Article
Agriculture, Multidisciplinary
Jialong Sun, Wei Li, Xuerui Zhu, Saisai Jiao, Yunwei Chang, Siwei Wang, Shijie Dai, Ruimin Xu, Menghua Dou, Qianjin Li, Jianlin Li
Summary: A novel multiplex mycotoxin surface-enhanced Raman spectroscopy (SERS) immunoassay was established using antigen-modified silica photonic crystal microspheres (SPCMs) and gold nanoparticles (AuNPs) for multiplex detection with high sensitivity and good recovery rates. The method exhibited high specificity and repeatability, while overcoming the drawbacks of fluorescence and chemiluminescence background signals.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Analytical
Ruipeng Chen, Shuang Li, Yunfeng Sun, Bingyang Huo, Yating Xia, Yingkai Qin, Shuning Li, Baodi Shi, Defu He, Jun Liang, Zhixian Gao
Summary: The study describes the design and fabrication of a SERS aptasensor for simultaneous detection of ZEN and OTA in wheat and corn samples, achieving good detection performance with a wide linear range and low detection limits.
Article
Chemistry, Analytical
Di Liu, Huimin Gao, Wenji Jiang, Su Yan, Hao Liu, Junjie Chen, Sisi Wen, Wei Zhang, Xu Wang, Bing Zhao, Wei Song
Summary: In this study, three-dimensional Ag aerogel-supported Hg single-atom catalysts were used as an efficient SERS substrate for monitoring enhanced oxidase-like reactions. The effect of Hg2+ concentrations on the SERS properties of 3D Hg/Ag aerogel networks was investigated, and an optimized addition of Hg2+ resulted in specific enhancement. The formation of Ag-supported Hg SACs was confirmed using HAADF-STEM imaging and XPS measurement, and the oxidase-like catalytic mechanism of Hg/Ag SACs was revealed using DFT. This research provides a mild synthetic strategy for fabricating Ag aerogel-supported Hg single atoms with promising prospects in various catalytic fields.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Hai -Ling Liu, Kan Zhan, Kang Wang, Xing-Hua Xia
Summary: Scientists have successfully combined surface-enhanced Raman scattering (SERS) with nanopore technologies to improve the accuracy of single-molecule detection. This review summarizes the recent advances in SERS combined with nanopore techniques, including the mechanism and fabrication methods of SERS substrates, as well as the applications and future prospects of this approach.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Ramlah Khamis, Karthik B. Shanmugasundaram, Quan Zhou, Jennifer Lu, Zhen Zhang, Michelle M. Hill, Abu Ali Ibn Sina, Matt Trau, Alain Wuethrich
Summary: Endoscopy and tissue biopsy are the standard methods for diagnosing esophageal adenocarcinoma, but they are invasive and not suitable for population screening. In this study, a surface-enhanced Raman scattering lectin-immunoassay was developed to accurately measure serum levels of specific proteins. The results suggest that this method could be a promising liquid biopsy platform for screening esophageal adenocarcinoma.
ACS APPLIED NANO MATERIALS
(2023)
Review
Engineering, Environmental
Saowalak Adunphatcharaphon, Christopher T. Elliott, Thanasat Sooksimuang, Ratthaphol Charlermroj, Awanwee Petchkongkaew, Nitsara Karoonuthaisiri
Summary: Mycotoxins pose serious threats to public health, the economy, and the environment. The co-contamination of multiple hazardous mycotoxins in commodities and the environment adds complexity to the problem. This review discusses emerging rapid immuno-based multiplex methods for detecting mycotoxins in agricultural products and feed ingredients published within the past five years, including lateral flow, fluorescence polarization, chemiluminescence, surface plasmon resonance, surface enhanced Raman scattering, electrochemical sensor, and nanoarray. The future trend of detection methods for multiple mycotoxins is predicted to rely on advancements in sensor technologies, nanomaterial-based enhancing and reporting signals, rapid sample preparation, and quantitative analysis capacity.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Eun Hye Koh, Won-Chul Lee, Yeong-Jin Choi, Joung-Il Moon, Jinah Jang, Sung-Gyu Park, Jaebum Choo, Dong-Ho Kim, Ho Sang Jung
Summary: A wearable SERS sensor has been developed for molecular sweat sensing, with the capability of measuring Raman signals without detachment from the skin. Through a multi-layer design, the sensor can absorb sweat, protect the skin, enhance signal, and has great potential for drug detection applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Engineering, Electrical & Electronic
Nguyen Tran Truc Phuong, Le Hong Tho, Tan Tai Nguyen, Nguyen Nhat Nam, Kieu The Loan Trinh
Summary: Mxenes, a type of two-dimensional transition metal carbides, nitrides, and carbonitrides, exhibit excellent properties such as large specific surface area and good electrical conductivity. Recent studies have shown that Mxenes have great potential in optical sensing technology, particularly in surface plasmon resonance (SPR) sensors. This review presents the latest advances in 2D MXenes and their composites for SPR/LSPR-based sensing, covering fabrication methods, properties, and potential applications in optical sensing systems.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Spectroscopy
Jiang Wang, Hua Xu, Li Luo, Nannan Li, Chunxia Qiao, Jianfeng Wu, Lei Guo, Jianwei Xie
Summary: This study presents a reliable sandwich immunoassay based on surface-enhanced Raman scattering for the detection and differentiation of active ricin protein. The method has the potential to be applied in the timely response of ricin-related risk assessment in terrorist events and human intoxication.
