity, accuracy and precision in detecting Hg2+ in real-world water samples, with a sensitivity 4-fold higher than that of pure AIEgen probes. This TR hydrogel-based chemosensor holds promising potential as a robust, fast and effective platform for sensitive Hg2+ detection.
Article
Medicine, Research & Experimental
Hong Duan, Tongtong Ma, Xiaolin Huang, Bao Gao, Lingyan Zheng, Xirui Chen, Yonghua Xiong, Xiaoyuan Chen
Summary: This study presents a pH-regulated gold in situ growth (GISG) strategy to amplify the colorimetric signal and improve the performance of traditional gold nanoparticle-based immunochromatographic assay (AuNP-ICA). By lowering the pH of the growth solution, the reducibility of hydroxylamine is weakened, resulting in the crystallization and growth of Au3+ on the AuNP surface instead of self-nucleation. The proposed GISG strategy shows improved sensitivity, low background, robust operation, and good reproducibility. It has the potential to enable ultrasensitive and rapid diagnosis of viral infections and redefine immunochromatographic diagnostics.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
