Article
Chemistry, Physical
Xiaoying Wu, Xiaoli Tian, Zihe Jiang, Yun Wang, Tingting Jiang, Yuhua Feng, Zhenglong Zhang, Hongyu Chen
Summary: By controlling the interfacial energy between Au seeds and deposited Au, non-wetting growth of Au on Au seeds results in the formation of homometallic core-satellite nanostructures. The plasmonic coupling between the core and satellites can be modulated by varying the growth kinetics, allowing for tuning of the plasmonic absorptions from visible to near-infrared range. This synthetic advance provides a new approach for nanosynthesis and opens up possibilities for sophisticated functional designs.
Article
Chemistry, Physical
Jiannan Zhu, Jing Huang, Jiawei Dai, Rong Chen, Xiaoqi Fu, Zhengyun Wang, Hongfang Liu, Guangfang Li
Summary: This study investigates the size effect of plasmonic Au@Pd core-satellite nanoparticles on the photocatalytic formic acid (FA) dehydrogenation under visible light. The results show that the smallest nanoparticles with the highest absorption/extinction ratio possess the best catalytic performance. Additionally, large nanoparticles with high scattering exhibit unexpectedly enhanced activities by raising the reaction temperature or shortening the interparticle distance.
ACS APPLIED ENERGY MATERIALS
(2022)
Review
Biochemical Research Methods
Patrick Severin Sfragano, Serena Pillozzi, Gerolama Condorelli, Ilaria Palchetti
Summary: In order to address cancer-related issues, the biosensing field is constantly searching for new biomarkers that can be non-invasively analyzed. Extracellular vesicles (EVs) have emerged as promising biomarkers that can provide direct information on diseases. However, there is a lack of practical and effective quantitative procedures for EV detection due to difficulties in the pre-analytical and analytical phases. This review aims to provide a comprehensive overview of recent progress in EV detection using electrochemical and photoelectrochemical biosensors.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Edwin J. Ortiz-Riano, Diana L. Mancera-Zapata, Martha Ulloa-Ramirez, Fernando Arce-Vega, Eden Morales-Narvaez
Summary: Macromolecular association is important in biomedical sciences. This study presents a real-time biosensing platform using graphene oxide-modified microwell plates and fluorophore-labeled proteins to determine protein-binding constants. The platform proves to be comparable and consistent with existing methods in determining protein kinetics constants.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Siqi Gao, Renbin Zhou, Soham Samanta, Junle Qu, Tymish Y. Ohulchanskyy
Summary: This review summarizes recent progress in the development of various plasmon-enhanced luminescence (PEL)-based biosensors and bioimaging platforms for diverse biological and biomedical applications. The study evaluates the performance improvement of PEL-based biosensors in efficiently detecting biomarkers (proteins and nucleic acids) in point-of-care tests and discusses the pros and cons of recently developed PEL-based biosensing platforms on substrates or in solutions. It also includes a brief discussion on integrating PEL-based biosensing platforms into microfluidic devices as a promising multi-responsive detection method. The review presents comprehensive details about the recent advances in the development of various PEL-based multi-functional (passive targeting, active targeting, and stimuli-responsive) bioimaging probes, highlighting the scope of future improvements in devising robust PEL-based nanosystems to achieve more effective diagnostic and therapeutic insights by enabling imaging-guided therapy.
ANALYTICA CHIMICA ACTA
(2023)
Review
Chemistry, Analytical
Xiaowen Ou, Yuqi Liu, Mingxing Zhang, Li Hua, Shenshan Zhan
Summary: Plasmonic gold nanostructures, with unique optical properties and good biocompatibility, are ideal for developing methods in biosensing and bioimaging. This review summarizes the applications and techniques of biosensing and bioimaging in vitro and in vivo using plasmonic gold nanostructures.
Article
Biochemistry & Molecular Biology
Agnieszka Paziewska-Nowak, Marcin Urbanowicz, Kamila Sadowska, Dorota Genowefa Pijanowska
Summary: The paper describes the development and utility of a novel DNA oligonucleotide-based affinity bioreceptor for lactoferrin. The research investigates the affinity of different types of oligonucleotides to the target protein using surface plasmon resonance method. The selected DNA sequence showed high affinity to lactoferrin and demonstrated its potential as a bioreceptor for lactoferrin determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Xiaoqing Qian, Feng Xie, Huabing Wei, Daxiang Cui
Summary: Exosomal miRNAs are potential biomarkers for predicting gastric cancer development. This study identified differentially expressed miRNAs in serum and urine exosomes of GC patients, with specific up-regulated miRNAs identified. The interaction network of these miRNAs' targets may provide insights into molecular mechanisms of GC development.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Bingqian Lin, Jinting Jiang, Jingxuan Jia, Xiang Zhou
Summary: Liquid biopsy, as a noninvasive detection technique, plays a key role in cancer diagnosis, disease monitoring, and prognostic assessment; exosomes, as potential biomarkers, are crucial bioinformation carriers for intercellular communication; the development of sensitive, convenient, and reliable exo-miRNA assays will provide new perspectives for medical diagnosis.