JOURNAL OF RAMAN SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Jin Wang, Zheng Tan, Chengcheng Zhu, Li Xu, Xing-Hua Xia, Chen Wang
Summary: A size-controlled Au@Cu-BTC nanomaterial was synthesized for specific and simultaneous imaging of multiple protein expression levels on cell membranes. The nanoprobes showed good specificity, stability, and multichannel imaging capabilities. This nanomaterial holds promising applications in biosensing and therapeutic fields, enabling simultaneous detection of varied proteins on cell surfaces with high sensitivity and accuracy.
Article
Chemistry, Physical
Xiao Liang, Pu Zhang, Minghai Ma, Tao Yang, Xiangwei Zhao, Rui Zhang, Minxuan Jing, Rundong Song, Lei Wang, Jinhai Fan
Summary: A ratiometric SERS assay was developed for non-invasive detection of bladder tumor, showing excellent stability, high sensitivity, high specificity, and potential for clinical diagnosis with superior results compared to current methods.
Article
Chemistry, Physical
Puran Pandey, Siela Vongphachanh, Jongwon Yoon, Bokyoung Kim, Chel-Jong Choi, Jung Inn Sohn, Woong-Ki Hong
Summary: This study demonstrated the use of AgNWNF-coated stretchable PDMS substrates as SERS sensors with strong effects. The adhesion strength of AgNWNEs on UVO-treated PDMS substrates was significantly stronger than that of AgNWNFs on untreated PDMS.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Multidisciplinary
Younju Joung, Kihyun Kim, Seungwoo Lee, Byung-Seon Chun, Sangyeop Lee, Joonki Hwang, Suji Choi, Taejoon Kang, Mi-Kyung Lee, Lingxin Chen, Jaebum Choo
Summary: This study developed a portable surface-enhanced Raman scattering (SERS)-LFA reader based on localized surface plasmon effects to improve the detection sensitivity of commercial LFA strips. Testing 54 clinical samples, the SERS-LFA reader demonstrated a significantly reduced false-negative rate compared to commercial LFA strips.
Review
Chemistry, Analytical
Vahid Eskandari, Saeideh Mehmandoust, Zahra Farahani, Negin Poorbeik Mohammad, Amin Hadi
Summary: The special features of liposome-based drug delivery systems have proven useful in overcoming biological and pharmacodynamic challenges. Liposomes, especially those used for targeted drug delivery to pathological tissues, are considered the simplest mimic of biological cells in medicine, attracting the attention of many researchers. Surface-enhanced Raman scattering (SERS) offers nondestructive analysis and high detection sensitivity, making it ideal for single molecular detection. This study reviews recent literature on SERS-based biosensors for enhancing diagnostic and therapeutic platforms, drug delivery systems, and pharmaceutical applications, aiming to aid researchers in making more advanced and successful systems in this sensitive and important field.
VIBRATIONAL SPECTROSCOPY
(2023)
Article
Engineering, Electrical & Electronic
Nguyen La Ngoc Tran, Bach Thang Phan, Hanh Kieu Thi Ta, Tran Thi Kim Chi, Bui Thi Thu Hien, Nguyen Tran Truc Phuong, Chi Cuong Nguyen, Tan Le Hoang Doan, Nhu Hoa Thi Tran
Summary: This study successfully synthesized and utilized Au NPs/IRMOF-3 material for Raman signal enhancement. By combining localized surface plasmon resonance and porous structure, the nanosensor showed high sensitivity and stability.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)