Article
Cell Biology
Changan Zhao, Jiyu Miao, Ruifang Sun, Rui Liang, Wenhu Chen, Yi Gao, Xiaofei Wang, Shuiping Han, Wenbao Zhao, Ting Lei, Chen Huang
Summary: Gastric cancer (GC) is one of the major causes of cancer-related deaths worldwide, and there is a lack of specific biomarkers for early diagnosis and universally accepted therapy for advanced GC. This study found that lower levels of miR-5701 were associated with GC, and overexpression of miR-5701 inhibited GC cell proliferation and migration while promoting apoptosis. The study also identified FGFR2 as a target of miR-5701 in GC. Furthermore, experiments in mice showed that GC cells overexpressing miR-5701 had smaller tumors and fewer lung metastases. The study also revealed that MBD1 and HDAC3 directly inhibited miR-5701 expression, suggesting the potential use of exogenously administered miR-5701 or agents that elevate endogenous miR-5701 to inhibit GC and improve patient prognosis.
Article
Chemistry, Analytical
Yi-Chen Chen, Yu-Chen Chou, Jui-Han Chang, Li-Ting Chen, Chun-Jen Huang, Lai-Kwan Chau, Yen-Ling Chen
Summary: A dual-functional gold-iron oxide core-satellite hybrid nanoparticle structure is proposed as a signal reporter and preconcentrator for low abundance analytes in a nanoplasmonic biosensor, demonstrating an 18-fold improvement in limit of detection for detecting DNA compared to traditional methods. This easy-to-prepare structure shows promise for high-sensitivity and low-cost point-of-care applications.
Article
Chemistry, Multidisciplinary
Haiyang Su, Xinxing Li, Lin Huang, Jing Cao, Mengji Zhang, Vadanasundari Vedarethinam, Wen Di, Zhiqian Hu, Kun Qian
Summary: The article introduces a mesoporous PdPtAu alloy designed to characterize metabolic profiles in human blood, enabling precise diagnosis of early gastric cancer by optimizing elemental composition and surface structure.
ADVANCED MATERIALS
(2021)
Article
Green & Sustainable Science & Technology
B. B. Chen, S. Chang, M. -L Liu, J. Lv, Y. Wang, R. W. Qian, D. -W Li
Summary: Luminescent lanthanum hydroxycarbonates (LaCO3OH) with strong solid-state luminescence and highly effective solution room temperature phosphorescence were prepared. The LaCO3OH core-satellite superstructures (LaCO3OH-CSSs) showed superior photocatalytic activities and could efficiently degrade model rhodamine 6G (R6G) dyes. The phosphorescent LaCO3OH-CSSs have potential applications in water pollution treatment.
MATERIALS TODAY SUSTAINABILITY
(2023)
Article
Nanoscience & Nanotechnology
Jun Guan, Jingtian Hu, Yi Wang, Max J. H. Tan, George C. Schatz, Teri W. Odom
Summary: An ultralong-range coupling was demonstrated between photonic lattices in bilayer and multilayer moire architectures, which is mediated by dark surface lattice resonances in the vertical direction. Two-dimensional plasmonic nanoparticle lattices enable twist-angle-controlled directional lasing emission, even when the lattices are spatially separated by distances exceeding three orders of magnitude of lattice periodicity. The discovery of far-field interlattice coupling opens the possibility of using the out-of-plane dimension for optical manipulation on the nanoscale and microscale.
NATURE NANOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Seemesh Bhaskar, Naga Sai Visweswar Kambhampati, K. M. Ganesh, Mahesh P. Sharma, Venkatesh Srinivasan, Sai Sathish Ramamurthy
Summary: The study demonstrates a quest for auxiliary plasmonic materials with lossless properties by utilizing a unique plasmonic response from stratified high refractive index-graphene oxide and low refractive index-polymethyl methacrylate multistack. The platform achieved a zero-normal steering emission and directional graphene oxide plasmon-coupled emission, and showed potential for diverse biosensing applications. Experimental validation of the platform's superiority in achieving a low detection limit of human IFN-gamma was conducted, along with significant fluorescence emission enhancements on a lossless substrate using various nanoparticles, paving the way for unique light-matter interactions for next-generation plasmonic and biomedical technologies.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)